Klaus Linde

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Acupuncture for patients with migraine: a randomized controlled trial
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    JAMA 293:2118-25. 2005
  2. ncbi request reprint Summary consensus statement of the Review Board of the Swiss Complementary Medicine Evaluation Programme, (Programme Evaluation Komplementärmedizin, PEK) regarding the PEK process and products
    Harald Walach
    University of Northampton, School of Social Sciences and Samueli Institute for Information Biology, UK
    Homeopathy 95:28-30. 2006
  3. pmc Individual patient data meta-analysis of acupuncture for chronic pain: protocol of the Acupuncture Trialists' Collaboration
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Trials 11:90. 2010
  4. pmc An interdisciplinary intervention to prevent falls in community-dwelling elderly persons: protocol of a cluster-randomized trial [PreFalls]
    Wolfgang A Blank
    Institute of General Practice, Technische Universitaet Muenchen, Germany
    BMC Geriatr 11:7. 2011
  5. ncbi request reprint [Should acupuncture be reimbursed? Three acupuncture programmes of German Statutory Health Insurance Funds (SHI) and their scientific evaluation]
    Klaus Linde
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Technische Universitat Munchen
    Z Arztl Fortbild Qualitatssich 98:467-8. 2004
  6. ncbi request reprint St John's wort for depression: meta-analysis of randomised controlled trials
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Br J Psychiatry 186:99-107. 2005
  7. ncbi request reprint Characteristics and quality of systematic reviews of acupuncture, herbal medicines, and homeopathy
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Forsch Komplementarmed Klass Naturheilkd 10:88-94. 2003
  8. ncbi request reprint Large-scale observational studies of hypericum extracts in patients with depressive disorders--a systematic review
    K Linde
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Kaiserstr 9, Munich 80801, Germany
    Phytomedicine 12:148-57. 2005
  9. ncbi request reprint Should systematic reviews include non-randomized and uncontrolled studies? The case of acupuncture for chronic headache
    Klaus Linde
    Institute for Social Medicine and Epidemiology, Charite Hospital, Humboldt Universitat, 10098, Berlin, Germany
    J Clin Epidemiol 55:77-85. 2002
  10. pmc How objective are systematic reviews? Differences between reviews on complementary medicine
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Kaiserstrasse 9, 80801 München, Germany
    J R Soc Med 96:17-22. 2003

Detail Information

Publications90

  1. ncbi request reprint Acupuncture for patients with migraine: a randomized controlled trial
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    JAMA 293:2118-25. 2005
    ..Acupuncture is widely used to prevent migraine attacks, but the available evidence of its benefit is scarce...
  2. ncbi request reprint Summary consensus statement of the Review Board of the Swiss Complementary Medicine Evaluation Programme, (Programme Evaluation Komplementärmedizin, PEK) regarding the PEK process and products
    Harald Walach
    University of Northampton, School of Social Sciences and Samueli Institute for Information Biology, UK
    Homeopathy 95:28-30. 2006
    ..But the responsible authorities changed this process. In the following, the review board comments both on this process and on the products...
  3. pmc Individual patient data meta-analysis of acupuncture for chronic pain: protocol of the Acupuncture Trialists' Collaboration
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Trials 11:90. 2010
    ..The Acupuncture Trialists' Collaboration, a group of trialists, statisticians and other researchers, was established to synthesize patient-level data from several recently published large, high-quality trials...
  4. pmc An interdisciplinary intervention to prevent falls in community-dwelling elderly persons: protocol of a cluster-randomized trial [PreFalls]
    Wolfgang A Blank
    Institute of General Practice, Technische Universitaet Muenchen, Germany
    BMC Geriatr 11:7. 2011
    ..In the Prevent Falls (PreFalls) trial we aim to investigate the effectiveness of a pre-tested multi-modal intervention compared to usual care in this setting...
  5. ncbi request reprint [Should acupuncture be reimbursed? Three acupuncture programmes of German Statutory Health Insurance Funds (SHI) and their scientific evaluation]
    Klaus Linde
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Technische Universitat Munchen
    Z Arztl Fortbild Qualitatssich 98:467-8. 2004
    ..Details of the three programmes will be presented in the following chapters...
  6. ncbi request reprint St John's wort for depression: meta-analysis of randomised controlled trials
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Br J Psychiatry 186:99-107. 2005
    ..Extracts of Hypericum perforatum (St John's wort) are widely used to treat depression. Evidence for its efficacy has been criticised on methodological grounds...
  7. ncbi request reprint Characteristics and quality of systematic reviews of acupuncture, herbal medicines, and homeopathy
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Forsch Komplementarmed Klass Naturheilkd 10:88-94. 2003
    ..We aimed to describe the approaches and characteristics of systematic reviews on three major complementary therapies and to assess their methodological quality...
  8. ncbi request reprint Large-scale observational studies of hypericum extracts in patients with depressive disorders--a systematic review
    K Linde
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Kaiserstr 9, Munich 80801, Germany
    Phytomedicine 12:148-57. 2005
    ..The quality of reporting was insufficient in the majority of publications. The available studies show that hypericum extract are well tolerated and seem to be effective in routine treatment of mild to moderate depressive disorders...
  9. ncbi request reprint Should systematic reviews include non-randomized and uncontrolled studies? The case of acupuncture for chronic headache
    Klaus Linde
    Institute for Social Medicine and Epidemiology, Charite Hospital, Humboldt Universitat, 10098, Berlin, Germany
    J Clin Epidemiol 55:77-85. 2002
    ....
  10. pmc How objective are systematic reviews? Differences between reviews on complementary medicine
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Kaiserstrasse 9, 80801 München, Germany
    J R Soc Med 96:17-22. 2003
    ..This analysis shows that, at least in the three areas examined, systematic reviews often differ considerably. Readers should be aware that apparently minor decisions in the review process can have major impact...
  11. ncbi request reprint How informed is consent in sham-controlled trials of acupuncture?
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    J Altern Complement Med 10:379-85. 2004
    ..We asked acupuncture therapists to provide original patient information leaflets in order to study how interventions were described in more detail...
  12. ncbi request reprint The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture
    K Linde
    Institute for Social Medicine and Epidemiology, Charite, Humboldt University, Berlin, Germany
    Int J Epidemiol 30:526-31. 2001
    ..To investigate the methodological quality of randomized controlled trials in three areas of complementary medicine...
  13. pmc Systematic reviews of complementary therapies - an annotated bibliography. Part 1: acupuncture
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Munchen, Kaiserstr 9, 80801 München, Germany
    BMC Complement Altern Med 1:3. 2001
    ..Information on conditions, interventions, methods, results and conclusions was extracted using a pretested form and summarized descriptively...
  14. pmc Systematic reviews of complementary therapies - an annotated bibliography. Part 2: herbal medicine
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Munchen, Kaiserstr 9, 80801 München, Germany
    BMC Complement Altern Med 1:5. 2001
    ..Information on conditions, interventions, methods, results and conclusions was extracted using a pre-tested form and summarized descriptively...
  15. pmc Systematic reviews of complementary therapies - an annotated bibliography. Part 3: homeopathy
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Munchen, Kaiserstr 9, 80801 München, Germany
    BMC Complement Altern Med 1:4. 2001
    ..Information on conditions, interventions, methods, results and conclusions was extracted using a pretested form and summarized descriptively...
  16. ncbi request reprint Acupuncture for osteoarthritic pain: an observational study in routine care
    K Linde
    Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstrasse 9, 80801 Munich, Germany
    Rheumatology (Oxford) 45:222-7. 2006
    ..To investigate characteristics and outcomes of patients undergoing acupuncture treatment for osteoarthritic pain under conditions of routine care in the framework of statutory health insurance in Germany...
  17. ncbi request reprint The acupuncture randomised trial (ART) for tension-type headache--details of the treatment
    Dieter Melchart
    Centre for Complementary Medicine Research, Technische Universitat Munchen, Munich, Germany
    Acupunct Med 23:157-65. 2005
    ....
  18. ncbi request reprint The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Pain 128:264-71. 2007
    ..03 (1.26-3.26) and 2.35 (1.68-3.30), respectively. Results from the 6-month follow-up were similar. In conclusion, in our trials a significant association was shown between better improvement and higher outcome expectations...
  19. ncbi request reprint Interventions and physician characteristics in a randomized multicenter trial of acupuncture in patients with low-back pain
    Benno Brinkhaus
    Institute of Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    J Altern Complement Med 12:649-57. 2006
    ..Descriptions of the interventions used in acupuncture studies are often incomplete. The aim of this paper is to describe participating trial physicians and interventions in a randomised trial of acupuncture for low back pain...
  20. ncbi request reprint Acupuncture for chronic headaches--an epidemiological study
    Dieter Melchart
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Headache 46:632-41. 2006
    ..Furthermore, we investigated correlations between different outcomes...
  21. doi request reprint The impact of psychosomatic co-morbidity on discordance with respect to reasons for encounter in general practice
    Antonius Schneider
    Institute of General Practice, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    J Psychosom Res 74:82-5. 2013
    ....
  22. ncbi request reprint Treatment in a randomized multicenter trial of acupuncture for migraine (ART migraine)
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technical University of Munich, Germany
    Forsch Komplementmed 13:101-8. 2006
    ..This paper aims to describe the characteristics of physicians and interventions of a large, multicenter randomized trial of acupuncture for migraine (ART Migraine) in order to enable acupuncturists to assess the study interventions...
  23. doi request reprint Correlations of headache diary parameters, quality of life and disability scales
    Andrea Hoppe
    Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Headache 49:868-78. 2009
    ..We aimed to investigate (1) to which extent headache diary variables correlate among each other; (2) to which extent they correlate with generic measures of quality of life and disability; (3) and whether correlations vary over time...
  24. ncbi request reprint Randomized trial vs. observational study of acupuncture for migraine found that patient characteristics differed but outcomes were similar
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    J Clin Epidemiol 60:280-7. 2007
    ..To compare patient characteristics and outcomes between a randomized controlled trial (RCT) and an observational study (OS) of acupuncture treatment in patients with migraine...
  25. doi request reprint Biomonitoring of mercury in patients with complaints attributed to dental amalgam, healthy amalgam bearers, and amalgam-free subjects: a diagnostic study
    Dieter Melchart
    Technical University Munich, Munich, Germany
    Clin Toxicol (Phila) 46:133-40. 2008
    ..To investigate the suitability of measurements of mercury (Hg) concentration as a means of identifying patients with health complaints attributed to dental amalgam...
  26. doi request reprint Acupuncture in patients with seasonal allergic rhinitis: a randomized trial
    Benno Brinkhaus
    Charité University Medical Center and German Red Cross Hospital Westend, Berlin, Germany
    Ann Intern Med 158:225-34. 2013
    ..Chinese translation..
  27. doi request reprint Differential effectiveness of placebo treatments: a systematic review of migraine prophylaxis
    Karin Meissner
    Institute of General Practice, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany2Institute of Medical Psychology, Ludwig Maximilians University Munich, Munich, Germany
    JAMA Intern Med 173:1941-51. 2013
    ..Although systematic variations of improvements in placebo control groups would have important implications for the interpretation of placebo-controlled trials, the knowledge base on the subject is weak...
  28. ncbi request reprint Acupuncture for chronic low back pain in routine care: a multicenter observational study
    Wolfgang Weidenhammer
    Department of Internal Medicine II, Center for Complementary Medicine Research, Technische Universitat Munchen, Germany
    Clin J Pain 23:128-35. 2007
    ..To investigate patient characteristics and outcomes after undergoing acupuncture treatment for chronic low back pain (cLBP) in Germany and to analyze chronification, pain grading, and depression as predictors for treatment outcomes...
  29. ncbi request reprint Effectiveness and tolerability of acupuncture compared with metoprolol in migraine prophylaxis
    Andrea Streng
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    Headache 46:1492-502. 2006
    ..In a randomized controlled multicenter trial extending over 24 weeks, we investigated whether acupuncture is as effective and safe as metoprolol in the prophylactic treatment of migraine under conditions similar to routine care...
  30. ncbi request reprint Pragmatic randomized trial evaluating the clinical and economic effectiveness of acupuncture for chronic low back pain
    Claudia M Witt
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    Am J Epidemiol 164:487-96. 2006
    ..The incremental cost-effectiveness ratio was euro10,526 (euros) per quality-adjusted life year. Acupuncture plus routine care was associated with marked clinical improvements in these patients and was relatively cost-effective...
  31. ncbi request reprint Acupuncture in patients with chronic low back pain: a randomized controlled trial
    Benno Brinkhaus
    Institute of Social Medicine, Epidemiology, and Health Economics, Charite, University Medical Center, Berlin, Germany
    Arch Intern Med 166:450-7. 2006
    ..Acupuncture is widely used by patients with low back pain, although its effectiveness is unclear. We investigated the efficacy of acupuncture compared with minimal acupuncture and with no acupuncture in patients with chronic low back pain...
  32. pmc Acupuncture in patients with tension-type headache: randomised controlled trial
    Dieter Melchart
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    BMJ 331:376-82. 2005
    ..To investigate the effectiveness of acupuncture compared with minimal acupuncture and with no acupuncture in patients with tension-type headache...
  33. doi request reprint How do patients from eastern and western Germany compare with regard to their preferences for shared decision making?
    Johannes Hamann
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Germany
    Eur J Public Health 22:469-73. 2012
    ..This shift towards more patient engagement by health professionals and towards more desire by patients for participation may be partly based on socio-political factors...
  34. pmc Treatment of depressive disorders in primary care--protocol of a multiple treatment systematic review of randomized controlled trials
    Klaus Linde
    Institute of General Practice, Technische Universitat Munchen, Orleansstrasse 47, Munich, Germany
    BMC Fam Pract 12:127. 2011
    ..We aim to systematically review and compare the available evidence for the effectiveness of pharmacological, psychological, and combined treatments for patients with depressive disorders in primary care...
  35. ncbi request reprint Integrating patient preferences in clinical trials: a pilot study of acupuncture versus midazolam for gastroscopy
    Dieter Melchart
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat, Munich, Germany
    J Altern Complement Med 8:265-74. 2002
    ....
  36. ncbi request reprint Treatment of patients with chronic headaches in a hospital for traditional Chinese medicine in Germany. A randomised, waiting list controlled trial
    Dieter Melchart
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Complement Ther Med 12:71-8. 2004
    ..To investigate the effectiveness of a clinical treatment program with traditional Chinese medicine for migraine and tension-type headache...
  37. ncbi request reprint Acupuncture for chronic pain within the research program of 10 German Health Insurance Funds--basic results from an observational study
    W Weidenhammer
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technical University Munich, Kaiserstr 9, 80801 München, Germany
    Complement Ther Med 15:238-46. 2007
    ..To investigate which patients receive acupuncture in the framework of statutory health insurance in Germany, how treatment was carried out, and what results were achieved...
  38. doi request reprint Physicians' attitudes, diagnostic process and barriers regarding depression diagnosis in primary care: a systematic review of qualitative studies
    Isabelle Schumann
    Institute of General Practice, Technische Universitat Munchen, Munich, Germany
    Fam Pract 29:255-63. 2012
    ..Findings of diagnostic studies using standardized psychiatric interviews as a gold standard suggest that family physicians (FPs) both under- and over-diagnose depression...
  39. ncbi request reprint [St. John's wort for depression--development of a Cochrane review from 1993 to 1996]
    Klaus Linde
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Technische Universitat Munchen
    Z Evid Fortbild Qual Gesundhwes 102:487-92. 2008
    ..Only one trial included in the 1996 version is still part of the 2008 version. Despite the large number of available trials and improvements in review methodology the current evidence is more difficult to interpret than in 1996...
  40. doi request reprint Are sham acupuncture interventions more effective than (other) placebos? A re-analysis of data from the Cochrane review on placebo effects
    Klaus Linde
    Institute of General Practice, Technische Universitat Munchen, Munich, Germany
    Forsch Komplementmed 17:259-64. 2010
    ..We re-analyzed the data from this review to investigate whether effects associated with sham acupuncture differed from those of other 'physical placebos'...
  41. doi request reprint Acupuncture in seasonal allergic rhinitis (ACUSAR)--design and protocol of a randomised controlled multi-centre trial
    Benno Brinkhaus
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    Forsch Komplementmed 17:95-102. 2010
    ..We report on the study design and protocol of a randomised controlled trial (Acupuncture in Seasonal Allergic Rhinitis, ACUSAR) that investigates the efficacy of acupuncture in the treatment of seasonal allergic rhinitis (SAR)...
  42. doi request reprint [On the reliability of the description of morphological characteristics in traditional Chinese tongue diagnostics]
    Yanqing Li
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Wolfgangstrasse 8, Munich, Germany
    Forsch Komplementmed 16:98-104. 2009
    ..The assessment of the tongue is a crucial diagnostic tool of traditional Chinese medicine. In a series of studies we aimed to investigate to what extent independent raters agree in the description of morphological tongue characteristics...
  43. ncbi request reprint [Program for evaluation of patient care with acupuncture--the scientific comparison of models and results]
    Dieter Melchart
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Technische Universitat Munchen
    Z Arztl Fortbild Qualitatssich 98:471-3. 2004
  44. ncbi request reprint Adverse effects of St. John's Wort: a systematic review
    Lars Knüppel
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    J Clin Psychiatry 65:1470-9. 2004
    ....
  45. ncbi request reprint "Quality profiling" for complementary medicine: the example of a hospital for traditional Chinese medicine
    Dieter Melchart
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Munchen, Germany
    J Altern Complement Med 9:193-206. 2003
    ....
  46. doi request reprint St. John's wort - an overview
    Klaus Linde
    Centre for Complementary Medicine Research, Department for Internal Medicine II, Technical University of Munich, Germany
    Forsch Komplementmed 16:146-55. 2009
    ..John's wort products. If the risk of interactions is adequately taken into account, high quality Hypericum extracts are an effective and safe tool in the hand of qualified health profession-als in primary care...
  47. doi request reprint Patients of an interdisciplinary cancer treatment center: use of, knowledge about, and demand for CAM treatment options
    Axel Eustachi
    Centre for Complementary Medicine Research, Department of Internal Medicine, Technical University, Munich, Germany
    Integr Cancer Ther 8:56-62. 2009
    ..Objective: to assess the use of, knowledge about, and the demand for information concerning complementary and alternative medicine (CAM) in cancer patients...
  48. doi request reprint Use of placebos and nonspecific and complementary treatments by German physicians--rationale and development of a questionnaire for a nationwide survey
    Klaus Linde
    Institut fur Allgemeinmedizin, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Forsch Komplementmed 20:361-7. 2013
    ..In this article we explain the theoretical considerations behind the study approach and the development of the questionnaire...
  49. doi request reprint [The gap between research and practice--a survey among participants in continuing medical education events]
    Sabine Icsezer
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen, Deutschland
    Forsch Komplementmed 15:261-7. 2008
    ..To investigate to which extent physicians participating in specialization and continuing medical education courses read clinical research articles and how relevant they deem this for their practical work...
  50. ncbi request reprint Acupuncture and acupressure for the prevention of chemotherapy-induced nausea--a randomised cross-over pilot study
    Dieter Melchart
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 München, Germany
    Support Care Cancer 14:878-82. 2006
    ..To investigate whether a combination of acupuncture and acupressure is effective for reducing chemotherapy-induced nausea and vomiting...
  51. ncbi request reprint Prospective investigation of adverse effects of acupuncture in 97 733 patients
    Dieter Melchart
    Munich, Germany and Zurich, Switzerland
    Arch Intern Med 164:104-5. 2004
  52. ncbi request reprint [Structure, realization and data synopsis of an observational study as part of the patient care evaluation programme on acupuncture (PEP-AC) drafted by German statutory insurance institutions]
    W Weidenhammer
    Zentrum fur naturheilkundliche Forschung, II Med Klinik und Poliklinik, TU Munchen
    Gesundheitswesen 67:264-73. 2005
    ..The results indicated that we cannot claim global representativeness for the sample-based findings, but there is no reason to assume a "positive" selection...
  53. ncbi request reprint Acupuncture in patients with osteoarthritis of the knee: a randomised trial
    C Witt
    Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Centre, Berlin, Germany
    Lancet 366:136-43. 2005
    ..We investigated the efficacy of acupuncture compared with minimal acupuncture and with no acupuncture in patients with osteoarthritis of the knee...
  54. ncbi request reprint Acupuncture versus placebo versus sumatriptan for early treatment of migraine attacks: a randomized controlled trial
    D Melchart
    Department of Internal Medicine II, Center for Complementary Medicine Research, Technical University, Kaiserstrasse 9, 80801 Munich, Germany
    J Intern Med 253:181-8. 2003
    ..To investigate whether acupuncture is superior to placebo and equivalent to sumatriptan for the early treatment of an acute migraine attack...
  55. ncbi request reprint [Acupuncture for chronic pain patients. Treatment outcomes--the role of the acupuncturist]
    W Weidenhammer
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, TU Munchen
    Schmerz 20:418, 420-2, 424-32. 2006
    ..These longer term effects were more pronounced for physicians offering additional complementary methods in their practice. Improvement after acupuncture and patient satisfaction were positively correlated...
  56. ncbi request reprint Treatment outcomes in patients with migraine: an ex-post-facto comparison of two in-patient facilities
    W Weidenhammer
    Zentrum fur naturheilkundliche Forschung, II Med Klinik und Poliklinik, Technische Universitat Munchen, Kaiserstrasse 9, D 80801 Munich, Germany
    Forsch Komplementarmed Klass Naturheilkd 11:30-5. 2004
    ..Available data were subordinately analysed in order to compare both studies...
  57. doi request reprint Diagnostic accuracy of clinical symptoms in obstructive airway diseases varied within different health care sectors
    Antonius Schneider
    Institute of General Practice, Klinikum rechts der Isar, Technische Universitat Munchen, Orleansstrasse 47, 81667 München, Germany
    J Clin Epidemiol 65:846-54. 2012
    ..To determine the diagnostic accuracy and diagnostic patterns of clinical symptoms in patients suspected to suffer from obstructive airway diseases (OADs) within different health care sectors...
  58. ncbi request reprint Prognos in the diagnosis of amalgam hypersensitivity a diagnostic case-control study
    Wolfgang Kohler
    Centre for Complementary Medicine Research, Department of Internal Medicine II, echnische Universität München, Germany
    Forsch Komplementmed 14:18-24. 2007
    ..We aimed to investigate whether the Prognos device might be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings...
  59. pmc Placebo interventions, placebo effects and clinical practice
    Klaus Linde
    Institute of General Practice, Technische Universitat Munchen, 81667 Munich, Germany
    Philos Trans R Soc Lond B Biol Sci 366:1905-12. 2011
    ....
  60. ncbi request reprint Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy--a pilot study
    Dieter Melchart
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Kaiserstrasse 9, 80801 Munich, Germany
    Phytother Res 16:138-42. 2002
    ..The results of this pilot study suggest that EPS-EPO VIIa might be effective in reducing chemotherapy-induced leukopenia. The efficacy and safety should be investigated in further studies...
  61. ncbi request reprint Systematic reviews of herbal medicines--an annotated bibliography
    K Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat, Munchen, Germany
    Forsch Komplementarmed Klass Naturheilkd 10:17-27. 2003
    ..To provide a comprehensive collection and a summary of systematic reviews of clinical trials on herbal medicines...
  62. ncbi request reprint Acupuncture Randomized Trials (ART) in patients with chronic low back pain and osteoarthritis of the knee - design and protocols
    B Brinkhaus
    Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Klinikum Charit, Humboldt Universitat zu Berlin, Berlin, Germany
    Forsch Komplementarmed Klass Naturheilkd 10:185-91. 2003
    ....
  63. ncbi request reprint Echinacea root extracts for the prevention of upper respiratory tract infections: a double-blind, placebo-controlled randomized trial
    D Melchart
    Center for Complementary Medicine Research, Technische Universitat, Munich, Germany
    Arch Fam Med 7:541-5. 1998
    ..To investigate the safety and efficacy of 2 extracts of echinacea for preventing upper respiratory tract infections...
  64. pmc Homeopathy for depression: a randomized, partially double-blind, placebo-controlled, four-armed study (DEP-HOM)
    Ubiratan C Adler
    Institute for Social Medicine, Epidemiology and Health Economics, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 8:e74537. 2013
    ..The specific clinical benefit of the homeopathic consultation and of homeopathic remedies in patients with depression has not yet been investigated...
  65. pmc Kidney function and clinical recommendations of drug dose adjustment in geriatric patients
    Marlies Karsch-Völk
    Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    BMC Geriatr 13:92. 2013
    ....
  66. pmc Can near-peer medical students effectively teach a new curriculum in physical examination?
    Wolfgang A Blank
    Institute of General Practice, Technische Universitat Munchen, Orleansstr, 47, 81667 Munich, Germany
    BMC Med Educ 13:165. 2013
    ....
  67. pmc Effects of a general practice guided web-based weight reduction program--results of a cluster-randomized controlled trial
    Michael Mehring
    Institute of General Practice, Technische Universitat Munchen, Orleansstr 47, Munich 81667, Germany
    BMC Fam Pract 14:76. 2013
    ..The aim of this trial was to examine the short-term effectiveness of a web-based coaching program in combination with an accompanied telephone counselling regarding weight reduction in a primary care setting...
  68. pmc The development of general practice as an academic discipline in Germany - an analysis of research output between 2000 and 2010
    Antonius Schneider
    Antonius Schneider Institute of General Practice, Klinikum rechts der Isar, Technische Universität München Orleansstrasse 47, 81667, Munich, Germany
    BMC Fam Pract 13:58. 2012
    ..2 Mio were introduced in Germany from 2002 to February 2012. We aim to provide an overview of publications reporting original data and systematic reviews from German academic family medicine published between 2000 and 2010...
  69. doi request reprint Most like it but some don't--attitudes of vocational trainees in general practice towards evidence-based medicine
    Wolfgang A Blank
    Institute of General Practice, Technische Universitat Munchen, Munich, Germany
    J Eval Clin Pract 17:615-20. 2011
    ..In particular, we were interested in which aspects the answers of doctors with an overall negative attitude towards EBM differed from those with a positive attitude...
  70. doi request reprint Strain-counterstrain to treat restrictions of the mobility of the cervical spine in patients with neck pain: a sham-controlled randomized trial
    Reinhold Klein
    Institute of General Practice, Techni sche Universität München, Munich, Germany
    Complement Ther Med 21:1-7. 2013
    ..We aimed to investigate whether a single strain-counterstrain intervention is more effective than a sham intervention in improving restricted cervical range of motion in patients with neck pain...
  71. doi request reprint Effects of verbal suggestion on coronary arteries: results of a randomized controlled experimental investigation during coronary angiography
    Joram Ronel
    Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am Heart J 162:507-11. 2011
    ..We, therefore, performed an experiment to investigate whether a verbal suggestion (VS) integrated in a cardiologic procedure has an impact on diameters of coronary arteries...
  72. pmc Unlimited access to health care--impact of psychosomatic co-morbidity on utilisation in German general practices
    Antonius Schneider
    Institute of General Practice, Klinikum rechts der Isar, Technische Universitat Munchen, Orleansstrasse 47, 81667 München, Germany
    BMC Fam Pract 12:51. 2011
    ..The aim of this study was to evaluate the impact on practice visits, referrals and periods of disability in German general practices and to identify predictors of health care utilisation...
  73. pmc How large are the nonspecific effects of acupuncture? A meta-analysis of randomized controlled trials
    Klaus Linde
    Institute of General Practice, Technische Universitat Munchen, Orleansstrasse 47, D 81667 Munich, Germany
    BMC Med 8:75. 2010
    ..This raises the question whether (sham) acupuncture is associated with particularly potent nonspecific effects. We aimed to investigate the size of nonspecific effects associated with acupuncture interventions...
  74. doi request reprint Multifactorial lifestyle interventions in the primary and secondary prevention of cardiovascular disease and type 2 diabetes mellitus--a systematic review of randomized controlled trials
    Lucia Angermayr
    Competence Centre of Complementary Medicine and Naturopathy, Technische Universitat Munchen, Kaiserstr 9, 80801, Munich, Germany
    Ann Behav Med 40:49-64. 2010
    ..The evidence base for multifactorial lifestyle interventions is weak. Effects on surrogate measures seem minor, but there may be clinically relevant effects on major clinical endpoints...
  75. ncbi request reprint Change in quality of life in the year following cardiac rehabilitation
    J Muller-Nordhorn
    Institute of Social Medicine, Epidemiology, and Health Economics, Charite Hospital, Humboldt University of Berlin, Berlin, Germany
    Qual Life Res 13:399-410. 2004
    ..63, -0.52), and CABG as indication for admission (1.68; 95% CI: 0.36, 3.01). The identification of predictors of HRQoL in the present study may aid in the further development and evaluation of cardiac rehabilitation programmes...
  76. ncbi request reprint Sham interventions in randomized clinical trials of acupuncture--a review
    F Dincer
    Department of Clinical Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Munich, Germany
    Complement Ther Med 11:235-42. 2003
    ....
  77. ncbi request reprint Acupuncture Randomized Trials (ART) in patients with migraine or tension-type headache--design and protocols
    D Melchart
    Zentrum fur naturheilkundliche Forschung, II Medizinische Klinik und Poliklinik, TU Munchen, Germany
    Forsch Komplementarmed Klass Naturheilkd 10:179-84. 2003
    ....
  78. ncbi request reprint [The specific placebo effect]
    K Linde
    Zentrum fur naturheilkundliche Forschung, Technische Universitat Munchen, Kaiserstrasse 9, 80801 München, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:729-35. 2006
    ..This model would better explain the contradictory results reported in placebo research. Further implications for research and health care decision making are discussed...
  79. ncbi request reprint Invited commentary on Hyland ME: methodology for the scientific evaluation of complementary and alternative medicine
    K Linde
    Department of Internal Medicine II, Centre for Complementary Medicine Research, Technische Universitat Munchen, Munich, Germany
    Complement Ther Med 11:154-5. 2003
  80. ncbi request reprint Updating systematic reviews
    Klaus Linde
    Center of Complementary Medicine Research at the Technical University of Munich, Germany
    Explore (NY) 2:363-4. 2006
  81. ncbi request reprint Meta-analysis: acupuncture for osteoarthritis of the knee
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, Kernan Hospital Mansion, Baltimore, Maryland 21207, USA
    Ann Intern Med 146:868-77. 2007
    ..Knee osteoarthritis is a major cause of pain and functional limitation...
  82. doi request reprint Echinacea for preventing and treating the common cold
    Karin Woelkart
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl Franzens University, Graz, Austria
    Planta Med 74:633-7. 2008
    ..In the meantime two further meta-analyses have been published. In the present mini-review, these latest meta-analyses are evaluated and discussed...
  83. ncbi request reprint Summary consensus statement of the PEK review board regarding the PEK process and the PEK products
    Harald Walach
    University of Northampton, School of Social Sciences, Samueli Institute for Information Biology, Boughton Green Road, Northampton NN2 7AL, United Kingdom
    J Altern Complement Med 12:347-8. 2006
  84. ncbi request reprint Matched-pair study showed higher quality of placebo-controlled trials in Western phytotherapy than conventional medicine
    Reto Brignoli
    Tradyser Consulting GmbH, Loosstrasse 19, Ruschlikon, Switzerland
    Forsch Komplementmed 14:308-15. 2007
  85. ncbi request reprint St John's wort and depression
    Klaus Linde
    JAMA 288:447-8; author reply 448-9. 2002
  86. doi request reprint Acupuncture in migraine: investigation of autonomic effects
    Marcus Backer
    Complementary and Integrative Medicine, Department of Internal Medicine V, University of Duisburg Essen, Kliniken Essen Mitte, Germany
    Clin J Pain 24:106-15. 2008
    ..As acupuncture has been shown to exhibit considerable autonomic effects, we tested whether the clinical effects of acupuncture in migraine prophylaxis are mediated by changes of the autonomic regulation...
  87. ncbi request reprint Are the clinical effects of homoeopathy placebo effects?
    Klaus Linde
    Lancet 366:2081-2; author reply 2083-6. 2005
  88. ncbi request reprint [Is research on complementary medicine a waste of time and money?]
    Klaus Linde
    Forsch Komplementarmed Klass Naturheilkd 12:252-3. 2005
  89. ncbi request reprint A critical overview of homeopathy
    Wayne B Jonas
    Samueli Institute for Information Biology, 121 South Saint Asaph Street, Suite 200, Alexandria, VA 22314, USA
    Ann Intern Med 138:393-9. 2003
    ..Homeopathy deserves an open-minded opportunity to demonstrate its value by using evidence-based principles, but it should not be substituted for proven therapies...
  90. doi request reprint The need for CAM research training
    Claudia M Witt
    Forsch Komplementmed 15:69-70. 2008