Research Topics
Genomes and Genes | Hubertus HochreinSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
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Publications
Of men, mice and pigs: looking at their plasmacytoid dendritic cells [corrected]Hubertus Hochrein
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Immunology 112:26-7. 2004
Human and mouse plasmacytoid dendritic cellsHubertus Hochrein
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Hum Immunol 63:1103-10. 2002....- Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathwaysHubertus Hochrein
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
Proc Natl Acad Sci U S A 101:11416-21. 2004..Heat treatment of HSV-1 abolished maturation and IFN-alpha production from all TLR9-deficient DC but not WT DC. Thus pDC and non-pDC produce IFN-alpha in response to HSV-1 via both TLR9-independent and -dependent pathways... - Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Florian Heil
Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
Science 303:1526-9. 2004..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8... - Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathwaysKei Yasuda
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany
J Immunol 174:6129-36. 2005..Endosomal compartmentalization of TLR9 may thus reflect an evolutionary strategy to avoid TLR9 activation by self-DNA... - Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient miceBarbara Spies
Institute of Medical Microbiology, Immunology, and Hygiene, , Munich, Germany
J Immunol 171:5908-12. 2003..Overall, these results negate a dominant role of CpG-DNA/TLR9 interactions in long-term vaccination protocols... - Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cellsAntje Heit
Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
J Immunol 170:2802-5. 2003..These findings imply that TLR9 does not trigger endocytosis of CpG-OVA conjugates, but activates DCs downstream of endocytosis... - The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamilyFlorian Heil
Institute for Medical Microbiology, Hygiene and Immunology, Munich, Germany
Eur J Immunol 33:2987-97. 2003..We thus conclude that TLR7, 8 and 9 form a functional subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments... - Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein BimSusanne Kirschnek
Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
J Immunol 174:671-9. 2005..Phagocytosis-induced apoptosis was strongly reduced in Bim(-/-) macrophages. These data provide the molecular context of a form of apoptosis that may serve to dispose of terminally differentiated phagocytes... 
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modificationMarina Oldenburg
Institute of Medical Microbiology, University of Duisburg Essen, Essen, Germany
Science 337:1111-5. 2012..Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13...- Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4Stephan Spiller
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
J Biol Chem 282:13190-8. 2007..On the other hand, simultaneous blockage of both of the two TLRs might effectively inhibit infection-induced pathology... - CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleenMichael Neuenhahn
Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
Immunity 25:619-30. 2006..Thus, CD8alpha(+) DCs appear to play an important role for efficient bacterial entry into the spleen, which is of relevance for subsequent immune responses... - CpG-DNA aided cross-presentation of soluble antigens by dendritic cellsTobias Maurer
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Eur J Immunol 32:2356-64. 2002..Our studies show that stimulatory CpG-ODN linked to Ag fulfill a dual role: enhancement of Ag uptake yielding efficient Ag cross-presentation by DC and in addition, their activation into professional DC... - Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulusMeredith O'Keeffe
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
J Exp Med 196:1307-19. 2002..Hence as well as activating preexistant DCs, microbial infection induces a wave of production of a new DC subtype. The functional implications of this shift in the DC network remain to be determined... - The long-term but not the short-term antiviral effect of IFN-alpha depends on Flt3 ligand and pDCSabine Vollstedt
Institute for Virology, University of Zurich, Zurich, Switzerland
Eur J Immunol 36:1231-40. 2006..The transfer of pDC to mice lacking FL enhanced viral resistance. Therefore, the induction and function of pDC, normally controlled by IFN-alpha/beta and FL, are decisive for viral resistance in neonatal mice... - Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-alpha productionEtiena Basner-Tschakarjan
Laboratory of Experimental Dermatology, Department of Dermatology, University of Bonn, Germany
J Gene Med 8:1300-6. 2006..pDC required TLR9 to detect the presence of recAd whereas cDC also recognized recAd independently of TLR9. These unique immunostimulatory properties support the future development of recombinant Ad as a vector for DNA vaccine approaches... - Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cellsDavid Vremec
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Blood 109:1165-73. 2007..However, IKDCs, which efficiently produced IFN-gamma and showed immediate cytotoxicity on NK target cells, did not produce IFN-alpha under these conditions... - M-CSF: a novel plasmacytoid and conventional dendritic cell poietinBen Fancke
Research Department, Bavarian Nordic GmbH, Martinsried, Germany
Blood 111:150-9. 2008..It is noteworthy that using mice deficient in FL indicated that the M-CSF-driven generation of pDCs and cDCs in vitro and in vivo was independent of endogenous FL... - Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protectionChristofer Samuelsson
Department of Research, Bavarian Nordic, Martinsried, Germany
J Clin Invest 118:1776-84. 2008..Therefore, these data suggest an essential role for TLR9 in the defense against poxviruses. In addition, postexposure application of MVA may protect against lethal poxvirus infection... - Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signalsMeredith O'Keeffe
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 106:3457-64. 2005..Collectively, these findings establish that NF-kappaB1 and c-Rel, while largely dispensable for TLR-9-induced cDC activation, are critical for regulating differentiation and survival programs during pDC activation... - Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in miceMeredith O'Keeffe
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
Blood 99:2122-30. 2002..Such selective expansion of DC populations and alterations in their cytokine-secretion capacity have implications for clinical use of the studied cytokines in immune modulation... - IL-1 beta enhances CD40 ligand-mediated cytokine secretion by human dendritic cells (DC): a mechanism for T cell-independent DC activationThomas Luft
Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
J Immunol 168:713-22. 2002..The synergy between CD40L and IL-1beta highlights a potent, T cell-independent mechanism for DC activation during the earliest stages of inflammatory responses... - Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursorsMeredith O'Keeffe
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 101:1453-9. 2003..These findings indicate the close relationship between human and mouse DCs, provided cells are obtained directly from equivalent source materials... - Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsetsThomas Luft
The Melbourne Tumour Biology Branch, The Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Blood 100:1362-72. 2002..These findings have important implications for the clinical utility of DCs in immunotherapy... - A regulatory role for CD37 in T cell proliferationAnnemiek B van Spriel
Leukocyte Membrane Protein Laboratory, Austin Research Institute, Victoria, Australia
J Immunol 172:2953-61. 2004..In the presence of CD28 costimulation, CD37 engagement still significantly reduced proliferation. Taken together, these results demonstrate a regulatory role for CD37 in T cell proliferation by influencing early events of TCR signaling... - Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major: inverse relationship to interleukin-12 productionSandrine Henri
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Infect Immun 70:3874-80. 2002..The parasite-driven redistribution of MHC class II to this compartment indicates that infected DCs should be able to present parasite antigen... - IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cellsThomas Luft
Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Int Immunol 14:367-80. 2002..In this way, type I IFN play a dual role as DC maturation factors and enhancers of CD40L-mediated DC activation... - The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4Norbert W Brattig
Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
J Immunol 173:437-45. 2004..Thus, filarial helminths, through products of their endobacteria such as WSP, acquire characteristics of a typical microbial pathogen inducing immune responses via TLR2 and TLR4... - LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survivalHelmut Butzkueven
The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
Nat Med 8:613-9. 2002..We also demonstrate that this therapeutic effect complements endogenous LIF receptor signaling, which already serves to limit oligodendrocyte loss during immune attack. Our results provide a novel approach for the treatment of MS... - Activation of plasmacytoid dendritic cellsMartina Fuchsberger
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Immunol Cell Biol 83:571-7. 2005..This review concentrates on the pathways to activation of pDC, examining the activating ligands, receptors and signalling molecules that are known to be involved, and the relevance of these activation pathways to human disease... - Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarizationClaudia Traidl-Hoffmann
ZAUM-Center for Allergy and Environment, Division of Environmental Dermatology and Allergy GSF/TUM, , 80802 Munich, Germany
J Exp Med 201:627-36. 2005....