Hans Joachim Anders

Summary

Affiliation: Klinikum Grosshadern
Country: Germany

Publications

  1. pmc A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
    J Clin Invest 109:251-9. 2002
  2. ncbi request reprint Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:1504-13. 2004
  3. ncbi request reprint Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
  4. ncbi request reprint Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 14:317-26. 2003
  5. ncbi request reprint Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    FASEB J 18:534-6. 2004
  6. ncbi request reprint Toll-like receptor-7 modulates immune complex glomerulonephritis
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:141-9. 2006
  7. pmc Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction
    Veronika Skuginna
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e19204. 2011
  8. ncbi request reprint Phenotyping renal leukocyte subsets by four-color flow cytometry: characterization of chemokine receptor expression
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilian University, Munich, Germany
    Nephron Exp Nephrol 93:e63. 2003
  9. ncbi request reprint Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10
    Sufyan G Sayyed
    Nephrological Center, Medizinische Poliklinik, Ludwig Maximilians University, Munich, Germany
    Nephrol Dial Transplant 25:1811-7. 2010
  10. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011

Collaborators

Detail Information

Publications71

  1. pmc A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
    J Clin Invest 109:251-9. 2002
    ..We therefore conclude that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure...
  2. ncbi request reprint Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:1504-13. 2004
    ..This is the first evidence that, in advanced chronic renal injury, blockade of CCR1 can halt disease progression and improve renal function by selective inhibition of interstitial leukocyte recruitment and fibrosis...
  3. ncbi request reprint Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
    ..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates...
  4. ncbi request reprint Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 14:317-26. 2003
    ..This mechanism may be relevant during infection-triggered exacerbation of human immune-complex GN and other immune-mediated diseases in general...
  5. ncbi request reprint Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    FASEB J 18:534-6. 2004
    ..We conclude that TLR9 activation triggers disease activity of systemic autoimmunity, for example, lupus nephritis, and that adaptive and innate immune mechanisms contribute to the CpG-DNA-induced progression of lupus nephritis...
  6. ncbi request reprint Toll-like receptor-7 modulates immune complex glomerulonephritis
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:141-9. 2006
    ....
  7. pmc Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction
    Veronika Skuginna
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e19204. 2011
    ..Together, postobstructive renal interstitial fibrosis and tubular atrophy develop independent of SIGIRR, TLR2, TLR9, and MyD88. These data argue against a significant role of these molecules in renal fibrosis...
  8. ncbi request reprint Phenotyping renal leukocyte subsets by four-color flow cytometry: characterization of chemokine receptor expression
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilian University, Munich, Germany
    Nephron Exp Nephrol 93:e63. 2003
    ..They demonstrate that flow cytometric analysis of single cell suspensions prepared from inflamed kidneys is a rapid and reliable technique to characterize and quantify surface receptor expression on infiltrating renal leukocyte subsets...
  9. ncbi request reprint Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10
    Sufyan G Sayyed
    Nephrological Center, Medizinische Poliklinik, Ludwig Maximilians University, Munich, Germany
    Nephrol Dial Transplant 25:1811-7. 2010
    ..The current study examined the role of histone epigenetics in development and progression of nephropathy in db/db mice...
  10. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
    ..Together, the NLRP3-ASC-caspase-1 axis does not contribute to intrinsic glomerular inflammation via glomerular parenchymal cells as these cannot produce IL-1β during sterile inflammation...
  11. ncbi request reprint CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Immunol 170:5658-66. 2003
    ....
  12. doi request reprint MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice
    Shrikant R Mulay
    Renal Division, Medizinische Klinik and Poliklinik IV, Universitat Munchen, Germany
    Kidney Int 81:1199-211. 2012
    ..Thus, MDM2 links inflammation and epithelial healing during AKI. These additional biological functions need to be regarded when considering MDM2 inhibition therapy...
  13. doi request reprint Podocyte loss involves MDM2-driven mitotic catastrophe
    Shrikant R Mulay
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat, Munchen, Germany
    J Pathol 230:322-35. 2013
    ..MDM2 blockade with nutlin-3a could be a novel therapeutic strategy to prevent renal inflammation, podocyte loss, glomerulosclerosis, proteinuria, and progressive kidney disease...
  14. doi request reprint Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice
    Julia Lichtnekert
    Nephrologisches Zentrum, Medizinische Poliklinik, Campus Innenstadt, Klinikum der Universität München LMU, 80336 Munchen, Germany
    J Immunol 187:3413-21. 2011
    ..These results implicate that recombinant activated protein C might be useful for the treatment of human SLE...
  15. pmc Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease
    Murthy N Darisipudi
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Pathol 179:116-24. 2011
    ....
  16. pmc Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus
    Maciej Lech
    Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e20118. 2011
    ..Vice versa, loss-of-function mutations in the Ptx3 gene might represent a genetic risk factor for pulmonary (but not renal) manifestations of systemic lupus or other autoimmune diseases...
  17. pmc Mdm2 promotes systemic lupus erythematosus and lupus nephritis
    Ramanjaneyulu Allam
    Medizinische Poliklinik, Universitat Munchen, Pettenkoferstraße 8a, D 80336 MUnchen, Germany
    J Am Soc Nephrol 22:2016-27. 2011
    ..Antagonizing Mdm2 may have therapeutic potential in lupus nephritis...
  18. ncbi request reprint Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    Prashant S Patole
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Am Soc Nephrol 16:1326-38. 2005
    ..g., glomerular mesangial cells, to produce cytokines and chemokines, factors that can aggravate autoimmune tissue injury, e.g., lupus nephritis...
  19. pmc IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production
    Maciej Lech
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 22:1443-52. 2011
    ..Because these adaptive immune effectors are essential for the evolution of lupus nephritis, we conclude that IRF4 promotes the development of lupus nephritis despite suppressing antigen-presenting cells...
  20. doi request reprint Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus
    Maciej Lech
    Medizinische Poliklinik, Campus Innenstadt, Klinikum der Universität München LMU, Germany
    Ann Rheum Dis 70:2207-17. 2011
    ..Interleukin-1 receptor-associated kinase (IRAK)-M suppresses Toll-like receptor (TLR)-mediated activation of innate immunity during infection. A similar role was hypothesised for IRAK-M in autoimmunity...
  21. ncbi request reprint Microbial nucleic acids pay a Toll in kidney disease
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Physiol Renal Physiol 291:F509-16. 2006
    ..In this review, we summarize recent advances in this field and discuss new hypotheses for the pathogenesis of kidney diseases that are triggered by infectious organisms...
  22. ncbi request reprint Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice
    Prashant S Patole
    Nephrological Center, Medizinische Poliklinik, Universitat Munchen, Pettenkoferstr 8a 80336 München, Germany
    Nephrol Dial Transplant 21:3062-73. 2006
    ..Toll-like receptors (TLRs) may be involved in this phenomenon, because TLRs have potent immunostimulatory functions when exposed to selected pathogen-associated molecules...
  23. ncbi request reprint Chemokine receptor CCR1: a new target for progressive kidney disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University of Munich, Germany
    Am J Nephrol 25:365-72. 2005
    ..Identification of new targets may add to the therapeutic options in chronic kidney disease...
  24. ncbi request reprint Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice
    Onkar Kulkarni
    Nephrological Center, Ludwig Maximilians University, 80336 Munich, Germany
    J Am Soc Nephrol 18:2350-8. 2007
    ..Thus, mNOX-E36-based inhibition of CCL2 represents a novel strategy for the treatment of autoimmune tissue injury, such as lupus nephritis...
  25. doi request reprint The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration
    Adriana Migliorini
    Nephrological Center, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München Ludwig Maximilian University, Campus Innenstadt, Munich, Germany
    Am J Pathol 183:431-40. 2013
    ....
  26. ncbi request reprint Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    Rahul D Pawar
    Medizinische Poliklinik, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 18:1721-31. 2007
    ..Hence, TLR-7 is proposed as a novel and potential therapeutic target in systemic lupus erythematosus...
  27. pmc Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Pathol 172:628-37. 2008
    ....
  28. pmc The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
    Volha Ninichuk
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Am J Pathol 170:1267-76. 2007
    ..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...
  29. doi request reprint Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis
    Maciej Lech
    Medizinische Poliklinik, University of Munich, Germany
    J Pathol 220:596-607. 2010
    ..Thus, TIR8/SIGIRR protects from hydrocarbon oil-induced lupus by suppressing the TLR7-mediated activation of dendritic cells, via its intracellular BB loop...
  30. doi request reprint Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor-α-mediated podocyte loss
    Mi Ryu
    Nephrologisches Zentrum, Medizinische Poliklinik der LMU, University of München, Munchen, Germany
    Kidney Int 79:189-98. 2011
    ..Hence, factors that modulate the phenotype of renal macrophages can affect the progression of Alport nephropathy and, potentially, other types of chronic kidney diseases...
  31. doi request reprint An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
    Sufyan G Sayyed
    Nephrologisches Zentrum, Medizinische Poliklinik, University of Munich, Germany
    Kidney Int 80:68-78. 2011
    ..This successful pre-clinical trial suggests that this antagonist may now be ready for testing in humans with the nephropathy of diabetes mellitus...
  32. doi request reprint Pseudoviral immunity - a novel concept for lupus
    Hans Joachim Anders
    Medizinische Poliklinik, University of Munich, Pettenkoferstr 8a, 80336 Munich, Germany
    Trends Mol Med 15:553-61. 2009
    ..Therefore, self nucleic acid-driven 'pseudoviral' immunity is evolving as another concept in understanding the pathogenesis of lupus and may offer novel targets for therapy...
  33. doi request reprint Interferon-alpha and -beta in kidney inflammation
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    Kidney Int 77:848-54. 2010
    ..Finally, we propose areas of research that may help unravel the roles of type I interferons and interferon-related genes in the renal field...
  34. doi request reprint Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice
    Onkar Kulkarni
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Pharmacol Exp Ther 328:371-7. 2009
    ..We propose anti-Ccl2 Spiegelmer therapy as a novel strategy to reduce CYC toxicity in the treatment of severe lupus...
  35. ncbi request reprint Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
    ..Therefore, CCR1 is a promising target for therapeutic intervention in leukocyte-mediated fibrotic tissue injury, e.g. progressive renal fibrosis...
  36. doi request reprint Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif
    Julia Lichtnekert
    Medizinische Poliklinik, Klinikum der Universität Innenstadt, Pettenkoferstr 8a, 80336 Munich, Germany
    Am J Physiol Renal Physiol 296:F867-74. 2009
    ..We therefore conclude that apoptotic cell RNA is a poor activator of Trif signaling in mesangial cells and that necrotic cells' releases rather activate mesangial cells via the Tlr2/Myd88 signaling pathway...
  37. ncbi request reprint Current paradigms about chemokines as therapeutic targets
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    Nephrol Dial Transplant 19:2948-51. 2004
  38. pmc Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokines
    Volker Vielhauer
    Medizinische Poliklinik, Campus Innenstadt, Ludwig Maximilians University Munich, Munich, Germany
    Am J Pathol 175:119-31. 2009
    ....
  39. pmc Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome
    Murthy Narayana Darisipudi
    Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e19588. 2011
    ..We conclude that beyond their effects on fungal growth, these antifungal drugs directly activate the host's innate immunity...
  40. doi request reprint Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice
    Maciej Lech
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Int Immunol 22:717-28. 2010
    ..These data suggest that the cell-type-, organ- and species-specific expression and regulation need to be considered in the design and interpretation of related studies...
  41. ncbi request reprint Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure
    Saraswati Lassen
    Medizinische Poliklinik, Universitat Munchen, Munchen, Germany
    J Immunol 185:1976-83. 2010
    ....
  42. ncbi request reprint Chemokines in lupus nephritis
    Onkar Kulkarni
    Department of Nephrology, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Munich, Germany
    Front Biosci 13:3312-20. 2008
    ..In this review we summarise the available experimental and human data on the expression and functional role of chemokines and chemokine receptors in lupus nephritis...
  43. ncbi request reprint Signaling danger: toll-like receptors and their potential roles in kidney disease
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universität München Junenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:854-67. 2004
    ..Here the authors provide an overview on the biology of TLR, summarize the present data on their expression in the kidney, and provide an outlook for the potential roles of TLR in kidney disease...
  44. ncbi request reprint Toll-like receptors: emerging concepts in kidney disease
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Curr Opin Nephrol Hypertens 16:177-83. 2007
    ..To summarize the recent advances in the role of Toll-like receptors (TLRs) in innate immunity, with a special focus on recent studies addressing the expression and function of TLRs in kidney disease...
  45. ncbi request reprint Functional consequences of integrin-linked kinase activation in podocyte damage
    Vicente de Paulo Castro Teixeira
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    Kidney Int 67:514-23. 2005
    ..The aim of this study was to elucidate the molecular mechanisms of ILK dependant phenotype regulation in podocytes...
  46. ncbi request reprint Targeting the chemokine network in renal inflammation
    Vaclav Eis
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    Arch Immunol Ther Exp (Warsz) 52:164-72. 2004
    ....
  47. doi request reprint A novel pathogenetic concept-antiviral immunity in lupus nephritis
    Adriana Migliorini
    Department of Nephrology, Medizinische Poliklinik, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Nat Rev Nephrol 8:183-9. 2012
    ..In this article we summarize the available data indicating that innate immunity triggers antiviral immunity in systemic lupus erythematosus. We also discuss the related implications for innovative therapeutic strategies...
  48. pmc Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes
    Anil Bhanudas Gaikwad
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munchen, Germany
    Am J Pathol 176:1079-83. 2010
    ..These data suggest that renal failure alters cardiac histone H3 epigenetics, which foster cardiomyocyte hypertrophy in type 2 diabetes...
  49. doi request reprint The danger control concept in kidney disease: mesangial cells
    Adriana Migliorini
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat, Munchen, Germany
    J Nephrol 26:437-49. 2013
    ..However, these mechanisms often result in maladaptive processes that destroy the complex glomerular ultrastructure rather than help to regain tissue homeostasis...
  50. doi request reprint Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy
    Sebastian Clauss
    Nephrological Center, Medical Policlinic, University of München, Germany
    J Pathol 218:40-7. 2009
    ..We conclude that Ccl2 mediates the recruitment of glomerular and interstitial macrophages but this mechanism does not contribute to the progression of Alport nephropathy in Col4a3-deficient mice...
  51. doi request reprint Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
    Ramanjaneyulu Allam
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    J Immunol 186:2714-8. 2011
    ..All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. Together, certain antibiotics have the potential to directly activate innate immunity of the host...
  52. doi request reprint Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus
    Hans Joachim Anders
    Medizinische Poliklinik, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, Munich, Germany
    Eur J Immunol 38:1795-9. 2008
    ..This finding highlights the need to address the significance of TLR7 in human lupus in terms of both genetic risk and as a therapeutic option...
  53. ncbi request reprint [Chronic kidney disease]
    Hans Joachim Anders
    Nephrologisches Zentrum, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Munchen
    Med Klin (Munich) 100:714-21. 2005
    ..New data from multiple multicenter trials have changed existing treatment guidelines. New drugs have become available. This update provides an overview about new treatment guidelines for patients with chronic kidney disease...
  54. ncbi request reprint Identifying and validating novel targets with in vivo disease models: guidelines for study design
    Hans Joachim Anders
    Medizinische Poliklinik, Universitat Munchen, Pettenkoferstrasse 8a, 80336 Munchen, Germany
    Drug Discov Today 12:446-51. 2007
    ..Altogether, the presentation of target validation studies should meet defined criteria similar to those used in human trials...
  55. pmc Lech, m., et Al., quantitative expression of C-type lectin receptors in humans and mice. Int. J. Mol. Sci. 2012, 13, 10113-10131
    Maciej Lech
    Medical Clinic and Policlinic IV, Nephrological Center, University of Munich, 80336 Munich, Germany
    Int J Mol Sci 13:17294. 2012
    ..e., the galectins. These errors have been amended in an amended version of the manuscript, which is available from the International Journal of Molecular Sciences website. The authors and publisher apologize for the inconvenience. [...]...
  56. pmc Renal co-morbidity in patients with rheumatic diseases
    Hans Joachim Anders
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstraße 8a, 80336 Munchen, Germany
    Arthritis Res Ther 13:222. 2011
    ....
  57. ncbi request reprint Chemokines and chemokine receptors as therapeutic targets in chronic kidney disease
    Volker Vielhauer
    Medizinische Poliklinik, Klinikum der Universitat Munchen, Campus Innenstadt, Ludwig Maximilians University, Pettenkoferstr 8a, 80336 Munich, Germany
    Front Biosci (Schol Ed) 1:1-12. 2009
    ....
  58. pmc Toll-like receptor and accessory molecule mRNA expression in humans and mice as well as in murine autoimmunity, transient inflammation, and progressive fibrosis
    Santhosh Kumar Vankyala Ramaiah
    Medical Clinic and Policlinic IV, Nephrological Center, University of Munich, Munich 80336, Germany
    Int J Mol Sci 14:13213-30. 2013
    ....
  59. doi request reprint B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE)
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Munchen, Germany
    Nephrol Dial Transplant 24:3708-12. 2009
    ..Here, we ask whether serum levels of CXCL13 correlate with disease activity and renal involvement in SLE patients...
  60. pmc Viral RNA and DNA trigger common antiviral responses in mesangial cells
    Ramanjaneyulu Allam
    Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 20:1986-96. 2009
    ..We conclude that 3P-RNA and double-stranded DNA trigger a common, TLR-independent, antiviral response in glomerular mesangial cells, which may promote glomerulonephritis in the setting of viral infection...
  61. ncbi request reprint CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Kidney Int 66:2264-78. 2004
    ..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis...
  62. ncbi request reprint Chemokines and chemokine receptors as therapeutic targets in lupus nephritis
    Volker Vielhauer
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany
    Semin Nephrol 27:81-97. 2007
    ....
  63. ncbi request reprint Chemokines and chemokine receptors are involved in the resolution or progression of renal disease
    Hans Joachim Anders
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Munich, Germany
    Kidney Int 63:401-15. 2003
    ....
  64. ncbi request reprint Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    Prashant S Patole
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Kidney Int 68:2582-7. 2005
    ..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation...
  65. ncbi request reprint Blockade of chemokine-mediated tissue injury in lupus nephritis
    Volker Vielhauer
    Department of Nephrology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Pettenkoferstr 8a, 80336 Munich, Germany
    Endocr Metab Immune Disord Drug Targets 6:313-21. 2006
    ....
  66. ncbi request reprint Expression of the chemokine receptor CCR1 in human renal allografts
    Verena Mayer
    Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Nephrol Dial Transplant 22:1720-9. 2007
    ..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts...
  67. pmc The contribution of B cells to renal interstitial inflammation
    Florian Heller
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Am J Pathol 170:457-68. 2007
    ..CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system...
  68. doi request reprint Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    Emina Savarese
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Arthritis Rheum 58:1107-15. 2008
    ....
  69. ncbi request reprint Bone marrow-derived progenitor cells and renal fibrosis
    Volha Ninichuk
    Medical Policlinic, University of Munich, Germany
    Front Biosci 13:5163-73. 2008
    ..However, in the process of tissue fibrosis the contribution of either cell type is less clear. Here we discuss current concepts on how different bone marrow-derived progenitor cell populations may contribute to renal fibrosis...
  70. pmc Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
    Maciej Lech
    Medical Policlinic, University of Munich, 80336 Munich, Germany
    J Exp Med 205:1879-88. 2008
    ..These data identify Sigirr as a novel SLE susceptibility gene in mice...
  71. ncbi request reprint Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue
    Christoph A Reichel
    Institute for Surgical Research, Arbeitsgruppe Klinische Biochemie, University of Munich, Germany
    J Leukoc Biol 79:114-22. 2006
    ..In conclusion, these in vivo data demonstrate that Ccr1, Ccr2, and Ccr5 mediate the postischemic recruitment of neutrophils through effects on intravascular adherence and subsequent transmigration...