Andrea Kleindienst

Summary

Country: Germany

Publications

  1. ncbi request reprint A critical analysis of the role of the neurotrophic protein S100B in acute brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Georg August University, Gottingen, Germany
    J Neurotrauma 23:1185-200. 2006
  2. ncbi request reprint Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Neurotrauma 22:645-55. 2005
  3. ncbi request reprint Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat
    Andrea Kleindienst
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 21:541-7. 2004
  4. pmc The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat
    Giovanna Fazzina
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:453-61. 2010
  5. doi request reprint The role of vasopressin V1A receptors in cytotoxic brain edema formation following brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Virginia Commonwealth University, 1101 E Marshall St, 23298, Richmond, VA, USA
    Acta Neurochir (Wien) 155:151-64. 2013
  6. ncbi request reprint Assessment of cerebral S100B levels by proton magnetic resonance spectroscopy after lateral fluid-percussion injury in the rat
    Andrea Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurosurg 102:1115-21. 2005
  7. ncbi request reprint S100B protein is released by in vitro trauma and reduces delayed neuronal injury
    Karen A Willoughby
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Neurochem 91:1284-91. 2004
  8. doi request reprint Brain-derived protein concentrations in the cerebrospinal fluid: contribution of trauma resulting from ventricular drain insertion
    Sebastian Brandner
    Department of Neurosurgery, University of Erlangen Nurnberg, Germany
    J Neurotrauma 30:1205-10. 2013
  9. doi request reprint The atrial natriuretic peptide does not serve osmoregulation but predicts outcome following brain injury
    Andrea Kleindienst
    Department of Neurosurgery, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 114:277-81. 2012
  10. ncbi request reprint The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications
    Andrea Kleindienst
    Department of Neurosurgery, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Prog Brain Res 161:317-25. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint A critical analysis of the role of the neurotrophic protein S100B in acute brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Georg August University, Gottingen, Germany
    J Neurotrauma 23:1185-200. 2006
    ....
  2. ncbi request reprint Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Neurotrauma 22:645-55. 2005
    ..These observations provide compelling evidence for the therapeutic potential of S100B in improving functional recovery following TBI...
  3. ncbi request reprint Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat
    Andrea Kleindienst
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 21:541-7. 2004
    ..The exact mechanism by which S100B exerts its neuroprotective or neurotrophic influence remains unknown and needs to be elucidated by further investigation...
  4. pmc The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat
    Giovanna Fazzina
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:453-61. 2010
    ..021). A downregulation of AQP4 in the ischemic area paralleling the reduction in brain edema formation following PMA treatment suggests that the effect was mediated by AQP4 modulation...
  5. doi request reprint The role of vasopressin V1A receptors in cytotoxic brain edema formation following brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Virginia Commonwealth University, 1101 E Marshall St, 23298, Richmond, VA, USA
    Acta Neurochir (Wien) 155:151-64. 2013
    ..The present study was designed to quantify the V(1A) receptor mediated regional brain edema formation in two clinically relevant experimental models, brain injury combined with secondary insult and focal ischemia...
  6. ncbi request reprint Assessment of cerebral S100B levels by proton magnetic resonance spectroscopy after lateral fluid-percussion injury in the rat
    Andrea Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurosurg 102:1115-21. 2005
    ..Given that no data exist about the temporal profile of cerebral S100B levels following TBI and their correlation to serum levels, the authors examined whether proton magnetic resonance (MR) spectroscopy is capable of measuring S100B...
  7. ncbi request reprint S100B protein is released by in vitro trauma and reduces delayed neuronal injury
    Karen A Willoughby
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Neurochem 91:1284-91. 2004
    ....
  8. doi request reprint Brain-derived protein concentrations in the cerebrospinal fluid: contribution of trauma resulting from ventricular drain insertion
    Sebastian Brandner
    Department of Neurosurgery, University of Erlangen Nurnberg, Germany
    J Neurotrauma 30:1205-10. 2013
    ..Thus, the tampering of brain-derived protein concentrations in the CSF by diagnostic or therapeutic procedures has to be considered in the interpretation of neuromarker levels...
  9. doi request reprint The atrial natriuretic peptide does not serve osmoregulation but predicts outcome following brain injury
    Andrea Kleindienst
    Department of Neurosurgery, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 114:277-81. 2012
    ..e., high cortisol (p = 0.05) and prolactin (p < 0.001) levels. We conclude that MR-proANP measurements reveal a significant predictive function for the prognosis of TBI...
  10. ncbi request reprint The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications
    Andrea Kleindienst
    Department of Neurosurgery, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Prog Brain Res 161:317-25. 2007
    ..Finally, we report recent experimental findings suggesting a possible therapeutic potential of S100B...
  11. ncbi request reprint Neuroprotein dynamics in the cerebrospinal fluid: intraindividual concomitant ventricular and lumbar measurements
    Sebastian Brandner
    Department of Neurosurgery, University of Erlangen Nurnberg, Erlangen, Germany
    Eur Neurol 70:189-94. 2013
    ..However, insufficient information is available on the rostrocaudal distribution of neuroproteins in the CSF to guarantee an appropriate interpretation of ventricular versus lumbar concentrations...
  12. ncbi request reprint Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein, interleukin 6, C-reactive protein, white blood cell count, erythrocyte sedimentation rate and body temperature
    Andreas Klinger
    Department of Neurosurgery, University of Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Acta Neurochir (Wien) 155:2177-82; discussion 2182. 2013
    ..To minimize the associated morbidity and mortality, a surveillance program is crucial to monitor for perioperative infections...
  13. doi request reprint Shunt-dependent hydrocephalus following subarachnoid hemorrhage correlates with increased S100B levels in cerebrospinal fluid and serum
    S Brandner
    Department of Neurosurgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 114:217-20. 2012
    ..Assessment of S100B levels in CSF and serum may be useful as a predictive parameter for shunt dependency in patients with posthemorrhagic hydrocephalus following aneurysmal SAH...
  14. doi request reprint Neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: a prospective longitudinal evaluation
    Andrea Kleindienst
    Department of Neurosurgery, University Erlangen Nuremberg, Erlangen, Germany
    J Neurotrauma 26:1435-46. 2009
    ....
  15. doi request reprint Industrial nail gun injury to the anterior skull base: a case report and review of the literature
    Bernhard J Schaller
    Department of Neurological Surgery, University of Gottingen, Germany
    J Trauma 64:E29-32. 2008
  16. doi request reprint Surgery for craniopharyngioma
    Michael Buchfelder
    Department of Neurosurgery, University of Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Pituitary 16:18-25. 2013
    ..In the present brief review, the surgical techniques and outcomes of operations in craniopharyngiomas with special focus on the resulting morbidity and mortality are summarized...
  17. doi request reprint Development of an experimental model to study the pathophysiology of cerebral salt wasting following subarachnoid hemorrhage
    Andrea Kleindienst
    Department of Neurosurgery, University Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 114:399-403. 2012
    ..We conclude that first, the rat model of SAH is suitable for studying CSW, second the increase in intracranial pressure generates the delayed hyponatremia, and third, the ADH release does not mediate natriuresis...
  18. ncbi request reprint The modulation of aquaporin-4 by using PKC-activator (phorbol myristate acetate) and V1a receptor antagonist (SR49059) following middle cerebral artery occlusion/reperfusion in the rat
    Kenji Okuno
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Acta Neurochir Suppl 102:431-6. 2008
    ..To investigate if edema formation is affected by the reduction of AQP4 expression, we utilized PMA and SR49059 following middle cerebral artery occlusion model (MCAo), and measured AQP4 expression by Western-Blot (WB) techniques...
  19. pmc The Passage of S100B from Brain to Blood Is Not Specifically Related to the Blood-Brain Barrier Integrity
    Andrea Kleindienst
    Department of Neurosurgery, University Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Cardiovasc Psychiatry Neurol 2010:801295. 2010
    ..591). In conclusion, we could not confirm S100B measurements to reliably predict outcome, and a compromised blood-CSF barrier did not affect the passage of S100B from CSF to serum...
  20. ncbi request reprint Influence of GH substitution therapy in deficient adults on the recurrence rate of hormonally inactive pituitary adenomas: a case control study
    Michael Buchfelder
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Endocrinol 157:149-56. 2007
    ..Since GH substitution is considered to promote tumour regrowth, adequate treatment is performed with some reservation. Therefore, we aimed to elucidate the effect of GH replacement therapy on tumour recurrence following surgery...
  21. doi request reprint CRH and SRIF have opposite effects on the Wnt/β-catenin signalling pathway through PKA/GSK-3β in corticotroph pituitary cells
    Muhammad Nasir Khan Khattak
    Department of Neurosurgery, University of Erlangen Nuremberg, Erlangen, Germany
    Cancer Invest 28:797-805. 2010
    ..Our data demonstrate an important role of the Wnt/β-catenin pathway in the proliferative control of pituitary corticotroph cells and describe a mechanism for its regulation by CRH and SRIF...