Stephan Kissler

Summary

Country: Germany

Publications

  1. pmc The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
    Kay D Gerold
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Diabetes 60:1955-63. 2011
  2. doi From genome-wide association studies to etiology: probing autoimmunity genes by RNAi
    Stephan Kissler
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97080 Wurzburg, Germany
    Trends Mol Med 17:634-40. 2011
  3. doi IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes
    Julie Joseph
    University of Wurzburg, Wurzburg, Germany
    J Immunol 188:216-21. 2012
  4. pmc PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant
    Peilin Zheng
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Diabetes 62:896-904. 2013
  5. doi Studying autoimmunity by in vivo RNA interference
    Stephan Kissler
    Rudolf Virchow Center DFG Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Methods Mol Biol 555:109-18. 2009

Collaborators

Detail Information

Publications5

  1. pmc The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
    Kay D Gerold
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Diabetes 60:1955-63. 2011
    ..In this study, we investigated the contribution of sCTLA-4 to immune regulation with the aim to elucidate the functional basis of the disease association of CTLA4...
  2. doi From genome-wide association studies to etiology: probing autoimmunity genes by RNAi
    Stephan Kissler
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97080 Wurzburg, Germany
    Trends Mol Med 17:634-40. 2011
    ..This review discusses how the experimental use of RNAi is invaluable in bridging the gap between the identification of susceptibility genes and the elucidation of their functional contribution to autoimmune disease...
  3. doi IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes
    Julie Joseph
    University of Wurzburg, Wurzburg, Germany
    J Immunol 188:216-21. 2012
    ..We concluded that IL-17 is dispensable, at least in large part, in the pathogenesis of autoimmune diabetes...
  4. pmc PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant
    Peilin Zheng
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Diabetes 62:896-904. 2013
    ..Overall, to our knowledge, this is the first functional study of Ptpn22 within a model of type 1 diabetes, and the data do not support a loss of function for the PTPN22 disease variant...
  5. doi Studying autoimmunity by in vivo RNA interference
    Stephan Kissler
    Rudolf Virchow Center DFG Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Methods Mol Biol 555:109-18. 2009
    ..Lentiviral RNAi offers several advantages compared to conventional transgenesis or knockout technology, and these, as well as the technique's weaknesses, are discussed herein...