Michael Quante

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Cell 21:36-51. 2012
  2. ncbi request reprint The gastrointestinal tumor microenvironment
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Gastroenterology 145:63-78. 2013
  3. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
  4. doi request reprint Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
    Wataru Shibata
    Department of Medicine, Division of Digestive and Liver Disease, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gut 62:192-200. 2013
  5. pmc Barrett esophagus: what a mouse model can teach us about human disease
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Munchen, Germany
    Cell Cycle 11:4328-38. 2012
  6. pmc TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Gastroenterology 139:2018-2027.e2. 2010
  7. pmc Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    Michael Quante
    Division of Digestive and Liver Diseases, Columbia University, New York, NY 10025, USA
    Cancer Cell 19:257-72. 2011
  8. doi request reprint Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis
    Zhigang Song
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, USA
    Lab Invest 90:426-35. 2010
  9. pmc Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma
    Reena Shakya
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 73:885-96. 2013
  10. pmc In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Dept of Medicine, Columbia Univ Medical Center, 1130 St Nicholas Ave, ICRC 923, New York, NY, USA
    Am J Physiol Gastrointest Liver Physiol 300:G334-44. 2011

Collaborators

Detail Information

Publications15

  1. pmc Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Cell 21:36-51. 2012
    ..Our data suggest that BE and EAC arise from gastric progenitors due to a tumor-promoting IL-1β-IL-6 signaling cascade and Dll1-dependent Notch signaling...
  2. ncbi request reprint The gastrointestinal tumor microenvironment
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Gastroenterology 145:63-78. 2013
    ....
  3. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
    ....
  4. doi request reprint Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
    Wataru Shibata
    Department of Medicine, Division of Digestive and Liver Disease, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gut 62:192-200. 2013
    ..Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of SDF-1 to gastric carcinogenesis...
  5. pmc Barrett esophagus: what a mouse model can teach us about human disease
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Munchen, Germany
    Cell Cycle 11:4328-38. 2012
    ..The data, taken together, suggest potential origins of BE from the gastric cardia, a role of bile acid and hypergatrinemia for carcinogenesis, a growing importance for columnar-like epithelium and a critical role for Notch signaling...
  6. pmc TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Gastroenterology 139:2018-2027.e2. 2010
    ....
  7. pmc Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    Michael Quante
    Division of Digestive and Liver Diseases, Columbia University, New York, NY 10025, USA
    Cancer Cell 19:257-72. 2011
    ..Therefore, carcinogenesis involves expansion and relocation of BM-niche cells to the tumor to create a niche to sustain cancer progression...
  8. doi request reprint Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis
    Zhigang Song
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, USA
    Lab Invest 90:426-35. 2010
    ..Collectively, these findings provide new insights into the mechanism by which tobacco products are likely to promote carcinogenesis in the setting of chronic pancreatitis...
  9. pmc Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma
    Reena Shakya
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 73:885-96. 2013
    ..These data show that DAC is effective against PDAC in vivo and provide a rationale for future studies combining hypomethylating agents with cytokines and immunotherapy...
  10. pmc In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Dept of Medicine, Columbia Univ Medical Center, 1130 St Nicholas Ave, ICRC 923, New York, NY, USA
    Am J Physiol Gastrointest Liver Physiol 300:G334-44. 2011
    ..This transgenic mouse provides a useful tool to study the regulation of mouse gastrin gene in vivo, thus contributing to our understanding of the mechanisms involved in transcriptional control of the gastrin gene...
  11. pmc Stem cells in gastroenterology and hepatology
    Michael Quante
    Division of Digestive and Liver Diseases, Columbia University Medical Center, Irving Cancer Research Center, 1130 St Nicholas Avenue, Room 925, 9th Floor, New York, NY 10032, USA
    Nat Rev Gastroenterol Hepatol 6:724-37. 2009
    ....
  12. pmc p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells
    Shui Ping Tu
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 297:G385-96. 2009
    ..p53 induces cell apoptosis and inhibits cell migration in part by downregulating TFF2 expression through an AP-1-like site, suggesting that TFF2 may be an important downstream target of p53...
  13. ncbi request reprint Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinoma
    Marc Tänzer
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    Pharmacol Ther 140:133-47. 2013
    ..While many biomarkers seem to be very promising, especially if used as panels, further development is urgently needed to address practical considerations of biomarkers in cancer treatment. ..
  14. pmc Inflammation and stem cells in gastrointestinal carcinogenesis
    Michael Quante
    Division of Digestive and Liver Diseases, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    Physiology (Bethesda) 23:350-9. 2008
    ..Here, we review the link between inflammation and gastrointestinal carcinogenesis and the relationship between stem cells and cancer stem cells...
  15. pmc Correlation between serum gastrin and cellular proliferation in Barrett's esophagus
    Daniel A Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Therap Adv Gastroenterol 4:89-94. 2011
    ..Longitudinal studies of patients with BE are needed to determine whether hypergastrinemia is a risk factor for the development of dysplasia and adenocarcinoma or could be used as a biomarker for disease progression...