Research Topics
Species | S BauerSummaryAffiliation: Klinikum rechts der Isar Country: Germany Publications
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Detail Information
Publications
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognitionS Bauer
Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany
Proc Natl Acad Sci U S A 98:9237-42. 2001..The optimal CpG motif for hTLR9 was GTCGTT, whereas the optimal murine sequence was GACGTT. Overall, these data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating CpG-DNA...
Bacterial CpG-DNA licenses TLR9S Bauer
Institute for Medical Microbiology, Hygiene and Immunology, Trogerstrasse 9, 81675 Munich, Germany
Curr Top Microbiol Immunol 270:145-54. 2002..This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed...- Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responsesC J Kirschning
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Germany
Int J Med Microbiol 291:251-60. 2001..Further understanding of recognition and cellular signaling activated through the ancient host defense system represented by Toll will eventually lead to means for its therapeutic modulation... - TNFalpha-mediated induction of PAI-1 restricts invasion of HTR-8/SVneo trophoblast cellsA V Huber
Department of Obstetrics and Gynecology, Medical University of Vienna, AKH, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Placenta 27:127-36. 2006..The data suggest that TNFalpha restricts trophoblast invasion mainly by increasing the expression of PAI-1. Induction of the inhibitor may involve TNFalpha-stimulated activation of NFkappaB... - Expression pattern of collagen XVIII and its cleavage product, the angiogenesis inhibitor endostatin, at the fetal-maternal interfaceJ Pollheimer
Department of Obstetrics and Gynecology, Medical University of Vienna, AKH, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Placenta 25:770-9. 2004..Moreover, supplementation of recombinant endostatin increased MMP-2 expression in villous explant cultures and SGHPL-5 cells suggesting that the inhibitor may modulate extravillous trophoblast differentiation... - Identification and characterisation of regions in the cellular protein LaXp180 and the Listeria monocytogenes surface protein ActA necessary for the interaction of the two proteinsS Bauer
, , Am Hubland, , Germany
Mol Genet Genomics 268:607-17. 2003.... - Production of pro- and anti-inflammatory cytokines of human placental trophoblasts in response to pathogenic bacteriaG Griesinger
Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria
J Soc Gynecol Investig 8:334-40. 2001..Induction of both inflammation-promoting and inflammation-inhibiting cytokines by bacterial products could play a role in modulating the inflammatory response associated with chorioamnionitis... - P2X(2), P2X(2-2) and P2X(5) receptor subunit expression and function in rat thoracolumbar sympathetic neuronsH Schädlich
Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
J Neurochem 79:997-1003. 2001..Apparently there exist two types of P2X(2) receptor-bearing sympathetic neurons: one major population expressing the unspliced isoform and another minor population expressing the P2X(2-2) splice variant... - Somatostatin inhibits stem cell factor messenger RNA expression by Sertoli cells and stem cell factor-induced DNA synthesis in isolated seminiferous tubulesI Goddard
, , F-69921 Oullins, France
Biol Reprod 65:1732-42. 2001..Combined RT-PCR and immunohistochemical approaches point toward spermatogonia and Leydig cells as the source of testicular SRIF. These data argue in favor of paracrine/autocrine SRIF actions in testis... - The surrogate light chain in B-cell developmentF Melchers
Basel Institute for Immunology, Switzerland
Immunol Today 14:60-8. 1993..Here, Fritz Melchers and colleagues review the structures of the VpreB and lambda 5 genes in mouse and their relatives in humans, describe their pattern of expression, and speculate on their possible evolution and functions... - Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblastsM Knöfler
Department of Obstetrics and Gynecology, University of Vienna, Austria
Endocrinology 141:3737-48. 2000..We conclude that differentiation-dependent transcription of the CGalpha gene in villous trophoblasts is mainly governed by increasing expression of AP-2alpha and PKA-dependent phosphorylation of CREB-1 and ATF-1... - An activating immunoreceptor complex formed by NKG2D and DAP10J Wu
DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
Science 285:730-2. 1999..Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors... - Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICAS Bauer
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Science 285:727-9. 1999..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses... - Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insightsM E Percy
Department of Physiology, University of Toronto, Ontario, Canada
Analyst 123:41-50. 1998..Possible functions for ferritin H protein derived from the novel message and for the elongated 3'UTR and 5'UTR are discussed... - Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cellsV Groh
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Science 279:1737-40. 1998..Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract... - RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cellsC Renner
Med Klinik I, University of Saarlandes, Homburg, Germany
J Immunol 159:1276-83. 1997.... - Characterization of the human jumonji geneJ L Berge-lefranc
INSERM U406, Marseille, France
Hum Mol Genet 5:1637-41. 1996..In view of these observations, we propose JMJ as a candidate gene for developmental defects of the central nervous system in the human. The human JMJ gene maps at position 6p24-6p23... - SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coliA Ludwig
Biozentrum, Universitat Wurzburg, Theodor Boveri Institut, Mikrobiologie Am Hubland, Germany
Mol Gen Genet 249:474-86. 1995..slyA- and slyB-related genes were also obtained by PCR from E. coli, Shigella sp. and Citrobacter diversus but not from several other gram-negative bacteria tested... - Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsisE E Baiyee
Institut fuer Immunologie, Universitaetsklinikum Essen, Essen, Germany
Clin Exp Immunol 145:456-62. 2006..Immunosuppression in the early phase after trauma seems not to be associated with a disturbed sensing of bacterial DNA...