Research Topics
Species | Thomas MisgeldSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
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Detail Information
Publications
Imaging axonal transport of mitochondria in vivoThomas Misgeld
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Methods 4:559-61. 2007..We show that axon damage and recovery lead to early and sustained changes in anterograde and retrograde transport. In vivo imaging of mitochondria will be a useful tool to analyze this essential organelle...- In vivo imaging of single axons in the mouse spinal cordThomas Misgeld
Institute for Neuroscience, Technical University, Munich, Germany
Nat Protoc 2:263-8. 2007..This approach allows direct observation of axonal degeneration and regeneration in mouse models of spinal cord pathology for several hours or repetitively over the course of several days... 
Lysosomal activity associated with developmental axon pruningJae W Song
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 28:8993-9001. 2008..We propose that lysosomal activity is a central feature of synapse elimination. Moreover, staining for lysosomal activity may serve as a marker for regions of the developing nervous system undergoing axon pruning...- Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injuryFlorence M Bareyre
Department of Molecular and Cellular Biology, Harvard University, Sherman Fairchild Building, Room 143, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Med 11:1355-60. 2005..Some of these new collaterals form additional direct synapses onto motoneurons. We propose that CST-YFP mice will be useful for evaluating strategies designed to maximize such remodeling and to promote regeneration... - In vivo imaging of axonal degeneration and regeneration in the injured spinal cordMartin Kerschensteiner
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Med 11:572-7. 2005..These results suggest that time-lapse imaging of spinal cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration... - Death of an axon: studying axon loss in development and diseaseThomas Misgeld
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA, USA
Histochem Cell Biol 124:189-96. 2005.... 
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosisIvana Nikic
Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
Nat Med 17:495-9. 2011..Finally, axonal changes consistent with FAD can be detected in acute human multiple sclerosis lesions. In summary, our data suggest that inflammatory axon damage might be spontaneously reversible and thus a potential target for therapy...- Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lostTerrance T Kummer
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Curr Opin Neurobiol 16:74-82. 2006..These recent studies challenge the widely-held paradigms, although not the results that led to them, and suggest a new model for neuromuscular synaptogenesis... - Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitterThomas Misgeld
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:11088-93. 2005..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system... - In vivo imaging of the diseased nervous systemThomas Misgeld
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
Nat Rev Neurosci 7:449-63. 2006..We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges... - Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyesElisa Romanelli
Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, Munich, Germany
Nat Protoc 8:481-90. 2013..Surgical exposure and preparation of the spinal cord can be achieved in less than 1 h, and then dyes need to be applied for 30-60 min before the labeled spinal cord can be imaged for several hours... - Axon branch removal at developing synapses by axosome sheddingDerron L Bishop
Department of Molecular and Cellular and Biology, Harvard University, Cambridge, MA 02138, USA
Neuron 44:651-61. 2004..After this engulfment, the axosome's contents mix with the cytoplasm of the glial cell. Axosome shedding might underlie other forms of axon loss and may provide a pathway for interactions between axons and glia... - Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specificTimm Schubert
Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
J Neurophysiol 100:304-16. 2008..Our data suggest that presynaptic modulation of glutamate transmission from bipolar cells matures rapidly and is differentially coordinated for GABAergic and glycinergic synapses onto distinct bipolar cell subclasses... - Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivoY Albert Pan
Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, Missouri 63110, USA
J Neurosci 23:11479-88. 2003..Because neuropathy is the major dose-limiting side effect of vincristine, we propose that its efficacy could be enhanced by coadministration of FK506 analogs that are neuroactive but not immunosuppressive... - Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosisMartin Kerschensteiner
Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
J Exp Med 200:1027-38. 2004..This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it... - Nerve-independent formation of a topologically complex postsynaptic apparatusTerrance T Kummer
Dept. of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, USA
J Cell Biol 164:1077-87. 2004..These results reveal the sequence of steps by which a topologically complex domain forms on a cell and suggest an unexpected nerve-independent role for the postsynaptic cell in generating this topological complexity... - BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?Christine Stadelmann
Institute for Neuropathology, Charite, Humboldt University, Berlin, Germany
Brain 125:75-85. 2002....