G Nikisch

Summary

Affiliation: Klinikum Fulda
Country: Germany

Publications

  1. doi request reprint Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Fulda, Germany
    J Psychopharmacol 25:896-907. 2011
  2. doi request reprint Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Fulda, Germany
    J Clin Psychopharmacol 30:496-503. 2010
  3. doi request reprint Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    J Psychiatr Res 44:754-9. 2010
  4. ncbi request reprint Involvement and role of antidepressant drugs of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor function
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Neuro Endocrinol Lett 30:11-6. 2009
  5. ncbi request reprint Three-year follow-up of a patient with early-onset Alzheimer's disease with presenilin-2 N141I mutation - case report and review of the literature
    G Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Eur J Med Res 13:579-84. 2008
  6. doi request reprint Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Pharmacol Res 58:344-7. 2008
  7. doi request reprint [Familial Alzheimer's disease with presenilin 2 N141I mutation. A case report]
    G Nikisch
    Klinikum Fulda gAG, Klinik fur Psychiatrie und Psychotherapie, Fulda
    Fortschr Neurol Psychiatr 76:606-9. 2008
  8. doi request reprint CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, D 36043 Fulda, Germany
    Eur Psychiatry 23:356-9. 2008
  9. ncbi request reprint Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda, P O Box 2364, 36013, Fulda, Germany
    Psychopharmacology (Berl) 181:751-60. 2005
  10. ncbi request reprint Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Box 2364, Klinikum Fulda, D 36013 Fulda, Germany
    J Clin Psychopharmacol 24:283-90. 2004

Collaborators

Detail Information

Publications13

  1. doi request reprint Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Fulda, Germany
    J Psychopharmacol 25:896-907. 2011
    ..These results suggest that ABCB1 genetic polymorphisms may be a predictive marker of quetiapine treatment in schizophrenia...
  2. doi request reprint Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Fulda, Germany
    J Clin Psychopharmacol 30:496-503. 2010
    ..038). Because, unfortunately, schizophrenic patients experience relapses even with the best available treatments, monitoring of CSF drug and metabolite levels might prove to be useful in tailoring individually adjusted treatments...
  3. doi request reprint Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    J Psychiatr Res 44:754-9. 2010
    ..This suggests that CSF monoamine metabolites levels reflect the effects of quetiapine treatment on neurotransmitters in vivo and indicates that monitoring plasma and CSF quetiapine and norquetiapine levels may be of clinical relevance...
  4. ncbi request reprint Involvement and role of antidepressant drugs of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor function
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Neuro Endocrinol Lett 30:11-6. 2009
    ..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
  5. ncbi request reprint Three-year follow-up of a patient with early-onset Alzheimer's disease with presenilin-2 N141I mutation - case report and review of the literature
    G Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Eur J Med Res 13:579-84. 2008
    ..Follow-up MRI and 18F-FDG PET studies showed progression of atrophy of the left entorhinal cortex with relative sparing of the hippocampus and progressive hypometabolism of both temporoparietal lobes and left frontal lobe...
  6. doi request reprint Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany
    Pharmacol Res 58:344-7. 2008
    ..These findings should be replicated in future studies with larger groups of patients. Because of the small number of subjects in the present study, future studies with larger groups of patients, also with different ethnicities...
  7. doi request reprint [Familial Alzheimer's disease with presenilin 2 N141I mutation. A case report]
    G Nikisch
    Klinikum Fulda gAG, Klinik fur Psychiatrie und Psychotherapie, Fulda
    Fortschr Neurol Psychiatr 76:606-9. 2008
    ..Follow-up 18F-FDG PET studies showed progressive hypometabolism of both temporoparietal lobes and left frontal lobe...
  8. doi request reprint CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, D 36043 Fulda, Germany
    Eur Psychiatry 23:356-9. 2008
    ..Findings of NPY increase and CRH decrease were similar to those following chronic treatment with citalopram, indicating that these changes might constitute one of the common underpinnings of antidepressant treatment modalities...
  9. ncbi request reprint Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda, P O Box 2364, 36013, Fulda, Germany
    Psychopharmacology (Berl) 181:751-60. 2005
    ..A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a well-documented neurobiological finding in major depression. Moreover, clinically effective therapy with antidepressant drugs may normalize the HPA axis activity...
  10. ncbi request reprint Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Box 2364, Klinikum Fulda, D 36013 Fulda, Germany
    J Clin Psychopharmacol 24:283-90. 2004
    ..572, P = 0.01). The demonstrated correlations between pharmacokinetic parameters and the clinical outcome as well as 5-HIAA changes indicate that monitoring of plasma S-CIT, CSF S-CIT and CSF S-CIT-PROP may be of clinical relevance...
  11. ncbi request reprint Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda, Germany
    Int J Neuropsychopharmacol 8:403-10. 2005
    ..Significant NPY and CRH changes in CSF following treatment as well as correlations to changes in HAMD support the hypothesis that these two peptides play a role in affective disorders and are markers of therapeutic response...
  12. ncbi request reprint Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?
    Aleksander A Mathe
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, Psychiatry M56, E 141 86 Stockholm, Sweden
    Physiol Behav 92:226-31. 2007
    ..Consequently, if these data are confirmed, the ethical and medical question that will be asked is whether it is permissible and advisable to consider prophylactically treating persons at risk...
  13. ncbi request reprint Mirtazapine enantiomers in blood and cerebrospinal fluid
    Pierre Baumann
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, DP CHUV, Prilly Lausanne, Suisse
    Neuropsychobiology 54:179-81. 2006
    ..For R-(-)-MIR, the CSF/plasma ratio varied between 0.08 and 0.31. Further studies are needed to test the hypothesis that there are possible differences in the transport mechanisms of the enantiomers of MIR at the blood-CSF barrier...