A J Beer

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
  2. doi Phenotyping of tumor biology in patients by multimodality multiparametric imaging: relationship of microcirculation, alphavbeta3 expression, and glucose metabolism
    Stephan Metz
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 51:1691-8. 2010
  3. doi Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging
    Matthias Eiber
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    Invest Radiol 45:15-23. 2010
  4. ncbi Application of RGD-containing peptides as imaging probes for alphavbeta3 expression
    Ingrid Dijkgraaf
    Technische Universitat Munchen, Department of Nuclear Medicine, Klinikum rechts der Isar, 81675 Munchen, Germany
    Front Biosci (Landmark Ed) 14:887-99. 2009
  5. doi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
  6. doi PET imaging of αvβ3 expression in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich 81675, Germany
    Methods Mol Biol 680:183-200. 2011
  7. doi Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:255-9. 2008
  8. ncbi Comparison of integrin alphaVbeta3 expression and glucose metabolism in primary and metastatic lesions in cancer patients: a PET study using 18F-galacto-RGD and 18F-FDG
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:22-9. 2008
  9. ncbi [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
  10. ncbi [Molecular imaging with new PET tracers]
    A J Beer
    Klinik und Poliklinik fur Nuklearmedizin, Klinikum rechts der Isar der Technischen Universitat Munchen
    Radiologe 47:8-17. 2007

Detail Information

Publications33

  1. ncbi Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  2. doi Phenotyping of tumor biology in patients by multimodality multiparametric imaging: relationship of microcirculation, alphavbeta3 expression, and glucose metabolism
    Stephan Metz
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 51:1691-8. 2010
    ..We analyzed the spatial relationship of α(v)β(3) expression, glucose metabolism, and perfusion by PET and DCE MRI, focusing on tumor heterogeneity...
  3. doi Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging
    Matthias Eiber
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    Invest Radiol 45:15-23. 2010
    ..In this retrospective feasibility study diffusion-weighted magnetic resonance imaging (DWI) was evaluated as a potential tool for characterization of pelvic lymph nodes in patients with prostate cancer...
  4. ncbi Application of RGD-containing peptides as imaging probes for alphavbeta3 expression
    Ingrid Dijkgraaf
    Technische Universitat Munchen, Department of Nuclear Medicine, Klinikum rechts der Isar, 81675 Munchen, Germany
    Front Biosci (Landmark Ed) 14:887-99. 2009
    ..In this review a brief overview on the currently used RGD-containing peptides as imaging probes for noninvasive visualization of alphavbeta3 expression using PET, SPECT, MRI, OI and US is given...
  5. doi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
    ..The various advantages and disadvantages of several imaging techniques will be discussed in this article...
  6. doi PET imaging of αvβ3 expression in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich 81675, Germany
    Methods Mol Biol 680:183-200. 2011
    ..Finally, the performance of PET will be compared to other methods of imaging of αvβ3 expression, like magnetic resonance imaging, ultrasound, or optical imaging...
  7. doi Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:255-9. 2008
    ..The integrin alpha(v)beta(3) is a key player in angiogenesis and metastasis. Our aim was to study the uptake patterns of the alpha(v)beta(3)-selective PET tracer (18)F-galacto-RGD in invasive ductal breast cancer...
  8. ncbi Comparison of integrin alphaVbeta3 expression and glucose metabolism in primary and metastatic lesions in cancer patients: a PET study using 18F-galacto-RGD and 18F-FDG
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 49:22-9. 2008
    ..We evaluated whether assessment of alpha(v)beta(3) expression and of glucose metabolism with PET using (18)F-galacto-RGD and (18)F-FDG provides complementary information in cancer patients...
  9. ncbi [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
    ..Our aim was to study the feasibility of PET imaging with [(18)F]Galacto-RGD in patients with squamous cell carcinoma of the head and neck (SCCHN)...
  10. ncbi [Molecular imaging with new PET tracers]
    A J Beer
    Klinik und Poliklinik fur Nuklearmedizin, Klinikum rechts der Isar der Technischen Universitat Munchen
    Radiologe 47:8-17. 2007
    ..Moreover, gene expression can be imaged as well. While most of these approaches are currently in the first phases of clinical evaluation, imaging of hypoxia and proliferation might be integrated into the daily routine in the near future...
  11. ncbi Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET). Here, we show, in man, that the intensity of [18F]Galacto-RGD uptake correlates with alpha(v)beta3 expression...
  12. ncbi Comparison of 16-MDCT and MRI for characterization of kidney lesions
    Ambros J Beer
    Department of Radiology, Technische Universitaet Munichen, Ismaninger Strasse 21, Munich, Germany, 81675
    AJR Am J Roentgenol 186:1639-50. 2006
    ..The objective of our study was to compare the diagnostic performance of 16-MDCT with that of MRI in the characterization of kidney lesions...
  13. ncbi PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
    ..18)F-Galacto-RGD is a new tracer for PET imaging of alpha v beta3, a receptor involved in a variety of pathologic processes including angiogenesis and metastasis. Our aim was to study the dosimetry of (18)F-galacto-RGD in humans...
  14. ncbi Adenocarcinomas of esophagogastric junction: multi-detector row CT to evaluate early response to neoadjuvant chemotherapy
    Ambros J Beer
    Department of Radiology, Technische Universitaet Muenchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany
    Radiology 239:472-80. 2006
    ..To prospectively evaluate multi-detector row computed tomography (CT) in the assessment of early response during neoadjuvant chemotherapy for adenocarcinoma of the esophagogastric junction (AEG)...
  15. ncbi Molecular imaging of αvß3 expression in cancer patients
    F C Gaertner
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Q J Nucl Med Mol Imaging 54:309-26. 2010
    ..Moreover, an outlook will be presented on potential clinical applications of imaging of αvß3 expression...
  16. ncbi Comparison of changes in tumor metabolic activity and tumor size during chemotherapy of adenocarcinomas of the esophagogastric junction
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 46:2029-34. 2005
    ..We evaluated the temporal relationship between chemotherapy-induced changes in tumor glucose use and tumor size...
  17. doi Radiolabelled RGD peptides for imaging and therapy
    F C Gaertner
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany
    Eur J Nucl Med Mol Imaging 39:S126-38. 2012
    ..A perspective will be presented on the future clinical use of radiolabelled RGD peptides including an outlook on potential applications for radionuclide therapy...
  18. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    ..We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbeta3 expression with positron emission tomography (PET)...
  19. pmc Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
    Oliver Schnell
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Neuro Oncol 11:861-70. 2009
    ..These data suggest that [(18)F] Galacto-RGD PET successfully identifies alpha(v)beta(3) expression in patients with GBM and might be a promising tool for planning and monitoring individualized cancer therapies targeting this integrin...
  20. doi Comparison of 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography (FLT PET) and FDG PET/CT for the detection and characterization of pancreatic tumours
    K Herrmann
    Department of Nuclear Medicine, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany
    Eur J Nucl Med Mol Imaging 39:846-51. 2012
    ....
  21. ncbi [MSCT for staging and response evaluation of esophageal cancer]
    K Holzapfel
    Institut für Röntgendiagnostik, Klinikum rechts der Isar, TU Munchen
    Radiologe 47:101-9. 2007
    ..First results of CT volumetry for response evaluation are promising; however, PET and PET/CT with the glucose analogue FDG are the standard methods to evaluate response to neoadjuvant therapy...
  22. doi Whole-body MRI including diffusion-weighted imaging (DWI) for patients with recurring prostate cancer: technical feasibility and assessment of lesion conspicuity in DWI
    Matthias Eiber
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    J Magn Reson Imaging 33:1160-70. 2011
    ....
  23. doi [Functional imaging in bladder cancer]
    T Maurer
    Urologische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Straße 22, 81675 Munchen, Deutschland
    Urologe A 52:509-14. 2013
    ..Although promising results could be obtained for PET/CT investigations to some extent, the true value cannot be determined at present...
  24. ncbi PET/CT with Gluc-Lys-([(18)F]FP)-TOCA: correlation between uptake, size and arterial perfusion in somatostatin receptor positive lesions
    Hinrich Wieder
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:264-71. 2008
    ....
  25. pmc Inversion-recovery single-shot cardiac MRI for the assessment of myocardial infarction at 1.5 T with a dedicated cardiac coil
    M Wildgruber
    Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Br J Radiol 85:e709-15. 2012
    ..5 T using a dedicated cardiac coil...
  26. ncbi Imaging of hypoxia using PET and MRI
    F C Gaertner
    Technische Universitat Munchen, Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany
    Curr Pharm Biotechnol 13:552-70. 2012
    ..This article provides an overview over the various methods, with a particular emphasis on PET and MRI for imaging of hypoxia, and reviews their performance in preclinical and clinical studies...
  27. ncbi [Nuclear medical diagnostics for liver tumors]
    A K Buck
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, TU, 81675, Ismaninger Strasse 22, Munchen, Germany
    Internist (Berl) 48:21-4, 26-9. 2007
    ..Molecular imaging with PET allows the quantification of metabolic processes which can be used for the assessment of an early response to treatment...
  28. ncbi Assessment of tumor volumes in skull base glomus tumors using Gluc-Lys[(18)F]-TOCA positron emission tomography
    Sabrina T Astner
    Klinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 73:1135-40. 2009
    ..To assess a threshold for Gluc-Lys[(18)F]-TOCA positron emission tomography (PET) in target volume delineation of glomus tumors in the skull base and to compare with MRI-based target volume delineation...
  29. pmc Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
    Oliver Schnell
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Brain Pathol 18:378-86. 2008
    ....
  30. ncbi Multimodal tumor therapy in a 31-year-old pregnant woman with Wilms tumor
    T Maurer
    Department of Urology, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Urol Int 83:364-7. 2009
    ..Generally, treatment should follow the guidelines established for the pediatric setting...
  31. doi Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munich, Germany
    Mol Imaging Biol 13:352-61. 2011
    ..The aim of the study was to compare the functional parameters standardized uptake value (SUV) in PET and apparent diffusion coefficient (ADC) value in DWI of lymph nodes in prostate cancer patients...
  32. ncbi Dynamic near-real-time magnetic resonance imaging for analyzing the velopharyngeal closure in comparison with videofluoroscopy
    Ambros J Beer
    Department of Radiology, Klinikum rechts der Isar, University of Technology Munich, Munich, Germany
    J Magn Reson Imaging 20:791-7. 2004
    ..To demonstrate the feasibility of dynamic magnetic resonance imaging (MRI) with near-real-time temporal resolution ("real-time MRI") for analyzing the velopharyngeal closure in comparison with multiview videofluoroscopy...
  33. ncbi Value of 11C-choline PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings
    Maria Picchio
    Department of Nuclear Medicine, IBFM CNR, Scientific Institute H San Raffaele, Milan, Italy
    J Nucl Med 47:938-44. 2006
    ..This study was performed to compare the diagnostic accuracies of contrast-enhanced CT and PET with (11)C-choline for the staging of urothelial bladder cancer...