Christian Sorg

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
  2. doi request reprint Imaging Neurodegeneration: Steps Toward Brain Network-Based Pathophysiology and Its Potential for Multi-modal Imaging Diagnostics
    C Sorg
    Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675, Munchen, Germany
    Clin Neuroradiol 25:177-81. 2015
  3. doi request reprint Asymmetric loss of parietal activity causes spatial bias in prodromal and mild Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:798-804. 2012
  4. ncbi request reprint Impact of Alzheimer's disease on the functional connectivity of spontaneous brain activity
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Curr Alzheimer Res 6:541-53. 2009
  5. doi request reprint Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:69-77. 2012
  6. doi request reprint White matter hyperintensities predict amyloid increase in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 33:2766-73. 2012
  7. doi request reprint Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease
    Susanne Neufang
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    J Alzheimers Dis 25:309-21. 2011
  8. doi request reprint Aberrant topology of striatum's connectivity is associated with the number of episodes in depression
    Chun Meng
    1 Department of Neuroradiology, Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany
    Brain 137:598-609. 2014
  9. doi request reprint Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease
    Kathrin Koch
    Department of Neuroradiology TUM Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, 81675 Munich, Germany
    Cereb Cortex 25:4678-88. 2015
  10. doi request reprint Repeated pain induces adaptations of intrinsic brain activity to reflect past and predict future pain
    Valentin Riedl
    Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Neuroimage 57:206-13. 2011

Collaborators

Detail Information

Publications41

  1. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
    ..We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs...
  2. doi request reprint Imaging Neurodegeneration: Steps Toward Brain Network-Based Pathophysiology and Its Potential for Multi-modal Imaging Diagnostics
    C Sorg
    Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675, Munchen, Germany
    Clin Neuroradiol 25:177-81. 2015
    ..The aim of the current study is to present and highlight some paradigmatic findings in intrinsic network-based pathophysiology of neurodegenerative diseases and its potential for new network-based multimodal tools in imaging diagnostics...
  3. doi request reprint Asymmetric loss of parietal activity causes spatial bias in prodromal and mild Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:798-804. 2012
    ....
  4. ncbi request reprint Impact of Alzheimer's disease on the functional connectivity of spontaneous brain activity
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Curr Alzheimer Res 6:541-53. 2009
    ..Finally, rs-fMRI seems to have the potential to produce connectivity-related biomarkers that distinguish AD and healthy aging...
  5. doi request reprint Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:69-77. 2012
    ..Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics...
  6. doi request reprint White matter hyperintensities predict amyloid increase in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 33:2766-73. 2012
    ..The extent of WMH might be a relevant factor to be assessed in antiamyloid drug trials...
  7. doi request reprint Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease
    Susanne Neufang
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    J Alzheimers Dis 25:309-21. 2011
    ..We conclude that, at very early stages of AD, the reduction of effective connectivity in fronto-parietal circuits is related to regional gray matter volume and contributes to impairments in top-down attentional control...
  8. doi request reprint Aberrant topology of striatum's connectivity is associated with the number of episodes in depression
    Chun Meng
    1 Department of Neuroradiology, Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany
    Brain 137:598-609. 2014
    ..Data suggest that the reorganization of striatal connectivity may interact with the course of episodes in depression thereby contributing to depressive relapse risk. ..
  9. doi request reprint Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease
    Kathrin Koch
    Department of Neuroradiology TUM Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, 81675 Munich, Germany
    Cereb Cortex 25:4678-88. 2015
    ..Data provide evidence that disrupted intrinsic network connectivity links Aβ-pathology with cognitive impairment in early AD. ..
  10. doi request reprint Repeated pain induces adaptations of intrinsic brain activity to reflect past and predict future pain
    Valentin Riedl
    Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Neuroimage 57:206-13. 2011
    ..Other ICNs of the intrinsic architecture remained unchanged. Due to the ubiquitous occurrence of ICNs in several species, we suggest intrinsic brain activity as an integrative mechanism reflecting accumulated experiences...
  11. doi request reprint Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Nucl Med 57:204-7. 2016
    ..It is a matter of debate whether to analyze these images visually or using automated techniques. Therefore, we compared the usefulness of both imaging methods and both analyzing strategies to predict dementia due to AD...
  12. doi request reprint Link between hippocampus' raised local and eased global intrinsic connectivity in AD
    Lorenzo Pasquini
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany TUM Neuroimaging Center, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 11:475-84. 2015
    ..Because of widespread network degeneration, it has been suggested that increasing HP disconnection from the DMN may lead to progressive disinhibition of intra-HP synchronized activity...
  13. pmc LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neuroimage Clin 4:411-6. 2014
    ..We aimed to elucidate the association of this polymorphism with in-vivo brain amyloid load of AD patients using amyloid PET with [(11)C]PiB...
  14. pmc A biased competition account of attention and memory in Alzheimer's disease
    Kathrin Finke
    Department of Psychology, General and Experimental Psychology Neuro Cognitive Psychology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Philos Trans R Soc Lond B Biol Sci 368:20130062. 2013
    ..This account integrates a large amount of previously unrelated findings of changed behaviour and brain networks and favours a brain mechanism-centred view on AD. ..
  15. pmc Aberrant dependence of default mode/central executive network interactions on anterior insular salience network activity in schizophrenia
    Andrei Manoliu
    To whom correspondence should be addressed Department of Psychiatry and Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munchen, Germany tel 49 89 4140 4665, fax 49 89 4140 7665, E mail
    Schizophr Bull 40:428-37. 2014
    ..Data provide evidence for an aberrant dependence of DMN/CEN interactions on anterior insular SN activity, linking impaired insula, DMN, CEN activity, and psychosis in schizophrenia. ..
  16. doi request reprint Local activity determines functional connectivity in the resting human brain: a simultaneous FDG-PET/fMRI study
    Valentin Riedl
    Departments of Neuroradiology, Nuclear Medicine, and Psychiatry, and Technische Universität München Neuroimaging Center, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munchen, Germany, The Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom, and Department of Nuclear Medicine, Uniklinik Köln, 50937 Koln, Germany
    J Neurosci 34:6260-6. 2014
    ....
  17. pmc Increased intrinsic brain activity in the striatum reflects symptom dimensions in schizophrenia
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Schizophr Bull 39:387-95. 2013
    ..Results were controlled for volumetric and medication effects. These data provide first evidence that in schizophrenia intrinsic activity is changed in the striatum and corresponds to disorder states and symptom dimensions...
  18. doi request reprint Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
    Christine Preibisch
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Magn Reson Imaging 34:1295-302. 2011
    ..To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique...
  19. doi request reprint Grey-matter atrophy in Alzheimer's disease is asymmetric but not lateralized
    Sabine Derflinger
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 25:347-57. 2011
    ..We conclude that, in principle, brain atrophy in AD is asymmetric rather than lateralized. At the individual level however, asymmetry contributes to cognitive deficits...
  20. doi request reprint Prefrontal hypometabolism in Alzheimer disease is related to longitudinal amyloid accumulation in remote brain regions
    Elisabeth Klupp
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 56:399-404. 2015
    ....
  21. pmc Prediction of Alzheimer's disease using individual structural connectivity networks
    Junming Shao
    Department of Neuroradiology of Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurobiol Aging 33:2756-65. 2012
    ..Our finding provides evidence that ISCNs are sensitive to the impact of earliest stages of AD. ISCNs may be useful as a white matter-based imaging biomarker to distinguish healthy aging from AD...
  22. doi request reprint Predicting effective connectivity from resting-state networks in healthy elderly and patients with prodromal Alzheimer's disease
    Susanne Neufang
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Brain Mapp 35:954-63. 2014
    ..We conclude that functional connectivity and effective connectivity are interrelated in healthy brains but this relationship is aberrant in very early AD...
  23. pmc Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Street 22, 81675 Munchen, Germany
    ScientificWorldJournal 2012:712048. 2012
    ..Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring...
  24. doi request reprint Cognitive rehabilitation in patients with mild cognitive impairment
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Int J Geriatr Psychiatry 24:163-8. 2009
    ..To explore the benefits of a multi-component cognitive rehabilitation programme in patients with mild cognitive impairment (MCI)...
  25. ncbi request reprint Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues
    Robert Perneczky
    Department of Psychiatry, Technische Universitat Munchen, Germany
    Age Ageing 35:240-5. 2006
    ..The concept of an ADL threshold that separates MCI from dementia, however, appears to be improbable for several reasons...
  26. pmc Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease
    Nicholas Myers
    1 Department of Neuroradiology, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany2 TUM Neuroimaging Centre, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany3 Department of Experimental Psychology, Oxford University, 9 South Parks Road, Oxford OX1 3UD, UK
    Brain 137:2052-64. 2014
    ....
  27. pmc Insular Dysfunction Reflects Altered Between-Network Connectivity and Severity of Negative Symptoms in Schizophrenia during Psychotic Remission
    Andrei Manoliu
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universität München Munich, Germany Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany TUM Neuroimaging Center, Technische Universität München Munich, Germany
    Front Hum Neurosci 7:216. 2013
    ..Together with our previous results, data suggest specific SN/DMN/CEN reorganization in schizophrenia with distinct insular pathways for distinct symptom dimensions...
  28. doi request reprint In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions
    Elisabeth Klupp
    1 Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Connect 4:371-83. 2014
    ....
  29. ncbi request reprint [Von Economo neurons and insular cortex - the bridge between soma and psyche]
    Christian Sorg
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universitat Munchen
    Neuropsychiatr 24:64-6. 2010
    ..It almost appears as if spindle cells would reach out from the realm of subconscious gut-feelings into the premises of conscious prefrontal planning...
  30. doi request reprint Cognitive emotion regulation enhances aversive prediction error activity while reducing emotional responses
    Satja Mulej Bratec
    Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany TUM NIC Neuroimaging Center, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Graduate School of Systemic Neurosciences, Ludwig Maximilians Universitat Munchen, 82152 Planegg Martinsried, Germany Electronic address
    Neuroimage 123:138-48. 2015
    ..Our data, therefore, provide first-time evidence that beyond reducing emotional responses, cognitive emotion regulation affects learning by enhancing prediction error-related activity, potentially via tegmental dopaminergic pathways. ..
  31. doi request reprint Metabolic connectivity mapping reveals effective connectivity in the resting human brain
    Valentin Riedl
    Department of Neuroradiology, Klinikum rechts der Isar, Technischen Universitaet Muenchen, 81675 Muenchen, Germany Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitaet Muenchen, 81675 Muenchen, Germany Neuroimaging Center, Klinikum rechts der Isar, Technischen Universitaet Muenchen, 81675 Muenchen, Germany
    Proc Natl Acad Sci U S A 113:428-33. 2016
    ..We propose MCM as a novel approach for inferring EC from neuronal energy metabolism that is ideally suited to study signaling hierarchies in the brain and their defects in brain disorders. ..
  32. doi request reprint A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease
    Marc Wermke
    Department of Nuclear Medicine, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:S12-24. 2008
    ..A new comprehensive model will be introduced integrating these heterogeneous findings and explaining their impact on cognitive performance...
  33. pmc Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons
    Lorenzo Pasquini
    1 Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Connect 4:323-36. 2014
    ..The observed link of aging and AD with intrinsic brain activity supports the view that lifespan intrinsic activity may contribute critically to the pathogenesis of AD...
  34. doi request reprint Interference control in adult ADHD: no evidence for interference control deficits if response speed is controlled by delta plots
    Alexander Soutschek
    General and Experimental Psychology, Department of Psychology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Acta Psychol (Amst) 143:71-8. 2013
    ..These results challenge the conclusions of the previous studies, in that they indicate that interference control is not impaired in adult ADHD...
  35. ncbi request reprint Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 21:158-62. 2006
    ..However, even mild degrees of cognitive deterioration are known to have negative effects on complex ADL...
  36. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
    ..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
  37. doi request reprint Patients with pain disorder show gray-matter loss in pain-processing structures: a voxel-based morphometric study
    Michael Valet
    Neurologische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Psychosom Med 71:49-56. 2009
    ..Psychological factors are thought to play a major role. Recent neuroimaging studies evidenced altered pain processing in patients suffering from this disorder...
  38. doi request reprint Correspondence Between Aberrant Intrinsic Network Connectivity and Gray-Matter Volume in the Ventral Brain of Preterm Born Adults
    Josef G Bäuml
    Department of Neuroradiology, TUM NIC Neuroimaging Center, Technische Universitat Munchen, Munchen, Germany
    Cereb Cortex 25:4135-45. 2015
    ..These results provide evidence that preterm birth has long-lasting effects on functional connectivity of intrinsic networks, and these changes are specifically related to structural alterations in ventral brain GM. ..
  39. doi request reprint Functional connectivity and grey matter volume of the striatum in schizophrenia
    Kathrin Koch
    Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM Neuroimaging Center TUM NIC of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig Maximilians Universitat, Biocenter, Munich Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, TUM Neuroimaging Center TUM NIC of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig Maximilians Universitat, Biocenter, Munich Claudia Schachtzabel, MA, Gerd Wagner, PhD, C Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, OH
    Br J Psychiatry 205:204-13. 2014
    ..Alterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia...
  40. doi request reprint The neural correlates of planning and executing actual tool use
    Marie Luise Brandi
    TUM Neuroimaging Center, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany, Department of Sport and Health Sciences, Institute of Movement Science, Technische Universitat Munchen, 80992 Munich, Germany, and Graduate School of Systemic Neurosciences, Ludwig Maximilians Universitat Munchen, 82152 Planegg Martinsried, Germany
    J Neurosci 34:13183-94. 2014
    ..These results provide evidence for left-lateralized occipito-temporo-parieto-frontal network of everyday tool use, which may help to characterize specific deficits in patients suffering from apraxia. ..