Robert Rosenberg

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. doi request reprint The prognostic value of lymph node ratio in a population-based collective of colorectal cancer patients
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 251:1070-8. 2010
  2. doi request reprint Prognosis of patients with colorectal cancer is associated with lymph node ratio: a single-center analysis of 3,026 patients over a 25-year time period
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Ann Surg 248:968-78. 2008
  3. doi request reprint Does a rectal cancer of the upper third behave more like a colon or a rectal cancer?
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Munich, Germany
    Dis Colon Rectum 53:761-70. 2010
  4. doi request reprint Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevance
    Dietrich Doll
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    World J Surg 33:340-7. 2009
  5. ncbi request reprint Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Clin Oncol 22:1807-14. 2004
  6. doi request reprint The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 252:797-804. 2010
  7. ncbi request reprint Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer
    Franziska Rohde
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Cancer 121:1717-23. 2007
  8. doi request reprint Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer
    Caroline Rimkus
    Department of Surgery, Immunology and Hygiene, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Clin Gastroenterol Hepatol 6:53-61. 2008
  9. ncbi request reprint Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumor-free circumferential resection margins and long-term survival
    Hinrich A Wieder
    Department of Radiology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany
    Radiology 243:744-51. 2007
  10. ncbi request reprint Prognostic impact of CK-20-positive cells in peripheral venous blood of patients with gastrointestinal carcinoma
    Jan Friederichs
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Chirurgisch Onkologisches Labor K049 Ismaningerstr 22, 81675, Munich, Germany
    World J Surg 29:422-8. 2005

Collaborators

Detail Information

Publications39

  1. doi request reprint The prognostic value of lymph node ratio in a population-based collective of colorectal cancer patients
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 251:1070-8. 2010
    ..We analyzed 3 previously identified cut-off values of lymph node ratios (0.17, 0.41, and 0.69) in a large population-based collective of patients with colorectal cancer for their prognostic value...
  2. doi request reprint Prognosis of patients with colorectal cancer is associated with lymph node ratio: a single-center analysis of 3,026 patients over a 25-year time period
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Ann Surg 248:968-78. 2008
    ..We examined the prognostic impact of lymph node ratio (relation of tumor-infiltrated to resected lymph nodes) in comparison to the pN category and other prognostic factors in patients with colorectal cancer...
  3. doi request reprint Does a rectal cancer of the upper third behave more like a colon or a rectal cancer?
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Munich, Germany
    Dis Colon Rectum 53:761-70. 2010
    ..This study aimed to evaluate whether cancers in the upper third of the rectum should be treated according to colon or rectal cancer guidelines...
  4. doi request reprint Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevance
    Dietrich Doll
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    World J Surg 33:340-7. 2009
    ..Neoadjuvant radiochemotherapy for rectal carcinoma reduces the number of lymph nodes in the resection specimen; the prognostic impact of this reduced lymph node yield has not been determined...
  5. ncbi request reprint Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Clin Oncol 22:1807-14. 2004
    ..The purpose of this study was to evaluate telomere length and human telomerase reverse transcriptase (hTERT) expression as markers for progression and prognosis of colorectal carcinoma...
  6. doi request reprint The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 252:797-804. 2010
    ..To provide a comprehensive characterization of neural invasion (NI) in rectal adenocarcinoma (RC), to establish a novel NI-severity scoring system, and to assess the prognostic value of NI with emphasis on its localization and severity...
  7. ncbi request reprint Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer
    Franziska Rohde
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Cancer 121:1717-23. 2007
    ..Thus, OPN is a transcriptional target of aberrant Wnt signaling, and OPN expression alone predicts survival in human colon cancer...
  8. doi request reprint Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer
    Caroline Rimkus
    Department of Surgery, Immunology and Hygiene, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Clin Gastroenterol Hepatol 6:53-61. 2008
    ..The aim of the study was to evaluate the capacity of gene expression signatures to identify responders and nonresponders pretherapeutically...
  9. ncbi request reprint Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumor-free circumferential resection margins and long-term survival
    Hinrich A Wieder
    Department of Radiology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany
    Radiology 243:744-51. 2007
    ..To retrospectively evaluate the prognostic importance of involvement of the circumferential resection margin predicted by using magnetic resonance (MR) imaging before neoadjuvant treatment in patients with rectal cancer...
  10. ncbi request reprint Prognostic impact of CK-20-positive cells in peripheral venous blood of patients with gastrointestinal carcinoma
    Jan Friederichs
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Chirurgisch Onkologisches Labor K049 Ismaningerstr 22, 81675, Munich, Germany
    World J Surg 29:422-8. 2005
    ..01) and the postoperative residual tumor status (R) (p < 0.01). The endoscopy procedure did not lead to an increased detection of CK-20 expression...
  11. doi request reprint Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer
    Ulrich Nitsche
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Ann Surg 256:763-71; discussion 771. 2012
    ..Individualized risk assessment in patients with UICC stage II colon cancer based on a panel of molecular genetic alterations...
  12. doi request reprint Prediction of prognosis is not improved by the seventh and latest edition of the TNM classification for colorectal cancer in a single-center collective
    Ulrich Nitsche
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Ann Surg 254:793-800; discussion 800-1. 2011
    ..To compare the prognostic value of the sixth and seventh editions of the TNM classification, and of additional prognostic factors, in colorectal cancer...
  13. ncbi request reprint Telomere length and hTERT expression in patients with colorectal carcinoma
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Recent Results Cancer Res 162:177-81. 2003
    ..Telomere length and hTERT expression play an important role in ageing and carcinogenesis. Both parameters were identified as prognostic factors in patients with colorectal carcinoma...
  14. ncbi request reprint Correlation of CK-20-positive cells in peripheral venous blood with serum CEA levels in patients with colorectal carcinoma
    Jan Friederichs
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    World J Surg 31:2329-34. 2007
    ..Here we report the correlation of CK-20-positive cells in peripheral venous blood with the serum CEA level of patients with colorectal cancer, which may represent a potential marker of the tumor load...
  15. doi request reprint Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma
    Ralf Gertler
    Department of Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer 112:2173-80. 2008
    ..The authors evaluated telomere length and telomerase subunits, hTR and hTERT, as prognostic markers in patients with Barrett carcinoma...
  16. ncbi request reprint Prognostic evaluation and review of immunohistochemically detected disseminated tumor cells in peritumoral lymph nodes of patients with pN0 colorectal cancer
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
    Int J Colorectal Dis 19:430-7. 2004
    ..We therefore evaluated the immunohistochemical detection rates and their prognostic value comparing three different monoclonal antibodies...
  17. doi request reprint The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstr 22, 81675, Munich, Germany
    Int J Colorectal Dis 24:191-200. 2009
    ....
  18. doi request reprint Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis
    Ulrich Nitsche
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institute of Statistics and Epidemiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institute of Pathology, Technische Universitat Munchen, Munich, Germany Division of Surgical Oncology, Department of Surgery, Oregon Health and Science University, Portland, OR Department of Surgery, Kantonsspital Baden, Baden, Switzerland
    Ann Surg 258:775-82; discussion 782-3. 2013
    ..To define the prognostic value of different histological subtypes of colorectal cancer...
  19. ncbi request reprint Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer
    Caroline Rimkus
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Cancer 120:207-11. 2007
    ..By multivariate analysis, MAD2L2 expression was retained as an independent prognostic parameter for patient survival. Thus, our results demonstrate that overexpression of MAD2L2 correlates with bad prognosis in colorectal cancer...
  20. doi request reprint The severity of neural invasion is associated with shortened survival in colon cancer
    Florian Liebl
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:50-61. 2013
    ..Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer...
  21. ncbi request reprint Identification of gene signatures for invasive colorectal tumor cells
    Anja H Wiese
    Institut für allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Cancer Detect Prev 31:282-95. 2007
    ..Gene signatures of sporadic colorectal carcinoma tissues and microdissected colorectal tumor cells were analyzed to identify stromal and tumor cell-specific markers, respectively...
  22. doi request reprint Defining a high-risk subgroup with colon cancer stages I and II for possible adjuvant therapy
    Ralf Gertler
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur J Cancer 45:2992-9. 2009
    ..Our aim is to identify clinicopathologic characteristics in colon cancer stages I and II, which are associated with an increased risk of tumour recurrence and tumour-related death...
  23. ncbi request reprint Prognostic potential of the telomerase subunit human telomerase reverse transcriptase in tumor tissue and nontumorous mucosa from patients with colorectal carcinoma
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Cancer 95:2103-11. 2002
    ..The objective of this study was to evaluate the use of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for the quantification of hTERT in tumor and nontumorous tissue samples...
  24. ncbi request reprint Impact of disseminated tumor cells in gastrointestinal cancer
    Stefan Thorban
    Technische University Munich, Chirurgische Klinik and Poliklinik, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munich, Germany
    Expert Rev Mol Diagn 6:333-43. 2006
    ..The impact of prognostic or predictive factors for new treatment protocols in patients with gastrointestinal cancer was evaluated as well as the correlation with clinical factors...
  25. ncbi request reprint Gene expression profiles of different clinical stages of colorectal carcinoma: toward a molecular genetic understanding of tumor progression
    Jan Friederichs
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Int J Colorectal Dis 20:391-402. 2005
    ..Colorectal cancer is one of the leading causes of cancer deaths in the Western world. A better understanding of the development and progression of colorectal carcinoma is needed to define novel targets and strategies for treatment...
  26. doi request reprint Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer
    Matthias Maak
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 257:1053-8. 2013
    ..The aim of this study was to independently validate a genomic signature developed both to assess recurrence risk in stage II patients and to assist in treatment decisions...
  27. doi request reprint Comparison of different SUV-based methods for response prediction to neoadjuvant radiochemotherapy in locally advanced rectal cancer by FDG-PET and MRI
    Ken Herrmann
    Department of Nuclear Medicine, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Mol Imaging Biol 13:1011-9. 2011
    ....
  28. doi request reprint High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
    Karina Bauer
    Institute of Pathology, Technische Universitat Munchen, Trogerstr 18, 81675 Munich, Germany
    Cell Oncol (Dordr) 35:197-205. 2012
    ..The expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer...
  29. doi request reprint Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas
    Jan Friederichs
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Langenbecks Arch Surg 395:373-9. 2010
    ..This study aimed to clarify expression patterns of therapeutically addressable receptor tyrosine kinases in colorectal cancer...
  30. doi request reprint Pouch vs. no pouch following total gastrectomy: meta-analysis and systematic review
    Ralf Gertler
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Gastroenterol 104:2838-51. 2009
    ..The aim of this report was to assess the value of pouch formation as a gastric substitute after total gastrectomy compared with reconstruction techniques without a pouch...
  31. doi request reprint Effect of preoperative radio(chemo)therapy on long-term functional outcome in rectal cancer patients: a systematic review and meta-analysis
    Martin Loos
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg Oncol 20:1816-28. 2013
    ..However, this multimodal treatment approach may be associated with late adverse effects. To determine the impact of pR(C)T on long-term anorectal, sexual, and urinary function, we performed a systematic review and meta-analysis...
  32. doi request reprint Variability of protein and phosphoprotein levels in clinical tissue specimens during the preanalytical phase
    Sibylle Gündisch
    Institute of Pathology, Technische Universitat Munchen, Trogerstrasse 18, D 81675 Munich, Germany
    J Proteome Res 11:5748-62. 2012
    ..Our study represents a proper approach for studying potential protein fluctuations in tissue specimens for future biomarker development programs...
  33. doi request reprint Tumor-specific targeting of pancreatic cancer with Shiga toxin B-subunit
    Matthias Maak
    Department of Surgery, Klinikum rechts der Isar, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Mol Cancer Ther 10:1918-28. 2011
    ..Moreover, this effect was effectively blocked by competing incubation with nonlabeled STxB, showing the specificity of the targeting. Thus, STxB constitutes a promising new tool for specific targeting of pancreatic cancer...
  34. ncbi request reprint Impact of grade of dysplasia in villous adenomas of Vater's papilla
    Claus Dieter Heidecke
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    World J Surg 26:709-14. 2002
    ..Therefore pylorus-preserving pancreaticoduodenectomy should be offered to patients with an HG dysplasia adenoma...
  35. ncbi request reprint Optimization of 3-dimensional imaging of the breast region with 3-dimensional laser scanners
    Laszlo Kovacs
    Department of Plastic and Reconstructive Surgery, Klinikum rechts der Isar of the Technical University Munich, Germany
    Ann Plast Surg 56:229-36. 2006
    ..Our findings show that the correct settings for 3D imaging of the breast region with a laser scanner can achieve an acceptable degree of accuracy and reproducibility...
  36. doi request reprint Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery
    Norbert Hüser
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Ann Surg 248:52-60. 2008
    ..The role of a defunctioning stoma in patients undergoing low anterior resection for rectal cancer is still the subject of controversy. Recent studies suggest reduced morbidity after low anterior rectal resection with a defunctioning stoma...
  37. ncbi request reprint Detection of circulating tumor cells in blood using an optimized density gradient centrifugation
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munich, Germany
    Recent Results Cancer Res 162:149-55. 2003
    ..This simplifies further immunocytochemical tumor cell detection and is a promising tool for the detection of circulating tumor cells in blood of tumor patients...
  38. ncbi request reprint Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of node-negative colorectal cancer patients
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik and Institut für Pathologie und Pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Clin Oncol 20:1049-55. 2002
    ....
  39. ncbi request reprint PET imaging with [18F]3'-deoxy-3'-fluorothymidine for prediction of response to neoadjuvant treatment in patients with rectal cancer
    Hinrich A Wieder
    Department of Nuclear Medicine, Technische Universitat Munchen, Munchen, Germany
    Eur J Nucl Med Mol Imaging 34:878-83. 2007
    ..Positron emission tomography (PET) using 18F-labelled 3'-deoxy-3'-fluorothymidine (FLT) was assessed for therapy monitoring in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy...