Matthias Riemenschneider

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease
    M Riemenschneider
    Department of Psychiatry, Neurochemistry and Neurogenetics Laboratory, TU München Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 25:1305-8. 2004
  2. ncbi Prion protein codon 129 polymorphism and risk of Alzheimer disease
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany
    Neurology 63:364-6. 2004
  3. ncbi The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Hum Mutat 27:532-7. 2006
  4. ncbi No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease
    M Riemenschneider
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU Munich, 81675 Munich, Germany
    Neurobiol Aging 28:883-4. 2007
  5. ncbi A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
  6. ncbi Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
    M Riemenschneider
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 8:343-7. 2003
  7. ncbi Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment
    M Riemenschneider
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Arch Neurol 59:1729-34. 2002
  8. ncbi A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 7:782-5. 2002
  9. ncbi Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurology 58:1622-8. 2002
  10. ncbi Apolipoprotein E polymorphism in German patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    J Neurol Neurosurg Psychiatry 72:639-41. 2002

Collaborators

Detail Information

Publications40

  1. ncbi Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease
    M Riemenschneider
    Department of Psychiatry, Neurochemistry and Neurogenetics Laboratory, TU München Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 25:1305-8. 2004
    ..None of the polymorphisms showed significant association with AD which contradicts recent findings on CH25H. From our results we conclude that the investigated genetic variations do not contribute to the genetic risk of AD...
  2. ncbi Prion protein codon 129 polymorphism and risk of Alzheimer disease
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany
    Neurology 63:364-6. 2004
    ..013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD...
  3. ncbi The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Hum Mutat 27:532-7. 2006
    ..The result may corroborate the implication of the lysosomal system in the pathogenesis of AD and is of particular importance if CSF tau is used as a diagnostic biomarker...
  4. ncbi No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease
    M Riemenschneider
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU Munich, 81675 Munich, Germany
    Neurobiol Aging 28:883-4. 2007
    ..Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD...
  5. ncbi A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
    ..Further functional investigations are warranted to elucidate the specific role of PLAU, respectively, PLAU variants in the metabolism of Abeta proteins...
  6. ncbi Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
    M Riemenschneider
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 8:343-7. 2003
    ..Although the results have to be confirmed in a larger sample, the preliminary data suggest that simultaneous measurement of total tau and P-tau in CSF may be useful to identify patients with CJD...
  7. ncbi Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment
    M Riemenschneider
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Arch Neurol 59:1729-34. 2002
    ..Cerebrospinal fluid tau protein and beta-amyloid 42 (Abeta42) protein are altered even in very mild Alzheimer disease (AD). So far, few data exist for subjects with mild cognitive impairment (MCI)...
  8. ncbi A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 7:782-5. 2002
    ..The results suggest that the BDNF C-270T polymorphism is a relevant risk factor for AD particularly in patients lacking the ApoE epsilon4 allele in this German sample...
  9. ncbi Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurology 58:1622-8. 2002
    ..CSF concentrations of tau and beta-amyloid protein-42 (Abeta42) have been extensively studied in AD. Few data are available concerning CSF levels of both proteins in patients with frontotemporal degeneration (FTD)...
  10. ncbi Apolipoprotein E polymorphism in German patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    J Neurol Neurosurg Psychiatry 72:639-41. 2002
    ..Inconclusive results have been reported in patients with frontotemporal degeneration which prompted this study of the apoE polymorphism in a German sample with frontotemporal degeneration...
  11. ncbi Association of CSF apolipoprotein E, Abeta42 and cognition in Alzheimer's disease
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry, Technische Universitat Munchen, Germany
    Neurobiol Aging 23:205-11. 2002
    ....
  12. ncbi Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association with apolipoprotein E genotype and cognitive decline
    M Riemenschneider
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, lsmaningerstrasse 22, 81675, Munich, Germany
    Neurosci Lett 284:85-8. 2000
    ..We conclude that measurement of Abeta42 in CSF might be helpful for identifying AD at an early stage and also for tracking the clinical course...
  13. ncbi Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia
    Simon M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Munich University of Technology, 81675 Munich, Germany
    Am J Psychiatry 164:1577-84. 2007
    ..The aim of this study was to investigate the MAPT haplotypes in relation to risk for, and functional alterations of glucose metabolism in, patients with frontotemporal dementia (FTD)...
  14. ncbi No association of TDP-43 with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Ismanigerstr 22, TU Munich, 81675 Munich, Germany
    Neurobiol Aging 30:157-9. 2009
    ..There is no evidence, that common variants in TDP-43 confer a strong risk to the development of sporadic FTD...
  15. ncbi Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Munich, Germany
    J Nucl Med 46:1625-32. 2005
    ....
  16. ncbi Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease
    Ruth Vukovich
    Department of Psychiatry and Psychotherapy, Neurochemistry and Neurogenetics Laboratory, Technische Universitat Munchen, Munchen, Germany
    Dement Geriatr Cogn Disord 27:474-80. 2009
    ..Their topographic origin and their association with synaptic dysfunction are still not well understood...
  17. ncbi No association of common VCP variants with sporadic frontotemporal dementia
    Axel Schumacher
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry, TU Munich, Germany
    Neurobiol Aging 30:333-5. 2009
    ..No significant association could be demonstrated. There is no evidence, that common variants in VCP confer a strong risk to the development of sporadic FTD...
  18. ncbi Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich 81675, Germany
    Biol Psychiatry 65:927-34. 2009
    ..The aim of the study was to determine the association between cerebral amyloid plaque load, as measured by means of the positron emission tomography (PET) tracer carbon-11-labeled Pittsburgh Compound B ([11C]PiB) and CSF Abeta42 in AD...
  19. ncbi Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures
    Jakob C Mueller
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technical University Munich TUM, Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 28:727-34. 2007
    ..A subgroup analysis indicated more prominent associations with AD in younger, and with MMSE in older patients. There may be two independent effects mediated by IDE variants, risk for AD and modification of disease progression...
  20. ncbi Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings
    N T Lautenschlager
    Department of Psychiatry and Psychotherapy, , Moehlstrasse 26, D-81675 Munich, Germany
    Dement Geriatr Cogn Disord 12:379-86. 2001
    ..Clinical, neuropsychological, brain imaging and CSF biochemical markers were examined. Findings were remarkably heterogeneous even in this highly selected group of patients. This suggests that MCI is aetiologically not uniform...
  21. ncbi No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Munich, Germany
    Neurobiol Aging 28:1789-90. 2007
    ..Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD...
  22. ncbi Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
    Alexander Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 30:1104-13. 2003
    ..A newly emerging reduction of rCMRglc in prefrontal cortical areas is associated with the transition from MCI to AD...
  23. ncbi Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients
    Eva Gross
    Department of Gynecology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 3:e4003. 2008
    ..As known deleterious mutations explain only a limited proportion of the drug-adverse events, we systematically searched for additional DPYD variations associated with enhanced drug toxicity...
  24. ncbi Association study between the D10S1423 microsatellite marker and Alzheimer's disease
    H Gohlke
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, , Ismaningerstr. 22, D-81675 Munich, Germany
    Neurobiol Aging 27:776.e1-776.e3. 2006
    ..015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14...
  25. ncbi COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression
    Achim Berthele
    Department of Neurology, Technical University Munich, Germany
    Neuroimage 28:185-93. 2005
    ..Moreover, the transcript was not detectable in the thalamus. Thus, mechanisms other than an enkephalin-dependent receptor turnover must be responsible for COMT-related differences in MOP binding site availability in the human brain...
  26. ncbi Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease
    S Schwarz
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurosci Lett 343:167-70. 2003
    ..In addition, the exon 9 SNP (rs868749) was not polymorphic in the studied population. We conclude that the previously identified polymorphism is not associated with AD...
  27. ncbi Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D 81675 Munich, Germany
    Neurobiol Aging 28:42-50. 2007
    ..To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant)...
  28. ncbi No association of lipase C polymorphisms with Alzheimer's disease
    S M Laws
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU Munchen, Munich, Germany
    Neurobiol Aging 31:2192-3. 2010
    ..Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD...
  29. ncbi Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study
    J Diehl
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Neurobiol Aging 25:1051-6. 2004
    ..To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD)...
  30. ncbi Cerebral glucose metabolism in patients with AD and different APOE genotypes
    A Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Neurology 64:102-7. 2005
    ..To examine the influence of the APOE epsilon4 allele on cerebral glucose metabolism in a large series of patients with Alzheimer disease (AD)...
  31. ncbi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
    ..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
  32. ncbi Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease
    S M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    Mol Psychiatry 12:510-7. 2007
    ..002, uncorrected). These findings provide functional evidence to support the genetic association of MAPT with AD...
  33. ncbi Genetic analysis of MAPT haplotype diversity in frontotemporal dementia
    S M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TU München, Ismaningerstr 22, D 81675 Munchen, Germany
    Neurobiol Aging 29:1276-8. 2008
    ..These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies...
  34. ncbi Potential biological markers for cerebrovascular disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int Psychogeriatr 15:89-97. 2003
    ..Among biochemical markers in the CSF, tau protein, phospho-tau, and beta amyloid protein are helpful to differentiate vascular dementia from Alzheimer's disease...
  35. ncbi Impact of the COMT Val(108/158)Met polymorphism on the mu-opioid receptor system in the human brain: mu-opioid receptor, met-enkephalin and beta-endorphin expression
    Markus C Kowarik
    Department of Neurology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Straße 22, 81675 Munich, Germany
    Neurosci Lett 506:214-9. 2012
    ..These results confirm the impact of the COMT Val(108/158)Met polymorphism on the MOP receptor system and may support the hypothesis of an enkephalin related turnover of MOP receptors at least in some brain structures...
  36. ncbi Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease
    H Hampel
    Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336, Munich, Germany
    Brain Res 823:104-12. 1999
    ....
  37. ncbi Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Philipps University Marburg, Rudolph Bultmann Str 8, 35039 Marburg, Germany
    Neurosci Lett 400:187-90. 2006
    ..Although LRP as well as RAP seem to play an essential role in the metabolism of alpha2M and APOE, there is no increase in the genetic risk for AD in patients carrying the investigated polymorphisms...
  38. ncbi [Associations between dementia and head circumference as a measure of brain reserve--results from the Bavarian School sisters study]
    Horst Bickel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar
    Psychiatr Prax 33:138-44. 2006
    ..The aim of the study was to examine the relationship of head circumference as a marker of maximal attained brain size to late-life cognitive impairment and dementia...
  39. ncbi TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels
    Simon M Laws
    Alzheimer s and Aging, School of Biomedical and Sports Science, Edith Cowan University, Joondalup, Australia
    Hum Mutat 26:29-35. 2005
    ..Further investigations are warranted to assess the significance of these novel findings...
  40. ncbi Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Friedrich Wilhelms University, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 342:132-4. 2003
    ..We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD...