Timo Grimmer

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Curr Alzheimer Res 10:82-5. 2013
  2. doi request reprint White matter hyperintensities predict amyloid increase in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 33:2766-73. 2012
  3. ncbi request reprint Clinical severity of Alzheimer's disease is associated with PIB uptake in PET
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 30:1902-9. 2009
  4. pmc Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich 81675, Germany
    Biol Psychiatry 65:927-34. 2009
  5. ncbi request reprint Effects of cholinesterase inhibitors on behavioural disturbances in Alzheimer's disease: a systematic review
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Drugs Aging 23:957-67. 2006
  6. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
  7. ncbi request reprint [Visualization of amyloid with positron emission tomography. Useful improvement in the diagnosis of dementia?]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Deutschland
    Nervenarzt 81:602-6. 2010
  8. doi request reprint [Current immune therapy for Alzheimer's disease]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Technische Universitat, Möhlstrasse 26, 81675 Munchen
    Nervenarzt 79:832-5. 2008
  9. ncbi request reprint Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: a prospective 18F-FDG-PET study
    T Grimmer
    Department of Psychiatry, Technical University Munich, Germany
    Dement Geriatr Cogn Disord 18:32-6. 2004
  10. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Curr Alzheimer Res 10:82-5. 2013
    ..Amyloid imaging enables to visualize a hallmark pathology of Alzheimer's disease (AD). Therefore we aimed to assess the usefulness of [(11)C]PiB PET for predicting clinical outcome of MCI patients after an interval of 2 years...
  2. doi request reprint White matter hyperintensities predict amyloid increase in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 33:2766-73. 2012
    ..The extent of WMH might be a relevant factor to be assessed in antiamyloid drug trials...
  3. ncbi request reprint Clinical severity of Alzheimer's disease is associated with PIB uptake in PET
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 30:1902-9. 2009
    ..In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD)...
  4. pmc Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich 81675, Germany
    Biol Psychiatry 65:927-34. 2009
    ..The aim of the study was to determine the association between cerebral amyloid plaque load, as measured by means of the positron emission tomography (PET) tracer carbon-11-labeled Pittsburgh Compound B ([11C]PiB) and CSF Abeta42 in AD...
  5. ncbi request reprint Effects of cholinesterase inhibitors on behavioural disturbances in Alzheimer's disease: a systematic review
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Drugs Aging 23:957-67. 2006
    ....
  6. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
    ..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
  7. ncbi request reprint [Visualization of amyloid with positron emission tomography. Useful improvement in the diagnosis of dementia?]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Deutschland
    Nervenarzt 81:602-6. 2010
    ..However, there are as yet no studies with large sample sizes. The possible use for the early diagnosis of AD should be viewed critically, particularly due to the lack of treatment options...
  8. doi request reprint [Current immune therapy for Alzheimer's disease]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Technische Universitat, Möhlstrasse 26, 81675 Munchen
    Nervenarzt 79:832-5. 2008
    ..Particularly Abeta42 and the clinical research are examined. Ethical and economic questions resulting from successful immunization against Abeta are discussed...
  9. ncbi request reprint Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: a prospective 18F-FDG-PET study
    T Grimmer
    Department of Psychiatry, Technical University Munich, Germany
    Dement Geriatr Cogn Disord 18:32-6. 2004
    ..The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD)...
  10. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  11. ncbi request reprint Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Alzheimers Dis 36:401-8. 2013
    ..g., soluble AβPPα and β (sAβPPα and sAβPPβ, respectively); sortilin-related receptor with A-type repeats (SORL1, also called LR11 or SORLA)] are factors crucially implicated in the formation of pathological hallmarks of AD...
  12. ncbi request reprint β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
    Amalia Tsolakidou
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Alzheimers Dement 9:386-91. 2013
    ..Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD)...
  13. doi request reprint Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:69-77. 2012
    ..Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics...
  14. doi request reprint Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease
    Stefan Forster
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med Mol Imaging 39:1927-36. 2012
    ..Based on this finding we now hypothesize that in early AD patients quantitative longitudinal decline in hypometabolism may be related to the amount of baseline amyloid deposition during a follow-up period of 2 years...
  15. doi request reprint Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay
    Stefan Forster
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:792-7. 2012
    ..The aim of this study was to examine longitudinal regional patterns of amyloid deposition and hypometabolism in the same population of mild AD subjects and to establish their regional relationship to each other...
  16. ncbi request reprint Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment
    Robert Perneczky
    Department of Psychiatry, Medicine Technische Universität Munchen, Germany
    J Geriatr Psychiatry Neurol 20:84-8. 2007
    ..001, uncorrected for multiple comparisons), which was independent from demographical variables. The authors conclude that clinical severity of impairments is already correlated with deficits in glucose metabolism in the stage of MCI...
  17. ncbi request reprint Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Munich, Germany
    J Nucl Med 46:1625-32. 2005
    ....
  18. pmc Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Street 22, 81675 Munchen, Germany
    ScientificWorldJournal 2012:712048. 2012
    ..Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring...
  19. doi request reprint Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 8:304-11. 2012
    ..The levels of the α-secretase-cleaved soluble APP (sAPPα) and β-secretase-cleaved soluble APP (sAPPβ) in cerebrospinal fluid (CSF) are likely to reflect these competing mechanisms...
  20. ncbi request reprint Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 21:158-62. 2006
    ..However, even mild degrees of cognitive deterioration are known to have negative effects on complex ADL...
  21. doi request reprint Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 28:543-52. 2012
    ....
  22. pmc Impaired cross-modal inhibition in Alzheimer disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    PLoS Med 2:e288. 2005
    ....
  23. doi request reprint Asymmetric loss of parietal activity causes spatial bias in prodromal and mild Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:798-804. 2012
    ....
  24. doi request reprint Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
    Christine Preibisch
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Magn Reson Imaging 34:1295-302. 2011
    ..To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique...
  25. ncbi request reprint Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances
    Susanne Bornschein
    Department of Psychiatry and Psychotherapy, Technical University TU of Munich, Klinikum rechts der Isar, Munich, Germany
    Scand J Work Environ Health 33:447-53. 2007
    ..In this study, a small group of well-characterized patients with idiopathic environmental intolerance were examined in order to identify such changes...
  26. ncbi request reprint Progression to dementia in clinical subtypes of mild cognitive impairment
    P Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany
    Dement Geriatr Cogn Disord 22:27-34. 2006
    ..To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI)...
  27. ncbi request reprint Local activity determines functional connectivity in the resting human brain: a simultaneous FDG-PET/fMRI study
    Valentin Riedl
    Departments of Neuroradiology, Nuclear Medicine, and Psychiatry, and Technische Universität München Neuroimaging Center, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munchen, Germany, The Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom, and Department of Nuclear Medicine, Uniklinik Köln, 50937 Koln, Germany
    J Neurosci 34:6260-6. 2014
    ....
  28. ncbi request reprint In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions
    Elisabeth Klupp
    1 Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Connect 4:371-83. 2014
    ....
  29. ncbi request reprint Cerebral glucose metabolism in patients with AD and different APOE genotypes
    A Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Neurology 64:102-7. 2005
    ..To examine the influence of the APOE epsilon4 allele on cerebral glucose metabolism in a large series of patients with Alzheimer disease (AD)...
  30. pmc Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease
    Nicholas Myers
    1 Department of Neuroradiology, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany2 TUM Neuroimaging Centre, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany3 Department of Experimental Psychology, Oxford University, 9 South Parks Road, Oxford OX1 3UD, UK
    Brain 137:2052-64. 2014
    ....
  31. ncbi request reprint Mapping scores onto stages: mini-mental state examination and clinical dementia rating
    Robert Perneczky
    Department of Psychiatry and Psychotherapy and the Institute of Medical Statistics and Epidemiology, Technische Universitat Munchen, Germany
    Am J Geriatr Psychiatry 14:139-44. 2006
    ..In the present study, the authors mapped Mini-Mental State Examination (MMSE) scores onto CDR categories to determine how well the MMSE performs as a surrogate of the CDR as a timesaving method of staging dementia...
  32. ncbi request reprint Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study
    J Diehl
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Neurobiol Aging 25:1051-6. 2004
    ..To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD)...
  33. pmc Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons
    Lorenzo Pasquini
    1 Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Connect 4:323-36. 2014
    ..The observed link of aging and AD with intrinsic brain activity supports the view that lifespan intrinsic activity may contribute critically to the pathogenesis of AD...
  34. ncbi request reprint Prominent hypometabolism of the right temporoparietal and frontal cortex in two left-handed patients with primary progressive aphasia
    Alexander Drzezga
    Nuklearmedizinische Klinik u Poliklinik, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    J Neurol 249:1263-7. 2002
    ..These findings support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity...
  35. doi request reprint Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
    ..To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo...
  36. ncbi request reprint Frontotemporal dementia, semantic dementia, and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis
    J Diehl
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    J Geriatr Psychiatry Neurol 18:39-44. 2005
    ....
  37. pmc Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1060-3. 2006
    ..Therefore, schooling seems to provide brain reserve against neurodegeneration...
  38. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
    ..Semantic dementia (SD)...
  39. ncbi request reprint Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D 81675 Munich, Germany
    Neurobiol Aging 28:42-50. 2007
    ..To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant)...
  40. ncbi request reprint Variability of Cognitive Performance during Hemodialysis: Standardization of Cognitive Assessment
    Susanne Tholen
    Department of Nephrology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 38:31-8. 2014
    ..Therefore, we strongly suggest a standardization, using the MoCA before hemodialysis in a separate room, in order to make testing results of future research in this field comparable. © 2014 S. Karger AG, Basel. ..
  41. doi request reprint Improving diagnosis of possible DLB: is there a role for MIBG myocardial scintigraphy?
    Clive Ballard
    From the Wolfson Centre for Age Related Diseases C B, King s College London, UK and the Department of Psychiatry and Psychotherapy T G, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Neurology 81:1730-1. 2013
    ..Further, the increased frequency of fluctuating confusion and of falls, and postural hypotension, may have important implications for clinical management.(2.) ..
  42. ncbi request reprint Do all patients with mild cognitive impairment progress to dementia?
    Panagiotis Alexopoulos
    J Am Geriatr Soc 54:1008-10. 2006