Janine Diehl-Schmid

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint [German-speaking memory clinics: state of the art and practical recommendations]
    J Diehl
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Z Gerontol Geriatr 36:189-96. 2003
  2. ncbi request reprint The Ekman 60 Faces Test as a diagnostic instrument in frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D 81675 Munich, Germany
    Arch Clin Neuropsychol 22:459-64. 2007
  3. ncbi request reprint Frontotemporal dementia, semantic dementia, and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis
    J Diehl
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    J Geriatr Psychiatry Neurol 18:39-44. 2005
  4. ncbi request reprint [Initial symptoms, survival and causes of death in 115 patients with frontotemporal lobar degeneration]
    J Diehl-Schmid
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen
    Fortschr Neurol Psychiatr 75:708-13. 2007
  5. ncbi request reprint Behavioral disturbances in the course of frontotemporal dementia
    J Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:352-7. 2006
  6. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
  7. ncbi request reprint [Misdemeanor in frontotemporal dementia]
    J Diehl
    Psychiatrische Klinik und Poliklinik der TU München, Ismaninger Str 22, 81675 Munchen
    Fortschr Neurol Psychiatr 74:203-10. 2006
  8. ncbi request reprint Extrapyramidal signs, primitive reflexes and incontinence in fronto-temporal dementia
    J Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    Eur J Neurol 14:860-4. 2007
  9. doi request reprint A 6-month, open-label study of memantine in patients with frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 23:754-9. 2008
  10. ncbi request reprint Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia
    Simon M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Munich University of Technology, 81675 Munich, Germany
    Am J Psychiatry 164:1577-84. 2007

Detail Information

Publications45

  1. ncbi request reprint [German-speaking memory clinics: state of the art and practical recommendations]
    J Diehl
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Z Gerontol Geriatr 36:189-96. 2003
    ..The following paper is a summary of the results of a workshop in Göttingen and gives practical recommendations based on the experiences of the memory clinics...
  2. ncbi request reprint The Ekman 60 Faces Test as a diagnostic instrument in frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D 81675 Munich, Germany
    Arch Clin Neuropsychol 22:459-64. 2007
    ..The results of the present study were consistent with the findings of prior studies on smaller patient samples...
  3. ncbi request reprint Frontotemporal dementia, semantic dementia, and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis
    J Diehl
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    J Geriatr Psychiatry Neurol 18:39-44. 2005
    ....
  4. ncbi request reprint [Initial symptoms, survival and causes of death in 115 patients with frontotemporal lobar degeneration]
    J Diehl-Schmid
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen
    Fortschr Neurol Psychiatr 75:708-13. 2007
    ..Mortality risk was significantly higher in patients with an early disease onset. Causes of death were varied, but pneumonia and sudden unexplained deaths were particularly frequent...
  5. ncbi request reprint Behavioral disturbances in the course of frontotemporal dementia
    J Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:352-7. 2006
    ..Objective: The aim of this study was to assess and compare the prevalence and severity of behavioral disturbances in patients with mild FTD and in patients with moderate/severe dementia...
  6. ncbi request reprint Longitudinal changes of cerebral glucose metabolism in semantic dementia
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 22:346-51. 2006
    ..Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET)...
  7. ncbi request reprint [Misdemeanor in frontotemporal dementia]
    J Diehl
    Psychiatrische Klinik und Poliklinik der TU München, Ismaninger Str 22, 81675 Munchen
    Fortschr Neurol Psychiatr 74:203-10. 2006
    ..10 patients with FTD and 3 patients with SD but none of the patients with AD had physically threatened spouses, relatives or strangers. In one case another person was hurt...
  8. ncbi request reprint Extrapyramidal signs, primitive reflexes and incontinence in fronto-temporal dementia
    J Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    Eur J Neurol 14:860-4. 2007
    ..The results have to be confirmed with larger or pooled patient samples from different ascertainment scenarios. If the results of the present study can be replicated, a revision of the consensus criteria from 1998 might be considered...
  9. doi request reprint A 6-month, open-label study of memantine in patients with frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 23:754-9. 2008
    ..To evaluate safety and effects on cognition and behavior of memantine 20 mg/day in the treatment of patients with frontotemporal dementia (FTD)...
  10. ncbi request reprint Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia
    Simon M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Munich University of Technology, 81675 Munich, Germany
    Am J Psychiatry 164:1577-84. 2007
    ..The aim of this study was to investigate the MAPT haplotypes in relation to risk for, and functional alterations of glucose metabolism in, patients with frontotemporal dementia (FTD)...
  11. ncbi request reprint Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Brain Res 1133:178-85. 2007
    ..05). We conclude that brain reserve is also present in NFPA...
  12. ncbi request reprint Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Int J Geriatr Psychiatry 22:1135-40. 2007
    ..This suggests that men can compensate more pathology than women...
  13. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
    ..Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB...
  14. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  15. ncbi request reprint No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Munich, Germany
    Neurobiol Aging 28:1789-90. 2007
    ..Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD...
  16. doi request reprint Caregiver burden and needs in frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Geriatr Psychiatry Neurol 26:221-9. 2013
    ..However, little is known about the specific problems, the factors that contribute to caregiver burden, and the needs of the FTD caregivers-particularly those needs that are accessible by external support strategies...
  17. doi request reprint Cognitive decline in the behavioral variant of frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry of Technische Universität München, Munich, Germany
    Int Psychogeriatr 23:230-7. 2011
    ..This is surprising because knowledge about the progression of symptoms is a precondition for the design of clinical drug trials...
  18. ncbi request reprint Brain reserve capacity in frontotemporal dementia: a voxel-based 18F-FDG PET study
    Robert Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 34:1082-7. 2007
    ..The results suggest that brain reserve capacity (BRC) allows patients with more years of schooling to cope better with AD pathology. The objective of this study was to provide initial evidence for BRC in frontotemporal dementia (FTD)...
  19. ncbi request reprint A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
    ..Further functional investigations are warranted to elucidate the specific role of PLAU, respectively, PLAU variants in the metabolism of Abeta proteins...
  20. doi request reprint Accelerated clinical decline in well-educated patients with frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, 81675 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 259:362-7. 2009
    ..There was a significant positive association between education and CDR-SOB monthly rate of change, indicating a faster decline in the well-educated. Education was the only significant predictor of clinical deterioration...
  21. ncbi request reprint Urinary incontinence and its functional anatomy in frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich Medical School, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:605-10. 2008
    ..The aim of the present study was therefore to explore if functional brain lesions were associated with UIC in patients suffering from frontotemporal lobar degenerations (FTLD)...
  22. doi request reprint Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Cogn Behav Neurol 26:73-7. 2013
    ..Our aim was to compare the frequency of criminal conduct in patients with behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and Alzheimer disease...
  23. doi request reprint Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 28:543-52. 2012
    ....
  24. ncbi request reprint Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study
    J Diehl
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Neurobiol Aging 25:1051-6. 2004
    ..To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD)...
  25. doi request reprint Patient participation in medical and social decisions in Alzheimer's disease
    Johannes Hamann
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Am Geriatr Soc 59:2045-52. 2011
    ....
  26. doi request reprint Health care utilization in frontotemporal lobar degeneration
    Janine Diehl-Schmid
    Department of Psychiatry, TU Munchen, Ismaninger Str 2281675, Munchen, Germany
    Alzheimer Dis Assoc Disord 26:166-70. 2012
    ..Fifty-one percent of the patients were treated with antidepressants, 23% with antipsychotics, and 34% with cholinesterase inhibitors or memantine. Forty percent of the patients received nonpharmacological treatment...
  27. doi request reprint Survival in a German population with frontotemporal lobar degeneration
    Sabine Nunnemann
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    Neuroepidemiology 37:160-5. 2011
    ..Furthermore, the objective of the study was to identify prognostic factors associated with survival and to examine causes of death...
  28. ncbi request reprint No association of TDP-43 with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Ismanigerstr 22, TU Munich, 81675 Munich, Germany
    Neurobiol Aging 30:157-9. 2009
    ..There is no evidence, that common variants in TDP-43 confer a strong risk to the development of sporadic FTD...
  29. ncbi request reprint [Efficacy of caregiver support groups for dementia]
    A Kurz
    Klinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen
    Nervenarzt 76:261-9. 2005
    ..S., Australia, and Finland have demonstrated that multimodal counseling programmes led by professionals significantly reduce the number of nursing home admissions and therefore may have considerable importance for health economics...
  30. ncbi request reprint Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: a prospective 18F-FDG-PET study
    T Grimmer
    Department of Psychiatry, Technical University Munich, Germany
    Dement Geriatr Cogn Disord 18:32-6. 2004
    ..The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD)...
  31. ncbi request reprint [Mild cognitive disorder. Questions of definition, diagnosis, prognosis and therapy]
    A Kurz
    Klinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen
    Nervenarzt 75:6-15. 2004
    ..Patients with early-stage Alzheimer's are an important target group for treatment interventions aiming at slowing the neurodegenerative process...
  32. ncbi request reprint [Features of frontotemporal dementia from the perspective of a special family support group]
    J Diehl
    Klinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Möhlstrasse 26, 81675 Munchen
    Nervenarzt 74:445-9. 2003
    ..Participants' evaluations of the novel intervention were very positive. We conclude from these initial observations that support groups are needed for caregivers of patients with FTD which are tailored to their specific needs...
  33. ncbi request reprint Frontotemporal dementia: patient characteristics, cognition, and behaviour
    J Diehl
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 17:914-8. 2002
    ....
  34. pmc Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1060-3. 2006
    ..Therefore, schooling seems to provide brain reserve against neurodegeneration...
  35. ncbi request reprint Gender differences in brain reserve : an (18)F-FDG PET study in Alzheimer's disease
    R Perneczky
    Dept of Psychiatry and Psychotherapy, Technical University of Munich, Ismaningerstr 22, 81675, Munchen, Germany
    J Neurol 254:1395-400. 2007
    ..Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men...
  36. doi request reprint Caregivers of patients with frontotemporal lobar degeneration: a review of burden, problems, needs, and interventions
    Sabine Nunnemann
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int Psychogeriatr 24:1368-86. 2012
    ..The aim of the current study is to systematically review publications on (1) burden, problems, and needs of FTLD caregivers, and (2) the feasibility and efficacy of caregiver interventions in FTLD...
  37. ncbi request reprint Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study
    J Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D 81675 Munich, Germany
    Neurobiol Aging 28:42-50. 2007
    ..To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant)...
  38. ncbi request reprint Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurology 58:1622-8. 2002
    ..CSF concentrations of tau and beta-amyloid protein-42 (Abeta42) have been extensively studied in AD. Few data are available concerning CSF levels of both proteins in patients with frontotemporal degeneration (FTD)...
  39. ncbi request reprint Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease
    M Riemenschneider
    Department of Psychiatry, Neurochemistry and Neurogenetics Laboratory, TU München Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 25:1305-8. 2004
    ..None of the polymorphisms showed significant association with AD which contradicts recent findings on CH25H. From our results we conclude that the investigated genetic variations do not contribute to the genetic risk of AD...
  40. pmc Apolipoprotein E polymorphism in German patients with frontotemporal degeneration
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    J Neurol Neurosurg Psychiatry 72:639-41. 2002
    ..Inconclusive results have been reported in patients with frontotemporal degeneration which prompted this study of the apoE polymorphism in a German sample with frontotemporal degeneration...
  41. ncbi request reprint A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 7:782-5. 2002
    ..The results suggest that the BDNF C-270T polymorphism is a relevant risk factor for AD particularly in patients lacking the ApoE epsilon4 allele in this German sample...
  42. ncbi request reprint Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment
    M Riemenschneider
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Arch Neurol 59:1729-34. 2002
    ..Cerebrospinal fluid tau protein and beta-amyloid 42 (Abeta42) protein are altered even in very mild Alzheimer disease (AD). So far, few data exist for subjects with mild cognitive impairment (MCI)...
  43. ncbi request reprint Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease
    S M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    Mol Psychiatry 12:510-7. 2007
    ..002, uncorrected). These findings provide functional evidence to support the genetic association of MAPT with AD...
  44. ncbi request reprint Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease
    S Schwarz
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurosci Lett 343:167-70. 2003
    ..In addition, the exon 9 SNP (rs868749) was not polymorphic in the studied population. We conclude that the previously identified polymorphism is not associated with AD...
  45. ncbi request reprint Genetic analysis of MAPT haplotype diversity in frontotemporal dementia
    S M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TU München, Ismaningerstr 22, D 81675 Munchen, Germany
    Neurobiol Aging 29:1276-8. 2008
    ..These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies...