R H Haubner

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU
    R Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med 27:283-91. 2000
  2. ncbi request reprint Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography
    R Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    Cancer Res 61:1781-5. 2001
  3. ncbi request reprint Radiotracer-based strategies to image angiogenesis
    R H Haubner
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Q J Nucl Med 47:189-99. 2003
  4. ncbi request reprint Synthesis and biological evaluation of a (99m)Tc-labelled cyclic RGD peptide for imaging the alphavbeta3 expression
    R Haubner
    Nuklearmedizinische Klinik, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Nuklearmedizin 43:26-32. 2004
  5. ncbi request reprint [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
  6. ncbi request reprint [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medical University of Innsbruck, A 6020 Innsbruck, Austria
    Nucl Med Biol 33:945-52. 2006
  7. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
  8. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
  9. ncbi request reprint Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
    Roland Haubner
    Universitätsklinik für Nuklearmedizin, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:54-63. 2006
  10. ncbi request reprint In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys)
    Susana Alves
    Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri Columbia School of Medicine, Columbia, Missouri 65211, USA
    Bioconjug Chem 18:530-7. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU
    R Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med 27:283-91. 2000
    ..5 h p.i., with an increase in contrast over time. These results suggest that sufficient tumour/background ratios for in vivo imaging of HSV1-tk expression with [123I]FIAU are reached as early as 1 h p.i...
  2. ncbi request reprint Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography
    R Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    Cancer Res 61:1781-5. 2001
    ..5; tumor:muscle, 10.2). First imaging results using a small animal positron emission tomograph suggest that this compound is suitable for noninvasive determination of the alpha(v)beta3 integrin status and therapy monitoring...
  3. ncbi request reprint Radiotracer-based strategies to image angiogenesis
    R H Haubner
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Q J Nucl Med 47:189-99. 2003
    ..Nevertheless, translation of these approaches into clinical settings allowing visualisation of tumour-induced angiogenesis in patients needs still to be demonstrated...
  4. ncbi request reprint Synthesis and biological evaluation of a (99m)Tc-labelled cyclic RGD peptide for imaging the alphavbeta3 expression
    R Haubner
    Nuklearmedizinische Klinik, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Nuklearmedizin 43:26-32. 2004
    ..The alphavbeta3 integrin is involved in tumour induced angiogenesis and tumour metastasis. We describe the synthesis and evaluation of a (99m)Tc-labelled RGD analogue for the visualisation of alphavbeta3 integrin expression...
  5. ncbi request reprint [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
    ..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
  6. ncbi request reprint [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medical University of Innsbruck, A 6020 Innsbruck, Austria
    Nucl Med Biol 33:945-52. 2006
    ..Tumor uptake studies showed specific targeting of alpha(v)beta(3)-receptor-positive tumors with tumor-to-organ ratios comparable to those of [(18)F]Galacto-RGD...
  7. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
    ..We sought to investigate the usefulness of integrated positron emission tomography (PET) and computed tomography (CT) for in vivo characterization of an angiogenesis-directed molecular intervention...
  8. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET). Here, we show, in man, that the intensity of [18F]Galacto-RGD uptake correlates with alpha(v)beta3 expression...
  9. ncbi request reprint Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
    Roland Haubner
    Universitätsklinik für Nuklearmedizin, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:54-63. 2006
    ..It summarises the preclinical and clinical data and discusses the potential of this class of tracer to characterise angiogenesis...
  10. ncbi request reprint In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys)
    Susana Alves
    Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri Columbia School of Medicine, Columbia, Missouri 65211, USA
    Bioconjug Chem 18:530-7. 2007
    ..50 +/- 0.29 and 0.71 +/- 0.08% ID/g in alphavbeta3 integrin positive (M21) and negative (M21L) tumors at 1 h postinjection (p.i.), respectively...
  11. ncbi request reprint Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice
    Manfred Kneilling
    Eberhard Karls University, Tubingen, Germany
    Arthritis Rheum 56:1806-16. 2007
    ....
  12. ncbi request reprint A fully automated synthesis for the preparation of 68Ga-labelled peptides
    Clemens Decristoforo
    Clinical Department of Nuclear Medicine, Medical University Innsbruck, Austria
    Nucl Med Commun 28:870-5. 2007
    ..So far, the synthesis of Ga-peptide radiopharmaceuticals is mainly based on semi-automated systems. Here we describe a fully automated approach for the synthesis of Ga-labelled peptides...
  13. ncbi request reprint [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
    ..Our aim was to study the feasibility of PET imaging with [(18)F]Galacto-RGD in patients with squamous cell carcinoma of the head and neck (SCCHN)...
  14. doi request reprint Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography
    Maria Picchio
    Nuclear Medicine Department, IBFM CNR, Scientific Institute H San Raffaele, Milan, Italy
    J Nucl Med 49:597-605. 2008
    ..The hypoxia-inducible factor-1 alpha (HIF-1 alpha) activates angiogenesis in response to cellular hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia...
  15. doi request reprint 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medizinische Universitat Innsbruck, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 35:1507-15. 2008
    ..Recently, we demonstrated using [(18)F]Galacto-RGD that monitoring of alphavbeta3 expression is feasible. Here, we introduce (68)Ga- and (111)In-labelled derivatives and compare them with [(18)F]Galacto-RGD...
  16. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
    ..18)F-Galacto-RGD is a new tracer for PET imaging of alpha v beta3, a receptor involved in a variety of pathologic processes including angiogenesis and metastasis. Our aim was to study the dosimetry of (18)F-galacto-RGD in humans...
  17. ncbi request reprint Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  18. ncbi request reprint Molecular (functional) imaging for radiotherapy applications: an RTOG symposium
    J D Chapman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 55:294-301. 2003
  19. ncbi request reprint Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer
    Frank M Bengel
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    Circulation 108:2127-33. 2003
    ..Radionuclide imaging of reporter gene expression may be useful for noninvasive monitoring of clinical cardiac gene therapy. Experience until now, however, has been limited to small animals...
  20. ncbi request reprint Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells
    Martina Anton
    Institute of Experimental Oncology, Technische Universitat Munchen, Germany
    J Gene Med 6:119-26. 2004
    ..Its expression is almost exclusively restricted to the sympathetic nervous system. In this study we evaluated whether the NET can be used as a reporter gene for non-invasive imaging of genetically modified cells with radiolabeled probes...
  21. ncbi request reprint Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat, Munich, Germany
    Curr Pharm Des 10:1439-55. 2004
    ..Further studies have to demonstrate that this approach can be translated to clinical settings allowing visualisation of alpha v beta 3-positive tumours and alpha v beta 3 expression during tumour-induced angiogenesis in patients...
  22. ncbi request reprint Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation
    Martina Anton
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 45:1743-6. 2004
    ..We sought to evaluate the usefulness of an adenoviral vector expressing mutant herpesviral thymidine kinase reporter gene (HSV1-sr39tk) and vascular endothelial growth factor (VEGF) 121 in independent expression cassettes (Ad4tk)...
  23. ncbi request reprint PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, 81675 Munich, Germany
    J Nucl Med 45:1917-23. 2004
    ..The aim of this study was to compare these 2 combinations with regard to specificity, imaging contrast, and reporter probe kinetics using dynamic PET in small and large animals...
  24. ncbi request reprint Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene
    Marcus V Simoes
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    J Nucl Med 46:98-105. 2005
    ..Myocardial kinetics of (124)I-FIAU are still poorly understood. This study aimed at a further investigation under controlled conditions using an isolated heart perfusion model...
  25. ncbi request reprint Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
    ..We studied a hapten-induced delayed-type hypersensitivity reaction (DTHR) as a model for inflammatory processes, since DTHRs are involved in many human autoimmune disorders...
  26. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    ..We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbeta3 expression with positron emission tomography (PET)...
  27. ncbi request reprint Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 32:1108-14. 2005
    ....
  28. pmc Radionuclide imaging: a molecular key to the atherosclerotic plaque
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Am Coll Cardiol 52:1-12. 2008
    ..This review gives an update on the relevant noninvasive plaque imaging approaches using nuclear imaging techniques to detect atherosclerotic vascular lesions...
  29. doi request reprint TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis
    Nele Müller-Hermelink
    Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Cancer Cell 13:507-18. 2008
    ..Thus, tumor-specific T cells can directly survey multistage carcinogenesis through cytokine signaling...