Anca Ligia Grosu

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Validation of a method for automatic image fusion (BrainLAB System) of CT data and 11C-methionine-PET data for stereotactic radiotherapy using a LINAC: first clinical experience
    Anca Ligia Grosu
    Department of Radiation Oncology, Technical University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 56:1450-63. 2003
  2. ncbi request reprint Positron emission tomography for radiation treatment planning
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany
    Strahlenther Onkol 181:483-99. 2005
  3. ncbi request reprint 11C-methionine PET improves the target volume delineation of meningiomas treated with stereotactic fractionated radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 66:339-44. 2006
  4. doi request reprint An interindividual comparison of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)- and L-[methyl-11C]methionine (MET)-PET in patients with brain gliomas and metastases
    Anca Ligia Grosu
    Department of Radiation Oncology, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Int J Radiat Oncol Biol Phys 81:1049-58. 2011
  5. doi request reprint Tumor shrinkage assessed by volumetric MRI in long-term follow-up after fractionated stereotactic radiotherapy of nonfunctioning pituitary adenoma
    Christine Kopp
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 82:1262-7. 2012
  6. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
  7. pmc Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
    Dusan Milanović
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg 79106, Germany
    Radiat Oncol 8:42. 2013
  8. ncbi request reprint Hypoxia imaging with FAZA-PET and theoretical considerations with regard to dose painting for individualization of radiotherapy in patients with head and neck cancer
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 69:541-51. 2007
  9. doi request reprint Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: a planning study on treatment concepts
    Vesna Prokic
    Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany
    Int J Radiat Oncol Biol Phys 85:264-70. 2013
  10. ncbi request reprint L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 63:64-74. 2005

Detail Information

Publications31

  1. ncbi request reprint Validation of a method for automatic image fusion (BrainLAB System) of CT data and 11C-methionine-PET data for stereotactic radiotherapy using a LINAC: first clinical experience
    Anca Ligia Grosu
    Department of Radiation Oncology, Technical University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 56:1450-63. 2003
    ..b) To validate the fully automatic CT/MET-PET image fusion technique with respect to accuracy and robustness. (c) To give a short glance at the clinical consequences for patients with brain tumors...
  2. ncbi request reprint Positron emission tomography for radiation treatment planning
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany
    Strahlenther Onkol 181:483-99. 2005
    ..To evaluate the impact of positron emission tomography (PET) on target volume delineation for radiation treatment planning...
  3. ncbi request reprint 11C-methionine PET improves the target volume delineation of meningiomas treated with stereotactic fractionated radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 66:339-44. 2006
    ..To evaluate the role of 11C-methionine positron emission tomography (MET-PET) in target volume delineation for meningiomas and to determine the interobserver variability...
  4. doi request reprint An interindividual comparison of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)- and L-[methyl-11C]methionine (MET)-PET in patients with brain gliomas and metastases
    Anca Ligia Grosu
    Department of Radiation Oncology, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Int J Radiat Oncol Biol Phys 81:1049-58. 2011
    ..This study compares the uptake of FET and MET in gliomas and metastases, as well as treatment-induced changes. Furthermore, it evaluates the gross tumor volume (GTV) of gliomas defined on PET and magnetic resonance imaging (MRI)...
  5. doi request reprint Tumor shrinkage assessed by volumetric MRI in long-term follow-up after fractionated stereotactic radiotherapy of nonfunctioning pituitary adenoma
    Christine Kopp
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 82:1262-7. 2012
    ..To evaluate tumor control and side effects associated with fractionated stereotactic radiotherapy (FSRT) in the management of residual or recurrent nonfunctioning pituitary adenomas (NFPAs)...
  6. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
    ..18)F-Galacto-RGD is a new tracer for PET imaging of alpha v beta3, a receptor involved in a variety of pathologic processes including angiogenesis and metastasis. Our aim was to study the dosimetry of (18)F-galacto-RGD in humans...
  7. pmc Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
    Dusan Milanović
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg 79106, Germany
    Radiat Oncol 8:42. 2013
    ..Our aim was to investigate whether the new Hsp90 inhibitor NVP-HSP990 increases radiosensitivity, thermosensitivity and radiothermosensitivity of human tumor cell lines...
  8. ncbi request reprint Hypoxia imaging with FAZA-PET and theoretical considerations with regard to dose painting for individualization of radiotherapy in patients with head and neck cancer
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 69:541-51. 2007
    ..To evaluate the role of hypoxia positron emission tomography (PET) using [18F]fluoroazomycin-arabinoside (FAZA) in head and neck cancer for radiation treatment planning using intensity-modulated radiotherapy and dose painting...
  9. doi request reprint Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: a planning study on treatment concepts
    Vesna Prokic
    Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany
    Int J Radiat Oncol Biol Phys 85:264-70. 2013
    ..Two treatment concepts were investigated: simultaneously integrated boost (SIB) and WBI followed by stereotactic fractionated radiation therapy sequential concept (SC)...
  10. ncbi request reprint L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 63:64-74. 2005
    ..The goal of this trial was to quantify the affect of MET-PET vs. with MRI in gross tumor volume definition for radiotherapy planning of high-grade gliomas...
  11. doi request reprint Tumor shrinkage assessed by volumetric MRI in the long-term follow-up after stereotactic radiotherapy of meningiomas
    Sabrina T Astner
    Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Strahlenther Onkol 186:423-9. 2010
    ..To evaluate tumor volume reduction in the follow-up of meningiomas after fractionated stereotactic radiotherapy (FSRT) or linac radiosurgery (RS) by using magnetic resonance imaging (MRI)...
  12. doi request reprint Stereotactic fractionated radiotherapy and LINAC radiosurgery in the treatment of vestibular schwannoma-report about both stereotactic methods from a single institution
    Christine Kopp
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technische Universität München, Munich, Germany
    Int J Radiat Oncol Biol Phys 80:1485-91. 2011
    ..To evaluate tumor control and side effects associated with radiosurgery (RS) and stereotactic fractionated radiotherapy (SFR) for vestibular schwannomas (VSs) in a group of patients treated at the same institution...
  13. pmc The influence of the combined treatment with Vadimezan (ASA404) and taxol on the growth of U251 glioblastoma xenografts
    Dusan Milanović
    Department of Radiation Oncology, University Hospital Freiburg, Germany
    BMC Cancer 12:242. 2012
    ..Therapy response was evaluated by measuring changes in tumor size and metabolic activity using 18F-FDG PET (Fluorodeoxyglucose - positron emision tomography) imaging...
  14. pmc Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells
    Elke Firat
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 7:e47357. 2012
    ....
  15. doi request reprint Evaluation of the SUV values calculation and 4D PET integration in the radiotherapy treatment planning system
    Vesna Jacob
    Klinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Munich, Germany
    Radiother Oncol 98:323-9. 2011
    ..To evaluate the SUV calculation and integration of the gated (4D) PET in the iPlan 4.0 treatment planning software (BrainLAB)...
  16. pmc Non-invasive in vivo imaging of tumor-associated CD133/prominin
    Chizuko Tsurumi
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 5:e15605. 2010
    ..Cancer stem cells are thought to play a pivotal role in tumor maintenance, metastasis, tumor therapy resistance and relapse. Hence, the development of methods for non-invasive in vivo detection of cancer stem cells is of great importance...
  17. ncbi request reprint Biological imaging in radiation oncology
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technical University of Munich, Germany
    Z Med Phys 15:141-5. 2005
    ..Clinical and experimental studies are required to define the real impact of these investigations in radiation treatment planning, and especially in the evaluation of therapy response...
  18. doi request reprint Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial
    Simon Kirste
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany
    Cancer 117:3788-95. 2011
    ..To investigate the activity of Boswellia serrata (BS) in radiotherapy-related edema, we conducted a prospective, randomized, placebo-controlled, double-blind, pilot trial...
  19. ncbi request reprint Retreatment of the spinal cord with palliative radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 52:1288-92. 2002
    ..We conducted this retrospective review of patients whose spinal cord was irradiated twice to evaluate the outcome in terms of palliation and long-term side effects...
  20. ncbi request reprint [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
    ..Our aim was to study the feasibility of PET imaging with [(18)F]Galacto-RGD in patients with squamous cell carcinoma of the head and neck (SCCHN)...
  21. ncbi request reprint Extensive local and systemic therapy in extraneural metastasized glioblastoma multiforme
    Sabrina T Astner
    Department of Radiation Oncology, Technical University of Munich, Germany
    Anticancer Res 26:4917-20. 2006
    ..In conclusion, liver metastases of GBM can be effectively treated by chemotherapy. This case report suggests suitable substances which can be chosen according to clinical circumstances...
  22. doi request reprint Molecular radiobiology meets clinical radiation oncology
    Elke Firat
    Department of Radiation Oncology, University of Freiburg, Freiburg, Germany
    Int J Radiat Biol 86:252-9. 2010
    ....
  23. doi request reprint Effect of 11C-methionine-positron emission tomography on gross tumor volume delineation in stereotactic radiotherapy of skull base meningiomas
    Sabrina T Astner
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 72:1161-7. 2008
    ....
  24. doi request reprint Effects of irradiation on the [Methyl-3H]choline uptake in the human prostate cancer cell lines LNCaP and PC3
    Korbinian Holzapfel
    Department of Nuclear Medicine, Technical University of Munich, Ismaninger Strasse 22, Munich, Germany
    Strahlenther Onkol 184:319-24. 2008
    ..Therefore, the aim of this study was to elucidate the effects of ionizing radiation on the choline uptake in an androgen-dependent (LNCaP) and an androgen-independent (PC3) prostate cancer cell line...
  25. doi request reprint Stereotactic fractionated radiotherapy for Klatskin tumours
    Felix Momm
    University Hospital Freiburg, Department of Radiation Oncology, Freiburg i Br, Germany
    Radiother Oncol 95:99-102. 2010
    ..6/13 patients received additional chemotherapy before or after SFRT...
  26. ncbi request reprint Carcinomatous meningitis appearing as acoustic neuromas: two cases
    Sabrina T Astner
    Department of Radiation Oncology, Technical University of Munich, Germany
    Strahlenther Onkol 183:279-83. 2007
    ..If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or carcinomatous meningitis...
  27. ncbi request reprint The role of postoperative radiotherapy after resection of a single brain metastasis. Combined analysis of 643 patients
    Carsten Nieder
    Radiation Oncology Unit, Department of Internal Medicine, Nordlandssykehuset HF, Bodø, Norway
    Strahlenther Onkol 183:576-80. 2007
    ....
  28. ncbi request reprint Practical integration of [18F]-FDG-PET and PET-CT in the planning of radiotherapy for non-small cell lung cancer (NSCLC): the technical basis, ICRU-target volumes, problems, perspectives
    Ursula Nestle
    Department of Nuclear Medicine, Saarland University Medical Centre, Hamburg Saar, Germany
    Radiother Oncol 81:209-25. 2006
    ..Finally, we give an idea of the possible future use of tracers other than [18F]-FDG in lung cancer...
  29. ncbi request reprint Response monitoring by positron emission tomography during radiotherapy of a squamous cell skin carcinoma
    Carsten Nieder
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    Onkologie 28:505-7. 2005
    ..Methods of biological response monitoring might be helpful in achieving a favorable therapeutic ratio...
  30. ncbi request reprint Implications of IMT-SPECT for postoperative radiotherapy planning in patients with gliomas
    Anca Ligia Grosu
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Radiat Oncol Biol Phys 54:842-54. 2002
    ..The goal of this study was to analyze the value of 123I-alpha-methyl-tyrosine-single photon emission CT (IMT-SPECT) in radiotherapy planning of patients with brain gliomas after surgical resection...
  31. ncbi request reprint Evaluation of late neurologic adverse events in patients with brain metastases from non-small cell lung cancer
    Carsten Nieder
    Department of Internal Medicine Oncology, Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Anticancer Res 27:1701-4. 2007
    ....