Thomas Misgeld

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Imaging axonal transport of mitochondria in vivo
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Methods 4:559-61. 2007
  2. ncbi request reprint In vivo imaging of single axons in the mouse spinal cord
    Thomas Misgeld
    Institute for Neuroscience, Technical University, Munich, Germany
    Nat Protoc 2:263-8. 2007
  3. pmc Lysosomal activity associated with developmental axon pruning
    Jae W Song
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 28:8993-9001. 2008
  4. ncbi request reprint In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
  5. ncbi request reprint Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury
    Florence M Bareyre
    Department of Molecular and Cellular Biology, Harvard University, Sherman Fairchild Building, Room 143, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:1355-60. 2005
  6. ncbi request reprint Death of an axon: studying axon loss in development and disease
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA, USA
    Histochem Cell Biol 124:189-96. 2005
  7. ncbi request reprint Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost
    Terrance T Kummer
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 16:74-82. 2006
  8. doi request reprint A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
    Ivana Nikic
    Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Nat Med 17:495-9. 2011
  9. doi request reprint Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes
    Elisa Romanelli
    Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Nat Protoc 8:481-90. 2013
  10. ncbi request reprint Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo
    Michael O Breckwoldt
    1 Institute for Neuronal Cell Biology, Technical University Munich, Munich, Germany 2 Institute of Clinical Neuroimmunology, Ludwig Maximilians University Munich, Munich, Germany 3
    Nat Med 20:555-60. 2014

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Imaging axonal transport of mitochondria in vivo
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Methods 4:559-61. 2007
    ..We show that axon damage and recovery lead to early and sustained changes in anterograde and retrograde transport. In vivo imaging of mitochondria will be a useful tool to analyze this essential organelle...
  2. ncbi request reprint In vivo imaging of single axons in the mouse spinal cord
    Thomas Misgeld
    Institute for Neuroscience, Technical University, Munich, Germany
    Nat Protoc 2:263-8. 2007
    ..This approach allows direct observation of axonal degeneration and regeneration in mouse models of spinal cord pathology for several hours or repetitively over the course of several days...
  3. pmc Lysosomal activity associated with developmental axon pruning
    Jae W Song
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 28:8993-9001. 2008
    ..We propose that lysosomal activity is a central feature of synapse elimination. Moreover, staining for lysosomal activity may serve as a marker for regions of the developing nervous system undergoing axon pruning...
  4. ncbi request reprint In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
    ..These results suggest that time-lapse imaging of spinal cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration...
  5. ncbi request reprint Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury
    Florence M Bareyre
    Department of Molecular and Cellular Biology, Harvard University, Sherman Fairchild Building, Room 143, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:1355-60. 2005
    ..Some of these new collaterals form additional direct synapses onto motoneurons. We propose that CST-YFP mice will be useful for evaluating strategies designed to maximize such remodeling and to promote regeneration...
  6. ncbi request reprint Death of an axon: studying axon loss in development and disease
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA, USA
    Histochem Cell Biol 124:189-96. 2005
    ....
  7. ncbi request reprint Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost
    Terrance T Kummer
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 16:74-82. 2006
    ..These recent studies challenge the widely-held paradigms, although not the results that led to them, and suggest a new model for neuromuscular synaptogenesis...
  8. doi request reprint A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
    Ivana Nikic
    Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Nat Med 17:495-9. 2011
    ..Finally, axonal changes consistent with FAD can be detected in acute human multiple sclerosis lesions. In summary, our data suggest that inflammatory axon damage might be spontaneously reversible and thus a potential target for therapy...
  9. doi request reprint Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes
    Elisa Romanelli
    Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Nat Protoc 8:481-90. 2013
    ..Surgical exposure and preparation of the spinal cord can be achieved in less than 1 h, and then dyes need to be applied for 30-60 min before the labeled spinal cord can be imaged for several hours...
  10. ncbi request reprint Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo
    Michael O Breckwoldt
    1 Institute for Neuronal Cell Biology, Technical University Munich, Munich, Germany 2 Institute of Clinical Neuroimmunology, Ludwig Maximilians University Munich, Munich, Germany 3
    Nat Med 20:555-60. 2014
    ..Thus, our approach allows us to identify heterogeneity among physiological and pathological redox signals, correlate such signals to functional and structural organelle dynamics and dissect the underlying mechanisms. ..
  11. ncbi request reprint In vivo imaging of the diseased nervous system
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Rev Neurosci 7:449-63. 2006
    ..We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges...
  12. pmc Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:11088-93. 2005
    ..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system...
  13. ncbi request reprint Axon branch removal at developing synapses by axosome shedding
    Derron L Bishop
    Department of Molecular and Cellular and Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 44:651-61. 2004
    ..After this engulfment, the axosome's contents mix with the cytoplasm of the glial cell. Axosome shedding might underlie other forms of axon loss and may provide a pathway for interactions between axons and glia...
  14. pmc Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific
    Timm Schubert
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurophysiol 100:304-16. 2008
    ..Our data suggest that presynaptic modulation of glutamate transmission from bipolar cells matures rapidly and is differentially coordinated for GABAergic and glycinergic synapses onto distinct bipolar cell subclasses...
  15. ncbi request reprint Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo
    Y Albert Pan
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 23:11479-88. 2003
    ..Because neuropathy is the major dose-limiting side effect of vincristine, we propose that its efficacy could be enhanced by coadministration of FK506 analogs that are neuroactive but not immunosuppressive...
  16. pmc Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    J Exp Med 200:1027-38. 2004
    ..This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it...
  17. pmc Nerve-independent formation of a topologically complex postsynaptic apparatus
    Terrance T Kummer
    Dept of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Cell Biol 164:1077-87. 2004
    ..These results reveal the sequence of steps by which a topologically complex domain forms on a cell and suggest an unexpected nerve-independent role for the postsynaptic cell in generating this topological complexity...
  18. ncbi request reprint BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?
    Christine Stadelmann
    Institute for Neuropathology, Charite, Humboldt University, Berlin, Germany
    Brain 125:75-85. 2002
    ....