Robert A J Oostendorp

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi Generation of murine stromal cell lines: models for the microenvironment of the embryonic mouse aorta-gonads-mesonephros region
    Robert A J Oostendorp
    The Stem Cell Physiology Laboratory, III, Medizinische Klinik, Klinikum rechts der Isar, Technical University, Munich, Germany
    Methods Mol Biol 290:163-72. 2005
  2. pmc Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction
    Andreas Stein
    Deutsches Herzzentrum der Technischen Universität München, Lazarettstr 36, 80636 München, Germany
    BMC Cardiovasc Disord 10:43. 2010
  3. ncbi Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells
    Robert A J Oostendorp
    Laboratory of Stem Cell Physiology, III Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munchen, Germany
    Stem Cells 26:2164-72. 2008
  4. ncbi Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Stem Cells 23:842-51. 2005
  5. doi Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources
    Nikolas Kaltz
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Exp Cell Res 316:2609-17. 2010
  6. ncbi CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression
    Katharina S Götze
    3rd Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Exp Hematol 35:1408-14. 2007
  7. ncbi Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    J Cell Sci 115:2099-108. 2002
  8. ncbi Role of secreted factors in the regulation of hematopoietic stem cells by the bone marrow microenvironment
    Pawandeep Kaur-Bollinger
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Front Biosci (Landmark Ed) 17:876-91. 2012
  9. doi How the niche regulates hematopoietic stem cells
    Jonas Renström
    III Medizinische Klinik and Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Chem Biol Interact 184:7-15. 2010
  10. ncbi Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche
    Christina Schreck
    III Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Ann N Y Acad Sci 1310:32-43. 2014

Collaborators

Detail Information

Publications22

  1. ncbi Generation of murine stromal cell lines: models for the microenvironment of the embryonic mouse aorta-gonads-mesonephros region
    Robert A J Oostendorp
    The Stem Cell Physiology Laboratory, III, Medizinische Klinik, Klinikum rechts der Isar, Technical University, Munich, Germany
    Methods Mol Biol 290:163-72. 2005
    ..These stromal cell clones are valuable tools for the study of the regulation of hematopoietic stem and progenitor cells in the midgestation mouse embryo...
  2. pmc Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction
    Andreas Stein
    Deutsches Herzzentrum der Technischen Universität München, Lazarettstr 36, 80636 München, Germany
    BMC Cardiovasc Disord 10:43. 2010
    ..Aim of this study was to evaluate intramyocardial application of eEPCs and EPO as compared to eEPCs or EPO alone in experimental MI...
  3. ncbi Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells
    Robert A J Oostendorp
    Laboratory of Stem Cell Physiology, III Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munchen, Germany
    Stem Cells 26:2164-72. 2008
    ..Our results show that the loss of repopulating activity during KL stimulation is counteracted by OSM through the downregulation of ERK pathway signaling. Disclosure of potential conflicts of interest is found at the end of this article...
  4. ncbi Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Stem Cells 23:842-51. 2005
    ..In summary, we show for the first time long-term maintenance of adult bone marrow HSCs in stroma noncontact cultures and identify some secreted molecules that may be involved in this support...
  5. doi Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources
    Nikolas Kaltz
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Exp Cell Res 316:2609-17. 2010
    ..Our observations may facilitate the study of lineage relationships in MSC as well as facilitate the development of more homogeneous cell populations for mesenchymal cell therapy...
  6. ncbi CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression
    Katharina S Götze
    3rd Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Exp Hematol 35:1408-14. 2007
    ..In conclusion, we demonstrate that CD133-enriched Lin(-)CD34(-) cord blood cells acquire CD34 prior to cell division and that long-term hematopoietic activity is associated exclusively with expression of CD34...
  7. ncbi Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    J Cell Sci 115:2099-108. 2002
    ..Interestingly, a few of these stromal clones express a recently described chordin-like protein, which is an inhibitor of bone morphogenic proteins and is preferentially expressed in cells of the mesenchymal lineage...
  8. ncbi Role of secreted factors in the regulation of hematopoietic stem cells by the bone marrow microenvironment
    Pawandeep Kaur-Bollinger
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Front Biosci (Landmark Ed) 17:876-91. 2012
    ..An understanding of how the niche participates in HSC maintenance and repair through soluble factors can offer new opportunities for the development of novel therapeutic tools against hematological malignancies...
  9. doi How the niche regulates hematopoietic stem cells
    Jonas Renström
    III Medizinische Klinik and Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Chem Biol Interact 184:7-15. 2010
    ..Detailed knowledge of the regulatory mechanisms operating between hematopoietic cells and their direct surroundings facilitates the study of how such signaling may be disrupted by environmental exposure...
  10. ncbi Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche
    Christina Schreck
    III Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Ann N Y Acad Sci 1310:32-43. 2014
    ..Thus, insights into the normal and altered functions of niche components will help to obtain a better understanding of normal and malignant hematopoiesis and how environmental factors affect these processes. ..
  11. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
    ..These results strongly suggest that during midgestation, not only the AM but also the UG subregion provides a potent microenvironment for growth and maintenance of the first HSCs...
  12. doi Non-invasive tracking of human haemopoietic CD34(+) stem cells in vivo in immunodeficient mice by using magnetic resonance imaging
    Markus Niemeyer
    Department of Gynaecology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Eur Radiol 20:2184-93. 2010
    ..To assess migration of CD34(+) human stem cells to the bone marrow of athymic mice by using magnetic resonance (MR) imaging and Resovist, a contrast agent containing superparamagnetic iron oxide (SPIO) particles...
  13. doi Altered adhesive properties of cord blood endothelial outgrowth cells expressing IL-1ra
    Philipp Fischer
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Immunol Cell Biol 88:313-20. 2010
    ..Therefore, icIL-ra transgenic CB-EOCs may prove to be beneficial in the treatment of IL-1beta- and TNFalpha-mediated inflammatory vasculopathies...
  14. doi In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes
    Nikolas Kaltz
    Third Department of Internal Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Stem Cells 26:2419-24. 2008
    ..Despite low-level expression of POU5F1, we were unable to precipitate POU5F1 protein in either BM-MSC or UVSC. These results demonstrate that MSC stemness does not correlate to expression of POU5F1 transcripts or its pseudogenes...
  15. doi Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells
    Jonas Renström
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Munich, Germany
    Cell Stem Cell 5:157-67. 2009
    ..Our results demonstrate that Sfrp1 is required to maintain HSC homeostasis through extrinsic regulation of beta-catenin...
  16. ncbi Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction
    Ilka Ott
    I Department of Medicine, Technical University Munich, Munich, Germany
    FASEB J 19:992-4. 2005
    ..Therefore, in vitro expanded EPC-derived endothelial cells may be beneficial in the treatment of ischemic disease...
  17. doi Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches
    Maria H Ledran
    North East Institute for Stem Cell Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Stem Cell 3:85-98. 2008
    ..Overall, our findings represent significant progress toward the goal of deriving functional hematopoietic stem cells from hESCs...
  18. ncbi The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
    Claudia Orelio
    Erasmus University Medical Centre, Department of Cell Biology and Genetics, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 103:4084-92. 2004
    ..Most important, our in vivo transplantation data show that Bcl-2 overexpression increases AGM and fetal liver HSC activity, strongly suggesting that apoptosis plays a role in HSC development...
  19. ncbi Comparison of iron oxide labeling properties of hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking in a xenotransplant mouse model XXX
    Heike E Daldrup-Link
    Department of Radiology, University of California San Francisco, UCSF Medical Center, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Acad Radiol 12:502-10. 2005
    ..To compare and optimize ferumoxides labeling of human hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking with a clinical 1.5 T MR scanner...
  20. ncbi Cell tracking with gadophrin-2: a bifunctional contrast agent for MR imaging, optical imaging, and fluorescence microscopy
    Heike E Daldrup-Link
    Department of Radiology, UCSF Medical Center, University of California in San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Eur J Nucl Med Mol Imaging 31:1312-21. 2004
    ....
  21. ncbi Targeting of hematopoietic progenitor cells with MR contrast agents
    Heike E Daldrup-Link
    Department of Radiology, Technical University, Ismaninger Str 22, 81675 Munich, Germany
    Radiology 228:760-7. 2003
    ..To label human hematopoietic progenitor cells with various magnetic resonance (MR) imaging contrast agents and to obtain 1.5-T MR images of them...
  22. ncbi Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    FASEB J 20:2559-61. 2006
    ..The understanding and modulation of these mechanisms may offer new treatment strategies for patients at high risk for atherosclerotic diseases...