Research Topics
Genomes and Genes | Petra VolandSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
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Detail Information
Publications
Interactions among the seven Helicobacter pylori proteins encoded by the urease gene clusterPetra Voland
Department of Medicine II, Technical University, 81675 Munich, Germany
Am J Physiol Gastrointest Liver Physiol 284:G96-G106. 2003....- Human immune response towards recombinant Helicobacter pylori urease and cellular fractionsPetra Voland
II. Medical Department, Gastroenterology, Hepatology, Infectious Diseases, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany
Vaccine 24:3832-9. 2006..It appears that outer membrane preparations of H. pylori, but not recombinant urease are more effective in inducing a Th1 polarized response in humans in vitro... - Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidaseChristian Schmees
Department of Medicine II, Technical University of Munich, Munich, Germany
Gastroenterology 132:1820-33. 2007..We aimed to identify the factor responsible for suppression of T-cell response and characterize this inhibitory effect on a cellular and molecular level... - Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosaRoland Rad
Department of Internal Medicine II and Gastroenterology, Bogenhausen Academic Teaching Hospital, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany
J Infect Dis 188:272-81. 2003..8-32.1) for severe granulocytic infiltration, 6.0 (95% CI, 2.4-15.5) for IM, and 2.4 (95% CI, 0.93-6.2) for AG. Combined bacterial/host genotyping thus may provide a clinical tool to identify patients at high risk of developing cancer... - Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitroNadia Hafsi
Department of Medicine II, Technical University, Munich, Germany
J Immunol 173:1249-57. 2004..Th1-polarized T cells were induced especially by incubation with membrane preparations of H. pylori, suggesting that membrane proteins may account for the specific adaptive immune response... - A secreted low-molecular-weight protein from Helicobacter pylori induces cell-cycle arrest of T cellsMarkus Gerhard
Department of Medicine II, Technical University, Munich, Germany
Gastroenterology 128:1327-39. 2005..pylori-induced G1 arrest. CONCLUSIONS: Induction of cell-cycle arrest in lymphocytes may be of major significance for the chronic persistence of bacteria in the human stomach... - Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccinationChristian Prinz
Department of Medicine II, Technical University, Ismaningerstr 22, 81675 Munich, Germany
Trends Microbiol 11:134-8. 2003..A more in-depth understanding of the immune response to H. pylori infection as well as additional information on suitable epitopes and adjuvants will be required before a successful vaccine can be developed... - Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pyloriRoland Rad
2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
Gastroenterology 133:150-163.e3. 2007..Among APCs, dendritic cells (DCs) have the unique capacity to deliver antigens from the periphery to T cells in secondary lymphoid organs... - H pylori and gastric cancer: shifting the global burdenChristian Prinz
Klinikum rechts der Isar, Technischen Universitat Munchen, II Medizinische Klinik und Poliklinik, Ismaninger Strasse 22, D 81675 Munchen, Germany
World J Gastroenterol 12:5458-64. 2006..In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identified and treated... - Helicobacter pylori induces apoptosis of rat gastric parietal cellsBruno Neu
Department of Medicine II, Technical University of Munich, Germany
Am J Physiol Gastrointest Liver Physiol 283:G309-18. 2002..In summary, cagE presence appears to be essential for H. pylori-induced apoptosis of gastric parietal cells, and this effect is dependent on the activation of NF-kappaB and production of nitric oxide... - VacA-associated inhibition of T-cell function: reviewed and reconsideredChristian Schmees
II. Medical Department, Technical University of Munich, Munich, Germany
Helicobacter 11:144-6. 2006..Some of these results have to be interpreted with caution and may just describe in vitro phenomena; others may reveal promising facts... 
Antigenic properties of HpaA and Omp18, two outer membrane proteins of Helicobacter pyloriPetra Voland
Department of Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
Infect Immun 71:3837-43. 2003..In summary, HpaA and Omp18 are recognized by human dendritic cells and induce their maturation as well as antigen presentation. HpaA and Omp18 of H. pylori thereby appear to have a specific antigenic potential in humans...- Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countriesFarzad O Olfat
Department of Medical Biochemistry and Biophysics, , SE-901 87 Ume, Sweden
FEMS Immunol Med Microbiol 44:151-6. 2005..This finding appears to reflect allelic variations of the babA2 gene in SWE, although adhesive properties of the strains are retained... - Current trends in the treatment of upper gastrointestinal diseaseGeorge Sachs
Geffen School of Medicine at UCLA and GWLA Health Center, Los Angeles, USA
Best Pract Res Clin Gastroenterol 16:835-49. 2002..Research continues in an attempt to find improved means of acid control and better methods for the eradication of H. pylori based on unique proteins expressed by the organism to resist gastric acidity...