S Leucht

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc Is the superior efficacy of new generation antipsychotics an artifact of LOCF?
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Bull 33:183-91. 2007
  2. doi request reprint Measurements of response, remission, and recovery in schizophrenia and examples for their clinical application
    Stefan Leucht
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München am Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    J Clin Psychiatry 75:8-14. 2014
  3. doi request reprint Pharmacological treatment of schizophrenia
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen, Germany
    Fortschr Neurol Psychiatr 81:e1-13. 2013
  4. doi request reprint Maintenance treatment with antipsychotic drugs for schizophrenia
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, Munchen, Germany
    Cochrane Database Syst Rev 5:CD008016. 2012
  5. pmc Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive study
    Marc De Hert
    University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    BMC Gastroenterol 11:17. 2011
  6. ncbi request reprint Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials
    S Leucht
    Psychiatrische Klinik, Technischen Universitat Munchen, Klinikum rechts der Isar, Germany
    Schizophr Res 35:51-68. 1999
  7. doi request reprint Evidence-based pharmacotherapy of schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen, Germany
    Int J Neuropsychopharmacol 14:269-84. 2011
  8. doi request reprint Second-generation antipsychotics for schizophrenia: can we resolve the conflict?
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Psychol Med 39:1591-602. 2009
  9. doi request reprint A meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Am J Psychiatry 166:152-63. 2009
  10. ncbi request reprint Clinical implications of Brief Psychiatric Rating Scale scores
    Stefan Leucht
    Klinik fürr Psychiatrie und Psychotherapie derTechnischen Universität München, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munchen, Germany
    Br J Psychiatry 187:366-71. 2005

Detail Information

Publications83

  1. pmc Is the superior efficacy of new generation antipsychotics an artifact of LOCF?
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Bull 33:183-91. 2007
    ..Ultimately, strategies to reduce dropout rates are needed...
  2. doi request reprint Measurements of response, remission, and recovery in schizophrenia and examples for their clinical application
    Stefan Leucht
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München am Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    J Clin Psychiatry 75:8-14. 2014
    ..The ultimate goal of recovery in schizophrenia treatment includes sustained symptom resolution and a return to full functioning. ..
  3. doi request reprint Pharmacological treatment of schizophrenia
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen, Germany
    Fortschr Neurol Psychiatr 81:e1-13. 2013
    ..Concerning maintenance treatment with antipsychotics we discuss indication, choice of drug, continuous versus intermittent treatment, duration of relapse prevention and dose...
  4. doi request reprint Maintenance treatment with antipsychotic drugs for schizophrenia
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, Munchen, Germany
    Cochrane Database Syst Rev 5:CD008016. 2012
    ..Antipsychotic drugs block the transmission of dopamine in the brain and reduce the acute symptoms of the disorder. This review examined whether antipsychotic drugs are also effective for relapse prevention...
  5. pmc Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive study
    Marc De Hert
    University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    BMC Gastroenterol 11:17. 2011
    ..They also have a number of side-effects. Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature...
  6. ncbi request reprint Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials
    S Leucht
    Psychiatrische Klinik, Technischen Universitat Munchen, Klinikum rechts der Isar, Germany
    Schizophr Res 35:51-68. 1999
    ..The methodological limitations of this review, the generalizability of the results and expectations from future research are discussed...
  7. doi request reprint Evidence-based pharmacotherapy of schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen, Germany
    Int J Neuropsychopharmacol 14:269-84. 2011
    ..Although the randomized evidence on a superiority of depot compared to oral treatment is not ideal, this approach suggests obvious advantages in assuring compliance...
  8. doi request reprint Second-generation antipsychotics for schizophrenia: can we resolve the conflict?
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Psychol Med 39:1591-602. 2009
    ..However, these drugs are important contributions to treatment, and most psychiatrists, let alone patients, would probably not want to do without them...
  9. doi request reprint A meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Am J Psychiatry 166:152-63. 2009
    ..The authors conducted a systematic review and meta-analysis of blinded studies comparing second-generation antipsychotics head-to-head...
  10. ncbi request reprint Clinical implications of Brief Psychiatric Rating Scale scores
    Stefan Leucht
    Klinik fürr Psychiatrie und Psychotherapie derTechnischen Universität München, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munchen, Germany
    Br J Psychiatry 187:366-71. 2005
    ..Despite the widespread use of the Brief Psychiatric Rating Scale (BPRS), the clinical meaning of its total score and cut-off values used to define treatment response are unclear...
  11. ncbi request reprint The concepts of remission and recovery in schizophrenia
    S Leucht
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Pharmacopsychiatry 39:161-70. 2006
    ..To examine the past and current research into the concepts of remission and recovery in schizophrenia...
  12. ncbi request reprint Amisulpride a selective dopamine antagonist and atypical antipsychotic: results of a meta-analysis of randomized controlled trials
    Stefan Leucht
    Klinik fr Psychiatrie und Psychotherapie der Technischen Universitt, Ismaningerstr 22, 81675, Muenchen, Germany
    Int J Neuropsychopharmacol 7:S15-20. 2004
    ....
  13. ncbi request reprint Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Klinikum rechts der Isarder, Technischen Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Clin Psychiatry 67:3-8. 2006
    ..Among the measures that have the potential to improve adherence to medication are psychosocial interventions, psychoeducation in the form of professional, peer-to-peer or family-to-family interventions, and shared decision making...
  14. ncbi request reprint Carbamazepine augmentation for schizophrenia: how good is the evidence?
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    J Clin Psychiatry 63:218-24. 2002
    ..The aim of this study was to undertake a systematic review and meta-analysis of the safety and efficacy of one frequently used adjunctive compound: carbamazepine...
  15. ncbi request reprint Doxepin plasma concentrations: is there really a therapeutic range?
    S Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Gernany
    J Clin Psychopharmacol 21:432-9. 2001
    ..Meanwhile, a preliminary working range of 50 to 250 ng/mL is proposed on the basis of critical reassessment of published data...
  16. ncbi request reprint Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials
    Stefan Leucht
    Klinik and Poliklinik für Psychiatrie und Psychotherapie der Technichen Universität München, Germany
    Am J Psychiatry 160:1209-22. 2003
    ..The authors performed a systematic review and meta-analysis of studies of the potential of new-generation antipsychotic drugs to improve adherence and decrease relapse rates in patients with schizophrenia...
  17. ncbi request reprint Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Am J Psychiatry 159:180-90. 2002
    ..The purpose of this article was to compare the atypical profile of amisulpride with that of the 5-HT(2)/D(2) antagonists...
  18. doi request reprint Equipercentile linking of the BPRS and the PANSS
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Muenchen, Germany
    Eur Neuropsychopharmacol 23:956-9. 2013
    ..A reason may be the higher number of items used in the PANSS. These results are important for the comparison of trials that used these rating scales. We present a detailed conversion table in an online supplement. ..
  19. ncbi request reprint Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy
    Werner Steimer
    Institut fur Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Chem 51:376-85. 2005
    ..We conducted a prospective blinded two-center study seeking correlations between CYP2C19 and CYP2D6 genotypes, drug concentrations, adverse events, and therapy response...
  20. doi request reprint Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome
    B Laika
    Institut fur Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Deutschland, Germany
    Pharmacogenomics J 10:20-9. 2010
    ..Side effects and weight gain, however, seem to be more influenced by serotonergic polymorphisms...
  21. ncbi request reprint The effect of family interventions on relapse and rehospitalization in schizophrenia--a meta-analysis
    G Pitschel-Walz
    Department of Psychiatry, Technical University, Munich, Germany
    Schizophr Bull 27:73-92. 2001
    ..This meta-analysis indicates that psychoeducational interventions are essential to schizophrenia treatment...
  22. ncbi request reprint Antidepressants for the negative symptoms of schizophrenia
    C Rummel
    Klinikum rechts der Isar, Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Möhlstr 26, Munich, Germany 81675
    Cochrane Database Syst Rev 3:CD005581. 2006
    ..Negative symptoms are common in people with schizophrenia and are often difficult to treat with antipsychotic drugs. Treatment often involves the use of various add-on medications such as antidepressants...
  23. ncbi request reprint Pharmacogenetics: a new diagnostic tool in the management of antidepressive drug therapy
    W Steimer
    Institute for Clinical Chemistry and Pathobiochemistry, Munich University of Technology, Ismaninger Str 22, 81675 Munich, Germany
    Clin Chim Acta 308:33-41. 2001
    ..Current knowledge in this young field of research is summarized...
  24. ncbi request reprint Shared decision making for in-patients with schizophrenia
    J Hamann
    Psychiatric Department, Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Möhlstrasse 26, 81675 Munich, Germany
    Acta Psychiatr Scand 114:265-73. 2006
    ..In the present study, the feasibility and effects of SDM for in-patients with schizophrenia should be evaluated...
  25. ncbi request reprint Are patients with schizophrenia under-treated with second-generation antipsychotics? A pilot study of the prescription practices of German psychiatrists
    J Hamann
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Munchen, Germany
    Pharmacopsychiatry 36:309-12. 2003
    ..They estimate that only about 10- 30 % of all patients with schizophrenia receive second-generation antipsychotics, a figure that lies significantly below the international average...
  26. ncbi request reprint Language bias in neuroscience--is the Tower of Babel located in Germany?
    S Heres
    Psychiatrische Klinik und Poliklinik, Technischen Universitaet Muenchen, Klinikum rechts der Isar, Ismaningerstrasse 22, Munich 81675, Germany
    Eur Psychiatry 19:230-2. 2004
    ..In the neurosciences a similar trend was seen but the findings were not statistically significant. The reason for this inconclusive finding might be the low number of RCTs published in German...
  27. doi request reprint DRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain
    J Popp
    Institut fur Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Pharmacogenomics J 9:71-7. 2009
    ....
  28. ncbi request reprint Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Biol Psychiatry 57:1543-9. 2005
    ....
  29. ncbi request reprint Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    Arch Gen Psychiatry 64:442-55. 2007
    ..Meta-analyses addressing the use of SGAs in the treatment of acute mania are lacking...
  30. doi request reprint Confirmation bias: why psychiatrists stick to wrong preliminary diagnoses
    R Mendel
    Department of Psychiatry, Technische Universitat Munchen, Germany
    Psychol Med 41:2651-9. 2011
    ..Experts assume that physicians' desire to confirm a preliminary diagnosis while failing to seek contradictory evidence is an important reason for wrong diagnoses. This tendency is called 'confirmation bias'...
  31. ncbi request reprint Shared decision making in psychiatry
    J Hamann
    Department of Psychiatry and Psychotherapy, Center for Disease Management, Technical University Munich, Germany
    Acta Psychiatr Scand 107:403-9. 2003
    ..In other medical fields, 'shared decision making' (a strategy for including patients in therapeutic decision processes) has been studied for several years now. This survey presents the potential of shared decision making for psychiatry...
  32. doi request reprint [Considerations about the efficacy of psychopharmacological drugs]
    S Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Deutschland
    Nervenarzt 82:1425-30. 2011
    ..Psychotropic drugs are efficacious, but they need to be prudently applied according to evidence-based criteria...
  33. doi request reprint Intermediate metabolizer: increased side effects in psychoactive drug therapy. The key to cost-effectiveness of pretreatment CYP2D6 screening?
    B Laika
    Institut fur Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 9:395-403. 2009
    ..Thus, not only poor and ultrarapid metabolizer but also IMs may benefit from CYP2D6 genotyping. This is of paramount interest since it greatly improves cost/benefit estimations for pretreatment CYP2D6 screening...
  34. ncbi request reprint Linking the PANSS, BPRS, and CGI: clinical implications
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Munich, Munchen, Germany
    Neuropsychopharmacology 31:2318-25. 2006
    ..Clinicians seem to base CGI ratings on relative change rather than on absolute change of symptoms...
  35. ncbi request reprint Do patients with schizophrenia wish to be involved in decisions about their medical treatment?
    Johannes Hamann
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Möhlstrasse 26, 81675 Munchen, Germany
    Am J Psychiatry 162:2382-4. 2005
    ..Little is known about the desire of patients with schizophrenia to be involved in medical decisions affecting their treatment...
  36. ncbi request reprint What does the PANSS mean?
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Res 79:231-8. 2005
    ..g. at least 20% or 50% reduction of the baseline score) are as yet unclear. We therefore compared the PANSS with simultaneous ratings of Clinical Global Impressions (CGI)...
  37. ncbi request reprint Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials
    Anja Basan
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    Schizophr Res 70:33-7. 2004
    ..Some of the single studies showed inconsistent beneficial effects on some aspects of response, but no overall superiority of valproate augmentation at study endpoints was shown...
  38. ncbi request reprint Antidepressants as add-on treatment to antipsychotics for people with schizophrenia and pronounced negative symptoms: a systematic review of randomized trials
    Christine Rummel
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Schizophr Res 80:85-97. 2005
    ..The combination of antipsychotics and antidepressants may be more effective in treating negative symptoms of schizophrenia than antipsychotics alone, but this finding needs to be corroborated by further large trials...
  39. ncbi request reprint Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    Werner Steimer
    Institut fur Klinische Chemie und Pathobiochemie, Technische Universitat Munchen, Munich, Germany
    Clin Chem 50:1623-33. 2004
    ..These may allow a much desired prediction of metabolic activity within the extensive metabolizer group. The functional consequences are still being discussed with few data available for clinical patients...
  40. doi request reprint How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials
    S Leucht
    Department of Psychiatry and Psychotherapy, Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Mol Psychiatry 14:429-47. 2009
    ..Whether methodological issues account in part for the relatively low efficacy ESs and the scarcity of adverse event differences compared with placebo needs to be established...
  41. doi request reprint Predicting antipsychotic drug response - replication and extension to six weeks in an international olanzapine study
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Res 101:312-9. 2008
    ..To use the degree of response after 2 weeks of treatment to predict non-response at 4 to 6 weeks...
  42. ncbi request reprint Olanzapine versus other atypical antipsychotics for schizophrenia
    Katja Komossa
    , , Moehlstrasse 26, , Germany, 81675
    Cochrane Database Syst Rev 3:CD006654. 2010
    ..Further large, well-designed trials are necessary to establish the relative effects of different second generation antipsychotic drugs...
  43. ncbi request reprint Shared decision making and long-term outcome in schizophrenia treatment
    Johannes Hamann
    Department of Psychiatry, Technische Universitat, Munich, Germany
    J Clin Psychiatry 68:992-7. 2007
    ..The aim of the present analysis was to study whether shared decision making (SDM) in antipsychotic drug choice would influence long-term outcome...
  44. ncbi request reprint The relative sensitivity of the Clinical Global Impressions Scale and the Brief Psychiatric Rating Scale in antipsychotic drug trials
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Germany
    Neuropsychopharmacology 31:406-12. 2006
    ..The fact that it takes only 1-2 min to fill in the CGI justifies its use in addition to more specific scales in drug trials for schizophrenia. Further development and evaluation of the CGI is warranted...
  45. ncbi request reprint Early prediction of antipsychotic nonresponse among patients with schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    J Clin Psychiatry 68:352-60. 2007
    ..We therefore attempted to identify what degree of nonresponse shortly after initiation of antipsychotic drug treatment predicts nonresponse at 4 weeks...
  46. ncbi request reprint Physicians' and patients' involvement in relapse prevention with antipsychotics in schizophrenia
    Johannes Hamann
    Psychiatry Department, Technische Universitat Munchen, Germany
    Psychiatr Serv 56:1448-50. 2005
    ..Accordingly, patients' knowledge of the optimal duration of maintenance therapy was poor...
  47. doi request reprint The deceleration capacity - a new measure of heart rate variability evaluated in patients with schizophrenia and antipsychotic treatment
    A Birkhofer
    Technische Universitat Munchen, Klinik fur Psychiatrie und Psychotherapie, Ismaninger Str 22, 81675 Munchen, Germany
    Eur Psychiatry 28:81-6. 2013
    ..The aim of the present paper was to calculate DC in patients with schizophrenia and to compare this measure with established parameters of heart rate variability (HRV)...
  48. ncbi request reprint European psychiatric treatment guidelines: is the glass half full or half empty?
    M Stiegler
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany
    Eur Psychiatry 20:554-8. 2005
    ..The main focus was the question of whether the development process of the guidelines followed basic principles of evidence-based medicine...
  49. doi request reprint How to read and understand and use systematic reviews and meta-analyses
    S Leucht
    Klinik and Poliklinik für Psychiatrie and Psychotherapie, Technische Universitat Munchen, Munchen, Germany
    Acta Psychiatr Scand 119:443-50. 2009
    ..Systematic reviews and meta-analyses are increasingly frequently used in the evaluation of medical treatments. This review explains the principles of the methodology, significance and limitations of systematic reviews...
  50. ncbi request reprint New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar, Munchen, Germany
    Lancet 361:1581-9. 2003
    ..We aimed to establish whether the new drugs induce fewer EPS than low-potency conventional antipsychotics...
  51. doi request reprint Comparative remission rates of schizophrenic patients using various remission criteria
    Romain Beitinger
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Möhlstr 28, 81675 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1643-51. 2008
    ..New standardized criteria for remission in schizophrenia were presented in 2005 which need to be examined in regard to their significance for clinical trials...
  52. ncbi request reprint Defining 'response' in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany
    Neuropsychopharmacology 32:1903-10. 2007
    ..We suggest a table presenting responder rates in 25 percent steps covering the whole range up to 100% reduction from baseline, which could be displayed together with recently presented criteria for remission...
  53. ncbi request reprint The attitude of patients towards antipsychotic depot treatment
    Stephan Heres
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technical University Munich, am Klinikum rechts der Isar, Moehlstrasse 26, D 81675 Munich, Germany
    Int Clin Psychopharmacol 22:275-82. 2007
    ..A considerable number of patients would accept a depot drug as a long-term treatment option. The gap between patients' acceptance and the low prescription rates can be narrowed by offering antipsychotic depots to more patients...
  54. ncbi request reprint On the concept of remission in schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675, Munich, Germany
    Psychopharmacology (Berl) 194:453-61. 2007
    ..Criteria for remission in schizophrenia have recently been presented. It is unclear how many acutely ill patients meet these criteria and how they compare with previously suggested definitions...
  55. ncbi request reprint Attitudes of psychiatrists toward antipsychotic depot medication
    Stephan Heres
    Klinik und Poliklinik fuer Psychiatrie und Psychotherapie der Technischen, Universitaet Muenchen am Klinikum rechts der, Muenchen, Germany
    J Clin Psychiatry 67:1948-53. 2006
    ..Nevertheless, long-acting injectable formulations are seldom prescribed in the treatment of schizophrenia...
  56. ncbi request reprint Measurement-based psychiatry: definitions of response, remission, stability, and relapse in schizophrenia
    Stefan Leucht
    Technische Universitat, Munchen, Klinikum rechts der Isar, Munich, Germany
    J Clin Psychiatry 67:1813-4. 2006
  57. ncbi request reprint Physical illness and schizophrenia: a review of the literature
    S Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Ismaningerstr, Munchen, Germany
    Acta Psychiatr Scand 116:317-33. 2007
    ..The lifespan of people with schizophrenia is shortened compared to the general population. We reviewed the literature on comorbid physical diseases in schizophrenia to provide a basis for initiatives to fight this unacceptable situation...
  58. ncbi request reprint Medical decision making in antipsychotic drug choice for schizophrenia
    Johannes Hamann
    Psychiatric Department, Technical University of Munich, Möhlstrasse 26, 81675 Munich, Germany
    Am J Psychiatry 161:1301-4. 2004
    ..The influence of patient and physician variables on antipsychotic drug choice for patients with schizophrenia was assessed...
  59. ncbi request reprint Amisulpride is an "atypical" antipsychotic associated with low weight gain
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Psychopharmacology (Berl) 173:112-5. 2004
    ..While most "atypicals" have a high affinity for both dopamine and serotonin receptors, amisulpride has only dopamine receptor action...
  60. doi request reprint Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Lancet 373:31-41. 2009
    ....
  61. ncbi request reprint How do psychiatrists choose among different antipsychotics?
    Johannes Hamann
    Department for Psychiatry and Psychotherapy, Technische Universitat, Möhlstrasse 26, 81675 Munich, Germany
    Eur J Clin Pharmacol 61:851-4. 2005
    ..We attempted to determine the decision rules psychiatrists use in the choice of antipsychotic drugs for inpatients with schizophrenia...
  62. pmc Methodological issues in current antipsychotic drug trials
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Bull 34:275-85. 2008
    ..The authors present practical examples to highlight the current problems and propose a concrete series of suggestions on how to further optimize antipsychotic drug trials in the future...
  63. ncbi request reprint Serotonin transporter polymorphisms and side effects in antidepressant therapy--a pilot study
    Johannes Popp
    Technische Universitat Munchen, Institut fur Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar Ismaninger Str 22 81675 München, Germany
    Pharmacogenomics 7:159-66. 2006
    ....
  64. ncbi request reprint Translating research into clinical practice: critical interpretation of clinical trials in schizophrenia
    Stefan Leucht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany
    Int Clin Psychopharmacol 21:S1-10. 2006
    ..Better training of clinicians in the interpretation of scientific results and the use of more meaningful clinical outcomes are both needed to effectively translate research into clinical practice...
  65. doi request reprint Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
    Susanne Rösner
    IFT, Institut für Therapieforschung, Munich, Germany
    J Psychopharmacol 22:11-23. 2008
    ..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
  66. doi request reprint How much more effective do depot antipsychotics have to be compared to oral antipsychotics before they are prescribed?
    Johannes Hamann
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Germany
    Eur Neuropsychopharmacol 20:276-9. 2010
    ..Other psychiatrist-related factors (e.g. age, gender, and work experience) did not influence attitudes toward depot...
  67. ncbi request reprint Psychiatric decision making in the adoption of a new antipsychotic in Germany
    Johannes Hamann
    Technische Universitat Munchen, Möhlstrasse 26, Muenchen, Germany 81675
    Psychiatr Serv 57:700-3. 2006
    ..Studies in somatic medicine have demonstrated delays in the implementation of new drugs, but data on psychiatric drugs are scarce. This study examined psychiatrists' adoption of a new antipsychotic...
  68. ncbi request reprint Lithium for schizophrenia revisited: a systematic review and meta-analysis of randomized controlled trials
    Stefan Leucht
    Zucker Hillside Hospital, Glen Oaks, N Y, USA
    J Clin Psychiatry 65:177-86. 2004
    ..Clinicians frequently use lithium to augment antipsychotic medication in schizophrenia. Therefore, we undertook a systematic review and meta-analysis of the use of lithium in the treatment of schizophrenia...
  69. ncbi request reprint Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies
    Christoph U Correll
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Schneider Children s Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:414-25. 2004
    ..This hypothesis was examined in a systematic review of studies involving open or controlled treatment with any second-generation antipsychotic...
  70. ncbi request reprint Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: an exploratory analysis of head-to-head comparison studies of second-generation antipsychotics
    Stephan Heres
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München am Klinikum rechts der Isar, Moehlstrasse 26, 81675 Munich, Germany
    Am J Psychiatry 163:185-94. 2006
    ....
  71. ncbi request reprint ABCB1 (P-glycoprotein/MDR1) gene G2677T/a sequence variation (polymorphism): lack of association with side effects and therapeutic response in depressed inpatients treated with amitriptyline
    Barbara Laika
    Clin Chem 52:893-5. 2006
  72. ncbi request reprint Extrapolation between measures of symptom severity and change: an examination of the PANSS and CGI
    Stephen Z Levine
    Bar Ilan University, Ramat Gan 52900, Israel
    Schizophr Res 98:318-22. 2008
    ..This research has not been replicated nor examined in individual trials. This study aims to examine the feasibility of extrapolation from the CGI to the PANSS across and within 4 large clinical trials of antipsychotic medication...
  73. ncbi request reprint Relationship between costs and symptoms in schizophrenia patients treated with antipsychotic medication: a review
    Serge Sevy
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 65:756-65. 2004
    ..The purpose of this review is to understand how changes in costs of illness are related to the effects of antipsychotic medications on symptoms in schizophrenia patients...
  74. ncbi request reprint Pretrial medication bias in randomized antipsychotic drug trials
    Stefan Leucht
    Am J Psychiatry 164:1266; author reply 1266-7. 2007
  75. pmc Unanswered questions in schizophrenia clinical trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, New York, NY, USA
    Schizophr Bull 34:302-9. 2008
  76. pmc Issues in psychopharmacology
    John M Kane
    The Zucker Hillside Hospital Glen Oaks, New York, NY, USA
    Schizophr Bull 34:258. 2008
  77. ncbi request reprint The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary
    John M Kane
    J Clin Psychiatry 64:5-19. 2003
    ..To aid clinical decision-making, a consensus survey of expert opinion on the pharmacologic treatment of psychotic disorders was undertaken to address questions not definitively answered in the research literature...
  78. ncbi request reprint Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    J Clin Psychiatry 69:514-9. 2008
    ....
  79. pmc Commentary on strategies for switching antipsychotics
    John M Davis
    Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    BMC Med 6:18. 2008
    ..In this issue, Ganguli et al. have carried out a randomized switching study, the data from which indicates the tactics that might be optimal. We put this paper into context, provide a critique and describe indications for switching...
  80. pmc Cochrane Schizophrenia Group
    Clive E Adams
    Division of Psychiatry, University of Nottingham, UK
    Schizophr Bull 34:259-65. 2008
  81. ncbi request reprint Medical decision making in the mental health field
    Johannes Hamann
    Psychiatr Serv 56:221. 2005
  82. ncbi request reprint Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time
    Thomas A Trikalinos
    Institute for Clinical Care Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    J Clin Epidemiol 57:1124-30. 2004
    ..We evaluated whether the certainty and estimates of efficacy and tolerability of mental health interventions change over time, as more trials appear on the same topics...
  83. pmc Has research informed us on the practical drug treatment of schizophrenia?
    John M Davis
    Schizophr Bull 34:403-5. 2008