C J Kirschning

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
    Stephan Spiller
    Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, 81675 Munich, Germany
    J Exp Med 205:1747-54. 2008
  2. ncbi request reprint TLR2: cellular sensor for microbial and endogenous molecular patterns
    C J Kirschning
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Curr Top Microbiol Immunol 270:121-44. 2002
  3. ncbi request reprint Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses
    C J Kirschning
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Germany
    Int J Med Microbiol 291:251-60. 2001
  4. ncbi request reprint Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    R M Vabulas
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 9, 81675 Munich, Germany
    J Biol Chem 276:31332-9. 2001
  5. pmc Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    S Bauer
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 98:9237-42. 2001
  6. pmc Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8
    Q Wang
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    Infect Immun 69:2270-6. 2001
  7. ncbi request reprint Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    C Werts
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 2:346-52. 2001
  8. ncbi request reprint Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
    B Opitz
    , , Humboldt-University, 10117 Berlin, Germany
    J Biol Chem 276:22041-7. 2001
  9. ncbi request reprint The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2
    K S Michelsen
    Institut für Mikrobiologie und Hygiene, University Medical Center Charite, Humboldt Universitat zu Berlin, 10117 Berlin, Germany
    J Biol Chem 276:25680-6. 2001
  10. ncbi request reprint MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components
    R Dziarski
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, IN 46408, USA
    J Immunol 166:1938-44. 2001

Collaborators

Detail Information

Publications16

  1. pmc TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
    Stephan Spiller
    Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, 81675 Munich, Germany
    J Exp Med 205:1747-54. 2008
    ....
  2. ncbi request reprint TLR2: cellular sensor for microbial and endogenous molecular patterns
    C J Kirschning
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Curr Top Microbiol Immunol 270:121-44. 2002
    ..Detailed understanding of the biology of TLR2 will probably contribute to the characterization of a number of infectious diseases and potentially help in the development of novel intervention strategies...
  3. ncbi request reprint Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses
    C J Kirschning
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Germany
    Int J Med Microbiol 291:251-60. 2001
    ..Further understanding of recognition and cellular signaling activated through the ancient host defense system represented by Toll will eventually lead to means for its therapeutic modulation...
  4. ncbi request reprint Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    R M Vabulas
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 9, 81675 Munich, Germany
    J Biol Chem 276:31332-9. 2001
    ..Initiation of signaling requires endocytosis of HSP60 that is effectively inhibited by serum component(s). The results revealed that adjuvanticity of HSP60 operates similar to that of classical pathogen-derived ligands...
  5. pmc Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    S Bauer
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 98:9237-42. 2001
    ..The optimal CpG motif for hTLR9 was GTCGTT, whereas the optimal murine sequence was GACGTT. Overall, these data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating CpG-DNA...
  6. pmc Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8
    Q Wang
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    Infect Immun 69:2270-6. 2001
    ..These data indicate that micrococci and PGN induce TLR2-dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK, and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2...
  7. ncbi request reprint Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    C Werts
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 2:346-52. 2001
    ..These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2...
  8. ncbi request reprint Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
    B Opitz
    , , Humboldt-University, 10117 Berlin, Germany
    J Biol Chem 276:22041-7. 2001
    ..In summary, the results presented here indicate that TLR-2 is the main receptor for Treponema glycolipid and LTA-mediated inflammatory response...
  9. ncbi request reprint The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2
    K S Michelsen
    Institut für Mikrobiologie und Hygiene, University Medical Center Charite, Humboldt Universitat zu Berlin, 10117 Berlin, Germany
    J Biol Chem 276:25680-6. 2001
    ..Finally, we provide evidence that TLR2 and TLR4 interaction with the appropriate ligand is essential for bacteria-induced maturation of DCs...
  10. ncbi request reprint MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components
    R Dziarski
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, IN 46408, USA
    J Immunol 166:1938-44. 2001
    ....
  11. ncbi request reprint Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin
    H Heine
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, MA 02118, USA
    J Immunol 162:6971-5. 1999
    ..These results imply that expression of TLR2 is sufficient but not essential for mammalian responses to endotoxin...
  12. ncbi request reprint The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4
    C Maldonado-Bernal
    Infectious Disease Medical Research Unit, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico
    Parasite Immunol 27:127-37. 2005
    ..In contrast to wild-type control and TLR2-/- animals succumbing to lethal shock syndrome, TLR4d/d mice were resistant to systemic LPPG challenge-induced pathology...
  13. ncbi request reprint Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction
    H H Mu
    Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA
    Cell Microbiol 7:789-97. 2005
    ..These results indicate that the SAg, MAM, interacts with both TLR2 and TLR4 and that TLR4 signalling might downregulate the MAM/TLR2 inflammatory response...
  14. ncbi request reprint Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages
    A Meier
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
    Cell Microbiol 5:561-70. 2003
    ....
  15. ncbi request reprint IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  16. ncbi request reprint Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins
    C J Kirschning
    Molecular Sepesis Research Laboratory, Max Delbrück Center for Molecular Medicine MDC, University Hospital Charite, Humboldt University, Berlin, Germany
    Genomics 46:416-25. 1997
    ..This high degree of similarity supports functional studies by others suggesting that like LBP, PLTP may also be able to bind and transport bacterial lipopolysaccharide...