- From genome-wide association studies to etiology: probing autoimmunity genes by RNAiStephan Kissler
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97080 Wurzburg, Germany
Trends Mol Med 17:634-40. 2011..This review discusses how the experimental use of RNAi is invaluable in bridging the gap between the identification of susceptibility genes and the elucidation of their functional contribution to autoimmune disease...
- The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell functionKay D Gerold
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
Diabetes 60:1955-63. 2011..In this study, we investigated the contribution of sCTLA-4 to immune regulation with the aim to elucidate the functional basis of the disease association of CTLA4...
- IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetesJulie Joseph
University of Wurzburg, Wurzburg, Germany
J Immunol 188:216-21. 2012..We concluded that IL-17 is dispensable, at least in large part, in the pathogenesis of autoimmune diabetes...
- Studying autoimmunity by in vivo RNA interferenceStephan Kissler
Rudolf Virchow Center DFG Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
Methods Mol Biol 555:109-18. 2009..Lentiviral RNAi offers several advantages compared to conventional transgenesis or knockout technology, and these, as well as the technique's weaknesses, are discussed herein...