A Drzezga

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
  2. doi request reprint First clinical experience with integrated whole-body PET/MR: comparison to PET/CT in patients with oncologic diagnoses
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 53:845-55. 2012
  3. ncbi request reprint [Scintigraphic procedures in internal medicine--indications, limits, possibilities]
    A Drzezga
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen
    Dtsch Med Wochenschr 130:2833-42; quiz 2843-6. 2005
  4. pmc Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
    Alexander Drzezga
    Department of Radiology, Massachusetts General Hospital and Harvard University Medical School, Boston, MA 02114, USA
    Brain 134:1635-46. 2011
  5. pmc Impaired cross-modal inhibition in Alzheimer disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    PLoS Med 2:e288. 2005
  6. doi request reprint Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
  7. ncbi request reprint Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 270:37-40. 1999
  8. pmc Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1060-3. 2006
  9. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
  10. ncbi request reprint Cerebral glucose metabolism in patients with AD and different APOE genotypes
    A Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Neurology 64:102-7. 2005

Detail Information

Publications64

  1. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
    ..Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB...
  2. doi request reprint First clinical experience with integrated whole-body PET/MR: comparison to PET/CT in patients with oncologic diagnoses
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 53:845-55. 2012
    ..The aim of this study was to evaluate the comparability of clinical performance between conventional PET/CT and PET/MR in patients with oncologic diseases...
  3. ncbi request reprint [Scintigraphic procedures in internal medicine--indications, limits, possibilities]
    A Drzezga
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen
    Dtsch Med Wochenschr 130:2833-42; quiz 2843-6. 2005
    ..The diagnostic potential of modern scintigraphic procedures such as PET for internal medicine is not yet sufficiently used and will continue to grow with hybrid systems, such as PET-CT and SPECT-CT...
  4. pmc Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
    Alexander Drzezga
    Department of Radiology, Massachusetts General Hospital and Harvard University Medical School, Boston, MA 02114, USA
    Brain 134:1635-46. 2011
    ....
  5. pmc Impaired cross-modal inhibition in Alzheimer disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    PLoS Med 2:e288. 2005
    ....
  6. doi request reprint Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
    ..To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo...
  7. ncbi request reprint Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 270:37-40. 1999
    ..05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies...
  8. pmc Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1060-3. 2006
    ..Therefore, schooling seems to provide brain reserve against neurodegeneration...
  9. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
    ..Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET)...
  10. ncbi request reprint Cerebral glucose metabolism in patients with AD and different APOE genotypes
    A Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Neurology 64:102-7. 2005
    ..To examine the influence of the APOE epsilon4 allele on cerebral glucose metabolism in a large series of patients with Alzheimer disease (AD)...
  11. ncbi request reprint Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study
    J Diehl
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Neurobiol Aging 25:1051-6. 2004
    ..To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD)...
  12. ncbi request reprint Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment
    M Riemenschneider
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Arch Neurol 59:1729-34. 2002
    ..Cerebrospinal fluid tau protein and beta-amyloid 42 (Abeta42) protein are altered even in very mild Alzheimer disease (AD). So far, few data exist for subjects with mild cognitive impairment (MCI)...
  13. ncbi request reprint Statistical brain mapping of 18F-FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains
    K Ishii
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, , , Germany
    J Nucl Med 42:548-57. 2001
    ..Deformation accuracy appears to be more prone to atrophy. These limitations need to be considered carefully in the application and interpretation of brain mapping analysis in atrophied brains...
  14. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  15. doi request reprint Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease
    Ruth Vukovich
    Department of Psychiatry and Psychotherapy, Neurochemistry and Neurogenetics Laboratory, Technische Universitat Munchen, Munchen, Germany
    Dement Geriatr Cogn Disord 27:474-80. 2009
    ..Their topographic origin and their association with synaptic dysfunction are still not well understood...
  16. ncbi request reprint Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Brain Res 1133:178-85. 2007
    ..05). We conclude that brain reserve is also present in NFPA...
  17. ncbi request reprint Lasting cortical activation after repetitive TMS of the motor cortex: a glucose metabolic study
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurology 54:956-63. 2000
    ..Cerebral [18F]fluorodeoxy-D-glucose PET ([18F]FDG-PET) was used to visualize the lasting neuronal activation after repetitive transcranial magnetic stimulation (rTMS) over the left hand area of the primary motor cortex (M1HAND)...
  18. ncbi request reprint Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease
    A L W Bokde
    Dementia and Neuroimaging Research Section, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Dement Geriatr Cogn Disord 20:352-7. 2005
    ..Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET)...
  19. ncbi request reprint Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
    Alexander Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 30:1104-13. 2003
    ..A newly emerging reduction of rCMRglc in prefrontal cortical areas is associated with the transition from MCI to AD...
  20. ncbi request reprint Gender differences in brain reserve : an (18)F-FDG PET study in Alzheimer's disease
    R Perneczky
    Dept of Psychiatry and Psychotherapy, Technical University of Munich, Ismaningerstr 22, 81675, Munchen, Germany
    J Neurol 254:1395-400. 2007
    ..Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men...
  21. ncbi request reprint Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies
    A Drzezga
    Nuklearmedizinische Klinik, TU Munchen, Ismaninger Strasse 22, 81675, Munich, Germany
    Pain 92:295-305. 2001
    ..In contrast to pain activation studies, no subcortical (i.e. thalamic) activations were detected and correlation analyses suggest differences in subjective processing of the two sensations...
  22. ncbi request reprint Brain correlates of fast and slow handwriting in humans: a PET-performance correlation analysis
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Moehlstrasse 28, D 81675 Munich, Germany
    Eur J Neurosci 14:726-36. 2001
    ....
  23. ncbi request reprint Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Munich, Germany
    J Nucl Med 46:1625-32. 2005
    ....
  24. ncbi request reprint Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions
    U Darsow
    Division of Environmental Dermatology and Allergy GSF TUM, Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany
    J Invest Dermatol 115:1029-33. 2000
    ..Other areas may be involved in emotional processing of sensations. Skin reactions wheal and flare also had significantly activated covariate areas in the central nervous system.J Invest Dermatol 115:1029-1033 2000..
  25. doi request reprint [Visualization of amyloid with positron emission tomography. Useful improvement in the diagnosis of dementia?]
    T Grimmer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Zentrum für kognitive Störungen, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Deutschland
    Nervenarzt 81:602-6. 2010
    ..However, there are as yet no studies with large sample sizes. The possible use for the early diagnosis of AD should be viewed critically, particularly due to the lack of treatment options...
  26. ncbi request reprint Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: a prospective 18F-FDG-PET study
    T Grimmer
    Department of Psychiatry, Technical University Munich, Germany
    Dement Geriatr Cogn Disord 18:32-6. 2004
    ..The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD)...
  27. doi request reprint Metabolic alterations associated with impaired clock drawing in Lewy body dementia
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Ismaninger Str 22, 81675 Munchen, Germany
    Psychiatry Res 181:85-9. 2010
    ..These findings also suggest that the CDT is an appropriate screening instrument for this disorder and that metabolic dysfunction, and therefore disease severity, is mirrored by performance on the test...
  28. ncbi request reprint Urinary incontinence and its functional anatomy in frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich Medical School, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:605-10. 2008
    ..The aim of the present study was therefore to explore if functional brain lesions were associated with UIC in patients suffering from frontotemporal lobar degenerations (FTLD)...
  29. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
    ..We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs...
  30. doi request reprint Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography
    Gjermund Henriksen
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, Munchen, Germany
    Eur J Nucl Med Mol Imaging 35:S75-81. 2008
    ..The proof of concept for in vivo targeting of beta-amyloid plaques (Abeta) in patients with Alzheimer's disease (AD) by means of nuclear imaging methods has been shown in recent clinical studies...
  31. doi request reprint Right prefrontal hypometabolism predicts delusions in dementia with Lewy bodies
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munchen, Germany
    Neurobiol Aging 30:1420-9. 2009
    ..VH and overall cognitive dysfunction were no significant predictors. These results underline the significance of right prefrontal damage for DEL in DLB...
  32. doi request reprint Fluoro-deoxy-glucose positron emission tomography correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Am J Geriatr Psychiatry 17:188-95. 2009
    ....
  33. pmc Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich 81675, Germany
    Biol Psychiatry 65:927-34. 2009
    ..The aim of the study was to determine the association between cerebral amyloid plaque load, as measured by means of the positron emission tomography (PET) tracer carbon-11-labeled Pittsburgh Compound B ([11C]PiB) and CSF Abeta42 in AD...
  34. doi request reprint Clinical severity of Alzheimer's disease is associated with PIB uptake in PET
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurobiol Aging 30:1902-9. 2009
    ..In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD)...
  35. doi request reprint Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 25:531-8. 2008
    ..To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH)...
  36. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
    ..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
  37. doi request reprint Activities of daily living, cerebral glucose metabolism, and cognitive reserve in Lewy body and Parkinson's disease
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 26:475-81. 2008
    ....
  38. ncbi request reprint Brain reserve capacity in frontotemporal dementia: a voxel-based 18F-FDG PET study
    Robert Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 34:1082-7. 2007
    ..The results suggest that brain reserve capacity (BRC) allows patients with more years of schooling to cope better with AD pathology. The objective of this study was to provide initial evidence for BRC in frontotemporal dementia (FTD)...
  39. ncbi request reprint Metabolically stabilized benzothiazoles for imaging of amyloid plaques
    Gjermund Henriksen
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
    J Med Chem 50:1087-9. 2007
    ..Two lead compounds have been identified with improved physicochemical characteristics for Abeta-plaque imaging in vivo...
  40. ncbi request reprint Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment
    Robert Perneczky
    Department of Psychiatry, Medicine Technische Universität Munchen, Germany
    J Geriatr Psychiatry Neurol 20:84-8. 2007
    ..001, uncorrected for multiple comparisons), which was independent from demographical variables. The authors conclude that clinical severity of impairments is already correlated with deficits in glucose metabolism in the stage of MCI...
  41. ncbi request reprint Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Int J Geriatr Psychiatry 22:1135-40. 2007
    ..This suggests that men can compensate more pathology than women...
  42. ncbi request reprint Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurology 58:1622-8. 2002
    ..CSF concentrations of tau and beta-amyloid protein-42 (Abeta42) have been extensively studied in AD. Few data are available concerning CSF levels of both proteins in patients with frontotemporal degeneration (FTD)...
  43. ncbi request reprint Linking actions and their perceivable consequences in the human brain
    Birgit Elsner
    Department of Cognition and Action, Max Planck Institute for Psychological Research, D 80799, Munich, Germany
    Neuroimage 17:364-72. 2002
    ..This integration process represents a highly flexible mechanism that helps to promote the learning, automatization, and control of voluntary..
  44. ncbi request reprint Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances
    Susanne Bornschein
    Department of Psychiatry and Psychotherapy, Technical University TU of Munich, Klinikum rechts der Isar, Munich, Germany
    Scand J Work Environ Health 33:447-53. 2007
    ..In this study, a small group of well-characterized patients with idiopathic environmental intolerance were examined in order to identify such changes...
  45. ncbi request reprint PET in patients with clear-cut multiple chemical sensitivity (MCS)
    S Bornschein
    Toxikologische Abteilung der II Medizinischen Klinik und Poliklinik, Technischen Universitat Munchen, Klinikum rechts der Isar, Munchen
    Nuklearmedizin 41:233-9. 2002
    ..These methods are often applied to MCS patients for diagnosis, although they never proved appropriate...
  46. ncbi request reprint Prominent hypometabolism of the right temporoparietal and frontal cortex in two left-handed patients with primary progressive aphasia
    Alexander Drzezga
    Nuklearmedizinische Klinik u Poliklinik, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    J Neurol 249:1263-7. 2002
    ..These findings support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity...
  47. doi request reprint Kinetic modelling of [11C]flumazenil using data-driven methods
    Isabelle Miederer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med Mol Imaging 36:659-70. 2009
    ..Therefore, in this study we compared invasive and noninvasive data-driven methods (Logan graphical analysis, LGA; multilinear reference tissue model, MRTM2; spectral analysis, SA; basis pursuit denoising, BPD) with the 1T model...
  48. doi request reprint Concept of functional imaging of memory decline in Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, München Munich, Germany
    Methods 44:304-14. 2008
    ....
  49. doi request reprint A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease
    Marc Wermke
    Department of Nuclear Medicine, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:S12-24. 2008
    ..A new comprehensive model will be introduced integrating these heterogeneous findings and explaining their impact on cognitive performance...
  50. ncbi request reprint Continuous transcranial magnetic stimulation during positron emission tomography: a suitable tool for imaging regional excitability of the human cortex
    H R Siebner
    Department of Neurology, , Moehlstrasse 28, 81675 Munich, Germany
    Neuroimage 14:883-90. 2001
    ..These data demonstrate that, by varying the variables of rTMS across scans, continuous rTMS during H(2)(15)O PET provides a noninvasive tool to study the regional excitability profile of a distinct cortical area...
  51. ncbi request reprint In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease
    Caroline Schultheiss
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munchen, Germany
    Angiogenesis 9:59-65. 2006
    ..In conclusion our results indicate that amyloid deposition in the vasculature leads to endothelial cell apoptosis and endothelial cell activation, which can be modulated by anti-angiogenic drugs...
  52. doi request reprint Basic pathologies of neurodegenerative dementias and their relevance for state-of-the-art molecular imaging studies
    Alexander Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:S4-11. 2008
    ..These facts justify strengthened scientific efforts to identify the pathologic origin of dementing disorders, to improve diagnosis, and to interfere therapeutically with the disease progression...
  53. doi request reprint SPECT/CT
    Andreas K Buck
    Department of Nuclear Medicine, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 49:1305-19. 2008
    ..This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications...
  54. ncbi request reprint Short-term modulation of regional excitability and blood flow in human motor cortex following rapid-rate transcranial magnetic stimulation
    Beatrice Takano
    Department of Neurology, Munich University of Technology, Munich, Germany
    Neuroimage 23:849-59. 2004
    ..This opens up new possibilities for studying acute reorganization at the systems level in the intact human brain...
  55. ncbi request reprint A fronto-parietal network is mediating improvement of motor function related to repetitive peripheral magnetic stimulation: A PET-H2O15 study
    Albrecht Struppler
    Sensorimotor Integration Research Group, Klinikum rechts der Isar der TUM, Psychiatrische Klinik 7 0, Ismaningerstr 22, 81675 Munchen, Germany
    Neuroimage 36:T174-86. 2007
    ..These results emphasize the positive therapeutic effect of RPMS and describe the physiological bases of its function on the central level...
  56. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
    ..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)...
  57. ncbi request reprint Positron emission tomography with [(18)F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD)
    Karsten Henkel
    Prionforschungsgruppe, Department of Neurology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Neurol 249:699-705. 2002
    ..Our results demonstrate that [(18)F]FDG-PET appears to be a sensitive investigation in CJD and could be useful to differentiate CJD from other neurodegenerative disorders...
  58. pmc Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease
    Christian Habeck
    Taub Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuroimage 40:1503-15. 2008
    ..Multivariate measures of AD utilize the covariance structure of imaging data and provide complementary, clinically relevant information that may be superior to univariate measures...
  59. ncbi request reprint Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia
    Simon M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Munich University of Technology, 81675 Munich, Germany
    Am J Psychiatry 164:1577-84. 2007
    ..The aim of this study was to investigate the MAPT haplotypes in relation to risk for, and functional alterations of glucose metabolism in, patients with frontotemporal dementia (FTD)...
  60. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  61. ncbi request reprint Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 187:86-94. 2006
    ..Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) by measuring cortical metabolic response to activation assesses integrity of neuronal transmission in vivo...
  62. ncbi request reprint Vowel sound extraction in anterior superior temporal cortex
    Jonas Obleser
    Fachgruppen Psychologie und Linguistik, Universitat Konstanz, Konstanz, Germany
    Hum Brain Mapp 27:562-71. 2006
    ..These findings also support the notion of an auditory "what" stream, with highly object-specialized areas anterior to primary auditory cortex...
  63. ncbi request reprint Long-term consequences of switching handedness: a positron emission tomography study on handwriting in "converted" left-handers
    Hartwig R Siebner
    Sobell Department of Neurophysiology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 22:2816-25. 2002
    ....
  64. doi request reprint Molecular imaging in dementia
    Alexander Drzezga
    Eur J Nucl Med Mol Imaging 35:S1-3. 2008