Alexa Klettner

Summary

Country: Germany

Publications

  1. ncbi request reprint The induction of heat shock proteins as a potential strategy to treat neurodegenerative disorders
    Alexa Klettner
    Universitatsklinikum Schleswig Holstein, Campus Kiel, Institute of Pharmacology, Kiel, Germany
    Drug News Perspect 17:299-306. 2004
  2. doi request reprint Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases
    Alexa Klettner
    Department of Ophthalmology, UKS H, Campus Kiel, Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1487-92. 2009
  3. doi request reprint VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione
    Yoko Miura
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 51:4848-55. 2010
  4. doi request reprint Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture
    Yoko Miura
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Ophthalmic Res 43:122-33. 2010
  5. doi request reprint Toll-like receptor 3 activation in retinal pigment epithelium cells - Mitogen-activated protein kinase pathways of cell death and vascular endothelial growth factor secretion
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Acta Ophthalmol 91:e211-8. 2013
  6. pmc Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway
    Alexa Klettner
    University of Kiel, University Medical Center, Department of Ophthalmology, Kiel, Germany
    Mol Vis 19:281-91. 2013
  7. ncbi request reprint Compatibility of recombinant tissue plasminogen activator and bevacizumab co-applied for neovascular age-related macular degeneration with submacular hemorrhage
    Alexa Klettner
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Arch Ophthalmol 130:875-881. 2012
  8. ncbi request reprint JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine
    Sevgi Eminel
    Institute of Pharmacology, Schleswig Holstein University Medical Center, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    J Biol Chem 279:55385-92. 2004
  9. ncbi request reprint FK506 and its analogs - therapeutic potential for neurological disorders
    Alexa Klettner
    Institute of Pharmacology, Christian Albrechts University, Kiel, Germany
    Curr Drug Targets CNS Neurol Disord 2:153-62. 2003
  10. doi request reprint Intracellular bevacizumab reduces phagocytotic uptake in RPE cells
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Arnold Heller Str 3, Haus 25, 24105, Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 248:819-24. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The induction of heat shock proteins as a potential strategy to treat neurodegenerative disorders
    Alexa Klettner
    Universitatsklinikum Schleswig Holstein, Campus Kiel, Institute of Pharmacology, Kiel, Germany
    Drug News Perspect 17:299-306. 2004
    ..Furthermore, recent data hint toward a protective role of Hsps in chronic neurological diseases. The induction of Hsps as a possible treatment for stroke, Alzheimer's disease and Huntington's disease is discussed...
  2. doi request reprint Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases
    Alexa Klettner
    Department of Ophthalmology, UKS H, Campus Kiel, Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1487-92. 2009
    ..Here, we focused on the influence of different mitogen-activated protein kinase (MAPK) (p38, Erk, JNK) on the secretion and expression of VEGF, with or without being challenged by oxidative stress...
  3. doi request reprint VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione
    Yoko Miura
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 51:4848-55. 2010
    ..To investigate the influence of VEGF antagonists on the barrier function of the retinal pigment epithelium and underlying mechanisms...
  4. doi request reprint Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture
    Yoko Miura
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Ophthalmic Res 43:122-33. 2010
    ..To evaluate the changes of morphological and functional characteristics of the retinal pigment epithelium (RPE)-choroid perfusion culture during cultivation...
  5. doi request reprint Toll-like receptor 3 activation in retinal pigment epithelium cells - Mitogen-activated protein kinase pathways of cell death and vascular endothelial growth factor secretion
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Acta Ophthalmol 91:e211-8. 2013
    ..The current study was conducted to elucidate the underlying pathways of TLR3 effects in the RPE...
  6. pmc Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway
    Alexa Klettner
    University of Kiel, University Medical Center, Department of Ophthalmology, Kiel, Germany
    Mol Vis 19:281-91. 2013
    ..Accordingly, the VEGF is constitutively expressed in RPE. In this study, the regulation of constitutive VEGF expression was investigated in an RPE/choroid organ culture...
  7. ncbi request reprint Compatibility of recombinant tissue plasminogen activator and bevacizumab co-applied for neovascular age-related macular degeneration with submacular hemorrhage
    Alexa Klettner
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Arch Ophthalmol 130:875-881. 2012
    ..To investigate the compatibility of recombinant tissue plasminogen activator (rtPA) and bevacizumab in vitro because during surgery, rtPA or rtPA-induced plasmin may cleave and inactivate bevacizumab...
  8. ncbi request reprint JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine
    Sevgi Eminel
    Institute of Pharmacology, Schleswig Holstein University Medical Center, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    J Biol Chem 279:55385-92. 2004
    ..Our data provide novel functional insights into the pathological role of individual JNK isoforms, the signalosome at the mitochondria, and the mode of JNK-induced release of cytochrome c...
  9. ncbi request reprint FK506 and its analogs - therapeutic potential for neurological disorders
    Alexa Klettner
    Institute of Pharmacology, Christian Albrechts University, Kiel, Germany
    Curr Drug Targets CNS Neurol Disord 2:153-62. 2003
    ..The induction of the heat shock response by immunophilin ligands might prove to be an interesting target for neuroregeneration and neuroprotection...
  10. doi request reprint Intracellular bevacizumab reduces phagocytotic uptake in RPE cells
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Arnold Heller Str 3, Haus 25, 24105, Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 248:819-24. 2010
    ..We have previously shown that bevacizumab, but not ranibizumab, is taken up by porcine RPE cells. In this study, the effects of bevacizumab and ranibizumab on proliferation, wound healing and phagocytosis of the RPE were investigated...
  11. doi request reprint Experimental microablation of choroidal tissue for autologous retinal pigment epithelium-choroid translocation with the pulsed electron avalanche knife (PEAK-fc)
    Felix Treumer
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Arnold Heller Strasse 3, Kiel, Germany
    Br J Ophthalmol 94:1378-81. 2010
    ..To test the microablation of excess graft choroidal tissue with the pulsed electron avalanche knife (PEAK-fc) in an in-vitro model of autologous retinal pigment epithelium (RPE)-choroid translocation...
  12. doi request reprint Quantifying FITC-labeled latex beads opsonized with photoreceptor outer segment fragments: an easy and inexpensive method of investigating phagocytosis in retinal pigment epithelium cells
    Alexa Klettner
    Department of Ophthalmology, University Medical Center, University of Kiel, Kiel, Germany
    Ophthalmic Res 46:88-91. 2011
    ..Moreover, in order to conduct these phagocytosis experiments, as laboratory equipment, in addition to cell culture equipment, only a centrifuge and a simple fluorescence microscope are needed...
  13. doi request reprint Multilayered Gore-Tex patch for temporary coverage of deep noninfectious corneal defects: surgical procedure and clinical experience
    Florian Rüfer
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Kiel, Germany
    Am J Ophthalmol 151:703-713.e2. 2011
    ..To evaluate the multilayer Gore-Tex patch as temporary coverage of deep, noninfectious corneal defects...
  14. doi request reprint Safety testing of indocyanine green with different surgical light sources and the protective effect of optical filters
    Jost Hillenkamp
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Kiel, Germany
    Retina 30:1685-91. 2010
    ..The purpose of this study was to assess the light-induced cytotoxicity of indocyanine green (ICG) using different light sources commonly used in macular surgery and to assess the effect of optical filters...
  15. doi request reprint Influence of alcohol consumption on incidence and severity of open-globe eye injuries in adults
    Florian Rüfer
    Department of Ophthalmology, University Hospital of Schleswig Holstein, Arnold Heller Str 3, Haus 25, 24105, Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1765-70. 2011
    ..To investigate the influence of alcohol consumption on the occurrence of open-globe injuries in adults...
  16. ncbi request reprint Comparison of the influence of aerobic and resistance exercise of the upper and lower limb on intraocular pressure
    Florian Rüfer
    Department of Ophthalmology, Christian Albrechts University, Kiel, GermanyDepartment of Sports Medicine, Christian Albrechts University, Kiel, GermanyEye Department, Technical University, Munich, Germany
    Acta Ophthalmol 92:249-52. 2014
    ..To compare the influence of aerobic and resistance exercise on intraocular pressure (IOP)...
  17. doi request reprint Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization
    Alexa Klettner
    Department of Ophthalmology, University Medical Center Schleswig Holstein, Kiel, Germany
    Int J Biochem Cell Biol 45:1457-67. 2013
    ..g. release of vascular endothelial growth factor (VEGF), causing choroidal neovascularization e.g. in wet AMD. This review ties together these crucial pathological threads in AMD...
  18. pmc The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
    Alexa Klettner
    Christian Albrechts University of Kiel, Institute of Pharmacology, Hospitalstrasse 4, 24105 Kiel, Germany
    Br J Pharmacol 138:1004-12. 2003
    ..The identification of the underlying signal transduction from application of immunophilin ligands to the expression of heat shock proteins represents a novel target cascade for neuroprotection...
  19. pmc Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro
    Michaela Dithmer
    University of Kiel, University Medical Center, Department of Ophthalmology, Kiel, Germany
    PLoS ONE 9:e89150. 2014
    ..In conclusion, fucoidan is a non-toxic agent that reduces VEGF expression and angiogenesis in vitro and may be of interest for further studies as a potential therapy against exudative age-related macular degeneration. ..
  20. ncbi request reprint Oxidative stress induced cellular signaling in RPE cells
    Alexa Klettner
    University of Kiel, University Medical Center, Department of Ophthalmology, Kiel, Germany
    Front Biosci (Schol Ed) 4:392-411. 2012
    ..In addition to signaling deciding cell fate, first insights in inflammatory and extracellular matrix-altering signaling are emerging...
  21. doi request reprint Isolation of porcine monocyte population: a simple and efficient method
    Christin Berg
    University Medical Center, Department of Ophthalmology, University of Kiel, Germany
    Vet Res Commun 37:239-41. 2013
    ..6 % (± 3.06 %). With this procedure, we established a reliable method to prepare and cultivate porcine monocytes which can be performed cost effectively and does not require special equipment...
  22. doi request reprint Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 49:4523-7. 2008
    ..In this study, the authors compare these VEGF inhibitors directly regarding their efficiency to neutralize VEGF in a quantifiable in vitro system...