Markus Knuf

Summary

Affiliation: Klinik Innere Medizin IV
Country: Germany

Publications

  1. pmc The burden of seasonal and pandemic influenza in infants and children
    Bernhard R Ruf
    Division of Infectious Diseases and Tropical Medicine, Klinikum Sankt Georg Leipzig, Leipzig, Germany
    Eur J Pediatr 173:265-76. 2014
  2. pmc Immunogenicity and safety of the quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine (MenACWY-TT) in 2-10-year-old children: results of an open, randomised, controlled study
    Markus Knuf
    Childrens Hospital, Dr Horst Schmidt Clinic, Ludwig Erhard Straße 100, 65199 Wiesbaden, Germany
    Eur J Pediatr 172:601-12. 2013
  3. doi request reprint Antibody persistence for 3 years following two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Children s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Pediatr 171:463-70. 2012
  4. doi request reprint Induction of immunologic memory following primary vaccination with the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine in infants
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg Universitat Mainz, University Medicine Mainz, Mainz, Germany
    Pediatr Infect Dis J 31:e31-6. 2012
  5. doi request reprint Comparative effects of carrier proteins on vaccine-induced immune response
    Markus Knuf
    Children s Hospital, Dr Horst Schmidt Klinik, Ludwig Erhard Strasse 100, 65199 Wiesbaden, Germany
    Vaccine 29:4881-90. 2011
  6. doi request reprint An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered with Infanrix™ hexa is immunogenic, with an acceptable safety profile in 12-23-month-old children
    Markus Knuf
    Pediatrics Infectious Diseases, University Medicine, Mainz, Germany
    Vaccine 29:4264-73. 2011
  7. doi request reprint Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles-mumps-rubella-varicella vaccine to children aged 11-21 months
    Markus Knuf
    Children s Hospital, Dr Horst Schmidt Klinik, Ludwig Erhard Str 100, Wiesbaden 65199, Germany
    Eur J Pediatr 169:925-33. 2010
  8. doi request reprint Immunogenicity of routinely used childhood vaccines when coadministered with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV)
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Pediatr Infect Dis J 28:S97-S108. 2009
  9. ncbi request reprint Immunogenicity of reduced antigen content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine
    Fred Zepp
    Children s Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 25:5248-52. 2007
  10. ncbi request reprint Immunogenicity and safety of two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Childrens Hospital, Johannes Gutenberg University Hospital, Mainz, Germany
    Pediatr Infect Dis J 25:12-8. 2006

Collaborators

Detail Information

Publications31

  1. pmc The burden of seasonal and pandemic influenza in infants and children
    Bernhard R Ruf
    Division of Infectious Diseases and Tropical Medicine, Klinikum Sankt Georg Leipzig, Leipzig, Germany
    Eur J Pediatr 173:265-76. 2014
    ..Studies in children confirm that vaccination reduces the incidence of seasonal influenza and the associated burden, underlining the importance of targeting this group in national immunisation policies...
  2. pmc Immunogenicity and safety of the quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine (MenACWY-TT) in 2-10-year-old children: results of an open, randomised, controlled study
    Markus Knuf
    Childrens Hospital, Dr Horst Schmidt Clinic, Ludwig Erhard Straße 100, 65199 Wiesbaden, Germany
    Eur J Pediatr 172:601-12. 2013
    ..This study has been registered at www.clinicaltrials.gov NCT00674583...
  3. doi request reprint Antibody persistence for 3 years following two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Children s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Pediatr 171:463-70. 2012
    ..After 3 years, the cumulative varicella breakthrough disease rate was 0.7% (two cases) in the MMRV group and 5.4% (five cases) in the MMR + V group...
  4. doi request reprint Induction of immunologic memory following primary vaccination with the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine in infants
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg Universitat Mainz, University Medicine Mainz, Mainz, Germany
    Pediatr Infect Dis J 31:e31-6. 2012
    ..Induction of immunologic memory was assessed following primary vaccination with 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV)...
  5. doi request reprint Comparative effects of carrier proteins on vaccine-induced immune response
    Markus Knuf
    Children s Hospital, Dr Horst Schmidt Klinik, Ludwig Erhard Strasse 100, 65199 Wiesbaden, Germany
    Vaccine 29:4881-90. 2011
    ..Clinical studies on the coadministration of conjugate vaccines reveal conflicting data with respect to immune interference and vaccine efficacy...
  6. doi request reprint An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered with Infanrix™ hexa is immunogenic, with an acceptable safety profile in 12-23-month-old children
    Markus Knuf
    Pediatrics Infectious Diseases, University Medicine, Mainz, Germany
    Vaccine 29:4264-73. 2011
    ..ACWY-TT and DTaP-HBV-IPV/Hib co-administration during the second year would facilitate introduction of ACWY-TT into routine toddler vaccination schedules...
  7. doi request reprint Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles-mumps-rubella-varicella vaccine to children aged 11-21 months
    Markus Knuf
    Children s Hospital, Dr Horst Schmidt Klinik, Ludwig Erhard Str 100, Wiesbaden 65199, Germany
    Eur J Pediatr 169:925-33. 2010
    ..In summary, the MMRV vaccine is well tolerated and highly immunogenic when administered either subcutaneously or intramuscularly to children in the second year of life...
  8. doi request reprint Immunogenicity of routinely used childhood vaccines when coadministered with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV)
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Pediatr Infect Dis J 28:S97-S108. 2009
    ....
  9. ncbi request reprint Immunogenicity of reduced antigen content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine
    Fred Zepp
    Children s Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 25:5248-52. 2007
    ..After the sixth dose booster, Tdap induced a vigorous immune response, consistent with protection against diphtheria, tetanus and pertussis diseases...
  10. ncbi request reprint Immunogenicity and safety of two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Childrens Hospital, Johannes Gutenberg University Hospital, Mainz, Germany
    Pediatr Infect Dis J 25:12-8. 2006
    ....
  11. doi request reprint Booster vaccination after neonatal priming with acellular pertussis vaccine
    Markus Knuf
    Department of Pediatrics, Johannes Gutenberg University, Mainz, Germany
    J Pediatr 156:675-8. 2010
    ..Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses...
  12. doi request reprint Two versus three doses of a meningococcal C conjugate vaccine concomitantly administered with a hexavalent DTaP-IPV-HBV/Hib vaccine in healthy infants
    Heinz J Schmitt
    Zentrum für Präventive Pädiatrie, Kinderklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrabe 1, 55131 Mainz, Germany
    Vaccine 26:2242-52. 2008
    ..Reactogenicity was similar in each group. MenC conjugate vaccine given concomitantly with DTaP-IPV-HBV/Hib to healthy infants in the first year of life using a two-dose schedule is as safe and immunogenic as a three-dose regimen...
  13. ncbi request reprint A combination vaccine against measles, mumps, rubella and varicella
    Markus Knuf
    Pediatric University Hospital, Johannes Gutenberg University, Mainz, Germany
    Drugs Today (Barc) 44:279-92. 2008
    ..For other countries considering introducing these vaccines, the advantages for children, parents and healthcare providers of protecting against four diseases in a single vaccine should be noted...
  14. doi request reprint A toll-like receptor 4 variant is associated with fatal outcome in children with invasive meningococcal disease
    Joerg Faber
    Children s Hospital, University of Mainz, Mainz, Germany
    Acta Paediatr 98:548-52. 2009
    ..Here, we analysed a possible association between the TLR4 variant Asp299Gly and disease outcome in children with invasive meningococcal disease...
  15. ncbi request reprint Age-dependent association of human mannose-binding lectin mutations with susceptibility to invasive meningococcal disease in childhood
    Joerg Faber
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Pediatr Infect Dis J 26:243-6. 2007
    ..Mannose-binding lectin (MBL) is an important factor of the innate immune system, and MBL-initiated complement activation is an important early defense mechanism against various bacterial infections, including invasive meningococcal disease...
  16. ncbi request reprint Immunogenicity and reactogenicity of acellular pertussis booster vaccines in children: standard pediatric versus a reduced-antigen content formulation
    Claudius U Meyer
    Pediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    Hum Vaccin 4:203-9. 2008
    ..Non-significant trends toward reduced reactogenicity of dTpa were observed. Many factors influence vaccine choice at preschool age. The dTpa vaccine was as immunogenic and possibly better tolerated than DTPa at this age...
  17. doi request reprint Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants
    Markus Knuf
    Paediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pediatr 152:655-60, 660.e1. 2008
    ..Because young infants are at highest risk of pertussis complications, this study assessed whether neonatal acellular pertussis (aP) vaccination could provide earlier immunity...
  18. pmc Antibody persistence and immune memory 15 months after priming with an investigational tetravalent meningococcal tetanus toxoid conjugate vaccine (MenACWY-TT) in toddlers and young children
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg University, Mainz, Germany
    Hum Vaccin Immunother 8:866-72. 2012
    ..Thus, a single dose of MenACWY-TT induced persisting antibodies in toddlers and children and immune memory in toddlers. This study has been registered at www.clinicaltrials.gov NCT00126984...
  19. pmc Immunogenicity, reactogenicity, and immune memory after primary vaccination with a novel Haemophilus influenzae-Neisseria meningitidis serogroup C conjugate vaccine
    Heinz J Schmitt
    Johannes Gutenberg Universitat, Langenbeckstr 1, 55101 Mainz, Germany
    Clin Vaccine Immunol 14:426-34. 2007
    ..A Hib-MenC-TT conjugate vaccine provides vaccination against two major pathogens in a single injection and is a suitable candidate for use in primary or booster vaccination schedules...
  20. ncbi request reprint Safety of reduced-antigen-content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine
    Fred Zepp
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    J Pediatr 149:603-610. 2006
    ..The safety of a booster dose of a reduced-antigen-content tetanus-diphtheria-acellular pertussis (Tdap) vaccine was evaluated in adolescents previously vaccinated with five doses of acellular pertussis-containing vaccine...
  21. ncbi request reprint Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
    Joerg Faber
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Pediatr Infect Dis J 25:80-1. 2006
    ..007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group...
  22. ncbi request reprint Repeated administration of a reduced-antigen-content diphtheria-tetanus-acellular pertussis and poliomyelitis vaccine (dTpa-IPV; Boostrix™ IPV)
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Universitatsmedizin, Rheinland Pfalz, Germany
    Hum Vaccin 6:554-61. 2010
    ..Repeated administration of a dTpa-IPV (dTpa-inactivated poliomyelitis; BoostrixTM Polio, GlaxoSmithKline)booster to adolescents, 5 years after their previous dose was evaluated...
  23. ncbi request reprint Linking C5 deficiency to an exonic splicing enhancer mutation
    Nicole Pfarr
    Children s Hospital of Johannes Gutenberg University of Mainz, Mainz, Germany
    J Immunol 174:4172-7. 2005
    ..This apparently inconsequential sequence alteration represents a noncanonical splicing mutation altering an ESE. Our finding sheds a new light on the role of putative silent/conservative mutations in disease-associated genes...
  24. doi request reprint Rapid detection of common pathogenic Aspergillus species by a novel real-time PCR approach
    Joerg Faber
    Children s Hospital, University of Mainz, Mainz, Germany
    Mycoses 52:228-33. 2009
    ..We describe a highly specific and sensitive real-time PCR approach to detect and differentiate the most common pathogenic Aspergillus species in a rapid 'same day' assay...
  25. ncbi request reprint Late results after PTCA for coronary stenosis after the arterial switch procedure for transposition of the great arteries
    Christoph Kampmann
    Division of Pediatric Cardiology, Hospital for Sick Children, Mainz, Germany
    Ann Thorac Surg 80:1641-6. 2005
    ..Late results after percutaneous transluminal coronary angioplasty (PTCA) for coronary stenosis after the arterial switch operation for d-transposition of the great arteries are reported...
  26. ncbi request reprint Tolerability of the Biken acellular pertussis vaccine in adults with or without previous vaccination against pertussis in childhood
    Markus Knuf
    Pediatric Immunology and Infectious Diseases, Center of Preventive Pediatrics, Johannes Gutenberg University, Mainz, Germany
    Med Klin (Munich) 99:495-9. 2004
    ..The results from this study were compared to data from published literature...
  27. ncbi request reprint Significance of patient categorization for perioperative management of children with tetralogy of Fallot, with special regard to co-existing malformations
    Markus Knuf
    University of Mainz, Children s Hospital, Mainz, Germany
    Cardiol J 17:20-8. 2010
    ..The aim of our study was to facilitate perioperative calculation of potential risk factors on the outcome of corrective surgery for children with tetralogy of Fallot...
  28. pmc Efficient maturation and cytokine production of neonatal DCs requires combined proinflammatory signals
    Doreen Krumbiegel
    Department of Pediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University, 55131 Mainz, Germany
    Clin Dev Immunol 12:99-105. 2005
    ..In conclusion, neonatal DCs can be stimulated to express maturation as well as costimulatory surface molecules. However, induction of maturation requires combined stimulation with multiple proinflammatory signals...
  29. doi request reprint Detection of respiratory viral infections in neonates treated for suspicion of nosocomial bacterial sepsis: a feasibility study
    Andre Kidszun
    From the Department of Neonatology Department of Paediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz Children s Hospital, Dr Horst Schmidt Klinik, Wiesbaden and Institute for Virology, University Medical Center of the Johannes Gutenberg University Mainz, Hochhaus am Augustusplatz, Mainz, Germany
    Pediatr Infect Dis J 33:102-4. 2014
    ..Respiratory viral infections were detected in 10% of these cases. This was comparable with the frequency of a blood-culture-proven sepsis. ..
  30. ncbi request reprint Changes in lymphocyte subsets after cardiac surgery in children
    Pirmin Habermehl
    Department of Paediatrics, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Pediatr 162:15-21. 2003
    ..In contrast, the proportion of T-cells expressing activation markers (CD25, CD45R0) decreased within 24 h after CPB, as did the number of cells expressing adhesion molecules (CD11b and ICAM)...
  31. doi request reprint Are meteorological parameters associated with acute respiratory tract infections?
    Jean Baptist du Prel
    Kinderklinik, Paediatrische Infektiologie and Zentrum Praeventive Paediatrie, Universitaetsmedizin, Johannes Gutenberg Universitaet, Mainz, Germany
    Clin Infect Dis 49:861-8. 2009
    ..Aiming at better predictions of the seasonal activity of ARI pathogens, we investigated the influence of climate on hospitalizations for ARIs...