Martina Anton

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. ncbi request reprint Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer
    Frank M Bengel
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    Circulation 108:2127-33. 2003
  2. ncbi request reprint Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation
    Martina Anton
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 45:1743-6. 2004
  3. ncbi request reprint Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector
    Stephan Vogt
    Department of Orthopaedic and Trauma Surgery, Technical University Munich, Munich, Germany
    Biomaterials 29:1242-9. 2008
  4. ncbi request reprint Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells
    Martina Anton
    Institute of Experimental Oncology, Technische Universitat Munchen, Germany
    J Gene Med 6:119-26. 2004
  5. ncbi request reprint Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene
    Marcus V Simoes
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    J Nucl Med 46:98-105. 2005
  6. doi request reprint Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1881-6. 2009
  7. doi request reprint Liposomal magnetofection
    Olga Mykhaylyk
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munchen, Germany
    Methods Mol Biol 605:487-525. 2010
  8. ncbi request reprint PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, 81675 Munich, Germany
    J Nucl Med 45:1917-23. 2004
  9. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
  10. doi request reprint Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells
    Yolanda Sanchez-Antequera
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munich, Germany
    Blood 117:e171-81. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer
    Frank M Bengel
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    Circulation 108:2127-33. 2003
    ..Radionuclide imaging of reporter gene expression may be useful for noninvasive monitoring of clinical cardiac gene therapy. Experience until now, however, has been limited to small animals...
  2. ncbi request reprint Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation
    Martina Anton
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 45:1743-6. 2004
    ..We sought to evaluate the usefulness of an adenoviral vector expressing mutant herpesviral thymidine kinase reporter gene (HSV1-sr39tk) and vascular endothelial growth factor (VEGF) 121 in independent expression cassettes (Ad4tk)...
  3. ncbi request reprint Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector
    Stephan Vogt
    Department of Orthopaedic and Trauma Surgery, Technical University Munich, Munich, Germany
    Biomaterials 29:1242-9. 2008
    ..Gene transfer was very stable over the time period analysed, rendering it a useful tool for future in vitro and in vivo studies on cartilage remodelling...
  4. ncbi request reprint Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells
    Martina Anton
    Institute of Experimental Oncology, Technische Universitat Munchen, Germany
    J Gene Med 6:119-26. 2004
    ..Its expression is almost exclusively restricted to the sympathetic nervous system. In this study we evaluated whether the NET can be used as a reporter gene for non-invasive imaging of genetically modified cells with radiolabeled probes...
  5. ncbi request reprint Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene
    Marcus V Simoes
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    J Nucl Med 46:98-105. 2005
    ..Myocardial kinetics of (124)I-FIAU are still poorly understood. This study aimed at a further investigation under controlled conditions using an isolated heart perfusion model...
  6. doi request reprint Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1881-6. 2009
    ..We investigated whether reporter gene PET can be used to detect the effects of atorvastatin and VEGF on survival of EPCs after transplantation in the rat heart...
  7. doi request reprint Liposomal magnetofection
    Olga Mykhaylyk
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munchen, Germany
    Methods Mol Biol 605:487-525. 2010
    ..The methods described here can be used to screen magnetic nanoparticles and formulations for the delivery of nucleic acids by liposomal magnetofection in any cell type...
  8. ncbi request reprint PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, 81675 Munich, Germany
    J Nucl Med 45:1917-23. 2004
    ..The aim of this study was to compare these 2 combinations with regard to specificity, imaging contrast, and reporter probe kinetics using dynamic PET in small and large animals...
  9. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
    ..We sought to investigate the usefulness of integrated positron emission tomography (PET) and computed tomography (CT) for in vivo characterization of an angiogenesis-directed molecular intervention...
  10. doi request reprint Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells
    Yolanda Sanchez-Antequera
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munich, Germany
    Blood 117:e171-81. 2011
    ..Upscaling to a clinically approved automated cell separation device was feasible. Hence, once optimized, validated, and approved, the method may greatly facilitate the generation of genetically engineered cells for cell therapies...
  11. doi request reprint Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force
    Nittaya Tresilwised
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munich 81675, Germany
    Mol Pharm 7:1069-89. 2010
    ..For systemic application, further modification of magnetic adenovirus complexes for shielding and retargeting of the whole magnetic virus complex entity is needed...
  12. doi request reprint Recent advances in magnetofection and its potential to deliver siRNAs in vitro
    Olga Mykhaylyk
    Institute of Experimental Oncology, Technische Universitat Munchen, Munich, Germany
    Methods Mol Biol 487:111-46. 2009
    ..The described protocols are also valuable for screening vector compositions and novel magnetic nanoparticle preparations to optimize siRNA transfection by magnetofection in every cell type...
  13. ncbi request reprint Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 32:1108-14. 2005
    ....
  14. doi request reprint Tetracycline-regulated bone morphogenetic protein 2 gene expression in lentivirally transduced primary rabbit chondrocytes for treatment of cartilage defects
    Daniela Wübbenhorst
    Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Arthritis Rheum 62:2037-46. 2010
    ....
  15. ncbi request reprint Cardiac reporter gene imaging using the human sodium/iodide symporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munchen, Germany
    Cardiovasc Res 65:195-202. 2005
    ..We investigated the feasibility of myocardial gene expression imaging in living rats using the human sodium/iodide symporter gene (hNIS) and widely available scintigraphic techniques...
  16. ncbi request reprint Enhancing and targeting nucleic acid delivery by magnetic force
    Christian Plank
    Institute of Experimental Oncology, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Expert Opin Biol Ther 3:745-58. 2003
    ..Exploiting the full potential of the technique requires an interdisciplinary research effort in magnetic field physics, magnetic particle chemistry, pharmaceutical formulation and medical application...
  17. doi request reprint Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1088-94. 2009
    ..This study assessed the feasibility and usefulness of combined PET and MRI for monitoring cell engraftment and survival after cell transplantation...
  18. doi request reprint The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation
    Jens Lutz
    Department of Nephrology, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    J Mol Med (Berl) 86:1329-39. 2008
    ..Our observations suggest that A20 maintains physiological homeostasis in kidneys exposed to I/R by protecting them from inflammation and injury...
  19. ncbi request reprint Magnetofection: enhancing and targeting gene delivery with superparamagnetic nanoparticles and magnetic fields
    Christian Plank
    Institute of Experimental Oncology, Technische Universitat Munchen, Munich, Germany
    J Liposome Res 13:29-32. 2003
  20. ncbi request reprint The magnetofection method: using magnetic force to enhance gene delivery
    Christian Plank
    Institute of Experimental Oncology, Technical University Munich, Ismaninger Str 22, D 81675 Munich, Germany
    Biol Chem 384:737-47. 2003
    ....
  21. ncbi request reprint Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis
    Sefer Elezkurtaj
    Institute for Biology, Humboldt University Berlin, at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    J Gene Med 6:1228-37. 2004
    ..Here, we investigated whether increased TIMP-1 levels in the liver achieved by adenoviral gene transfer will effectively inhibit liver metastasis of two independent tumor cell lines...
  22. ncbi request reprint Optimization of radiation controlled gene expression by adenoviral vectors in vitro
    Martina Anton
    Institut für Experimentelle Onkologie and Therapieforschung, Munchen, Germany
    Cancer Gene Ther 12:640-6. 2005
    ..6-2.3 with minor influence on the induced level of cytotoxicity. Introduction of insulating sequences in adenoviral vectors might allow tighter temporospatial control of gene expression by the radiation-inducible EGR-1 promoter...
  23. ncbi request reprint Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host
    Charlotte Kopitz
    Klinikum rechts der Isar der Technischen Universitat Munchen, Institut für Experimentelle Onkologie und Therapieforschung, Munich, Germany
    Cancer Res 65:8608-12. 2005
    ..Furthermore, organ-specific protease expression during tumor-host cell interactions could affect the success of antiproteolytic intervention against metastasis...