Research Topics
Genomes and Genes
| Thomas KornSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
| Collaborators
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Detail Information
Publications
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosisThomas Korn
Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munchen, Germany
Results Probl Cell Differ 51:43-74. 2010..It is likely that the discovery of Th17 cells and their relationship with T-regs will change our understanding of organ-specific autoimmune diseases in the years to come...- Pathophysiology of multiple sclerosisThomas Korn
Technische Universitat Munchen, Klinikum rechts der Isar, Department of Neurology, Ismaninger Str 22, 81675 Munchen, Germany
J Neurol 255:2-6. 2008..Here, current concepts of the commitment of T cells to pro-inflammatory effector T helper cell lineages including Th17 cells that appear to be important inducers of organ-specific autoimmunity will be discussed... - IL-17 and Th17 CellsThomas Korn
Technical University Munich, Department of Neurology, 81675 Munich, Germany
Annu Rev Immunol 27:485-517. 2009..Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease... - Development and function of interleukin 17-producing γδ T cellsThomas Korn
Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger, Munich, Germany
Ann N Y Acad Sci 1247:34-45. 2012..The role of γδT17 cells in animal models of autoimmunity will be discussed as well as the prerequisites for the development of human γδT17 cells and their potential importance for human disease conditions... 
Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAEVeit Rothhammer
Klinikum rechts der Isar, Department of Neurology, Technical University Munich, 81675 Munich, Germany
J Exp Med 208:2465-76. 2011..These observations have implications for the understanding of lesion localization, immunosurveillance, and drug design in multiple sclerosis...
Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alphaThomas Korn
Department of Neurology, Universitat des Saarlandes, Homburg, Germany
FASEB J 19:1878-80. 2005....- Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasisThomas Korn
Department of Neurology, Universitat des Saarlandes, Homburg, Germany
Glia 49:73-83. 2005..This T-cell-mediated regulation of MCT1 might contribute to a compensatory or protective mechanism in order to guarantee substrate pools for neurons and oligodendrocytes under inflammatory conditions... - Active immunization with amyloid-beta 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune systemPatrick Vollmar
Neurologische Uniklinik, Technische Universitat Munchen, Munich, Germany
J Immunol 185:6338-47. 2010..Thus, this study identifies adjuvant effects of Aβ(1-42), which result in a clinically relevant neurocognitive phenotype highlighting potential risks of Aβ immunotherapy... - Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNSTim Magnus
Department of Neurology, University of Homburg, D 66424 Homburg, Germany
J Neurosci 25:2537-46. 2005..Together, our data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage... - γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanismFranziska Petermann
Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
Immunity 33:351-63. 2010..Thus, IL-23, which by itself has no direct effect on Treg cells, is able to disarm Treg cell responses and promote antigen-specific effector T cell responses via activating γδ T cells... - Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cellsTim Magnus
Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, University of Homburg, D 66421 Homburg Saar, Germany
J Neuroimmunol 155:64-72. 2004..Thus, GM-CSF stimulation reduces the immunomodulatory functions of microglial cells... - Potassium channel KIR4.1 as an immune target in multiple sclerosisRajneesh Srivastava
Department of Neurology, Klinikum rechts der Isar, Technische Universitat, Munich, Germany
N Engl J Med 367:115-23. 2012..Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known... - 18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesionsDorothea Buck
Department of Neurology, Technische Universitat Munchen, Munich, Germany
J Nucl Med 53:1269-76. 2012..The aim of this study was to establish an MRI- and PET/CT-based imaging modality and to evaluate approved and promising PET tracers in experimental autoimmune encephalomyelitis (EAE), the animal model of MS... - Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunityJakob Loschko
II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, D 81675 Munich, Germany
J Immunol 187:6346-56. 2011..We conclude that Ag delivery to PDCs can be harnessed to inhibit Ag-specific immune responses and prevent Th cell-dependent autoimmunity... - Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis opticaSudhakar Reddy Kalluri
Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
PLoS ONE 6:e16083. 2011..However, AQP4 specific T helper cell responses that are required for the generation of anti-AQP4 antibodies and most likely also for the formation of intraparenchymal CNS lesions have not been characterized... - Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011Christoph Kleinschnitz
Department of Neurology, University Clinic of Würzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
Exp Transl Stroke Med 4:2. 2012..This first prize award ceremony was a great incentive for the next call for proposals now upcoming in 2012... - CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammationMarkus C Kowarik
Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
J Neuroinflammation 9:93. 2012.... - IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cellsThomas Korn
Technische Universitat Munchen, Department of Neurology, Ismaninger Strasse 22, 81675 Munchen, Germany
Proc Natl Acad Sci U S A 105:18460-5. 2008..These data identify IL-6 as an important target to modulate autoimmune responses and chronic inflammation... - Immune mechanisms of new therapeutic strategies in MS: teriflunomideMalte C Claussen
Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Munich, Germany
Clin Immunol 142:49-56. 2012.... - CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in miceChristian Weber
Institute for Cardiovascular Prevention, Ludwig Maximilians Universitat Munchen, Munich, Germany
J Clin Invest 121:2898-910. 2011..Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy... - Cytokines and effector T cell subsets causing autoimmune CNS diseaseFranziska Petermann
Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Munich, Germany
FEBS Lett 585:3747-57. 2011..Here, we will summarize new concepts of early and late T cell plasticity and the cytokine network that shapes T helper cell responses and lesion development in CNS specific autoimmunity... - TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosisArun K Mankan
Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Proc Natl Acad Sci U S A 108:6567-72. 2011..These results unravel so far unanticipated direct and indirect functions for IKKβ in myeloid progenitor survival and maintenance of innate and Th17 immunity and raise concerns about long-term IKKβ inhibition in IL-17-mediated diseases... - Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletionThomas Korn
Department of Neurology, Universitat des Saarlandes, Homburg, Germany
J Leukoc Biol 76:950-60. 2004..In conclusion, our observations underline that the immunomodulatory potential of leflunomide in effector cells of EAE is clinically relevant and is not exclusively dependent on the depletion of cellular pyrimidine pools... - Report on the 1st scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009Tim Magnus
Department of Neurology, University Clinic Hamburg Eppendorf, Martinistr, 52, D 20246 Hamburg, Germany
Exp Transl Stroke Med 2:7. 2010..ABSTRACT: Report on the 1st scientific meeting of the "Verein zur Forderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009A scientific meeting report... - Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen primingThomas Korn
Department of Neurology, Neuroimmunology Branch and MS Clinical Research Group, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
J Neuroimmunol 139:17-26. 2003..Protection from cell-mediated autoimmunity was not due to a Th2 bias, to the lack of IL-2 or a failure of Vav1(-/-) T cells in terms of chemotactic mobility...