Robert Perneczky

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc Soluble amyloid precursor protein β as blood-based biomarker of Alzheimer's disease
    R Perneczky
    Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, London, UK
    Transl Psychiatry 3:e227. 2013
  2. doi request reprint Head circumference, apolipoprotein E genotype and cognition in the Bavarian School Sisters Study
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, 22, Ismaninger Street, 81675 Munchen, Germany
    Eur Psychiatry 27:219-22. 2012
  3. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
  4. pmc Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Neurobiol Dis 43:79-85. 2011
  5. ncbi request reprint Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment
    Robert Perneczky
    Department of Psychiatry, Medicine Technische Universität Munchen, Germany
    J Geriatr Psychiatry Neurol 20:84-8. 2007
  6. doi request reprint [Cognitive reserve and its relevance for the prevention and diagnosis of dementia]
    R Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat, Munchen, Deutschland
    Nervenarzt 82:325-30, 332-35. 2011
  7. ncbi request reprint Gender differences in brain reserve : an (18)F-FDG PET study in Alzheimer's disease
    R Perneczky
    Dept of Psychiatry and Psychotherapy, Technical University of Munich, Ismaningerstr 22, 81675, Munchen, Germany
    J Neurol 254:1395-400. 2007
  8. ncbi request reprint Urinary incontinence and its functional anatomy in frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich Medical School, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:605-10. 2008
  9. pmc Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Neurology 75:137-42. 2010
  10. doi request reprint Right prefrontal hypometabolism predicts delusions in dementia with Lewy bodies
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munchen, Germany
    Neurobiol Aging 30:1420-9. 2009

Collaborators

Detail Information

Publications72

  1. pmc Soluble amyloid precursor protein β as blood-based biomarker of Alzheimer's disease
    R Perneczky
    Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, London, UK
    Transl Psychiatry 3:e227. 2013
    ..Further research is required to establish normal ranges and to replicate the results in independent cohorts including larger numbers of participants covering a wider spectrum of cognitive impairment...
  2. doi request reprint Head circumference, apolipoprotein E genotype and cognition in the Bavarian School Sisters Study
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, 22, Ismaninger Street, 81675 Munchen, Germany
    Eur Psychiatry 27:219-22. 2012
    ..The apolipoprotein E (APOE) ɛ4 allele is correlated with an earlier onset of Alzheimer's disease symptoms; larger head circumference has been associated with an individual resilience against cognitive impairment...
  3. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
    ..Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB...
  4. pmc Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Neurobiol Dis 43:79-85. 2011
    ..Our behavioural and imaging findings point to an association between saccade latency, executive function and the structural integrity within a well-defined oculomotor network...
  5. ncbi request reprint Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment
    Robert Perneczky
    Department of Psychiatry, Medicine Technische Universität Munchen, Germany
    J Geriatr Psychiatry Neurol 20:84-8. 2007
    ..001, uncorrected for multiple comparisons), which was independent from demographical variables. The authors conclude that clinical severity of impairments is already correlated with deficits in glucose metabolism in the stage of MCI...
  6. doi request reprint [Cognitive reserve and its relevance for the prevention and diagnosis of dementia]
    R Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat, Munchen, Deutschland
    Nervenarzt 82:325-30, 332-35. 2011
    ..Individuals with higher CR show more efficient activation for solving the same task, which helps them to preserve normal levels of cognitive performance for a longer period...
  7. ncbi request reprint Gender differences in brain reserve : an (18)F-FDG PET study in Alzheimer's disease
    R Perneczky
    Dept of Psychiatry and Psychotherapy, Technical University of Munich, Ismaningerstr 22, 81675, Munchen, Germany
    J Neurol 254:1395-400. 2007
    ..Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men...
  8. ncbi request reprint Urinary incontinence and its functional anatomy in frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich Medical School, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:605-10. 2008
    ..The aim of the present study was therefore to explore if functional brain lesions were associated with UIC in patients suffering from frontotemporal lobar degenerations (FTLD)...
  9. pmc Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Neurology 75:137-42. 2010
    ..Clinical and epidemiologic studies suggest that patients with Alzheimer disease (AD) with larger head circumference have better cognitive performance at the same level of brain pathology than subjects with smaller head circumference...
  10. doi request reprint Right prefrontal hypometabolism predicts delusions in dementia with Lewy bodies
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munchen, Germany
    Neurobiol Aging 30:1420-9. 2009
    ..VH and overall cognitive dysfunction were no significant predictors. These results underline the significance of right prefrontal damage for DEL in DLB...
  11. doi request reprint Metabolic alterations associated with impaired clock drawing in Lewy body dementia
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Ismaninger Str 22, 81675 Munchen, Germany
    Psychiatry Res 181:85-9. 2010
    ..These findings also suggest that the CDT is an appropriate screening instrument for this disorder and that metabolic dysfunction, and therefore disease severity, is mirrored by performance on the test...
  12. pmc Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer's disease: the MIRAGE study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Alzheimers Dis 17:855-62. 2009
    ..Most interestingly, the interaction term between education and MTA was significant suggesting that education modifies the relation of MTA to cognition. At any level of pathology, cognition remained higher for better educated individuals...
  13. doi request reprint Fluoro-deoxy-glucose positron emission tomography correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Am J Geriatr Psychiatry 17:188-95. 2009
    ....
  14. doi request reprint Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 25:531-8. 2008
    ..To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH)...
  15. doi request reprint Activities of daily living, cerebral glucose metabolism, and cognitive reserve in Lewy body and Parkinson's disease
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 26:475-81. 2008
    ....
  16. ncbi request reprint Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Int J Geriatr Psychiatry 22:1135-40. 2007
    ..This suggests that men can compensate more pathology than women...
  17. doi request reprint CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, 81675 Munchen, Germany
    Neurology 77:35-8. 2011
    ..To explore if soluble amyloid precursor proteins (sAPP) in CSF improve the identification of patients with incipient Alzheimer disease (AD) in a group of patients with mild cognitive impairment (MCI)...
  18. ncbi request reprint Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 21:158-62. 2006
    ..However, even mild degrees of cognitive deterioration are known to have negative effects on complex ADL...
  19. ncbi request reprint Mapping scores onto stages: mini-mental state examination and clinical dementia rating
    Robert Perneczky
    Department of Psychiatry and Psychotherapy and the Institute of Medical Statistics and Epidemiology, Technische Universitat Munchen, Germany
    Am J Geriatr Psychiatry 14:139-44. 2006
    ..In the present study, the authors mapped Mini-Mental State Examination (MMSE) scores onto CDR categories to determine how well the MMSE performs as a surrogate of the CDR as a timesaving method of staging dementia...
  20. ncbi request reprint Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues
    Robert Perneczky
    Department of Psychiatry, Technische Universitat Munchen, Germany
    Age Ageing 35:240-5. 2006
    ..The concept of an ADL threshold that separates MCI from dementia, however, appears to be improbable for several reasons...
  21. pmc Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1060-3. 2006
    ..Therefore, schooling seems to provide brain reserve against neurodegeneration...
  22. doi request reprint Accelerated clinical decline in well-educated patients with frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, 81675 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 259:362-7. 2009
    ..There was a significant positive association between education and CDR-SOB monthly rate of change, indicating a faster decline in the well-educated. Education was the only significant predictor of clinical deterioration...
  23. ncbi request reprint Brain reserve capacity in frontotemporal dementia: a voxel-based 18F-FDG PET study
    Robert Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 34:1082-7. 2007
    ..The results suggest that brain reserve capacity (BRC) allows patients with more years of schooling to cope better with AD pathology. The objective of this study was to provide initial evidence for BRC in frontotemporal dementia (FTD)...
  24. doi request reprint White matter hyperintensities predict amyloid increase in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 33:2766-73. 2012
    ..The extent of WMH might be a relevant factor to be assessed in antiamyloid drug trials...
  25. doi request reprint Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:69-77. 2012
    ..Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics...
  26. doi request reprint Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease
    Ruth Vukovich
    Department of Psychiatry and Psychotherapy, Neurochemistry and Neurogenetics Laboratory, Technische Universitat Munchen, Munchen, Germany
    Dement Geriatr Cogn Disord 27:474-80. 2009
    ..Their topographic origin and their association with synaptic dysfunction are still not well understood...
  27. doi request reprint Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Alzheimers Dis 36:401-8. 2013
    ..g., soluble AβPPα and β (sAβPPα and sAβPPβ, respectively); sortilin-related receptor with A-type repeats (SORL1, also called LR11 or SORLA)] are factors crucially implicated in the formation of pathological hallmarks of AD...
  28. doi request reprint β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
    Amalia Tsolakidou
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Alzheimers Dement 9:386-91. 2013
    ..Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD)...
  29. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  30. ncbi request reprint Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Brain Res 1133:178-85. 2007
    ..05). We conclude that brain reserve is also present in NFPA...
  31. doi request reprint The National Institute on Aging-Alzheimer's Association research criteria for mild cognitive impairment due to Alzheimer's disease: predicting the outcome
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:325-33. 2013
    ..The new NIA-AA MCI criteria represent a valuable research instrument that could be incorporated into the diagnostic process of the MCI syndrome after optimisation and refinement...
  32. ncbi request reprint Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia
    Simon M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Munich University of Technology, 81675 Munich, Germany
    Am J Psychiatry 164:1577-84. 2007
    ..The aim of this study was to investigate the MAPT haplotypes in relation to risk for, and functional alterations of glucose metabolism in, patients with frontotemporal dementia (FTD)...
  33. doi request reprint Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 28:543-52. 2012
    ....
  34. pmc Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Street 22, 81675 Munchen, Germany
    ScientificWorldJournal 2012:712048. 2012
    ..Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring...
  35. doi request reprint Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009
    ..The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments...
  36. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
    ..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
  37. ncbi request reprint The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Curr Alzheimer Res 10:82-5. 2013
    ..Amyloid imaging enables to visualize a hallmark pathology of Alzheimer's disease (AD). Therefore we aimed to assess the usefulness of [(11)C]PiB PET for predicting clinical outcome of MCI patients after an interval of 2 years...
  38. doi request reprint Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 8:304-11. 2012
    ..The levels of the α-secretase-cleaved soluble APP (sAPPα) and β-secretase-cleaved soluble APP (sAPPβ) in cerebrospinal fluid (CSF) are likely to reflect these competing mechanisms...
  39. doi request reprint A 6-month, open-label study of memantine in patients with frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 23:754-9. 2008
    ..To evaluate safety and effects on cognition and behavior of memantine 20 mg/day in the treatment of patients with frontotemporal dementia (FTD)...
  40. doi request reprint Asymmetric loss of parietal activity causes spatial bias in prodromal and mild Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:798-804. 2012
    ....
  41. doi request reprint Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
    Christine Preibisch
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Magn Reson Imaging 34:1295-302. 2011
    ..To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique...
  42. ncbi request reprint No association of TDP-43 with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Ismanigerstr 22, TU Munich, 81675 Munich, Germany
    Neurobiol Aging 30:157-9. 2009
    ..There is no evidence, that common variants in TDP-43 confer a strong risk to the development of sporadic FTD...
  43. ncbi request reprint Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances
    Susanne Bornschein
    Department of Psychiatry and Psychotherapy, Technical University TU of Munich, Klinikum rechts der Isar, Munich, Germany
    Scand J Work Environ Health 33:447-53. 2007
    ..In this study, a small group of well-characterized patients with idiopathic environmental intolerance were examined in order to identify such changes...
  44. ncbi request reprint Progression to dementia in clinical subtypes of mild cognitive impairment
    P Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany
    Dement Geriatr Cogn Disord 22:27-34. 2006
    ..To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI)...
  45. pmc Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany panos alexopoulos lrz tum de
    Dement Geriatr Cogn Disord 32:164-70. 2011
    ..Recently, genetic variants of the neuronal sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) have emerged as risk factors for the development of Alzheimer's disease (AD)...
  46. ncbi request reprint Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
    ..We conclude that the amyloid beta concentration ratio should replace the 'raw' concentrations of corresponding A beta peptides to improve reliability of the neurochemical dementia diagnosis...
  47. doi request reprint Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
    Tanja Richter-Schmidinger
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm 118:249-57. 2011
    ..BDNF Val66Met polymorphism seems to influence working memory function and modulate the effects of ageing on working memory in healthy young adults...
  48. doi request reprint Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Cogn Behav Neurol 26:73-7. 2013
    ..Our aim was to compare the frequency of criminal conduct in patients with behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and Alzheimer disease...
  49. ncbi request reprint Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  50. doi request reprint Neurobiology of cognitive disorders
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Curr Opin Psychiatry 22:546-51. 2009
    ..The consequences of these novel insights for therapeutic interventions are also explained...
  51. pmc Plasma proteomics for the identification of Alzheimer disease
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy Institute for Medical Statistics and Epidemiology, Technische Universitat Munchen, Munich, Germany Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK
    Alzheimer Dis Assoc Disord 27:337-42. 2013
    ..The study provides a piece of evidence in support of the feasibility of a blood-based biomarker approach in AD diagnostics; however, further research is required because of issues with replicability. ..
  52. doi request reprint Brain size and the compensation of Alzheimer's disease symptoms: a longitudinal cohort study
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 9:580-6. 2013
    ..In this study we examine whether ICV modulates the association between clinical disease progression on the one hand and brain atrophy or the apolipoprotein E genotype on the other...
  53. doi request reprint Patient participation in medical and social decisions in Alzheimer's disease
    Johannes Hamann
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Am Geriatr Soc 59:2045-52. 2011
    ....
  54. ncbi request reprint Impact of Alzheimer's disease on the functional connectivity of spontaneous brain activity
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Curr Alzheimer Res 6:541-53. 2009
    ..Finally, rs-fMRI seems to have the potential to produce connectivity-related biomarkers that distinguish AD and healthy aging...
  55. ncbi request reprint Behavioral disturbances in the course of frontotemporal dementia
    J Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:352-7. 2006
    ..Objective: The aim of this study was to assess and compare the prevalence and severity of behavioral disturbances in patients with mild FTD and in patients with moderate/severe dementia...
  56. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
    ..Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET)...
  57. doi request reprint [Current immune therapy for Alzheimer's disease]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Technische Universitat, Möhlstrasse 26, 81675 Munchen
    Nervenarzt 79:832-5. 2008
    ..Particularly Abeta42 and the clinical research are examined. Ethical and economic questions resulting from successful immunization against Abeta are discussed...
  58. doi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...
  59. ncbi request reprint The Alzheimer variant of lewy body disease: a pathologically confirmed case-control study
    R Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Munchen, Deutschland
    Dement Geriatr Cogn Disord 20:89-94. 2005
    ..Taken together, our findings suggest that Lewy body pathology may be present in patients who do not show the typical clinical features which distinguish DLB from AD...
  60. doi request reprint Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
    ..To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo...
  61. ncbi request reprint [Initial symptoms, survival and causes of death in 115 patients with frontotemporal lobar degeneration]
    J Diehl-Schmid
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen
    Fortschr Neurol Psychiatr 75:708-13. 2007
    ..Mortality risk was significantly higher in patients with an early disease onset. Causes of death were varied, but pneumonia and sudden unexplained deaths were particularly frequent...
  62. ncbi request reprint [Mild cognitive disorder. Questions of definition, diagnosis, prognosis and therapy]
    A Kurz
    Klinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen
    Nervenarzt 75:6-15. 2004
    ..Patients with early-stage Alzheimer's are an important target group for treatment interventions aiming at slowing the neurodegenerative process...
  63. doi request reprint Novel insights for the treatment of Alzheimer's disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:373-9. 2011
    ..Symptomatic treatments will continue to be needed, and psychosocial approaches will retain an essential role in supporting affected individuals and their families...
  64. doi request reprint Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer's disease
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:553-60. 2013
    ..The present study provides evidence in support of hFABP and VEGF in CSF as AD biomarker candidates to be used in combination with the established markers Aβ1-42, tTau, and pTau181...
  65. doi request reprint Amyloid clearance as a treatment target against Alzheimer's disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 24:61-73. 2011
    ..It may take longer than projected in ongoing trials for such neurobiological effects to translate into measurable changes of clinical progression...
  66. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
    ..Our findings reconfirm the hypothesis that alterations of biomarker concentrations occur early in a preclinical AD stage and that these alterations are also reflected in plasma...
  67. ncbi request reprint Multivariate network analysis of fiber tract integrity in Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Neuroimage 34:985-95. 2007
    ..In agreement with post-mortem evidence, our study demonstrates dissociation between intracortical and extracortical projecting fiber systems in AD in the living human brain...
  68. doi request reprint [Personality in old age]
    H Forstl
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, 81675 Munchen
    Nervenarzt 80:1275-82. 2009
    ....
  69. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  70. ncbi request reprint Do all patients with mild cognitive impairment progress to dementia?
    Panagiotis Alexopoulos
    J Am Geriatr Soc 54:1008-10. 2006
  71. pmc Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease
    Christian Habeck
    Taub Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuroimage 40:1503-15. 2008
    ..Multivariate measures of AD utilize the covariance structure of imaging data and provide complementary, clinically relevant information that may be superior to univariate measures...
  72. ncbi request reprint TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels
    Simon M Laws
    Alzheimer s and Aging, School of Biomedical and Sports Science, Edith Cowan University, Joondalup, Australia
    Hum Mutat 26:29-35. 2005
    ..Further investigations are warranted to assess the significance of these novel findings...