Wolfgang A Weber

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging
    W A Weber
    Departments of Nuclear Medicine, Surgery, Pathology, Radiology, and Medical Statistics, Technische Universitat Munchen, Munchen, Germany
    J Clin Oncol 19:3058-65. 2001
  2. ncbi request reprint Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use
    Wolfgang A Weber
    Nuklearmedizinische Klinik, Klinikum rechts der Isar, Ismaning Strabetae 22, 81675 Munchen, Germany
    J Clin Oncol 21:2651-7. 2003
  3. ncbi request reprint Induction chemotherapy in Barrett cancer: influence on surgical risk and outcome
    Joerg R Siewert
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 246:624-8; discussion 628-31. 2007
  4. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
  5. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
  6. ncbi request reprint Comparison of changes in tumor metabolic activity and tumor size during chemotherapy of adenocarcinomas of the esophagogastric junction
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 46:2029-34. 2005
  7. ncbi request reprint Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
  8. ncbi request reprint Prediction of tumor response by FDG-PET: comparison of the accuracy of single and sequential studies in patients with adenocarcinomas of the esophagogastric junction
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, Munich, Germany
    Eur J Nucl Med Mol Imaging 34:1925-32. 2007
  9. ncbi request reprint Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    J Clin Oncol 22:900-8. 2004
  10. ncbi request reprint Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy
    Anca L Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Int J Radiat Oncol Biol Phys 63:511-9. 2005

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging
    W A Weber
    Departments of Nuclear Medicine, Surgery, Pathology, Radiology, and Medical Statistics, Technische Universitat Munchen, Munchen, Germany
    J Clin Oncol 19:3058-65. 2001
    ..This study evaluates whether positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) may predict response early in the course of therapy...
  2. ncbi request reprint Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use
    Wolfgang A Weber
    Nuklearmedizinische Klinik, Klinikum rechts der Isar, Ismaning Strabetae 22, 81675 Munchen, Germany
    J Clin Oncol 21:2651-7. 2003
    ..To prospectively evaluate the use of positron emission tomography with the glucose analog fluorodeoxyglucose (FDG-PET) to predict response to chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC)...
  3. ncbi request reprint Induction chemotherapy in Barrett cancer: influence on surgical risk and outcome
    Joerg R Siewert
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 246:624-8; discussion 628-31. 2007
    ..To study the impact of induction chemotherapy on surgical risk and outcome in locally advanced Barrett cancer...
  4. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET). Here, we show, in man, that the intensity of [18F]Galacto-RGD uptake correlates with alpha(v)beta3 expression...
  5. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
    ..18)F-Galacto-RGD is a new tracer for PET imaging of alpha v beta3, a receptor involved in a variety of pathologic processes including angiogenesis and metastasis. Our aim was to study the dosimetry of (18)F-galacto-RGD in humans...
  6. ncbi request reprint Comparison of changes in tumor metabolic activity and tumor size during chemotherapy of adenocarcinomas of the esophagogastric junction
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 46:2029-34. 2005
    ..We evaluated the temporal relationship between chemotherapy-induced changes in tumor glucose use and tumor size...
  7. ncbi request reprint Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  8. ncbi request reprint Prediction of tumor response by FDG-PET: comparison of the accuracy of single and sequential studies in patients with adenocarcinomas of the esophagogastric junction
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, Munich, Germany
    Eur J Nucl Med Mol Imaging 34:1925-32. 2007
    ..To address this question we studied the time course of changes in tumor FDG-uptake in patients with locally advanced adenocarcinomas of the esophagogastric junction (AEG) treated with preoperative chemotherapy...
  9. ncbi request reprint Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    J Clin Oncol 22:900-8. 2004
    ....
  10. ncbi request reprint Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy
    Anca L Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Int J Radiat Oncol Biol Phys 63:511-9. 2005
    ..To develop a valid treatment strategy for recurrent high-grade gliomas using stereotactic hypofractionated reirradiation based on biologic imaging and temozolomide...
  11. doi request reprint Early metabolic response evaluation by fluorine-18 fluorodeoxyglucose positron emission tomography allows in vivo testing of chemosensitivity in gastric cancer: long-term results of a prospective study
    Katja Ott
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 14:2012-8. 2008
    ..The goal of the study was the definition of biologically different groups of patients prior to or early during induction therapy, with special emphasis on FDG non-avid tumors...
  12. doi request reprint Effect of 11C-methionine-positron emission tomography on gross tumor volume delineation in stereotactic radiotherapy of skull base meningiomas
    Sabrina T Astner
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 72:1161-7. 2008
    ....
  13. ncbi request reprint 11C-methionine PET improves the target volume delineation of meningiomas treated with stereotactic fractionated radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 66:339-44. 2006
    ..To evaluate the role of 11C-methionine positron emission tomography (MET-PET) in target volume delineation for meningiomas and to determine the interobserver variability...
  14. ncbi request reprint L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 63:64-74. 2005
    ..The goal of this trial was to quantify the affect of MET-PET vs. with MRI in gross tumor volume definition for radiotherapy planning of high-grade gliomas...
  15. ncbi request reprint Positron emission tomography for radiation treatment planning
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany
    Strahlenther Onkol 181:483-99. 2005
    ..To evaluate the impact of positron emission tomography (PET) on target volume delineation for radiation treatment planning...
  16. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    ..We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbeta3 expression with positron emission tomography (PET)...
  17. ncbi request reprint Fluorodeoxyglucose-positron emission tomography in adenocarcinomas of the distal esophagus and cardia
    Katja Ott
    Department of Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaningerstrasse 22, D 81675 Munich, Germany
    World J Surg 27:1035-9. 2003
    ..This finding strengthens the hypothesis that AEG I and AEG II are two different tumor entities...
  18. ncbi request reprint [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
    ..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
  19. ncbi request reprint Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
    ..We studied a hapten-induced delayed-type hypersensitivity reaction (DTHR) as a model for inflammatory processes, since DTHRs are involved in many human autoimmune disorders...
  20. ncbi request reprint Validation of a method for automatic image fusion (BrainLAB System) of CT data and 11C-methionine-PET data for stereotactic radiotherapy using a LINAC: first clinical experience
    Anca Ligia Grosu
    Department of Radiation Oncology, Technical University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 56:1450-63. 2003
    ..b) To validate the fully automatic CT/MET-PET image fusion technique with respect to accuracy and robustness. (c) To give a short glance at the clinical consequences for patients with brain tumors...
  21. ncbi request reprint Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging: results of a prospective trial
    Katja Ott
    Department of Surgery, Technische Universitä München, Munich, Germany
    J Clin Oncol 21:4604-10. 2003
    ..We prospectively evaluated the predictive value of therapy-induced reduction of tumor glucose use for subsequent response and patient survival in patients with gastric cancer treated by preoperative chemotherapy...
  22. ncbi request reprint Metabolic imaging predicts response, survival, and recurrence in adenocarcinomas of the esophagogastric junction
    Katja Ott
    Department of Surgery, Technische Universitaet Muenchen, Ismaningerstr 22, D 81675, Munich, Germany
    J Clin Oncol 24:4692-8. 2006
    ..The aim of this study was to prospectively validate these findings by using an a priori definition of metabolic response...
  23. ncbi request reprint Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction
    Nicolaus Andratschke
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 64:1513-8. 2006
    ..To test whether the clinically available growth factor erythropoietin (EPO) influences radiation-induced normal-tissue damage in a model of kidney dysfunction...
  24. ncbi request reprint O-(2-[(18)F]Fluoroethyl)- L-tyrosine (FET): a tracer for differentiation of tumour from inflammation in murine lymph nodes
    Friederike C Rau
    Nuklearmedizinische Klinik der Technischen Universität München, Ismaninger Strasse 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 29:1039-46. 2002
    ..FET, in contrast, proved to be a specific tracer for differentiating between tumour-infiltrated and inflammatory LNs in the murine models studied...
  25. ncbi request reprint Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells
    Martina Anton
    Institute of Experimental Oncology, Technische Universitat Munchen, Germany
    J Gene Med 6:119-26. 2004
    ..Its expression is almost exclusively restricted to the sympathetic nervous system. In this study we evaluated whether the NET can be used as a reporter gene for non-invasive imaging of genetically modified cells with radiolabeled probes...
  26. pmc 18F-FDG-PET/CT Imaging as an early survival predictor in patients with primary high-grade soft tissue sarcomas undergoing neoadjuvant therapy
    Ken Herrmann
    Division of Surgical Oncology, University of California at Los Angeles, 10833 Le Conte Avenue, Rm 54 140 CHS, Los Angeles, CA 90095, USA
    Clin Cancer Res 18:2024-31. 2012
    ..We prospectively evaluated whether 2[18F]fluoro-2-deoxy-d-glucose ((18)F-FDG)-PET/computed tomographic (CT) imaging after the initial cycle of neoadjuvant therapy could predict overall survival in these patients...
  27. ncbi request reprint Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma
    Malik E Juweid
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 25:571-8. 2007
    ..To develop guidelines for performing and interpreting positron emission tomography (PET) imaging for treatment assessment in patients with lymphoma both in clinical practice and in clinical trials...
  28. doi request reprint Technology Insight: advances in molecular imaging and an appraisal of PET/CT scanning
    Wolfgang A Weber
    Abteilung Nuklearmedizin, University of Freiburg, Hugstetterstrasse 56, 79106 Freiburg, Germany
    Nat Clin Pract Oncol 5:160-70. 2008
    ..In this Review we discuss the technical features of PET/CT, its economic aspects within the health-care system, and its role in diagnosis, staging, restaging and treatment monitoring as well as radiation planning in patients with cancer...
  29. ncbi request reprint Prognostic significance of fluorodeoxyglucose uptake in non-small cell lung cancer. A blurry picture?
    Wolfgang A Weber
    Clin Cancer Res 13:3105-6. 2007
  30. doi request reprint Reduction of glucose metabolic activity is more accurate than change in size at predicting histopathologic response to neoadjuvant therapy in high-grade soft-tissue sarcomas
    Vladimir Evilevitch
    Abteilung Nuklearmedizin University of Freiburg, Freiburg, Germany
    Clin Cancer Res 14:715-20. 2008
    ..The aim of this study was to prospectively evaluate whether positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET) allows for a more accurate evaluation of histopathologic response...
  31. doi request reprint Changes in tumor metabolism as readout for Mammalian target of rapamycin kinase inhibition by rapamycin in glioblastoma
    Liu Hua Wei
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Clin Cancer Res 14:3416-26. 2008
    ..The mechanisms underlying changes in metabolic activity were analyzed by measuring expression and functional activity of enzymes and transporters involved in the uptake of the studied imaging probes...
  32. ncbi request reprint PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial
    Florian Lordick
    Department of Surgery, Clinic rechts der Isar, Technical University of Munich, Munich, Germany
    Lancet Oncol 8:797-805. 2007
    ..We aimed to assess the feasibility of a PET-response-guided treatment algorithm and its potential effect on prognosis...
  33. doi request reprint Tumor cell metabolism imaging
    Christian Plathow
    Department of Nuclear Medicine, University of Freiburg, Freiburg, Germany
    J Nucl Med 49:43S-63S. 2008
    ..In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism...
  34. doi request reprint Treatment monitoring by 18F-FDG PET/CT in patients with sarcomas: interobserver variability of quantitative parameters in treatment-induced changes in histopathologically responding and nonresponding tumors
    Matthias R Benz
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California, USA
    J Nucl Med 49:1038-46. 2008
    ..Knowledge of the interobserver variability of quantitative parameters is important in sarcomas as these tumors are frequently large and demonstrate heterogeneous (18)F-FDG uptake...
  35. pmc Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs
    Wolfgang A Weber
    Nuclear Medicine, University of Freiberg, Germany
    Nat Clin Pract Oncol 5:44-54. 2008
    ..Examples include imaging of the expression and inhibition of drug targets, noninvasive tissue pharmacokinetics, and early assessment of the tumor response...
  36. doi request reprint Evaluation of [(18)F]gefitinib as a molecular imaging probe for the assessment of the epidermal growth factor receptor status in malignant tumors
    Helen Su
    Department of Molecular Medicine and Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 35:1089-99. 2008
    ..In this study, we asked whether PET with [(18)F]gefitinib may be used to study noninvasively the pharmacokinetics of gefitinib in vivo and to image the EGFR status of cancer cells...
  37. pmc Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    Derek W Bartlett
    Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:15549-54. 2007
    ..Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics...
  38. ncbi request reprint 18F-FDG PET in non-Hodgkin's lymphoma: qualitative or quantitative?
    Wolfgang A Weber
    University of Freiburg, Freiburg, Germany
    J Nucl Med 48:1580-2. 2007
  39. ncbi request reprint Monitoring cancer treatment with PET/CT: does it make a difference?
    Wolfgang A Weber
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
    J Nucl Med 48:36S-44S. 2007
    ..The review concludes with an outlook on how PET/CT could make a difference in drug development and clinical management for patients...
  40. ncbi request reprint Brown adipose tissue and nuclear medicine imaging
    Wolfgang A Weber
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Nucl Med 45:1101-3. 2004
  41. ncbi request reprint Imaging of esophageal and gastric cancer
    Wolfgang A Weber
    Department of Nuclear Medicine, Technische Universitaet Muenchen, Munich, Germany
    Semin Oncol 31:530-41. 2004
    ..Furthermore, quantitative measurements of tumor FDG uptake may predict histopathologic tumor response and patient outcome as early as 2 weeks after initiation of preoperative chemotherapy...
  42. ncbi request reprint Comparison between 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and positron emission tomography/computed tomography hardware fusion for staging of patients with lymphoma
    Martin Allen-Auerbach
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6942 USA
    Mol Imaging Biol 6:411-6. 2004
    ..We sought to determine whether integrated (hardware) fused PET/CT imaging results in further improvements in staging accuracy...
  43. ncbi request reprint Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET
    Christian Waldherr
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Nucl Med 46:114-20. 2005
    ..The aim of this study was to evaluate, whether PET with (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) may be used to monitor noninvasively the antiproliferative effects of tyrosine kinase inhibitors...
  44. ncbi request reprint Monitoring response to treatment in patients utilizing PET
    Norbert E Avril
    Division of Nuclear Medicine, Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Radiol Clin North Am 43:189-204. 2005
    ..In the future, PET imaging can also serve in the evaluation of new therapeutic agents, new experimental treatments, and specifically in monitoring clinical phase II studies...
  45. ncbi request reprint Comparison between 18F-FDG PET, in-line PET/CT, and software fusion for restaging of recurrent colorectal cancer
    Jong Ho Kim
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 6942, USA
    J Nucl Med 46:587-95. 2005
    ..The aim of this study was to compare PET with (18)F-FDG PET, in-line PET/CT, and software fusion of independently acquired CT and PET scans for staging of recurrent colorectal cancer (CRC)...
  46. ncbi request reprint Optimizing imaging protocols for overweight and obese patients: a lutetium orthosilicate PET/CT study
    Benjamin S Halpern
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 6942, USA
    J Nucl Med 46:603-7. 2005
    ..High photon attenuation and scatter in obese patients affect image quality. The purpose of the current study was to optimize lutetium orthosilicate (LSO) PET image acquisition protocols in patients weighing > or =91 kg (200 lb)...
  47. ncbi request reprint Use of PET for monitoring cancer therapy and for predicting outcome
    Wolfgang A Weber
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 6942, USA
    J Nucl Med 46:983-95. 2005
    ..This review focuses on the practical aspects of (18)F-FDG PET for treatment monitoring and on how to perform a quantitative assessment of tumor (18)F-FDG uptake in clinical studies...
  48. ncbi request reprint Performance of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography and integrated PET/CT in restaged breast cancer patients
    Barbara J Fueger
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, CA 90095 6942, USA
    Mol Imaging Biol 7:369-76. 2005
    ..This study was conducted to compare the clinical stage derived from 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) to that of integrated PET/computed tomography (CT) in restaged breast cancer patients...
  49. ncbi request reprint Chaperoning drug development with PET
    Wolfgang A Weber
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 6942, USA
    J Nucl Med 47:735-7. 2006
  50. ncbi request reprint Presurgical staging of non-small cell lung cancer: positron emission tomography, integrated positron emission tomography/CT, and software image fusion
    Benjamin S Halpern
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, AR 128 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095 6942, USA
    Chest 128:2289-97. 2005
    ..To compare the diagnostic accuracy of positron emission tomography (PET) and integrated PET/CT and to evaluate the performance of software fusion for staging of non-small cell lung cancer (NSCLC)...
  51. ncbi request reprint Molecular imaging in the development of cancer therapeutics
    Johannes Czernin
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Annu Rev Med 57:99-118. 2006
    ..We conclude with a proposal to integrate molecular imaging into the drug development process...
  52. ncbi request reprint Evaluation of thoracic tumors with 18F-fluorothymidine and 18F-fluorodeoxyglucose-positron emission tomography
    Cecelia S Yap
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center Nuclear Medicine, UCLA School of Medicine, AR 144 CHS, Los Angeles, CA 90095 6948, USA
    Chest 129:393-401. 2006
    ....
  53. ncbi request reprint Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer
    Norbert Avril
    University of Pittsburgh Medical Center, Division of Nuclear Medicine, 200 Lothrop St, Pittsburgh, PA, 15213, USA
    J Clin Oncol 23:7445-53. 2005
    ....
  54. ncbi request reprint Monitoring chemotherapy and radiotherapy of solid tumors
    Wolfgang A Weber
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 6942, USA
    Eur J Nucl Med Mol Imaging 33:27-37. 2006
    ....
  55. ncbi request reprint Impact of animal handling on the results of 18F-FDG PET studies in mice
    Barbara J Fueger
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 47:999-1006. 2006
    ..The aim of this study was to determine how these factors affect assessment of tumor glucose use by (18)F-FDG PET and to develop an imaging protocol that optimizes visualization of tumor xenografts...
  56. doi request reprint Combined assessment of metabolic and volumetric changes for assessment of tumor response in patients with soft-tissue sarcomas
    Matthias R Benz
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA
    J Nucl Med 49:1579-84. 2008
    ..The aim of this study was to determine whether combined assessment of tumor volume and metabolic activity improves the accuracy of (18)F-FDG PET for predicting histopathologic tumor response in patients with soft-tissue sarcomas...
  57. ncbi request reprint Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Anticancer Res 27:183-7. 2007
    ....
  58. ncbi request reprint Anesthesia and other considerations for in vivo imaging of small animals
    Isabel J Hildebrandt
    Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 6942, USA
    ILAR J 49:17-26. 2008
    ..Reproducible experimental conditions require clear, consistent reporting, in the study design and throughout the experiment, of the animal strain and gender, fasting, anesthesia, and how often individual animals were imaged...
  59. ncbi request reprint Positron emission tomography as an imaging biomarker
    Wolfgang A Weber
    Department of Molecular Medicine and Pharmacology, David Geffen School of Medicine, UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Clin Oncol 24:3282-92. 2006
    ..However, further prospective and randomized validation of PET is still required before PET controlled chemotherapy can be used in clinical practice...