T Andus

Summary

Affiliation: Klinikum Stuttgart
Country: Germany

Publications

  1. ncbi request reprint Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study
    T Andus
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Aliment Pharmacol Ther 17:409-14. 2003
  2. ncbi request reprint T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa
    G Rogler
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 11:1105-11. 1999
  3. ncbi request reprint Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells
    T Spottl
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Leukoc Biol 70:241-51. 2001
  4. ncbi request reprint Differential activation of cytokine secretion in primary human colonic fibroblast/myofibroblast cultures
    G Rogler
    Dept of Internal Medicine I, University of Regensburg, Germany
    Scand J Gastroenterol 36:389-98. 2001
  5. pmc Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 125:48-55. 2001
  6. ncbi request reprint Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization
    H Herfarth
    Department of Internal Medicine, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 19:147-52. 2004
  7. ncbi request reprint Treatment of pouchitis with dehydroepiandrosterone (DHEA) - a case report
    F H Klebl
    Department of Internal Medicine I, University of Regensburg, Germany
    Z Gastroenterol 41:1087-90. 2003
  8. ncbi request reprint Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 85:1340-4. 2000
  9. ncbi request reprint Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis
    K Schlottmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Int J Colorectal Dis 19:421-9. 2004
  10. ncbi request reprint Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Neuroimmunol 80:149-57. 1997

Detail Information

Publications23

  1. ncbi request reprint Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study
    T Andus
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Aliment Pharmacol Ther 17:409-14. 2003
    ..Dehydroepiandrosterone inhibits nuclear factor-kappaB and the secretion of interleukin-6 and interleukin-12 via the peroxisome proliferator-activated receptor alpha...
  2. ncbi request reprint T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa
    G Rogler
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 11:1105-11. 1999
    ....
  3. ncbi request reprint Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells
    T Spottl
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Leukoc Biol 70:241-51. 2001
    ..For the first time an intestine-like macrophage-phenotype could be induced in vitro. Interactions with IECs play an essential role during this differentiation, which is of functional relevance, e.g., for LPS-induced cytokine secretion...
  4. ncbi request reprint Differential activation of cytokine secretion in primary human colonic fibroblast/myofibroblast cultures
    G Rogler
    Dept of Internal Medicine I, University of Regensburg, Germany
    Scand J Gastroenterol 36:389-98. 2001
    ..We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients with mucosal inflammation...
  5. pmc Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 125:48-55. 2001
    ..In IBD macrophage-oxidative burst activity is increased and NADPH oxidase mRNA induced. Inhibition of NADPH oxidase could be a new therapeutical target in IBD and reduce mucosal tissue damage in active IBD...
  6. ncbi request reprint Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization
    H Herfarth
    Department of Internal Medicine, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 19:147-52. 2004
    ..This study investigated the optimal budesonide dose using a pH-dependent release formulation. The goal of treatment was the remission of CD (CDAI <150) within 6 weeks of treatment...
  7. ncbi request reprint Treatment of pouchitis with dehydroepiandrosterone (DHEA) - a case report
    F H Klebl
    Department of Internal Medicine I, University of Regensburg, Germany
    Z Gastroenterol 41:1087-90. 2003
    ..In a pilot trial DHEA was effective for the treatment of active ulcerative colitis. Pouchitis is a common complication after proctocolectomy for ulcerative colitis and still a therapeutical challenge...
  8. ncbi request reprint Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 85:1340-4. 2000
    ..As IL-6 may be a pathogenetic factor in age-related diseases, HRT-related inhibition of IL-6 secretion could be an important element for the favorable effects of HRT in postmenopausal women...
  9. ncbi request reprint Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis
    K Schlottmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Int J Colorectal Dis 19:421-9. 2004
    ..In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IEC) lines and primary human colonic epithelial cells (CEC)...
  10. ncbi request reprint Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Neuroimmunol 80:149-57. 1997
    ..05). Autonomic hyperreflexia was significantly associated with more severe inflammation and systemic disease in IBD. Hyperreflexia may be a response to inflammation or a pathogenetic element that drives mucosal inflammation...
  11. pmc Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice
    G Kojouharoff
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 107:353-8. 1997
    ..We conclude that in acute colitis IL-1 and TNF are beneficial, whereas in chronic colitis, TNF but not IL-1 seems to play a major role in perpetuation of chronic inflammation...
  12. ncbi request reprint Patient education in inflammatory bowel disease does not influence patients knowledge and long-term psychosocial well-being
    N Bregenzer
    Department of Internal Medicine, University of Regensburg, Regensburg, Germany
    Z Gastroenterol 43:367-71. 2005
    ..The aim of this prospective study was to analyze the effects of an education program in patients with inflammatory bowel disease...
  13. ncbi request reprint Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease
    N Bregenzer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Exp Clin Endocrinol Diabetes 114:1-5. 2006
    ..Vitamin D receptor alleles containing the polymorphism have been denoted by f and alleles lacking the site by F...
  14. ncbi request reprint Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 122:1987-2000. 2002
    ..Toll-like receptors (TLRs) TLR2 and TLR4 have been identified as signaling receptors activated by bacterial wall components...
  15. ncbi request reprint Association of HLA-DR genotypes and IL-1ra gene polymorphism with treatment failure of budesonide and disease patterns in Crohn's disease
    C M Gelbmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 13:1431-7. 2001
    ..However, it is not known whether certain HLA-DR genotypes or IL-1ra gene polymorphism are associated with responsiveness to treatment or different clinical patterns of disease...
  16. ncbi request reprint Severe acute cholestatic hepatitis by infiltration of monoclonal plasma cells in multiple myeloma
    C Barth
    Department of Internal Medicine, Gastroenterology, Hepatology and Oncology, Hospital Bad Cannstatt, Klinikum Stuttgart, Germany
    Z Gastroenterol 43:1129-32. 2005
    ..Plasma cell infiltration of the liver can be detected in 25 to 40% of patients with multiple myeloma. However, there are only rare cases of multiple myeloma clinically presenting as acute liver disease...
  17. pmc A rare case of hypalbuminaemic oedema
    M Merger
    Department of Internal Medicine, University of Regensburg, Germany
    Gut 54:320, 335. 2005
  18. ncbi request reprint Etiology and pathophysiology of inflammatory bowel disease--environmental factors
    T Andus
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat, Regensburg, Germany
    Hepatogastroenterology 47:29-43. 2000
    ..Inflammatory bowel diseases have multifactorial etiologies, which require a differentiated approach for treatment and prevention...
  19. ncbi request reprint Relation between dehydroepiandrosterone sulfate and blood pressure levels in a population-based sample
    H Schunkert
    , University of Regensburg, Germany
    Am J Hypertens 12:1140-3. 1999
    ..Taken together, we observed a consistent positive association between endogenous DHEAS and systolic blood pressure levels that was independent of other, similarly regulated, adrenal steroids...
  20. pmc Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6
    R Daig
    Department of Internal Medicine I, University of Regensburg, Germany
    Gut 46:350-8. 2000
    ..There is growing evidence that intestinal epithelial cells (IECs) are involved in the mucosal immune system...
  21. ncbi request reprint Induction and maintenance of clinical remission by interferon-beta in patients with steroid-refractory active ulcerative colitis-an open long-term pilot trial
    E Musch
    Department of Internal Medicine, Marienhospital Bottrop, Germany
    Aliment Pharmacol Ther 16:1233-9. 2002
    ..Shifting this disturbed ratio by means of TNF-antibodies or interferon has been shown to be helpful in treating Crohn's disease and multiple sclerosis, respectively...
  22. ncbi request reprint Replacement of conventional glucocorticoids by oral pH-modified release budesonide in active and inactive Crohn's disease: results of an open, prospective, multicenter trial
    T Andus
    Klinikum Stuttgart, Krankenhaus Bad Cannstatt, Stuttgart, Germany
    Dig Dis Sci 48:373-8. 2003
    ..In conclusion, switching from conventional GCS treatment to budesonide leads to a significant reduction of GCS related side effects in patients with CD without causing rapid deterioration of the disease...
  23. ncbi request reprint Successful treatment of steroid refractory active ulcerative colitis with natural interferon-beta--an open long-term trial
    E Musch
    Department of Internal Medicine, Marienhospital Bottrop, Germany
    Z Gastroenterol 45:1235-40. 2007
    ..0 vs. 0.5 MIU) could result in fewer relapse events...