Stephan Weidinger

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint [Shiny nail, spotted nail. Beau-Reil lines. When dermatoses entrench in the nails]
    S Weidinger
    Klinik und Poliklinik fur Dermatologie und Allergologie am Biederstein, Technische Universitat Munchen
    MMW Fortschr Med 145:38-40. 2003
  2. doi request reprint Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich and ZAUM Center for Allergy and Environment, Technische Universitat Munchen, Munich, Germany
    J Allergy Clin Immunol 123:1361-70.e7. 2009
  3. ncbi request reprint Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    J Allergy Clin Immunol 118:214-9. 2006
  4. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
  5. ncbi request reprint Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008
  6. ncbi request reprint IgE-mediated allergy against human seminal plasma
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    Chem Immunol Allergy 88:128-38. 2005
  7. ncbi request reprint Association of NOD1 polymorphisms with atopic eczema and related phenotypes
    Stephan Weidinger
    The Department of Dermatology and Allergy Biederstein, Technical University, Munich, Germany
    J Allergy Clin Immunol 116:177-84. 2005
  8. ncbi request reprint Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munich, Germany
    Curr Opin Allergy Clin Immunol 10:408-17. 2010
  9. ncbi request reprint Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway
    S Weidinger
    Department of Dermatology and Allergy, Institute for Medical Statistics and Epidemiology, Technical University Munich, Germany
    Hum Reprod 20:456-61. 2005
  10. pmc Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults
    S Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Biedersteiner St 29, 80802 Munich, Germany
    J Med Genet 41:658-63. 2004

Collaborators

Detail Information

Publications35

  1. ncbi request reprint [Shiny nail, spotted nail. Beau-Reil lines. When dermatoses entrench in the nails]
    S Weidinger
    Klinik und Poliklinik fur Dermatologie und Allergologie am Biederstein, Technische Universitat Munchen
    MMW Fortschr Med 145:38-40. 2003
    ..Matrix disorders, which are often observed, may manifest as such characteristic lesions as spots, tracheonychia or Beau's lines. Treatment is determined by the respective underlying disease...
  2. doi request reprint Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich and ZAUM Center for Allergy and Environment, Technische Universitat Munchen, Munich, Germany
    J Allergy Clin Immunol 123:1361-70.e7. 2009
    ..However, published studies demonstrate differences concerning design and effect size, and conflicting results for asthma have been reported...
  3. ncbi request reprint Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    J Allergy Clin Immunol 118:214-9. 2006
    ..One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation...
  4. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Our data furthermore confirm association of STAT6 variation with serum IgE levels...
  5. ncbi request reprint Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008
    ..However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies...
  6. ncbi request reprint IgE-mediated allergy against human seminal plasma
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    Chem Immunol Allergy 88:128-38. 2005
    ..The diagnosis of human seminal plasma allergy is based on history, demonstration of specific IgE antibodies in the serum and skin tests. Therapeutic options include allergen avoidance by use of condoms and attempts at desensitization...
  7. ncbi request reprint Association of NOD1 polymorphisms with atopic eczema and related phenotypes
    Stephan Weidinger
    The Department of Dermatology and Allergy Biederstein, Technical University, Munich, Germany
    J Allergy Clin Immunol 116:177-84. 2005
    ..NOD1 is located on chromosome 7p14-p15, a region that has been linked with atopy. Recently, polymorphisms of the closely related NOD2 have been associated with atopy-related traits...
  8. ncbi request reprint Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munich, Germany
    Curr Opin Allergy Clin Immunol 10:408-17. 2010
    ..Total IgE levels are considered a useful endophenotype for studying the genetics of atopic diseases. However, the role and significance of genetic factors influencing IgE regulation for atopic diseases as endpoints is unclear...
  9. ncbi request reprint Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway
    S Weidinger
    Department of Dermatology and Allergy, Institute for Medical Statistics and Epidemiology, Technical University Munich, Germany
    Hum Reprod 20:456-61. 2005
    ..In order to elucidate how tryptase via activation of PAR-2 acts in human spermatozoa, we studied intracellular signal transduction events...
  10. pmc Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults
    S Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Biedersteiner St 29, 80802 Munich, Germany
    J Med Genet 41:658-63. 2004
    ..Among candidate genes in this region is STAT6 (signal transducer and activator of transcription), which is essential for Th2 cell differentiation, recruitment, and effector function...
  11. ncbi request reprint Mast cell-sperm interaction: evidence for tryptase and proteinase-activated receptors in the regulation of sperm motility
    S Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    Hum Reprod 18:2519-24. 2003
    ....
  12. ncbi request reprint Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 122:560-8.e4. 2008
    ..These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date...
  13. ncbi request reprint Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data
    Hansjörg Baurecht
    Institute for Medical Statistics and Epidemiology IMSE, Technical University Munich TUM, Munich, Germany
    J Allergy Clin Immunol 120:1406-12. 2007
    ..However, studies published to date demonstrate differences concerning study design and strength of associations...
  14. ncbi request reprint Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:1430-5. 2008
    ..From these data, we conclude that a genetically determined FLG deficiency manifests as dry skin and features of ichthyosis vulgaris. In addition, FLG deficiency may also represent a risk factor for contact sensitization to allergens...
  15. doi request reprint Genetics of atopic dermatitis
    Caroline Bussmann
    Department of Dermatology and Allergy, University of Bonn, Germany
    J Dtsch Dermatol Ges 9:670-6. 2011
    ..Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease...
  16. ncbi request reprint Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility
    Karina Zitta
    Department of Dermatology and Allergy, Technical University Munich, Biedersteiner Strasse 29, Munich, Germany
    Asian J Androl 9:690-6. 2007
    ..To investigate mechanisms of tryptase-induced reduction of sperm motility and explore whether epidermal growth factor receptor (EGF-R) and protease activated receptor 2 (PAR-2)- associated pathways are involved...
  17. doi request reprint A comprehensive analysis of the COL29A1 gene does not support a role in eczema
    Aline Naumann
    Institute for Medical Statistics and Epidemiology IMSE, Technische Universitat Munchen, Munich, Germany
    J Allergy Clin Immunol 127:1187-94.e7. 2011
    ..However, thus far, not a single replication attempt has been published, and no definitive functional data have been provided...
  18. doi request reprint Filaggrin loss-of-function mutations and association with allergic diseases
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Muenchen, Neuherberg and ZAUM Center for Allergy and Environment, Technical University Munich, Biedersteiner Str 29, 80802 Munich, Germany
    Pharmacogenomics 9:399-413. 2008
    ..The observations on filaggrin provide striking new insights into the etiology of atopic diseases and might pave the way for the development of new therapeutic approaches...
  19. ncbi request reprint Association study of mast cell chymase polymorphisms with atopy
    S Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    Allergy 60:1256-61. 2005
    ..Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results...
  20. ncbi request reprint Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults
    S Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany
    Clin Exp Allergy 35:866-72. 2005
    ..CARD15 polymorphisms have been associated with Crohn's disease. Recently, associations with atopic phenotypes have been reported in children...
  21. doi request reprint Molecular genetics of atopic eczema
    Johannes Ring
    Department of Dermatology and Allergy Biederstein, Technische Universitat Munchen, Munich, Germany
    Chem Immunol Allergy 96:24-9. 2012
    ..Using genome-wide association studies, new genes with yet unknown functions have been determined to be associated with atopy and atopic eczema...
  22. ncbi request reprint Do gender-specific differences in eyelash length in 5- to 6-year-old preschoolchildren with and without atopic eczema exist? Results from the Miriam study conducted in Augsburg, Germany
    Matthias Möhrenschlager
    Munich, Germany
    Pediatr Dermatol 22:576-7. 2005
  23. ncbi request reprint Invasion of human keratinocytes by Staphylococcus aureus and intracellular bacterial persistence represent haemolysin-independent virulence mechanisms that are followed by features of necrotic and apoptotic keratinocyte cell death
    M Mempel
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Str 29, D 80802 Munich, Germany
    Br J Dermatol 146:943-51. 2002
    ..A crucial role has been attributed to staphylococcal haemolysins in the cytotoxicity to epidermal structures...
  24. ncbi request reprint The course of eczema in children aged 5-7 years and its relation to atopy: differences between boys and girls
    M Mohrenschlager
    Department of Dermatology and Allergy Biederstein, Technical University of Munich, Germany
    Br J Dermatol 154:505-13. 2006
    ..The concept and analyses of the nonatopic and atopic subtypes of eczema have gained increasing interest in recent studies. The course of these subtypes and differences between boys and girls have not been investigated so far...
  25. pmc Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders
    Monica B Frungieri
    Anatomisches Institut der Universität München, Universitat Munchen, Biedersteiner Strasse 29, Germany
    Proc Natl Acad Sci U S A 99:15072-7. 2002
    ..Therefore, our study describes as-yet-unknown interactions between mast cells and fibroblasts, which could be relevant for human fibrotic diseases...
  26. ncbi request reprint Monocyte-derived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to toll-like receptor ligands
    D Terhorst
    Department of Dermatology and Allergy, Biederstein, Technical University Munich, Munich, Germany
    Clin Exp Allergy 37:381-90. 2007
    ..Toll-like receptor (TLR) agonists are widely used as adjuvants in specific immune therapy protocols for patients with atopic disposition. Monocyte-derived dendritic cells (mDCs) are thought to be important target cells for these compounds...
  27. doi request reprint Filaggrin variants confer susceptibility to asthma
    W H Irwin McLean
    J Allergy Clin Immunol 121:1294-5; author reply 1295-6. 2008
  28. ncbi request reprint Lack of association between Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and atopic eczema
    Stephan Weidinger
    J Allergy Clin Immunol 118:277-9. 2006
  29. ncbi request reprint Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 115:828-33. 2005
    ..Human IL-18 is an inflammatory cytokine that plays a role in atopic diseases, such as atopic eczema (AE), by enhancing IL-4 and IL-13 production and stimulating the synthesis of IgE...
  30. ncbi request reprint Body burden of mercury is associated with acute atopic eczema and total IgE in children from southern Germany
    Stephan Weidinger
    J Allergy Clin Immunol 114:457-9. 2004
  31. ncbi request reprint Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis
    Stephan Weidinger
    J Invest Dermatol 127:724-6. 2007
  32. ncbi request reprint Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels
    Benedetta Belloni
    J Allergy Clin Immunol 120:1223-5. 2007
  33. ncbi request reprint The cradle of IgE autoreactivity in atopic eczema lies in early infancy
    Nadine Mothes
    J Allergy Clin Immunol 116:706-9. 2005
  34. ncbi request reprint Seasonality in symptom severity influenced by temperature or grass pollen: results of a panel study in children with eczema
    Ursula Kramer
    Institut fur umweltmedizinische Forschung IUF, Dusseldorf, Germany
    J Invest Dermatol 124:514-23. 2005
    ..This effect was stronger for children sensitized against pollen. Consideration of the individual type of eczema may help to arrange appropriate preventive and therapeutic measures...
  35. ncbi request reprint Prostate-specific antigen as allergen in human seminal plasma allergy
    Stephan Weidinger
    J Allergy Clin Immunol 117:213-5. 2006