A J Grau

Summary

Affiliation: Klinikum der Stadt Ludwigshafen
Country: Germany

Publications

  1. doi request reprint Childhood and adult social conditions and risk of stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany
    Cerebrovasc Dis 33:385-91. 2012
  2. ncbi request reprint [Fabry's disease: new therapeutic options for this lysosomal storage disorder]
    A J Grau
    Neurologische Universitätsklinik Heidelberg
    Nervenarzt 74:489-96. 2003
  3. ncbi request reprint The effect of infections and vaccinations on stroke risk
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen a Rh, Germany
    Expert Rev Neurother 6:175-83. 2006
  4. ncbi request reprint Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study
    Armin J Grau
    Neurology Department, University of Heidelberg, Germany
    Stroke 34:849-54. 2003
  5. ncbi request reprint [Niemann-Pick disease type C--a neurometabolic disease through disturbed intracellular lipid transport]
    A J Grau
    Neurologische Klinik, Universitat Heidelberg
    Nervenarzt 74:900-5. 2003
  6. ncbi request reprint Periodontal disease as a risk factor for ischemic stroke
    Armin J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 35:496-501. 2004
  7. ncbi request reprint Leukocyte count as an independent predictor of recurrent ischemic events
    Armin J Grau
    Neurologische Klinik, Klinikum der Stadt Ludwigshafen a Rh, Bremserstr 70, D 67063 Ludwigshafen, Germany
    Stroke 35:1147-52. 2004
  8. ncbi request reprint Influenza vaccination is associated with a reduced risk of stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen a Rh, Germany
    Stroke 36:1501-6. 2005
  9. doi request reprint Association between recent sports activity, sports activity in young adulthood, and stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany
    Stroke 40:426-31. 2009
  10. doi request reprint Quality monitoring of acute stroke care in Rhineland-Palatinate, Germany, 2001-2006
    Armin J Grau
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen am Rhein, Germany
    Stroke 41:1495-500. 2010

Detail Information

Publications43

  1. doi request reprint Childhood and adult social conditions and risk of stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany
    Cerebrovasc Dis 33:385-91. 2012
    ..Furthermore, we investigated whether social advancement compared to the parental generation is associated with reduced stroke risk...
  2. ncbi request reprint [Fabry's disease: new therapeutic options for this lysosomal storage disorder]
    A J Grau
    Neurologische Universitätsklinik Heidelberg
    Nervenarzt 74:489-96. 2003
    ..Early diagnosis of Fabry's disease is important in view of these new causal therapeutic options...
  3. ncbi request reprint The effect of infections and vaccinations on stroke risk
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen a Rh, Germany
    Expert Rev Neurother 6:175-83. 2006
    ..This report provides an overview on the influence of infection on stroke risk and potential anti-infective strategies that may play a future role in stroke prevention...
  4. ncbi request reprint Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study
    Armin J Grau
    Neurology Department, University of Heidelberg, Germany
    Stroke 34:849-54. 2003
    ..Combined antiplatelet agents may offer additive protection over single drugs after stroke. We investigated whether platelet activation is reduced under combined aspirin and clopidogrel compared with each drug alone...
  5. ncbi request reprint [Niemann-Pick disease type C--a neurometabolic disease through disturbed intracellular lipid transport]
    A J Grau
    Neurologische Klinik, Universitat Heidelberg
    Nervenarzt 74:900-5. 2003
    ..Alternatively or additionally, mutational analysis can be performed. Treatment is restricted to symptomatic measures, since there is no specific therapy...
  6. ncbi request reprint Periodontal disease as a risk factor for ischemic stroke
    Armin J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 35:496-501. 2004
    ..Chronic infectious diseases may increase the risk of stroke. We investigated whether periodontal disease, including periodontitis and gingivitis, is a risk factor for cerebral ischemia...
  7. ncbi request reprint Leukocyte count as an independent predictor of recurrent ischemic events
    Armin J Grau
    Neurologische Klinik, Klinikum der Stadt Ludwigshafen a Rh, Bremserstr 70, D 67063 Ludwigshafen, Germany
    Stroke 35:1147-52. 2004
    ..We investigated whether leukocyte and differential counts predict recurrent events and ischemic events in high-risk populations, and whether such events are preceded by acutely exacerbated inflammation...
  8. ncbi request reprint Influenza vaccination is associated with a reduced risk of stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen a Rh, Germany
    Stroke 36:1501-6. 2005
    ..We investigated whether influenza vaccination is associated independently with reduced odds of stroke and whether effects are confined to stroke subgroups and winter seasons and shared by other vaccinations...
  9. doi request reprint Association between recent sports activity, sports activity in young adulthood, and stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany
    Stroke 40:426-31. 2009
    ..We tested the hypothesis that both recent and early-adulthood sports activities are associated with reduced odds of stroke and analyzed their effects in stroke subtypes...
  10. doi request reprint Quality monitoring of acute stroke care in Rhineland-Palatinate, Germany, 2001-2006
    Armin J Grau
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen am Rhein, Germany
    Stroke 41:1495-500. 2010
    ..Quality monitoring projects are useful tools to improve the quality and to assess temporal trends of stroke care in larger populations...
  11. doi request reprint Association of symptoms of chronic bronchitis and frequent flu-like illnesses with stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen a Rh, Germany
    Stroke 40:3206-10. 2009
    ..We tested the hypothesis that chronic bronchitis and frequent flu-like illnesses are independently associated with the risk of stroke or transient ischemic attack (TIA)...
  12. doi request reprint Common infections and the risk of stroke
    Armin J Grau
    Neurology Department, Klinikum Ludwigshafen am Rhein, Bremserstrasse 79, Ludwigshafen am Rhein, Germany
    Nat Rev Neurol 6:681-94. 2010
    ..Here, we summarize and analyze the evidence for common acute and chronic infectious diseases as stroke risk factors...
  13. ncbi request reprint Course of platelet activation markers after ischemic stroke
    Lars Marquardt
    Department of Neurology, University of Heidelberg, Germany
    Stroke 33:2570-4. 2002
    ..The aim of this study was to evaluate the time course of platelet activation after ischemic stroke and to investigate whether platelet activation and inflammation are correlated with each other...
  14. doi request reprint Stroke due to atrial fibrillation in a population-based stroke registry (Ludwigshafen Stroke Study) CHADS(2) , CHA(2) DS(2) -VASc score, underuse of oral anticoagulation, and implications for preventive measures
    F Palm
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Eur J Neurol 20:117-23. 2013
    ..In a population-based stroke registry, we tested the hypothesis of low adherence to current guidelines as a main cause of high rates of AF-associated stroke...
  15. ncbi request reprint Association between acute cerebrovascular ischemia and chronic and recurrent infection
    A J Grau
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:1724-9. 1997
    ..We performed a case-control study to investigate whether chronic or recurrent respiratory, ear-nose-throat (ENT), and dental infections are risk factors for cerebrovascular ischemia...
  16. ncbi request reprint Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke
    A J Grau
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 192:41-7. 2001
    ..Elevated IL-8 may contribute to stroke pathophysiology by activating polymorphonuclear leukocyte (PMNL) activation early after ischemia...
  17. doi request reprint Etiology, risk factors and sex differences in ischemic stroke in the Ludwigshafen Stroke Study, a population-based stroke registry
    F Palm
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Cerebrovasc Dis 33:69-75. 2012
    ..In a population-based stroke registry we analyzed etiological subgroups of ischemic stroke and calculated sex-specific incidence and mortality rates...
  18. ncbi request reprint Association of cervical artery dissection with recent infection
    A J Grau
    Department of Neurology, University of Heidelberg, Germany
    Arch Neurol 56:851-6. 1999
    ..Cervical artery dissection (CAD) is an important cause of ischemic stroke in younger patients. However, its cause is insufficiently understood...
  19. ncbi request reprint Fever and infection early after ischemic stroke
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Neurol Sci 171:115-20. 1999
    ..In about half of the infected patients, infection was most probably acquired before stroke. Fever was associated with a more severe neurological deficit on admission...
  20. doi request reprint Leukocyte-platelet aggregates in acute and subacute ischemic stroke
    L Marquardt
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Cerebrovasc Dis 28:276-82. 2009
    ..We tested the hypothesis that leukocyte-platelet aggregates are increased after ischemic stroke and investigated the contribution of different leukocyte subtypes to such increase...
  21. ncbi request reprint Recent infection as a risk factor for intracerebral and subarachnoid hemorrhages
    A K Kunze
    Department of Neurology, University of Heidelberg, Heidelberg
    Cerebrovasc Dis 10:352-8. 2000
    ..049). There was no significant association between infection and ICH. Recent infection, primarily upper respiratory tract infection, may be a risk factor for SAH by contributing to the formation and rupture of aneurysms...
  22. ncbi request reprint Helicobacter pylori infection as an independent risk factor for cerebral ischemia of atherothrombotic origin
    A J Grau
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 186:1-5. 2001
    ..63; 95% ci 1.37-9.65) and multivariate analysis (OR 3.53; 95% ci 1.09-11.4). H. pylori seropositivity may be an independent risk factor for stroke of atherothrombotic origin...
  23. ncbi request reprint Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemia
    C Lichy
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Thromb Res 98:29-37. 2000
    ..Polymorphonuclear leukocyte thrombolytic activity may not be increased in acute cerebral ischemia. Miniplasminogen may be an interesting adjunct to plasminogen activators in acute stroke models...
  24. ncbi request reprint Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2559-66. 2001
    ..Data on risk factors for etiologic subtypes of ischemic stroke are still scant. The aim of this study was to characterize stroke subtypes regarding risk factor profile, outcome, and current treatment strategies...
  25. doi request reprint Stroke Incidence and Survival in Ludwigshafen am Rhein, Germany: the Ludwigshafen Stroke Study (LuSSt)
    Frederick Palm
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Stroke 41:1865-70. 2010
    ..To test this hypothesis and to provide data on stroke incidence and case-fatality rates, a population-based stroke register was initiated...
  26. ncbi request reprint Multiple levels of regulation of the interleukin-6 system in stroke
    Daniela Acalovschi
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 34:1864-9. 2003
    ..The purpose of this study was to investigate whether serum levels of the receptor subunits are changed after ischemic stroke and to define the role of genetic influences on IL-6 expression in acute stroke...
  27. ncbi request reprint Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia
    Peter Reismann
    Department Medicine I, University of Heidelberg, Germany
    J Neurol 251:853-8. 2004
    ..This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia...
  28. ncbi request reprint Inflammatory response after acute ischemic stroke
    Lars Marquardt
    Department of Neurology, Klinikum Ludwigshafen, Bremserstrasse 79, Ludwigshafen 67063, Germany
    J Neurol Sci 236:65-71. 2005
    ..This study aimed to characterize the time course of inflammatory parameters after acute ischemic stroke...
  29. doi request reprint Neurologic complications of Churg-Strauss syndrome--a prospective monocentric study
    J Wolf
    Department of Neurology, Klinikum der Stadt Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur J Neurol 17:582-8. 2010
    ..With this study, we intended to evaluate the frequency and types of neurologic manifestations and complications at time of diagnosis and during follow-up of patients with CSS...
  30. doi request reprint Gene expression in human peripheral blood mononuclear cells upon acute ischemic stroke
    C Grond-Ginsbach
    Dept of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol 255:723-31. 2008
    ..Ischemic stroke provokes a systemic inflammatory response. The purpose of this study was to characterize this response on the gene expression level in circulating mononuclear leukocytes from acute ischemic stroke (AIS) patients...
  31. ncbi request reprint [Cerebrotendinous xanthomatosis, a treatable metabolic disorder]
    R Heller
    Neurologische Klinik, Universitat Heidelberg
    Nervenarzt 73:1160-6. 2002
    ..Early diagnosis of CTX is important, since an effective therapy is available. Long-term therapy with chenodeoxycholic acid is effective for CTX, mainly in prevention of further deterioration...
  32. ncbi request reprint [Intracranial bleeding in acquired hemophilia]
    L Marquardt
    Neurologische Klinik, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Nervenarzt 77:1480-2. 2006
    ..After good initial recovery, intracerebral rebleeding occurred and the patient died from brainstem compression...
  33. ncbi request reprint Increased cytokine release by leucocytes in survivors of stroke at young age
    A J Grau
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Clin Invest 31:999-1006. 2001
    ..Enhanced stimulus-induced release of pro-inflammatory cytokines by leucocytes may contribute to the pathogenesis of ischaemic stroke...
  34. ncbi request reprint Investigating the association between influenza vaccination and reduced stroke risk
    Christoph Lichy
    University of Heidelberg Im Neuenheimer Feld, Department of Neurology, 400, 69120 Heidelberg, Germany
    Expert Rev Vaccines 5:535-40. 2006
    ..Although final proof of efficacy is still missing, patients with previous cerebral ischemia and subjects of any age at high risk of stroke should be encouraged to receive annual influenza vaccination...
  35. ncbi request reprint Association between cerebral ischemia and cytotoxin-associated gene-A-bearing strains of Helicobacter pylori
    Michael R Preusch
    Department of Neurology, University of Heidelberg, Germany
    Stroke 35:1800-4. 2004
    ..We investigated whether H. pylori and CagA seropositivity are independent risk factors for cerebral ischemia or its etiologic subtypes...
  36. doi request reprint Increased expression of cell-cell signaling genes by stimulated mononuclear leukocytes in patients with previous atherothrombotic stroke. A whole genome expression profile study
    Caspar Grond-Ginsbach
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur Neurol 62:30-9. 2009
    ..Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke...
  37. ncbi request reprint Successful treatment of acquired idiopathic generalized anhidrosis
    F Palm
    Department of Neurology, Klinikum Ludwigshafen, Bremserstrasse 79, 67063 Ludwigshafen, Germany
    Neurology 68:532-3. 2007
  38. ncbi request reprint Lack of evidence for pulmonary venous thrombosis in cryptogenic stroke: a magnetic resonance angiography study
    Armin J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1416-9. 2002
    ..We tested the hypothesis that pulmonary venous thrombosis (PVT) is a potential source of brain embolism in patients with cryptogenic stroke...
  39. ncbi request reprint The association of gingivitis and periodontitis with ischemic stroke
    Christof E Dorfer
    Policlinic for Conservative Dentistry and Periodontology, University of Heidelberg Dental School, Germany
    J Clin Periodontol 31:396-401. 2004
    ..The aim of this study was to assess the associations of different periodontal parameters with cerebral ischemia...
  40. ncbi request reprint A systemic review of the risk factors for cervical artery dissection
    Armin J Grau
    Stroke 36:2340; author reply 2340. 2005
  41. ncbi request reprint Inflammation and infections as risk factors for ischemic stroke
    Perttu J Lindsberg
    Department of Neurology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    Stroke 34:2518-32. 2003
    ....
  42. ncbi request reprint Antiplatelets versus anticoagulation in cervical artery dissection
    Stefan T Engelter
    Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Stroke 38:2605-11. 2007
    ..As a result, there are several putative arguments in favor as well as against immediate anticoagulation in CAD patients...
  43. ncbi request reprint Editorial comment: Stroke and the CD40-CD40 ligand system: at the hinge between inflammation and thrombosis
    Armin J Grau
    Stroke 34:1417-8. 2003