Research Topics
Genomes and Genes | Gunnar KleinSummaryCountry: Germany Publications
| Collaborators
|
Detail Information
Publications
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarctionDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
Circulation 122:145-55. 2010..By analyzing cardiomyocyte-specific gp130(Y757F) mutant mice, we investigated the effect of disturbed gp130 signaling after myocardial infarction...
Increased open probability of single cardiac L-type calcium channels in patients with chronic atrial fibrillation. role of phosphatase 2AGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Cardiovasc Res 59:37-45. 2003..However, it is unclear, whether this current reduction is related to a decrease in channel number or to alterations in channel function. Hence, we performed a single LCC analysis to assess channel gating and function in human AF...- Catheter-based cryoablation of atrial fibrillation: state of the artG Klein
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Minerva Cardioangiol 56:623-33. 2008..The favou-rable risk profile of cryoenergy might pave the way for cryoballoon ablation as a first-line treatment option in patients with paroxysmal AF... - Predictors of VT/VF-occurrence in ICD patients: results from the PROFIT-StudyGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Europace 8:618-24. 2006..Furthermore, in the era of prophylactic ICD therapy and limited healthcare resources, additional markers are needed for improved patient selection... - [Therapeutic strategies in inappropriate ICD therapy]Gunnar Klein
Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover
Herz 30:619-24. 2005..Thus, upgrading to biventricular ICD therapy should be considered in these patients... - Efficacy of pulmonary vein isolation by cryoballoon ablation in patients with paroxysmal atrial fibrillationGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Heart Rhythm 5:802-6. 2008..In terms of safety, cryoenergy has advantages compared with radiofrequency. A new cryoenergy balloon catheter has been recently developed to make AF ablation shorter and safer... - Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilonGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Germany
Circ Res 96:748-55. 2005.... - Right ventricular pacing is an independent predictor for ventricular tachycardia/ventricular fibrillation occurrence and heart failure events in patients with an implantable cardioverter-defibrillatorAjmal Gardiwal
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Europace 10:358-63. 2008.... - Cryoballoon pulmonary vein isolation temporarily modulates the intrinsic cardiac autonomic nervous systemHanno Oswald
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
J Interv Card Electrophysiol 29:57-62. 2010.... - Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with Pulsed Doppler Tei indexArnd Schaefer
Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
Eur J Echocardiogr 6:367-75. 2005..Thus, the aim of our study was to validate TDI and Pulsed Doppler Tei index and their reproducibility in mice after experimental anterior myocardial infarction (MI)... - Arrhythmia susceptibility in mice after therapy with beta-catenin-transduced hematopoietic progenitor cells after myocardial ischemia/reperfusionAjmal Gardiwal
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Cardiology 114:199-207. 2009..In this study, we investigated the cardiac electrophysiological properties of ex vivo expanded HPCs, generated by beta-catenin gene transfer, after transcoronary delivery in a murine model of ischemia/reperfusion (I/R) injury... - Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activationDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Circulation 109:2227-33. 2004..Because these conditions occur in myocardial ischemia and pressure overload, we investigated the regulation of CCN1 in cardiomyocytes in vitro and in the heart in vivo... - Effects of anesthesia on diastolic function in mice assessed by echocardiographyArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Echocardiography 22:665-70. 2005..However, the effect on diastolic function has not been investigated yet. The following study was conducted to evaluate the influence of different agents on diastolic left ventricular function in mice... - Comparison of N-terminal pro-brain natriuretic peptide versus electrophysiologic study for predicting future outcomes in patients with an implantable cardioverter defibrillator after myocardial infarctionHong Yu
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Am J Cardiol 100:635-9. 2007..In the era of primary prophylactic ICD implantation without preimplantation electrophysiologic study, higher NT-pro-BNP levels might help to improve risk-adjusted concomitant antiarrhythmic therapy and device selection... - A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathyDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, MHH, 30625 Hannover, Germany
Cell 128:589-600. 2007..Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM... - Sustained risk of recurrent thromboembolic events in patients with patent foramen ovale and paradoxical embolism: long-term follow-up over more than 15 yearsDieter Fischer
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Clin Res Cardiol 101:297-303. 2012..Therapeutic regimens range from no treatment to anticoagulation treatment to surgical or interventional closure. However, long-term follow-up is only available for up to 4 years... - Impact of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: results from the BOOST trialArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Eur Heart J 27:929-35. 2006..However, the impact of BMC therapy on LV diastolic function in patients after AMI has remained uncertain... - Effect of restoring sinus rhythm on sleep apnea in patients with atrial fibrillation or flutterChristoph Lissel
Department of Cardiology, Medical School Hannover, Hannover, Germany
Am J Cardiol 102:709-11. 2008..In conclusion, our study shows that AF should be regarded more as an innocent bystander than a causative or aggravating condition in SA... - Src family tyrosine kinases inhibit single L-type: Ca2+ channel activity in human atrial myocytesFrank Schroder
Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
J Mol Cell Cardiol 37:735-45. 2004..However, there are no data addressing the role of TKs in the control of single LTCC activity in human atrial cardiac myocytes, where changes in LTCC gating properties have been described in a number of disease states... - Left atrial substrate ablation in addition to pulmonary vein isolation in paroxysmal atrial fibrillation using a large 28-mm cryoballoonHanno Oswald
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Pacing Clin Electrophysiol 32:273-4. 2009..Left atrial-to-PV-junction ablation was then performed 3 months after the first procedure using a larger 28-mm balloon despite unrecovered isolation of all four PV, thereby curing symptomatic atrial fibrillation in this case... - Left ventricular assist improves autonomic imbalance in patients with persistent myocardial dysfunctionAjmal Gardiwal
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Int J Artif Organs 33:851-5. 2010..Reduced heart rate variability (HRV) as a result of autonomic derangement is evident in chronic heart failure and several studies have established the independent prognostic value of HRV in chronic heart failure... - Implantable defibrillator therapy for ventricular tachyarrhythmia in left ventricular assist device patientsHanno Oswald
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Street 1, Hannover 30625, Germany
Eur J Heart Fail 12:593-9. 2010..This study investigated the safety and efficacy of primary prevention ICD therapy and the rate of appropriate ICD interventions in LVAD patients... - Difference in humoral biomarkers for myocardial injury and inflammation in radiofrequency ablation versus cryoablationHanno Oswald
Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
Pacing Clin Electrophysiol 30:885-90. 2007..This study aimed to compare RF ablation and cryoablation for their impact on markers for myocardial injury and inflammation... - A prospective experience with the lead integrity alert: new certainties and new uncertaintiesThorben Koenig
Department of Cardiovascular Medicine, Hannover Medical School, D 30625 Hannover, Germany
Europace 11:1549-51. 2009..Additionally, our case illustrates the new problem of how to clinically handle a patient with a highly probable, but not completely certain, ICD-lead failure... - Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarctionThomas Korte
Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
Circulation 111:2282-90. 2005..Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process... - Relation of diastolic and systolic function, exercise capacity and brain natriuretic peptide in adults after Mustard procedure for transposition of the great arteriesArnd Schaefer
Clinic for Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Cardiology 117:112-7. 2010..To evaluate the relation of echocardiographic parameters of diastolic function, exercise capacity (expressed as peakVO(2)) and NT-proBNP in patients with transposition of the great arteries (TGA) and Mustard procedure... - Complete removal as a routine treatment for any cardiovascular implantable electronic device-associated infectionMaximilian Pichlmaier
Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
J Thorac Cardiovasc Surg 142:1482-90. 2011..Procedural risks and the success of eradicating infection were examined if involvement of the complete system was assumed in any cardiovascular implantable electronic device infection and complete removal was thus mandatory... - Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertensionJoern Tongers
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Am Heart J 153:127-32. 2007..Supraventricular tachyarrhythmias (SVTs) may compromise cardiac function and threaten prognosis in patients with PH, but the incidence and clinical relevance of SVTs in PH and chronic right ventricular failure have not been evaluated... - Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in miceArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
J Am Soc Echocardiogr 16:1144-9. 2003..Recently, Doppler tissue imaging (DTI) was introduced to evaluate diastolic function. The aim of our study was to validate DTI in the evaluation of diastolic function in mice... - Ablation of typical right atrial flutter in patients with pulmonary hypertensionUlrich Luesebrink
Department of Cardiovascular Medicine, Arrhythmology and Electrophysiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Heart Lung Circ 21:695-9. 2012..However, the influence of PAH on typical atrial flutter ablation procedure has not been systematically examined... - Four-chamber pacing in patients with poor ejection fraction but normal QRS durations undergoing open heart surgeryMaximilian Pichlmaier
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
Pacing Clin Electrophysiol 31:184-91. 2008..It has been unclear, whether biventricular or four-chamber pacing confers benefit upon patients with intact atrioventricular and interventricular conduction especially following surgery... - Reduced delayed rectifier K+ current, altered electrophysiology, and increased ventricular vulnerability in MLP-deficient miceAjmal Gardiwal
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
J Card Fail 13:687-93. 2007..In humans, MLP-expression is downregulated both in ischemic and dilative cardiomyopathy. In this study, we investigated the effects of MLP on the electrophysiologic phenotype in vivo and on outward potassium currents... - Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism: procedural and follow-up results after implantation of the Amplatzer®-occluder deviceDieter Fischer
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
J Interv Cardiol 24:85-91. 2011..The aim of the present study was to evaluate the follow-up results after implantation of the Amplatzer® occluder in patients with PFO using a consistent anticoagulation regimen... - Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftmentFlorian P Limbourg
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
Eur J Heart Fail 7:722-9. 2005..However, the cell population mediating myocardial recovery and the fate of the transplanted cells are still controversial... - Paclitaxcel-coated balloon plus bare metal stent vs. sirolimus-eluting stent in de novo lesions: an IVUS studyDieter Fischer
Clinic of Cardiology and Angiology, Hannover Medical School, Germany
EuroIntervention 8:450-5. 2012..Another approach is the treatment with drug-coated balloons. This approach has been proven for different indications, e.g., in-stent restenosis and treatment of peripheral artery disease... - Stable cystatin C serum levels confirm normal renal function in patients with dronedarone-associated increase in serum creatinineDavid Duncker
Department of Cardiovascular Medicine, Hannover Medical School, D 30625 Hannover, Germany
J Cardiovasc Pharmacol Ther 18:109-12. 2013..77 ± 0.108 to 0.77 ± 0.107 mg/L; P = .906). In conclusion, cystatin C represents an easily available and reliable biomarker for estimation of true renal function in patients on dronedarone treatment... - The role of cohabitant unusual bacterial species in infection of cardiovascular implantable electronic devices (CIED)Maximilian Pichlmaier
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
Technol Health Care 21:87-96. 2013..Asymptomatic bacterial colonisation of medical implants is increasingly recognised. The role of the often unusual bacteria is usually unknown however... - Diagnostic accuracy of handheld echocardiography for evaluation of aortic stenosisArnd Schaefer
Clinic for Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Echocardiography 27:481-6. 2010..We conducted this study to evaluate a handheld ultrasound device (HCU) in patients with suspected severe aortic stenosis (AS) in comparison to a standard echocardiography device (SE)... - Treatment of patients with recurrent or persistent infection of cardiac implantable electronic devicesLudmilla Knigina
Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
Europace 12:1275-81. 2010..Recurrence/persistence of infection then potentially poses an even more serious clinical problem... - Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytesJörn Tongers
Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
Cardiovasc Res 63:545-52. 2004..The inducible HO isoform, HO-1, confers protection against ischemia/reperfusion (I/R)-injury in the heart. We hypothesized that HO-1 and its catalytic by-products constitute an antihypertrophic signaling module in cardiac myocytes... - High prevalence of asymptomatic bacterial colonization of rhythm management devicesMaximilian Pichlmaier
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Strasse, D 30625 Hanover, Germany
Europace 10:1067-72. 2008..The aim of this study was to elucidate whether patients may be asymptomatic carriers of bacteria on their rhythm management device, possibly allowing later manifestation of infection... - Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarctionMartin Fuchs
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
FASEB J 17:2118-20. 2003.... - Implantable defibrillator with left ventricular assist device compatibilityHanno Oswald
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Interact Cardiovasc Thorac Surg 8:579-80. 2009..However, surgeons implanting the Heart Mate II in ICD patients should be aware of possible interactions and incompatible devices should not be recommended in HeartMate-II recipients... - Mechanism of coronary artery restenosis after stenting for acute myocardial infarctionArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Am J Cardiol 94:1037-40. 2004..Restenosis after stenting for AMI was primarily caused by stent underexpansion, not by neointima formation... - Chronic experiences with a single lead dual chamber implantable cardioverter defibrillator systemMichael Niehaus
Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Pacing Clin Electrophysiol 26:1937-43. 2003..The reliability of this system has to be proven in a prospective randomized study... - [Allopurinol-induced hypersensitivity syndrome resulting in death]Sören Laurisch
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Med Klin (Munich) 105:262-6. 2010..Considering the increasing prescription rate of allopurinol, the present case report intends to demonstrate the underestimated threat of AHS... - Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assayTibor Kempf
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Clin Chem 53:284-91. 2007..There has been increasing interest in using circulating GDF15 as a biomarker in patients, for example those with cardiovascular disease... - Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic miceFrank Schroder
Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Cardiovasc Res 60:268-77. 2003..Both nitric oxide (NO), signaling via cGMP, and acetylcholine, signaling via the muscarinic receptor, have been identified as negative regulators of beta-adrenoreceptor-stimulated LTCC activity in cardiac myocytes... - Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case seriesJulia Brinkmann
Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
Hypertension 60:1485-90. 2012..We conclude that reduced central sympathetic inhibition may be the exception rather than the rule after renal nerve ablation in unselected patients with difficult-to-control arterial hypertension... - Anaesthesia record system on handheld computers--pilot experience and uses for quality control and clinical guidelinesQiang Fu
Department of LIME, Karolinska Institutet, S 17177 Stockholm, Sweden
Comput Methods Programs Biomed 77:155-63. 2005..This information database is analyzed and used not only to give feedback to the individual doctor or center, but also to review the use of the guidelines provided and the results of their utilization...