Sven Moosmang

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    J Neurosci 25:9883-92. 2005
  2. ncbi Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Circ Res 98:105-10. 2006
  3. pmc Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, TU Munchen, Biedersteiner Strasse 29, D 80802 München, Germany
    EMBO J 22:6027-34. 2003
  4. ncbi Mouse models to study L-type calcium channel function
    Sven Moosmang
    Institut fur Pharmakologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802, Munchen, Germany
    Pharmacol Ther 106:347-55. 2005
  5. ncbi An essential role of Cav1.2 L-type calcium channel for urinary bladder function
    Jörg W Wegener
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, D 80802 München, Germany
    FASEB J 18:1159-61. 2004
  6. pmc Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570
    Anne Blaich
    Forschergruppe 923, Munich Center for Integrated Protein Science, and Institut für Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    Proc Natl Acad Sci U S A 107:10285-9. 2010
  7. ncbi Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites
    Tae Seong Lee
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Munchen, Germany
    J Biol Chem 281:25560-7. 2006
  8. pmc Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death
    Anne Blaich
    Forschergruppe, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munchen, Germany
    J Biol Chem 287:22616-25. 2012
  9. pmc Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel
    Julia Brandmayr
    Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munchen, Germany
    J Biol Chem 287:22584-92. 2012
  10. pmc Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif
    Montatip Poomvanicha
    Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    J Biol Chem 286:26702-7. 2011

Collaborators

Detail Information

Publications19

  1. ncbi Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    J Neurosci 25:9883-92. 2005
    ..2 channel-mediated Ca2+ influx to either process...
  2. ncbi Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Circ Res 98:105-10. 2006
    ..2SMAKO mice. These results demonstrate that the effect of the putative T-type Ca2+ channel-selective blocker mibefradil on blood pressure and small vessel myogenic tone is mediated by the Cav1.2 L-type Ca2+ channel...
  3. pmc Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, TU Munchen, Biedersteiner Strasse 29, D 80802 München, Germany
    EMBO J 22:6027-34. 2003
    ..2 channel. These results show that Cav1.2 calcium channels are key players in the hormonal regulation of blood pressure and development of myogenic tone...
  4. ncbi Mouse models to study L-type calcium channel function
    Sven Moosmang
    Institut fur Pharmakologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802, Munchen, Germany
    Pharmacol Ther 106:347-55. 2005
    ....
  5. ncbi An essential role of Cav1.2 L-type calcium channel for urinary bladder function
    Jörg W Wegener
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, D 80802 München, Germany
    FASEB J 18:1159-61. 2004
    ..These results show that the Cav1.2 Ca2+ channel is essential for normal bladder function. The Rho-kinase and Ca2+-release pathways cannot compensate the lack of the L-type Ca2+ channel...
  6. pmc Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570
    Anne Blaich
    Forschergruppe 923, Munich Center for Integrated Protein Science, and Institut für Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    Proc Natl Acad Sci U S A 107:10285-9. 2010
    ..Our results strongly support the notion that CaMKII-dependent phosphorylation of Cav1.2 at S1512 and S1570 mediates Ca(2+) current facilitation in the murine heart...
  7. ncbi Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites
    Tae Seong Lee
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Munchen, Germany
    J Biol Chem 281:25560-7. 2006
    ..2 protein was strongly decreased in the S1512A/S1570A double mutant. These results suggest that voltage-dependent facilitation of the Ca(v)1.2 channel depends on the phosphorylation of Ser1512/Ser1570 by calmodulin kinase II...
  8. pmc Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death
    Anne Blaich
    Forschergruppe, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munchen, Germany
    J Biol Chem 287:22616-25. 2012
    ..Treatment of mice with metoprolol and captopril reduced DCM in Ca(v)1.2(I1624E) hearts at day 10. We conclude that mutation of the IQ motif to IE leads to dilated cardiomyopathy and death...
  9. pmc Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel
    Julia Brandmayr
    Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munchen, Germany
    J Biol Chem 287:22584-92. 2012
    ..We conclude that phosphorylation of the C-terminal sites in Ca(v)β(2), Ser(1928), Ser(1512), and Ser(1570) of the Ca(v)1.2 protein is functionally not involved in the adrenergic regulation of the murine cardiac Ca(v)1.2 channel...
  10. pmc Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif
    Montatip Poomvanicha
    Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    J Biol Chem 286:26702-7. 2011
    ..The results show that the I/E mutation abolishes Ca(2+)/calmodulin-dependent regulation of Ca(v)1.2. The Ca(v)1.2(I1624E) mutation transforms the channel to a phenotype mimicking CDI...
  11. doi Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels
    Nicole Langwieser
    Institute for Pharmacology, Technical University Munich, 80802 Munich, Germany
    J Neurosci 30:8367-75. 2010
    ..Our results demonstrate for the first time the importance of the Ca(v)1.2 LTCC subtype in synaptic plasticity and fear memory acquisition...
  12. pmc Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice
    Toni Lemke
    Institut fur Pharmakologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    J Biol Chem 283:34738-44. 2008
    ..2 by PKA. Therefore, our data show that PKA phosphorylation of Ser(1928) of Ca(v)1.2 is not functionally involved in beta-adrenergic stimulation of Ca(v)1.2-mediated Ca(2+) influx into the cardiomyocyte...
  13. pmc Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth
    Katrin Domes
    From the Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    J Biol Chem 286:33863-71. 2011
    ..2 expression. These findings indicate that absence of the carboxyl-terminal tail differentially determines the fate of the cardiac and smooth muscle splice variant of the CaV1.2 channel in the mouse...
  14. pmc Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2
    Andreas Ludwig
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, D 80802 München, Germany
    EMBO J 22:216-24. 2003
    ..Our results define the physiological role of the HCN2 subunit as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity...
  15. ncbi Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus
    Alyssa L Tippens
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 506:569-83. 2008
    ..These findings provide the first detailed ultrastructural analysis of Ca(v)1.2 localization in the brain and support functionally diverse roles of these channels in the hippocampal formation...
  16. ncbi Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells
    Lubica Lacinova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovakia
    Life Sci 82:41-9. 2008
    ..2 channels are involved in regulating the intrinsic excitability of CA1 pyramidal neurons. This cellular mechanism may contribute to the known function of Ca(v)1.2 channels in supporting synaptic plasticity and memory...
  17. ncbi Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons
    Martin Fuhrmann
    Center of Neuropathology and Prion Research, Ludwig Maximilians University, 81377 Munich, Germany
    J Neurochem 98:1876-85. 2006
    ..does not directly affect the potassium channels underlying sI(AHP), but modulates these channels due to its effect on the intracellular free Ca(2+) concentration via a reduced Ca(2+) influx through l-type VGCCs...
  18. ncbi Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels
    Barbara Much
    Department Pharmazie Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 7, 81377 Munchen, Germany
    J Biol Chem 278:43781-6. 2003
    ..Taken together our results indicate that subunit heteromerization and glycosylation are important determinants of the formation of native HCN channels...
  19. pmc Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells
    Kirill Essin
    Department of Nephrology and Medical Intensive Care, Charite Campus Virchow Klinikum, Berlin, Germany
    J Physiol 584:205-19. 2007
    ..2 channels and ryanodine receptors (RyRs) is not required to initiate Ca(2+) sparks. Instead, Ca(v)1.2 channels contribute to global cytosolic [Ca(2+)], which in turn influences luminal SR calcium and thus Ca(2+) sparks...