Research Topics
Genomes and GenesSpecies | Rupert LangerSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
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Detail Information
Publications
The role of the pathologist in tissue banking: European Consensus Expert Group ReportGeneroso Bevilacqua
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
Virchows Arch 456:449-54. 2010....
Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy responseRupert Langer
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Clin Cancer Res 14:8279-87. 2008....- Prognostic significance of histopathological tumor regression after neoadjuvant chemotherapy in esophageal adenocarcinomasRupert Langer
Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
Mod Pathol 22:1555-63. 2009..Therefore, we strongly recommend the implementation of a standardized tumor regression grading system in pathological reports of esophageal adenocarcinomas treated by neoadjuvant chemotherapy... - High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patientsRupert Langer
Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
J Surg Oncol 102:503-8. 2010.... - Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagusRupert Langer
Institute of Pathology, TU Munchen, Munchen, Germany
BMC Cancer 8:70. 2008..In this study we investigated the glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in a series of human esophageal adenocarcinomas to determine their implications in cancer progression and prognosis... - Peripheral T-cell lymphoma with progression to a clonally related, Epstein Barr virus+, cytotoxic aggressive T-cell lymphoma: evidence for secondary EBV infection of an established malignant T-cell cloneRupert Langer
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
Am J Surg Pathol 34:1382-7. 2010..This case shows that secondary EBV infection of an established malignant T-cell clone can occur and may contribute to aggressive transformation of PTCL... - Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 casesRupert Langer
Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
Mod Pathol 24:495-501. 2011..We conclude that molecular analysis can identify targets for a specific therapy such as tyrosin kinase inhibitors as additional treatment option in these highly malignant tumors... - Assessment of ErbB2 (Her2) in oesophageal adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisationRupert Langer
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
Mod Pathol 24:908-16. 2011..Assessment of ErbB2 amplification can be equivalently performed by conventional fluorescence in situ hybridisation or other light-microscopy-based methods, such as the novel bright field double in situ hybridisation technique... 
Comparison of pretherapeutic and posttherapeutic expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatin-based neoadjuvant chemotherapyRupert Langer
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat, Munchen, Germany
Am J Clin Pathol 128:191-7. 2007..Down-regulation of chemotherapy metabolism-associated genes occurs after neoadjuvant chemotherapy and may modulate tumor response to chemotherapy...- Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomasJulia Slotta-Huspenina
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
PLoS ONE 7:e41420. 2012..Our approach may be helpful for identifying candidates for specific HSP/GRP-targeted therapies... - Adenocarcinomas of the esophagogastric junction are more likely to respond to preoperative chemotherapy than distal gastric cancerDaniel Reim
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Surg Oncol 19:2108-18. 2012..The aim of this retrospective analysis was to prove these findings in an experienced single-center large patient cohort because there are currently no recruiting prospective clinical trials... - Long-term outcome of 2920 patients with cancers of the esophagus and esophagogastric junction: evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee staging systemRalf Gertler
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Surg 253:689-98. 2011..We analyzed the long-term outcome of patients operated for esophageal cancer and evaluated the new seventh edition of the tumor-node-metastasis classification for cancers of the esophagus... - Significance of histopathological tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 casesKaren Becker
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Surg 253:934-9. 2011..An increasing number of patients with locally advanced gastric carcinomas (GC) are being treated with preoperative chemotherapy before surgery... - Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinomaRupert Langer
Institute of Pathology and Medical Statistics, Klinikum rechts der Isar, , Munich, Germany
Clin Cancer Res 11:7462-9. 2005..CONCLUSIONS: Our results indicate that determination of mRNA levels of few genes may be useful for the prediction of the success of neoadjuvant chemotherapy in individual cancer patients with locally advanced Barrett adenocarcinoma... - DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancerKathrin Mutze
Institute of Pathology, Technische Universitat Munchen, Trogerstr 18, 81675 Munchen, Germany
Eur J Cancer 47:1817-25. 2011..In vitro, DNMT1 expression and chemosensitivity were investigated for a functional relationship and the DNMT inhibitor decitabine (DAC) was tested as an alternative treatment option... - Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapyKatja Specht
Institute of Pathology, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany
Breast Cancer Res Treat 118:45-56. 2009..Whether the biomarker profile is chemotherapy-specific or whether it is a more general indicator of bad prognosis of breast cancer patients remains to be explored... - Discovery of new molecular subtypes in oesophageal adenocarcinomaDaniela Berg
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
PLoS ONE 6:e23985. 2011..After confirmation in other independent studies, our results could be the foundation for the development of a Her2-targeted treatment option for this new patient subgroup of oesophageal adenocarcinoma... - Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)Birgit Luber
Institut für allgemeine Pathologie und pathologische Anatomie, Technische Universitat Munchen, Trogerstraße 18, 81675 Munchen, Germany
BMC Cancer 11:509. 2011.... - How to classify adenocarcinomas of the esophagogastric junction: as esophageal or gastric cancer?Ralf Gertler
Department of Surgery, Technische Universitat Munchen, Munich, Germany
Am J Surg Pathol 35:1512-22. 2011..To evaluate whether so-called cardiac adenocarcinomas (adenocarcinomas of the esophagogastric junction type II and III, ie AEG II and III) are better staged as cancers of the esophagus or as cancers of the stomach... - Expression of class I histone deacetylases (HDAC1 and HDAC2) in oesophageal adenocarcinomas: an immunohistochemical studyRupert Langer
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
J Clin Pathol 63:994-8. 2010..Deregulation of HDACs has been detected in various human malignancies and may also influence response to chemotherapy... - Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survivalLukas Bauer
Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
PLoS ONE 7:e44566. 2012.... - Proposal for a multifactorial prognostic score that accurately classifies 3 groups of gastric carcinoma patients with different outcomes after neoadjuvant chemotherapy and surgeryKaren Becker
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Surg 256:1002-7. 2012..We have developed a multifactorial histopathological prognostic score (PRSC) for patients with gastric cancer treated with neoadjuvant chemotherapy before surgery for the accurate discrimination of patient subgroups with differing outcomes... - The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapyGüralp O Ceyhan
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Surg 252:797-804. 2010..To provide a comprehensive characterization of neural invasion (NI) in rectal adenocarcinoma (RC), to establish a novel NI-severity scoring system, and to assess the prognostic value of NI with emphasis on its localization and severity... - Prediction of prognosis is not improved by the seventh and latest edition of the TNM classification for colorectal cancer in a single-center collectiveUlrich Nitsche
Department of Surgery, Technische Universitat Munchen, Munich, Germany
Ann Surg 254:793-800; discussion 800-1. 2011..To compare the prognostic value of the sixth and seventh editions of the TNM classification, and of additional prognostic factors, in colorectal cancer... - Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancerKathrin Mutze
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
Ann Surg Oncol 17:3336-43. 2010..We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options... - (18)F-FDG PET-guided salvage neoadjuvant radiochemotherapy of adenocarcinoma of the esophagogastric junction: the MUNICON II trialChristian Meyer Zum Büschenfelde
3rd Department of Medicine Haematology and Medical Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
J Nucl Med 52:1189-96. 2011..Therefore, we initiated this prospective trial to improve the clinical outcome of metabolic nonresponders using a salvage neoadjuvant radiochemotherapy... - MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinomaMareike Elsner
Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
J Proteomics 75:4693-704. 2012..This article is part of a Special Issue entitled: Translational Proteomics... - Tumor classification of six common cancer types based on proteomic profiling by MALDI imagingStephan Meding
Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
J Proteome Res 11:1996-2003. 2012..These findings demonstrate that MALDI imaging-derived proteomic classifiers can discriminate between different tumor types at different organ sites and in the same site... - Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissuesSandra Rauser
Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
Clin Cancer Res 13:5115-23. 2007..We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome... - Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tractHeinz Hofler
Institute of Pathology, Technical University Munich, Germany
Recent Results Cancer Res 176:33-6. 2007..Our studies point to promising markers with potential use for chemotherapy response prediction of adenocarcinomas of the upper gastrointestinal tract, but prospective studies for validation are necessary... - Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arraysThorsten Wiech
Institute of Pathology, University Hospital Freiburg, Freiburg, Germany
Lab Invest 89:385-97. 2009..In conclusion, SNP microarrays are a valuable tool to detect DNA copy-number changes and LOH at a high resolution. Using this technique, we identified several novel genes and DNA regions associated with esophageal adenocarcinoma... - Clinical significance of the costimulatory molecule B7-H1 in Barrett carcinomaMartin Loos
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Ann Thorac Surg 91:1025-31. 2011..To date, no data are available on the role of B7-H1 in Barrett carcinoma. Therefore, we investigated the expression pattern and clinical significance of B7-H1 in a large cohort of patients with Barrett carcinoma... - Protein microarray-based comparison of HER2, estrogen receptor, and progesterone receptor status in core biopsies and surgical specimens from FFPE breast cancer tissuesDaniela Berg
Department of Pathology, Technische Universitat Munchen, Munich, Germany
Appl Immunohistochem Mol Morphol 19:300-5. 2011..These results might facilitate the implementation of RPPA technology in routine clinical settings... - High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinomaSandra Rauser
Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
BMC Cancer 10:608. 2010..Here we evaluated the impact of TILs on survival, recurrence, and metastasis in Barrett's cancer, particularly in stage I-IIA patients... - High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancerKarina Bauer
Institute of Pathology, Technische Universitat Munchen, Trogerstr 18, 81675 Munich, Germany
Cell Oncol (Dordr) 35:197-205. 2012..The expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer... - Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinomaBurkhard H A von Rahden
Department of Surgery, Technical University of Munich, Munich, Germany
Cancer Res 65:5038-44. 2005.... - Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutationsAnja Bremm
Technische Universitat Munchen, Klinikum rechts der Isar, Institut für allgemeine Pathologie und pathologische Anatomie, Munchen, Germany
Cancer Res 68:707-14. 2008..In summary, we describe activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin... - Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumorsSarah Schwitalla
Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
Cancer Cell 23:93-106. 2013..Thus, we propose a p53-controlled tumor-suppressive function that is independent of its well-established role in cell-cycle regulation, apoptosis, and senescence... - Long-term Outcome of 2920 Patients With Cancers of the Esophagus and Esophagogastric Junction: Evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee Staging SystemRalf Gertler
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Klinik für Allgemein, Viszeral und Thoraxchirurgie, Klinikum Nurnberg Nord, Nurnberg, Germany Institut für Pathologie und Pathologische Anatomie Institut für Medizinische Statistik und Epidemiologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Universitätsklinikum Heidelberg, Heidelberg, Germany
Ann Surg 253:689-98. 2011..We analyzed the long-term outcome of patients operated for esophageal cancer and evaluated the new seventh edition of the tumor-node-metastasis classification for cancers of the esophagus... - Proteomic analysis of PAXgene-fixed tissuesBilge Ergin
Institute of Pathology, Technische Universitat Munchen, Munich, Germany
J Proteome Res 9:5188-96. 2010..Taken together, we demonstrate here that PAXgene has great potential to serve as a novel multimodal fixative for modern pathology, enabling extensive protein biomarker studies on clinical tissue samples... - Testicular metastasis from adenocarcinoma of the esophagusSonja Gillen
Department of Surgery, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
Ann Thorac Surg 87:957-9. 2009..In most cases, the testicular tumor was accompanied by a hydrocele. Therefore, cancerous and metastatic lesions should be considered in the management of hydrocele and testicular masses... - The severity of neural invasion is associated with shortened survival in colon cancerFlorian Liebl
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Clin Cancer Res 19:50-61. 2013..Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer... - Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2Ivonne Regel
Department of Medicine II, Universitat Munchen, Munchen, Germany
Gastroenterology 143:99-109.e10. 2012..Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis... - The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatinMichael Schemann
Human Biology, Technische Universitat Munchen, Freising, Germany
Gastroenterology 138:266-74. 2010..Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode of action of GW427353 in human submucous neurons... - Successful evaluation of a new animal model using mice for esophageal adenocarcinomaMatthias Raggi
Department of Surgery, Klinikum rechts der Isar, TU Muenchen, Ismaningerstr 22, 81675, Munich, Germany
Langenbecks Arch Surg 395:347-50. 2010..However, as of now no such model exists, in the past predominately due to the high mortality involved with the surgical procedure to create a mixed duodenogastric reflux... - Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinomaBettina Albrecht
University Hospital Freiburg, Institute of Pathology, Freiburg i Br, Germany
J Pathol 203:780-8. 2004..The newly identified genes may include so far unknown biomarkers in BCA and are therefore a starting point for further studies elucidating their possible role in Barrett's carcinogenesis... - Tumor-specific targeting of pancreatic cancer with Shiga toxin B-subunitMatthias Maak
Department of Surgery, Klinikum rechts der Isar, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
Mol Cancer Ther 10:1918-28. 2011..Moreover, this effect was effectively blocked by competing incubation with nonlabeled STxB, showing the specificity of the targeting. Thus, STxB constitutes a promising new tool for specific targeting of pancreatic cancer... - Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survivalPetra Voland
II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Neuroendocrinology 89:66-78. 2009..We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis... - Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndromeSabine Buhner
Human Biology, Technische Universitat Munchen, Freising, Germany
Gastroenterology 137:1425-34. 2009..Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons... - High-grade supraclavicular soft tissue sarcoma as secondary malignancy after successful treatment of acute myeloid leukemia: case report and literature reviewMatthias Troeltzsch
Department of Oral and Maxillofacial Surgery, Technische Universiät München, Munich, Germany
J Oral Maxillofac Surg 70:2211-7. 2012..The presented case describes the appearance of a sarcoma 18 years after curative treatment of acute myeloid leukemia. This is only the second case of this type reported in published studies... - Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patientsLina Seiz
Klinische Forschergruppe der Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
Biol Chem 393:391-401. 2012..low KLK6 expression; hazard ratio (HR), 1.92; p=0.017; HR, 1.80; p=0.042, respectively]. These results indicate that KLK6 expressed by stromal cells may considerably contribute to the aggressiveness of ovarian cancer... - Imaging of proliferation in hepatocellular carcinoma with the in vivo marker 18F-fluorothymidineFlorian Eckel
Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
J Nucl Med 50:1441-7. 2009..We determined the ability of PET with the thymidine analog 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to detect hepatocellular carcinoma (HCC)... - Esophageal (Barrett's) adenocarcinoma is not associated with Epstein-Barr virus infection: an analysis of 162 casesMario Sarbia
Int J Cancer 117:698-700. 2005 - C609T polymorphism of the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinomaBurkhard H A von Rahden
Int J Cancer 113:506-8. 2005 - Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancerAxel Walch
Helmholtz Zentrum Munchen, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Institut fur Pathologie, Neuherberg, Germany
Mod Pathol 21:544-52. 2008..These results indicate that the investigated regulators of E-cadherin-mediated cell adhesion play a role in gastric carcinogenesis... - Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tractHeinz Hofler
Institute of Pathologyy, Technical University Munchen, Trogerstr 18, 81675 Munchen, Germany
Adv Exp Med Biol 587:115-20. 2006..Our studies point to promising markers with potential use for chemotherapy response prediction of adenocarcinomas of the upper gastrointestinal tract, but prospective studies for validation are necessary...