Rupert Langer

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
  2. doi request reprint Prognostic significance of histopathological tumor regression after neoadjuvant chemotherapy in esophageal adenocarcinomas
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    Mod Pathol 22:1555-63. 2009
  3. doi request reprint Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 14:8279-87. 2008
  4. doi request reprint High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    J Surg Oncol 102:503-8. 2010
  5. doi request reprint Peripheral T-cell lymphoma with progression to a clonally related, Epstein Barr virus+, cytotoxic aggressive T-cell lymphoma: evidence for secondary EBV infection of an established malignant T-cell clone
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Am J Surg Pathol 34:1382-7. 2010
  6. doi request reprint Assessment of ErbB2 (Her2) in oesophageal adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisation
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    Mod Pathol 24:908-16. 2011
  7. pmc Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus
    Rupert Langer
    Institute of Pathology, TU Munchen, Munchen, Germany
    BMC Cancer 8:70. 2008
  8. doi request reprint Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    Mod Pathol 24:495-501. 2011
  9. ncbi request reprint Comparison of pretherapeutic and posttherapeutic expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatin-based neoadjuvant chemotherapy
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat, Munchen, Germany
    Am J Clin Pathol 128:191-7. 2007
  10. pmc Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas
    Julia Slotta-Huspenina
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 7:e41420. 2012

Detail Information

Publications57

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
    ....
  2. doi request reprint Prognostic significance of histopathological tumor regression after neoadjuvant chemotherapy in esophageal adenocarcinomas
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    Mod Pathol 22:1555-63. 2009
    ..Therefore, we strongly recommend the implementation of a standardized tumor regression grading system in pathological reports of esophageal adenocarcinomas treated by neoadjuvant chemotherapy...
  3. doi request reprint Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 14:8279-87. 2008
    ....
  4. doi request reprint High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    J Surg Oncol 102:503-8. 2010
    ....
  5. doi request reprint Peripheral T-cell lymphoma with progression to a clonally related, Epstein Barr virus+, cytotoxic aggressive T-cell lymphoma: evidence for secondary EBV infection of an established malignant T-cell clone
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Am J Surg Pathol 34:1382-7. 2010
    ..This case shows that secondary EBV infection of an established malignant T-cell clone can occur and may contribute to aggressive transformation of PTCL...
  6. doi request reprint Assessment of ErbB2 (Her2) in oesophageal adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisation
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    Mod Pathol 24:908-16. 2011
    ..Assessment of ErbB2 amplification can be equivalently performed by conventional fluorescence in situ hybridisation or other light-microscopy-based methods, such as the novel bright field double in situ hybridisation technique...
  7. pmc Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus
    Rupert Langer
    Institute of Pathology, TU Munchen, Munchen, Germany
    BMC Cancer 8:70. 2008
    ..In this study we investigated the glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in a series of human esophageal adenocarcinomas to determine their implications in cancer progression and prognosis...
  8. doi request reprint Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    Mod Pathol 24:495-501. 2011
    ..We conclude that molecular analysis can identify targets for a specific therapy such as tyrosin kinase inhibitors as additional treatment option in these highly malignant tumors...
  9. ncbi request reprint Comparison of pretherapeutic and posttherapeutic expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatin-based neoadjuvant chemotherapy
    Rupert Langer
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat, Munchen, Germany
    Am J Clin Pathol 128:191-7. 2007
    ..Down-regulation of chemotherapy metabolism-associated genes occurs after neoadjuvant chemotherapy and may modulate tumor response to chemotherapy...
  10. pmc Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas
    Julia Slotta-Huspenina
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 7:e41420. 2012
    ..Our approach may be helpful for identifying candidates for specific HSP/GRP-targeted therapies...
  11. doi request reprint Adenocarcinomas of the esophagogastric junction are more likely to respond to preoperative chemotherapy than distal gastric cancer
    Daniel Reim
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg Oncol 19:2108-18. 2012
    ..The aim of this retrospective analysis was to prove these findings in an experienced single-center large patient cohort because there are currently no recruiting prospective clinical trials...
  12. doi request reprint Long-term outcome of 2920 patients with cancers of the esophagus and esophagogastric junction: evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee staging system
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 253:689-98. 2011
    ..We analyzed the long-term outcome of patients operated for esophageal cancer and evaluated the new seventh edition of the tumor-node-metastasis classification for cancers of the esophagus...
  13. doi request reprint Significance of histopathological tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 cases
    Karen Becker
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 253:934-9. 2011
    ..An increasing number of patients with locally advanced gastric carcinomas (GC) are being treated with preoperative chemotherapy before surgery...
  14. ncbi request reprint Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma
    Rupert Langer
    Institute of Pathology and Medical Statistics, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 11:7462-9. 2005
    ..We analyzed pretherapeutic gene expression patterns of patients with locally advanced adenocarcinomas of the esophagus with regard to response to neoadjuvant chemotherapy...
  15. doi request reprint Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria
    Michaela Aichler
    Research Unit of Analytical Pathology, Institute of Pathology, Helmholtz Zentrum München German Research Centre for Environmental Health, Neuherberg, Germany
    J Pathol 230:410-9. 2013
    ..This connection between mitochondrial respiration and chemosensitivity is relevant to anticancer therapeutics that target the mitochondrial electron transport chain...
  16. doi request reprint DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer
    Kathrin Mutze
    Institute of Pathology, Technische Universitat Munchen, Trogerstr 18, 81675 Munchen, Germany
    Eur J Cancer 47:1817-25. 2011
    ..In vitro, DNMT1 expression and chemosensitivity were investigated for a functional relationship and the DNMT inhibitor decitabine (DAC) was tested as an alternative treatment option...
  17. doi request reprint Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapy
    Katja Specht
    Institute of Pathology, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany
    Breast Cancer Res Treat 118:45-56. 2009
    ..Whether the biomarker profile is chemotherapy-specific or whether it is a more general indicator of bad prognosis of breast cancer patients remains to be explored...
  18. pmc Discovery of new molecular subtypes in oesophageal adenocarcinoma
    Daniela Berg
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 6:e23985. 2011
    ..After confirmation in other independent studies, our results could be the foundation for the development of a Her2-targeted treatment option for this new patient subgroup of oesophageal adenocarcinoma...
  19. pmc Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    Birgit Luber
    Institut für allgemeine Pathologie und pathologische Anatomie, Technische Universitat Munchen, Trogerstraße 18, 81675 Munchen, Germany
    BMC Cancer 11:509. 2011
    ....
  20. doi request reprint How to classify adenocarcinomas of the esophagogastric junction: as esophageal or gastric cancer?
    Ralf Gertler
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Am J Surg Pathol 35:1512-22. 2011
    ..To evaluate whether so-called cardiac adenocarcinomas (adenocarcinomas of the esophagogastric junction type II and III, ie AEG II and III) are better staged as cancers of the esophagus or as cancers of the stomach...
  21. doi request reprint Expression of class I histone deacetylases (HDAC1 and HDAC2) in oesophageal adenocarcinomas: an immunohistochemical study
    Rupert Langer
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    J Clin Pathol 63:994-8. 2010
    ..Deregulation of HDACs has been detected in various human malignancies and may also influence response to chemotherapy...
  22. doi request reprint The severity of neural invasion is associated with shortened survival in colon cancer
    Florian Liebl
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:50-61. 2013
    ..Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer...
  23. pmc Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survival
    Lukas Bauer
    Institute of Pathology, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 7:e44566. 2012
    ....
  24. doi request reprint Proposal for a multifactorial prognostic score that accurately classifies 3 groups of gastric carcinoma patients with different outcomes after neoadjuvant chemotherapy and surgery
    Karen Becker
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 256:1002-7. 2012
    ..We have developed a multifactorial histopathological prognostic score (PRSC) for patients with gastric cancer treated with neoadjuvant chemotherapy before surgery for the accurate discrimination of patient subgroups with differing outcomes...
  25. doi request reprint The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 252:797-804. 2010
    ..To provide a comprehensive characterization of neural invasion (NI) in rectal adenocarcinoma (RC), to establish a novel NI-severity scoring system, and to assess the prognostic value of NI with emphasis on its localization and severity...
  26. doi request reprint Prediction of prognosis is not improved by the seventh and latest edition of the TNM classification for colorectal cancer in a single-center collective
    Ulrich Nitsche
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Ann Surg 254:793-800; discussion 800-1. 2011
    ..To compare the prognostic value of the sixth and seventh editions of the TNM classification, and of additional prognostic factors, in colorectal cancer...
  27. doi request reprint Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer
    Kathrin Mutze
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    Ann Surg Oncol 17:3336-43. 2010
    ..We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options...
  28. doi request reprint (18)F-FDG PET-guided salvage neoadjuvant radiochemotherapy of adenocarcinoma of the esophagogastric junction: the MUNICON II trial
    Christian Meyer Zum Büschenfelde
    3rd Department of Medicine Haematology and Medical Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 52:1189-96. 2011
    ..Therefore, we initiated this prospective trial to improve the clinical outcome of metabolic nonresponders using a salvage neoadjuvant radiochemotherapy...
  29. doi request reprint MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma
    Mareike Elsner
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    J Proteomics 75:4693-704. 2012
    ..This article is part of a Special Issue entitled: Translational Proteomics...
  30. doi request reprint Tumor classification of six common cancer types based on proteomic profiling by MALDI imaging
    Stephan Meding
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    J Proteome Res 11:1996-2003. 2012
    ..These findings demonstrate that MALDI imaging-derived proteomic classifiers can discriminate between different tumor types at different organ sites and in the same site...
  31. doi request reprint Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays
    Thorsten Wiech
    Institute of Pathology, University Hospital Freiburg, Freiburg, Germany
    Lab Invest 89:385-97. 2009
    ..In conclusion, SNP microarrays are a valuable tool to detect DNA copy-number changes and LOH at a high resolution. Using this technique, we identified several novel genes and DNA regions associated with esophageal adenocarcinoma...
  32. doi request reprint Clinical significance of the costimulatory molecule B7-H1 in Barrett carcinoma
    Martin Loos
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Thorac Surg 91:1025-31. 2011
    ..To date, no data are available on the role of B7-H1 in Barrett carcinoma. Therefore, we investigated the expression pattern and clinical significance of B7-H1 in a large cohort of patients with Barrett carcinoma...
  33. ncbi request reprint Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract
    Heinz Hofler
    Institute of Pathology, Technical University Munich, Germany
    Recent Results Cancer Res 176:33-6. 2007
    ..Our studies point to promising markers with potential use for chemotherapy response prediction of adenocarcinomas of the upper gastrointestinal tract, but prospective studies for validation are necessary...
  34. ncbi request reprint Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues
    Sandra Rauser
    Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Clin Cancer Res 13:5115-23. 2007
    ..We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome...
  35. doi request reprint Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations
    Anja Bremm
    Technische Universitat Munchen, Klinikum rechts der Isar, Institut für allgemeine Pathologie und pathologische Anatomie, Munchen, Germany
    Cancer Res 68:707-14. 2008
    ..In summary, we describe activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin...
  36. doi request reprint High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
    Karina Bauer
    Institute of Pathology, Technische Universitat Munchen, Trogerstr 18, 81675 Munich, Germany
    Cell Oncol (Dordr) 35:197-205. 2012
    ..The expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer...
  37. doi request reprint Protein microarray-based comparison of HER2, estrogen receptor, and progesterone receptor status in core biopsies and surgical specimens from FFPE breast cancer tissues
    Daniela Berg
    Department of Pathology, Technische Universitat Munchen, Munich, Germany
    Appl Immunohistochem Mol Morphol 19:300-5. 2011
    ..These results might facilitate the implementation of RPPA technology in routine clinical settings...
  38. pmc High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma
    Sandra Rauser
    Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    BMC Cancer 10:608. 2010
    ..Here we evaluated the impact of TILs on survival, recurrence, and metastasis in Barrett's cancer, particularly in stage I-IIA patients...
  39. ncbi request reprint Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma
    Bettina Albrecht
    University Hospital Freiburg, Institute of Pathology, Freiburg i Br, Germany
    J Pathol 203:780-8. 2004
    ..The newly identified genes may include so far unknown biomarkers in BCA and are therefore a starting point for further studies elucidating their possible role in Barrett's carcinogenesis...
  40. ncbi request reprint Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma
    Burkhard H A von Rahden
    Department of Surgery, Technical University of Munich, Munich, Germany
    Cancer Res 65:5038-44. 2005
    ....
  41. doi request reprint Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 23:93-106. 2013
    ..Thus, we propose a p53-controlled tumor-suppressive function that is independent of its well-established role in cell-cycle regulation, apoptosis, and senescence...
  42. doi request reprint Proteomic analysis of PAXgene-fixed tissues
    Bilge Ergin
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    J Proteome Res 9:5188-96. 2010
    ..Taken together, we demonstrate here that PAXgene has great potential to serve as a novel multimodal fixative for modern pathology, enabling extensive protein biomarker studies on clinical tissue samples...
  43. ncbi request reprint Long-term Outcome of 2920 Patients With Cancers of the Esophagus and Esophagogastric Junction: Evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee Staging System
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Klinik für Allgemein, Viszeral und Thoraxchirurgie, Klinikum Nurnberg Nord, Nurnberg, Germany Institut für Pathologie und Pathologische Anatomie Institut für Medizinische Statistik und Epidemiologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Universitätsklinikum Heidelberg, Heidelberg, Germany
    Ann Surg 253:689-98. 2011
    ..We analyzed the long-term outcome of patients operated for esophageal cancer and evaluated the new seventh edition of the tumor-node-metastasis classification for cancers of the esophagus...
  44. doi request reprint Testicular metastasis from adenocarcinoma of the esophagus
    Sonja Gillen
    Department of Surgery, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Ann Thorac Surg 87:957-9. 2009
    ..In most cases, the testicular tumor was accompanied by a hydrocele. Therefore, cancerous and metastatic lesions should be considered in the management of hydrocele and testicular masses...
  45. doi request reprint Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2
    Ivonne Regel
    Department of Medicine II, Universitat Munchen, Munchen, Germany
    Gastroenterology 143:99-109.e10. 2012
    ..Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis...
  46. doi request reprint The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 138:266-74. 2010
    ..Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode of action of GW427353 in human submucous neurons...
  47. doi request reprint Successful evaluation of a new animal model using mice for esophageal adenocarcinoma
    Matthias Raggi
    Department of Surgery, Klinikum rechts der Isar, TU Muenchen, Ismaningerstr 22, 81675, Munich, Germany
    Langenbecks Arch Surg 395:347-50. 2010
    ..However, as of now no such model exists, in the past predominately due to the high mortality involved with the surgical procedure to create a mixed duodenogastric reflux...
  48. doi request reprint Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival
    Petra Voland
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Neuroendocrinology 89:66-78. 2009
    ..We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis...
  49. doi request reprint Tumor-specific targeting of pancreatic cancer with Shiga toxin B-subunit
    Matthias Maak
    Department of Surgery, Klinikum rechts der Isar, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Mol Cancer Ther 10:1918-28. 2011
    ..Moreover, this effect was effectively blocked by competing incubation with nonlabeled STxB, showing the specificity of the targeting. Thus, STxB constitutes a promising new tool for specific targeting of pancreatic cancer...
  50. doi request reprint Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    Sabine Buhner
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 137:1425-34. 2009
    ..Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons...
  51. doi request reprint High-grade supraclavicular soft tissue sarcoma as secondary malignancy after successful treatment of acute myeloid leukemia: case report and literature review
    Matthias Troeltzsch
    Department of Oral and Maxillofacial Surgery, Technische Universiät München, Munich, Germany
    J Oral Maxillofac Surg 70:2211-7. 2012
    ..The presented case describes the appearance of a sarcoma 18 years after curative treatment of acute myeloid leukemia. This is only the second case of this type reported in published studies...
  52. doi request reprint Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients
    Lina Seiz
    Klinische Forschergruppe der Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
    Biol Chem 393:391-401. 2012
    ..low KLK6 expression; hazard ratio (HR), 1.92; p=0.017; HR, 1.80; p=0.042, respectively]. These results indicate that KLK6 expressed by stromal cells may considerably contribute to the aggressiveness of ovarian cancer...
  53. doi request reprint Imaging of proliferation in hepatocellular carcinoma with the in vivo marker 18F-fluorothymidine
    Florian Eckel
    Department of Internal Medicine II, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1441-7. 2009
    ..We determined the ability of PET with the thymidine analog 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to detect hepatocellular carcinoma (HCC)...
  54. ncbi request reprint Esophageal (Barrett's) adenocarcinoma is not associated with Epstein-Barr virus infection: an analysis of 162 cases
    Mario Sarbia
    Int J Cancer 117:698-700. 2005
  55. ncbi request reprint C609T polymorphism of the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinoma
    Burkhard H A von Rahden
    Int J Cancer 113:506-8. 2005
  56. doi request reprint Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer
    Axel Walch
    Helmholtz Zentrum Munchen, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Institut fur Pathologie, Neuherberg, Germany
    Mod Pathol 21:544-52. 2008
    ..These results indicate that the investigated regulators of E-cadherin-mediated cell adhesion play a role in gastric carcinogenesis...
  57. ncbi request reprint Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract
    Heinz Hofler
    Institute of Pathologyy, Technical University Munchen, Trogerstr 18, 81675 Munchen, Germany
    Adv Exp Med Biol 587:115-20. 2006
    ..Our studies point to promising markers with potential use for chemotherapy response prediction of adenocarcinomas of the upper gastrointestinal tract, but prospective studies for validation are necessary...