Thomas Korn

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. doi request reprint Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis
    Thomas Korn
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Results Probl Cell Differ 51:43-74. 2010
  2. doi request reprint Pathophysiology of multiple sclerosis
    Thomas Korn
    Technische Universitat Munchen, Klinikum rechts der Isar, Department of Neurology, Ismaninger Str 22, 81675 Munchen, Germany
    J Neurol 255:2-6. 2008
  3. doi request reprint IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
  4. pmc Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
    Veit Rothhammer
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, 81675 Munich, Germany
    J Exp Med 208:2465-76. 2011
  5. pmc Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica
    Sudhakar Reddy Kalluri
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 6:e16083. 2011
  6. doi request reprint Development and function of interleukin 17-producing γδ T cells
    Thomas Korn
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger, Munich, Germany
    Ann N Y Acad Sci 1247:34-45. 2012
  7. ncbi request reprint Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    FASEB J 19:1878-80. 2005
  8. ncbi request reprint Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    Glia 49:73-83. 2005
  9. pmc γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
    Franziska Petermann
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Immunity 33:351-63. 2010
  10. doi request reprint Active immunization with amyloid-beta 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune system
    Patrick Vollmar
    Neurologische Uniklinik, Technische Universitat Munchen, Munich, Germany
    J Immunol 185:6338-47. 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis
    Thomas Korn
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Results Probl Cell Differ 51:43-74. 2010
    ..It is likely that the discovery of Th17 cells and their relationship with T-regs will change our understanding of organ-specific autoimmune diseases in the years to come...
  2. doi request reprint Pathophysiology of multiple sclerosis
    Thomas Korn
    Technische Universitat Munchen, Klinikum rechts der Isar, Department of Neurology, Ismaninger Str 22, 81675 Munchen, Germany
    J Neurol 255:2-6. 2008
    ..Here, current concepts of the commitment of T cells to pro-inflammatory effector T helper cell lineages including Th17 cells that appear to be important inducers of organ-specific autoimmunity will be discussed...
  3. doi request reprint IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
    ..Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease...
  4. pmc Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
    Veit Rothhammer
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, 81675 Munich, Germany
    J Exp Med 208:2465-76. 2011
    ..These observations have implications for the understanding of lesion localization, immunosurveillance, and drug design in multiple sclerosis...
  5. pmc Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica
    Sudhakar Reddy Kalluri
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 6:e16083. 2011
    ..However, AQP4 specific T helper cell responses that are required for the generation of anti-AQP4 antibodies and most likely also for the formation of intraparenchymal CNS lesions have not been characterized...
  6. doi request reprint Development and function of interleukin 17-producing γδ T cells
    Thomas Korn
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger, Munich, Germany
    Ann N Y Acad Sci 1247:34-45. 2012
    ..The role of γδT17 cells in animal models of autoimmunity will be discussed as well as the prerequisites for the development of human γδT17 cells and their potential importance for human disease conditions...
  7. ncbi request reprint Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    FASEB J 19:1878-80. 2005
    ....
  8. ncbi request reprint Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    Glia 49:73-83. 2005
    ..This T-cell-mediated regulation of MCT1 might contribute to a compensatory or protective mechanism in order to guarantee substrate pools for neurons and oligodendrocytes under inflammatory conditions...
  9. pmc γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
    Franziska Petermann
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Immunity 33:351-63. 2010
    ..Thus, IL-23, which by itself has no direct effect on Treg cells, is able to disarm Treg cell responses and promote antigen-specific effector T cell responses via activating γδ T cells...
  10. doi request reprint Active immunization with amyloid-beta 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune system
    Patrick Vollmar
    Neurologische Uniklinik, Technische Universitat Munchen, Munich, Germany
    J Immunol 185:6338-47. 2010
    ..Thus, this study identifies adjuvant effects of Aβ(1-42), which result in a clinically relevant neurocognitive phenotype highlighting potential risks of Aβ immunotherapy...
  11. ncbi request reprint Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS
    Tim Magnus
    Department of Neurology, University of Homburg, D 66424 Homburg, Germany
    J Neurosci 25:2537-46. 2005
    ..Together, our data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage...
  12. ncbi request reprint Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cells
    Tim Magnus
    Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, University of Homburg, D 66421 Homburg Saar, Germany
    J Neuroimmunol 155:64-72. 2004
    ..Thus, GM-CSF stimulation reduces the immunomodulatory functions of microglial cells...
  13. ncbi request reprint Enriched CD161high CCR6+ γδ T cells in the cerebrospinal fluid of patients with multiple sclerosis
    Lucas Schirmer
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    JAMA Neurol 70:345-51. 2013
    ..To investigate the expression of CD161 (KLRB1) and CCR6 on human γδ T cells in blood and cerebrospinal fluid (CSF) of patients with a clinically isolated syndrome (CIS) and multiple sclerosis (MS) in relapse...
  14. doi request reprint Potassium channel KIR4.1 as an immune target in multiple sclerosis
    Rajneesh Srivastava
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat, Munich, Germany
    N Engl J Med 367:115-23. 2012
    ..Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known...
  15. pmc IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    Thomas Korn
    Technische Universitat Munchen, Department of Neurology, Ismaninger Strasse 22, 81675 Munchen, Germany
    Proc Natl Acad Sci U S A 105:18460-5. 2008
    ..These data identify IL-6 as an important target to modulate autoimmune responses and chronic inflammation...
  16. pmc CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
    Markus C Kowarik
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    J Neuroinflammation 9:93. 2012
    ....
  17. doi request reprint 18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions
    Dorothea Buck
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 53:1269-76. 2012
    ..The aim of this study was to establish an MRI- and PET/CT-based imaging modality and to evaluate approved and promising PET tracers in experimental autoimmune encephalomyelitis (EAE), the animal model of MS...
  18. doi request reprint Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity
    Jakob Loschko
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, D 81675 Munich, Germany
    J Immunol 187:6346-56. 2011
    ..We conclude that Ag delivery to PDCs can be harnessed to inhibit Ag-specific immune responses and prevent Th cell-dependent autoimmunity...
  19. ncbi request reprint IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1
    Christina Heinemann
    1 Klinikum rechts der Isar, Department of Neurology, Technische Universitat Munchen, Ismaninger Straße 22, 81675 Munich, Germany 2
    Nat Commun 5:3770. 2014
    ..Thus, the balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines whether tissue inflammation is perpetuated or resolves. ..
  20. pmc CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Clin Invest 121:2898-910. 2011
    ..Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy...
  21. pmc TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
    Arun K Mankan
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 108:6567-72. 2011
    ..These results unravel so far unanticipated direct and indirect functions for IKKβ in myeloid progenitor survival and maintenance of innate and Th17 immunity and raise concerns about long-term IKKβ inhibition in IL-17-mediated diseases...
  22. ncbi request reprint Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    J Leukoc Biol 76:950-60. 2004
    ..In conclusion, our observations underline that the immunomodulatory potential of leflunomide in effector cells of EAE is clinically relevant and is not exclusively dependent on the depletion of cellular pyrimidine pools...
  23. pmc Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011
    Christoph Kleinschnitz
    Department of Neurology, University Clinic of Würzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    Exp Transl Stroke Med 4:2. 2012
    ..This first prize award ceremony was a great incentive for the next call for proposals now upcoming in 2012...
  24. ncbi request reprint Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions
    Lucas Schirmer
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Neurol 75:810-28. 2014
    ..Serum antibodies against the glial potassium channel KIR4.1 are found in a subpopulation of multiple sclerosis (MS) patients. Little is known about the expression of KIR4.1 in human normal brain tissue and in MS lesions...
  25. pmc Immunology of neuromyelitis optica: a T cell-B cell collaboration
    Meike Mitsdoerffer
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann N Y Acad Sci 1283:57-66. 2013
    ..Here, we review immunologic aspects of NMO, placing recent findings in the biology of T-B cell cooperation into perspective with autoimmunity of the CNS...
  26. doi request reprint Immune mechanisms of new therapeutic strategies in MS: teriflunomide
    Malte C Claussen
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Munich, Germany
    Clin Immunol 142:49-56. 2012
    ....
  27. doi request reprint Cytokines and effector T cell subsets causing autoimmune CNS disease
    Franziska Petermann
    Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Munich, Germany
    FEBS Lett 585:3747-57. 2011
    ..Here, we will summarize new concepts of early and late T cell plasticity and the cytokine network that shapes T helper cell responses and lesion development in CNS specific autoimmunity...
  28. doi request reprint Novel monoclonal antibodies for therapy of multiple sclerosis
    Benjamin Knier
    Technische Universitat Munchen, Klinikum rechts der Isar, Department of Neurology, Ismaninger Str 22, 81675 Munich, Germany 49 89 4140 4601 49 89 4140 7681
    Expert Opin Biol Ther 14:503-13. 2014
    ..With the introduction of natalizumab, the importance of monoclonal antibodies in the therapy of multiple sclerosis (MS) has dramatically increased during the past years...
  29. doi request reprint Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
    Mathias Gelderblom
    Department of Neurology, Center for Molecular Neurobiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Blood 120:3793-802. 2012
    ..We propose that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke...
  30. pmc Report on the 1st scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009
    Tim Magnus
    Department of Neurology, University Clinic Hamburg Eppendorf, Martinistr, 52, D 20246 Hamburg, Germany
    Exp Transl Stroke Med 2:7. 2010
    ..ABSTRACT: Report on the 1st scientific meeting of the "Verein zur Forderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009A scientific meeting report...
  31. ncbi request reprint Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming
    Thomas Korn
    Department of Neurology, Neuroimmunology Branch and MS Clinical Research Group, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
    J Neuroimmunol 139:17-26. 2003
    ..Protection from cell-mediated autoimmunity was not due to a Th2 bias, to the lack of IL-2 or a failure of Vav1(-/-) T cells in terms of chemotactic mobility...