Irene Esposito

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi [New insights into the origin of pancreatic cancer. Role of atypical flat lesions in pancreatic carcinogenesis]
    I Esposito
    Institut für allgemeine Pathologie und pathologische Anatomie, Technische Universitat Munchen, Trogerstr 18, 81675 Munchen
    Pathologe 33:189-93. 2012
  2. ncbi Most pancreatic cancer resections are R1 resections
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Ann Surg Oncol 15:1651-60. 2008
  3. ncbi Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1447-64. 2007
  4. ncbi Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells
    Shailesh V Shrikhande
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 26:3265-73. 2006
  5. ncbi Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Cell Mol Med 14:1166-79. 2010
  6. ncbi Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 11:497-508. 2009
  7. ncbi Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus
    Armin Kolb
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 8:1527-33. 2009
  8. ncbi Pancreatic tumor cells influence the composition of the extracellular matrix
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Germany
    Biochem Biophys Res Commun 322:943-9. 2004
  9. ncbi Consensus transcriptome signature of perineural invasion in pancreatic carcinoma
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
    Mol Cancer Ther 8:1494-504. 2009
  10. ncbi Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:2421-33. 2007

Detail Information

Publications61

  1. ncbi [New insights into the origin of pancreatic cancer. Role of atypical flat lesions in pancreatic carcinogenesis]
    I Esposito
    Institut für allgemeine Pathologie und pathologische Anatomie, Technische Universitat Munchen, Trogerstr 18, 81675 Munchen
    Pathologe 33:189-93. 2012
    ....
  2. ncbi Most pancreatic cancer resections are R1 resections
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Ann Surg Oncol 15:1651-60. 2008
    ..Although general guidelines for the processing of pancreatic specimens have been established, there is currently no widely accepted standardized protocol for pathological examination, especially with respect to resection margins...
  3. ncbi Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1447-64. 2007
    ..The aim of this study was to analyze the impact of the PSC-specific matrix protein periostin on tumor responses to radiochemotherapy...
  4. ncbi Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells
    Shailesh V Shrikhande
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 26:3265-73. 2006
    ..It confers resistance to apoptosis induction by chemotherapeutic agents. The aim of this study was to evaluate the influence of XIAP in pancreatic cancer...
  5. ncbi Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Cell Mol Med 14:1166-79. 2010
    ..Analysis of human and different transgenic mouse pancreatic cancers demonstrated that moesin is a phenotypic marker for anaplastic carcinoma, suggesting that this ERM protein plays a specific role in pancreatic carcinogenesis...
  6. ncbi Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 11:497-508. 2009
    ..Although both cancer and stellate cells (PSCs) secrete proangiogenic factors, pancreatic cancer is a scirrhous and hypoxic tumor. The impact of cancer-PSCs interactions on angiogenesis was analyzed...
  7. ncbi Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus
    Armin Kolb
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 8:1527-33. 2009
    ..Therefore, this analysis might help to identify PDAC in patients with new-onset DM in the age group at risk. Larger clinical trials have to confirm these findings...
  8. ncbi Pancreatic tumor cells influence the composition of the extracellular matrix
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Germany
    Biochem Biophys Res Commun 322:943-9. 2004
    ..These findings indicate that malignant cells can actively influence the composition of the ECM through TGFbeta1 and other soluble factors, altering their microenvironment in a tumor-favorable way...
  9. ncbi Consensus transcriptome signature of perineural invasion in pancreatic carcinoma
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
    Mol Cancer Ther 8:1494-504. 2009
    ..The established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta...
  10. ncbi Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:2421-33. 2007
    ..Furthermore, negative clinicopathological correlations suggest that SEMA3A might represent a novel intervention target but not a treatment option for pancreatic cancer patients...
  11. ncbi Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature
    Martin Loos
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Virchows Arch 450:719-26. 2007
    ..Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas...
  12. ncbi Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Histol Histopathol 23:819-26. 2008
    ..The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies...
  13. ncbi Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma
    Junchao Guo
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Mol Med 17:761-7. 2006
    ..Together with the known function of YAP65 in different growth and differentiation regulating pathways, it is suggested that this gene plays a role in the normal and diseased pancreas...
  14. ncbi Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center
    Christoph W Michalski
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    Ann Surg Oncol 15:186-92. 2008
    ..The value of re-exploration for pancreatic ductal adenocarcinoma after the initial diagnosis of unresectability is unclear...
  15. ncbi Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Neoplasia 9:8-17. 2007
    ..In conclusion, SPARCL1 expression in pancreatic tissues is highly correlated with level of vascularity. Its anti-invasive effects and reduced expression in metastasis indicate tumor-suppressor function...
  16. ncbi Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Am J Gastroenterol 104:171-81. 2009
    ....
  17. ncbi Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas
    Hany Kayed
    Department of General Surgery, The University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Carcinog 42:183-92. 2005
    ....
  18. ncbi Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 60:885-95. 2007
    ..To determine the role of two antiapoptotic proteins of the inhibitor of apoptosis protein family, cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 (cIAP2), in human pancreatic carcinogenesis...
  19. ncbi Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Pancreas 35:212-7. 2007
    ..The aim of the study was to find support for either of the 2 models through the analysis of a large panel of human pancreatic tissues...
  20. ncbi Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
    Hum Pathol 40:50-7. 2009
    ..This phenomenon may explain the low rate of local relapses after tumor resection in pancreatic endocrine tumors despite the high frequency of neural invasion...
  21. ncbi Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway
    Igor Paron
    Institute of Pathology, Helmholtz Zentrum Munchen, Germany
    PLoS ONE 6:e21684. 2011
    ..Aim of this study was the functional characterization of the effects of TNC on biologic relevant properties of pancreatic cancer cells...
  22. ncbi Autoimmune pancreatitis complicated by carcinoma of the pancreatobiliary system: a case report and review of the literature
    Martin Loos
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Institut fur Pathologie, Technische Universitat Munchen, Technische Universitat Munchen, Munchen, Germany
    Pancreas 40:151-4. 2011
    ....
  23. ncbi Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer
    Tamar Samkharadze
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Gastroenterol 106:968-80. 2011
    ..Its role in pancreatic fibrosis and neuropathy is unknown...
  24. ncbi Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling
    Alexander Herner
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Int J Cancer 129:2349-59. 2011
    ..Glutamate might serve as a molecular switch that decreases the threshold of K-ras-induced oncogenic signalling and increases the chance of malignant transformation of pancreatic cancer precursor lesions...
  25. ncbi Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Oncogene 24:4421-32. 2005
    ..In conclusion, loss of BNIP3 expression occurs late in pancreatic cancer, contributes to resistance to chemotherapy, and correlates with a worsened prognosis...
  26. ncbi Expression analysis of PMP22/Gas3 in premalignant and malignant pancreatic lesions
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Histochem Cytochem 53:885-93. 2005
    ..Its expression in PanIN lesions and some pancreatic cancer cells in vitro and in vivo suggests a role of PMP22 in the neoplastic transformation process from the normal pancreas to pre-malignant lesions to pancreatic cancer...
  27. ncbi Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
    Martin Loos
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    BMC Cancer 9:463. 2009
    ..Therefore, we investigated the expression pattern and clinical significance of B7-H3 expression in human pancreatic cancer...
  28. ncbi The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Clin Gastroenterol Hepatol 6:1155-61. 2008
    ..Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed...
  29. ncbi Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:447-53. 2004
    ..These data suggest that the neoplasm most likely represents a new pancreatic tumor entity, which we would like to refer to as microcystic tubulopapillary tumor...
  30. ncbi Autoimmune pancreatocholangitis, non-autoimmune pancreatitis and primary sclerosing cholangitis: a comparative morphological and immunological analysis
    Irene Esposito
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 3:e2539. 2008
    ..Aim of this study was the comprehensive evaluation of a series of AIPC patients, who were diagnosed and treated in a European institution between January 2003 and July 2006...
  31. ncbi Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
    Michaela Aichler
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    J Pathol 226:723-34. 2012
    ..In conclusion, PDAC development in Kras(G12D/+); Ptf1a-Cre(ex1/+) mice starts from ADM and a similar process might also take place in patients with a strong family history of PDAC...
  32. ncbi Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 31:1919-25. 2007
    ..Therefore, we suggest that the tumor should be considered as an anaplastic variant of pancreatic ductal adenocarcinoma...
  33. ncbi Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer
    Xiaohua Jiang
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Histol Histopathol 25:1497-506. 2010
    ..In conclusion, reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene, as has already been shown for other malignancies of the gastrointestinal tract...
  34. ncbi Preoperative acute pancreatitis in periampullary tumors: implications for surgical management
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Digestion 75:165-71. 2007
    ..Currently there is no information about the impact of preoperative pancreatitis on the surgical management of periampullary tumors...
  35. ncbi The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Curr Mol Med 12:288-303. 2012
    ..In this review, the interaction of the epithelial tumor cells with the stroma in humans and in various animal models is scrutinized, and novel therapeutic options for uncoupling cancer-stroma interactions are discussed...
  36. ncbi Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 10:4776-83. 2004
    ..The aim of this study was to investigate the expression and significance of decorin in pancreatic cancer...
  37. ncbi Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    Histopathology 56:440-8. 2010
    ..As additional therapeutic options have not yet been investigated in undifferentiated pancreatic cancer, the aim was to analyse the expression of putative therapeutic targets that have shown promising results in various other neoplasms...
  38. ncbi Autoimmune pancreatitis associated with a large pancreatic pseudocyst
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    World J Gastroenterol 12:5904-6. 2006
    ..Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures...
  39. ncbi Differential diagnosis of non-epithelial tumors of the pancreas: malignant non-epithelial pancreatic tumor with focal pigmentation
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Germany
    Virchows Arch 444:190-3. 2004
    ....
  40. ncbi Pancreatic cancer microenvironment
    Jorg Kleeff
    Department of General Surgery, Division of Pancreatic Surgery and Molecular Pancreatic Research, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:699-705. 2007
    ..Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells to improve the outcome of this deadly disease...
  41. ncbi MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer
    Barbara M Grüner
    II Medizinische Klinik, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 7:e39424. 2012
    ....
  42. ncbi Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 110:668-76. 2004
    ....
  43. ncbi In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging
    Stefan Eser
    II Medizinische Klinik, Technische Universitat Munchen, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 108:9945-50. 2011
    ..Translation of this endoscopic technique into the clinic should tremendously improve detection of pancreatic neoplasia, thus reforming management of patients at risk for PDAC...
  44. ncbi MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival
    Caroline M Wernicke
    Children s Cancer Research and Roman Herzog Comprehensive Cancer Center, Laboratory of Functional Genomics and Transplantation Biology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Leuk Res 36:1185-92. 2012
    ..These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL...
  45. ncbi Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:119-26. 2004
    ..The relation of the pancreatic IPT to autoimmune pancreatitis is emphasized...
  46. ncbi Secondary sclerosing cholangitis after intensive care unit treatment: clues to the histopathological differential diagnosis
    Irene Esposito
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Oberschleissheim, Germany
    Virchows Arch 453:339-45. 2008
    ....
  47. ncbi Renal cancer cell metastasis into the pancreas: a single-center experience and overview of the literature
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 30:218-22. 2005
    ..Patients with a history of RCC should undergo a long-term follow-up to detect and evaluate for pancreatic metastases as well for metastasis to other organ sites...
  48. ncbi Chromosomal imbalances in sporadic neuroendocrine tumours of the thymus
    Ralf J Rieker
    Department of Pathology, University of Heidelberg, INF 220 221, 69120 Heidelberg, Germany
    Cancer Lett 223:169-74. 2005
    ..These CGH data show a degree of overlap with chromosomal imbalances commonly observed in advanced thymomas...
  49. ncbi Impaired islet turnover in human donor pancreata with aging
    Christina Reers
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:185-91. 2009
    ..So far it is unclear whether the proliferative capacity of pancreatic islets is restricted by senescence...
  50. ncbi Identification of differentially expressed proteins in triple-negative breast carcinomas using DIGE and mass spectrometry
    Daniela M Schulz
    Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    J Proteome Res 8:3430-8. 2009
    ..The identified marker proteins may advance a more detailed characterization of triple-negative breast cancers and may contribute to the development of better treatment strategies...
  51. ncbi Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models
    Sandra Diersch
    II Medizinische Klinik, Technische Universitat Munchen, Munchen, Germany
    Oncotarget 4:277-88. 2013
    ..Together, we define the Efemp1-p27(Kip1) axis as a potential marker module of PDAC cell sensitivity towards dual PI3K-mTOR inhibitors, which might help to better stratify patients in clinical trials...
  52. ncbi Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice
    Leonhard Stross
    Institutes of Virology, Immunology, and Hygiene, Technische Universität München Helmholtz Zentrum München, Munchen, Germany
    Hepatology 56:873-83. 2012
    ..CONCLUSION: Tregs limit immunomediated liver damage early after an acute infection of the liver, thereby contributing to conservation of tissue integrity and organ function at the cost of prolonging virus clearance...
  53. ncbi The stem cell factor-c-kit system and mast cells in human pancreatic cancer
    Irene Esposito
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Lab Invest 82:1481-92. 2002
    ..In conclusion, the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation...
  54. ncbi Association between gallstone-evoked pain, inflammation and proliferation of nerves in the gallbladder: a possible explanation for clinical differences
    Rene Hennig
    Departments of Surgery, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 42:878-84. 2007
    ..To investigate whether enhanced neuroproliferation could be involved in the pathogenesis of gallstone pain...
  55. ncbi DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma
    Kristina Hauer
    Children s Cancer Research Center and Department of Pediatrics, Roman Herzog Comprehensive Cancer Research Center and Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Res 73:967-77. 2013
    ..Our results provide strong evidence that DKK2 is a key player in Ewing sarcoma invasion and osteolysis and also in the differential phenotype of Ewing sarcoma cells...
  56. ncbi Validation of preclinical multiparametric imaging for prediction of necrosis in hepatocellular carcinoma after embolization
    Rickmer Braren
    Institute of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Hepatol 55:1034-40. 2011
    ..The aim of this work was to validate different imaging parameters as individual or combined predictors of tumor necrosis after TAE in an orthotopic rat HCC tumor model...
  57. ncbi Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques
    Antti Saraste
    Nuklearmedizinische Klinik und Poliklinik, Nuklearmedizinische Klinik der TU München, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    J Nucl Cardiol 19:775-84. 2012
    ..We studied whether diet intervention reduces uptake of α(v)β(3) integrin-targeted positron emission tomography tracer (18)F-galacto-RGD in mouse atherosclerotic plaques...
  58. ncbi Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007
    ..Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1)...
  59. ncbi Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine
    Guido Bocci
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma, 55, I-56126 Pisa, Italy
    Eur J Pharmacol 498:9-18. 2004
    ....
  60. ncbi Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice
    Karin Muller-Decker
    Eicosanoids and Tumor Development Section, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Gastroenterology 130:2165-78. 2006
    ..Cyclooxygenase (COX)-2, which is a key enzyme of prostaglandin (PG) biosynthesis, is overexpressed in around 75% of human carcinomas including those of the pancreas...
  61. ncbi Transcriptional network governing the angiogenic switch in human pancreatic cancer
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center DKFZ and University of Heidelberg Medical School, Heidelberg 69120, Germany
    Proc Natl Acad Sci U S A 104:12890-5. 2007
    ....