Genomes and Genes
C J Kirschning
Affiliation: Klinikum rechts der Isar
- TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in miceStephan Spiller
Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, 81675 Munich, Germany
J Exp Med 205:1747-54. 2008....
- TLR2: cellular sensor for microbial and endogenous molecular patternsC J Kirschning
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
Curr Top Microbiol Immunol 270:121-44. 2002..Detailed understanding of the biology of TLR2 will probably contribute to the characterization of a number of infectious diseases and potentially help in the development of novel intervention strategies...
- Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responsesC J Kirschning
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Germany
Int J Med Microbiol 291:251-60. 2001..Further understanding of recognition and cellular signaling activated through the ancient host defense system represented by Toll will eventually lead to means for its therapeutic modulation...
- Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cellsR M Vabulas
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 9, 81675 Munich, Germany
J Biol Chem 276:31332-9. 2001..Initiation of signaling requires endocytosis of HSP60 that is effectively inhibited by serum component(s). The results revealed that adjuvanticity of HSP60 operates similar to that of classical pathogen-derived ligands...
- Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognitionS Bauer
Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany
Proc Natl Acad Sci U S A 98:9237-42. 2001..The optimal CpG motif for hTLR9 was GTCGTT, whereas the optimal murine sequence was GACGTT. Overall, these data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating CpG-DNA...
- Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8Q Wang
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
Infect Immun 69:2270-6. 2001..These data indicate that micrococci and PGN induce TLR2-dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK, and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2...
- Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanismC Werts
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Immunol 2:346-52. 2001..These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2...
- Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocationB Opitz
, , Humboldt-University, 10117 Berlin, Germany
J Biol Chem 276:22041-7. 2001..In summary, the results presented here indicate that TLR-2 is the main receptor for Treponema glycolipid and LTA-mediated inflammatory response...
- The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2K S Michelsen
Institut für Mikrobiologie und Hygiene, University Medical Center Charite, Humboldt Universitat zu Berlin, 10117 Berlin, Germany
J Biol Chem 276:25680-6. 2001..Finally, we provide evidence that TLR2 and TLR4 interaction with the appropriate ligand is essential for bacteria-induced maturation of DCs...
- MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall componentsR Dziarski
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, IN 46408, USA
J Immunol 166:1938-44. 2001....
- Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxinH Heine
Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, MA 02118, USA
J Immunol 162:6971-5. 1999..These results imply that expression of TLR2 is sufficient but not essential for mammalian responses to endotoxin...
- The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4C Maldonado-Bernal
Infectious Disease Medical Research Unit, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico
Parasite Immunol 27:127-37. 2005..In contrast to wild-type control and TLR2-/- animals succumbing to lethal shock syndrome, TLR4d/d mice were resistant to systemic LPPG challenge-induced pathology...
- Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interactionH H Mu
Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA
Cell Microbiol 7:789-97. 2005..These results indicate that the SAg, MAM, interacts with both TLR2 and TLR4 and that TLR4 signalling might downregulate the MAM/TLR2 inflammatory response...
- Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophagesA Meier
Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
Cell Microbiol 5:561-70. 2003....
- IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) familyH Wesche
Tularik Inc, South San Francisco, California 94080, USA
J Biol Chem 274:19403-10. 1999..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
- Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteinsC J Kirschning
Molecular Sepesis Research Laboratory, Max Delbrück Center for Molecular Medicine MDC, University Hospital Charite, Humboldt University, Berlin, Germany
Genomics 46:416-25. 1997..This high degree of similarity supports functional studies by others suggesting that like LBP, PLTP may also be able to bind and transport bacterial lipopolysaccharide...