P Kirchhof

Summary

Country: Germany

Publications

  1. pmc Management of atrial fibrillation by primary care physicians in Germany: baseline results of the ATRIUM registry
    Thomas Meinertz
    Klinik und Poliklinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Germany
    Clin Res Cardiol 100:897-905. 2011
  2. ncbi request reprint Targeted pharmacological reversal of electrical remodeling after cardioversion--rationale and design of the Flecainide Short-Long (Flec-SL) trial
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Am Heart J 150:899. 2005
  3. ncbi request reprint Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, and Institute for Arteriosclerosis Research at the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 14:1027-33. 2003
  4. ncbi request reprint Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Europace 9:1006-23. 2007
  5. ncbi request reprint [Outcome parameters for AF trials--executive summary of an AFNET-EHRA consensus conference]
    P Kirchhof
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Herzschrittmacherther Elektrophysiol 18:259-68. 2007
  6. pmc Can we improve outcomes in AF patients by early therapy?
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    BMC Med 7:72. 2009
  7. ncbi request reprint Incessant supraventricular tachycardia with constant 1:2 atrioventricular ratio: a longitudinally dissociated atrioventricular node?
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    J Cardiovasc Electrophysiol 14:316-9. 2003
  8. ncbi request reprint Effect of sotalol and acute ventricular dilatation on action potential duration and dispersion of repolarization after defibrillation shocks
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    J Cardiovasc Pharmacol 41:640-8. 2003
  9. ncbi request reprint Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation
    Paulus Kirchhof
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Munster, Germany
    Basic Res Cardiol 100:112-21. 2005
  10. ncbi request reprint [Treatment of atrial fibrillation]
    P Kirchhof
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster
    Internist (Berl) 48:819-29; quiz 830-1. 2007

Detail Information

Publications93

  1. pmc Management of atrial fibrillation by primary care physicians in Germany: baseline results of the ATRIUM registry
    Thomas Meinertz
    Klinik und Poliklinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Germany
    Clin Res Cardiol 100:897-905. 2011
    ..In contrast to surveys in cardiologist settings, presentation and management of atrial fibrillation (AF) in primary care patients is less well studied...
  2. ncbi request reprint Targeted pharmacological reversal of electrical remodeling after cardioversion--rationale and design of the Flecainide Short-Long (Flec-SL) trial
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Am Heart J 150:899. 2005
    ....
  3. ncbi request reprint Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, and Institute for Arteriosclerosis Research at the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 14:1027-33. 2003
    ..Atrial APD and Polymorphic AT in LQTS...
  4. ncbi request reprint Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Europace 9:1006-23. 2007
    ..In addition to a careful selection of a relevant primary outcome parameter, coverage of outcomes in all major domains of AF-related morbidity and mortality is desirable for any clinical trial in AF...
  5. ncbi request reprint [Outcome parameters for AF trials--executive summary of an AFNET-EHRA consensus conference]
    P Kirchhof
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Herzschrittmacherther Elektrophysiol 18:259-68. 2007
  6. pmc Can we improve outcomes in AF patients by early therapy?
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    BMC Med 7:72. 2009
    ..The hypothesis that early diagnosis and early, comprehensive therapy of atrial fibrillation can improve outcomes requires formal testing in controlled trials...
  7. ncbi request reprint Incessant supraventricular tachycardia with constant 1:2 atrioventricular ratio: a longitudinally dissociated atrioventricular node?
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    J Cardiovasc Electrophysiol 14:316-9. 2003
    ....
  8. ncbi request reprint Effect of sotalol and acute ventricular dilatation on action potential duration and dispersion of repolarization after defibrillation shocks
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    J Cardiovasc Pharmacol 41:640-8. 2003
    ..Synchronization of repolarization, caused by both prolongation of short PS-APD and shortening of long PS-APD, is associated with successful defibrillation in the normal, acutely dilated, and sotalol-treated heart...
  9. ncbi request reprint Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation
    Paulus Kirchhof
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Munster, Germany
    Basic Res Cardiol 100:112-21. 2005
    ..We studied whether two antiarrhythmic drugs (sotalol, flecainide) prolong APD or induce PRR in the fibrillating human atrium...
  10. ncbi request reprint [Treatment of atrial fibrillation]
    P Kirchhof
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster
    Internist (Berl) 48:819-29; quiz 830-1. 2007
    ..It is likely that a multimodal therapeutic approach will in the future allow rhythm control therapy to become more effective...
  11. ncbi request reprint Effect of electrode position on the outcome of cardioversion
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Card Electrophysiol Rev 7:292-6. 2003
    ..We therefore suggest that an anterior-posterior electrode position should initially be used for external cardioversion of atrial fibrillation...
  12. ncbi request reprint Pauses after burst pacing provoke afterdepolarizations and torsades de pointes in a patient with long QT syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    Heart Rhythm 1:720-3. 2004
    ..High-rate burst pacing provoked afterdepolarizations and triggered torsades de pointes in this patient with long QT syndrome...
  13. ncbi request reprint A trial of self-adhesive patch electrodes and hand-held paddle electrodes for external cardioversion of atrial fibrillation (MOBIPAPA)
    Paulus Kirchhof
    Department of Cardiology and Angiology, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Eur Heart J 26:1292-7. 2005
    ..Whether the type of shock electrode affects cardioversion success is not known. We tested whether hand-held steel electrodes improve cardioversion outcome with monophasic or biphasic shocks when compared with adhesive patch electrodes...
  14. ncbi request reprint Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Muenster, Germany
    Circulation 114:1799-806. 2006
    ..To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac effects of heterozygous plakoglobin deficiency in mice...
  15. pmc Primary prevention of sudden cardiac death
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Heart 92:1873-8. 2006
  16. ncbi request reprint Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    J Mol Cell Cardiol 42:962-71. 2007
    ..An imbalance between prolonged intracellular calcium release and shortening of the ventricular action potential may contribute to genesis of arrhythmias in this model...
  17. ncbi request reprint New concepts for old drugs to maintain sinus rhythm in patients with atrial fibrillation
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Heart Rhythm 4:790-3. 2007
    ....
  18. ncbi request reprint Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, and Institute for Arteriosclerosis Research at the University of Münster, Münster 48129, Germany
    J Mol Cell Cardiol 36:691-700. 2004
    ..05) while prolonging APD. The combination of increased CaMKII activity and altered action potential characteristics facilitates ventricular arrhythmias in hypertrophic GC-A-/- hearts...
  19. ncbi request reprint T wave alternans does not assess arrhythmic risk in patients with Brugada syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Institute of Arteriosclerosis Research at the University of Münster, Germany
    Ann Noninvasive Electrocardiol 9:162-5. 2004
    ..We therefore tested whether TWA is an indicator for arrhythmias in Brugada syndrome with a focus on right precordial ECG leads...
  20. ncbi request reprint Amiodarone-induced postrepolarization refractoriness suppresses induction of ventricular fibrillation
    Paulus Kirchhof
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, University Hospital Munster, Munster, Germany
    J Pharmacol Exp Ther 305:257-63. 2003
    ..PRR without conduction slowing is a desirable feature of drugs designed to prevent ventricular arrhythmias...
  21. doi request reprint Diastolic isthmus length and 'vertical' isthmus angulation identify patients with difficult catheter ablation of typical atrial flutter: a pre-procedural MRI study
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Europace 11:42-7. 2009
    ..The intervention targets a defined anatomical structure, the so-called cavotricuspid isthmus (CTI). We sought to characterize CTI anatomy in vivo in patients with difficult and simple catheter ablation of atrial flutter...
  22. ncbi request reprint Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, D 48129 Munster, Germany
    Am J Physiol Heart Circ Physiol 285:H145-53. 2003
    ..0 of 9 WT mice, P < 0.05). In conclusion, A1AR regulate sinus nodal and AV nodal function in the mammalian heart in vivo. Enhanced expression of A1AR causes sinus nodal and AV nodal dysfunction and supraventricular arrhythmias...
  23. ncbi request reprint Prolonged QRS duration increases QT dispersion but does not relate to arrhythmias in survivors of acute myocardial infarction
    P Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, and Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Pacing Clin Electrophysiol 24:789-95. 2001
    ..Presence of late potentials, in contrast, relates to arrhythmic events but does not affect QT dispersion. Therefore, QT dispersion may not be an adequate parameter to assess arrhythmic risk in survivors of myocardial infarction...
  24. ncbi request reprint A novel nonfluoroscopic catheter visualization system (LocaLisa) to reduce radiation exposure during catheter ablation of supraventricular tachycardias
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, and Institute for Arteriosclerosis Research, University of Munster, Germany
    Am J Cardiol 90:340-3. 2002
  25. pmc Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
    Paulus Kirchhof
    University Hospital Munster, Munster, Germany
    Europace 14:8-27. 2012
    ..Relevant published literature for each section is covered, and suggestions for the improvement of management in each area are put forward. Combined, the propositions formulate a perspective to implement comprehensive management in AF...
  26. doi request reprint Impact of the type of centre on management of AF patients: surprising evidence for differences in antithrombotic therapy decisions
    P Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Straße 33, D 48149 Munster, Germany
    Thromb Haemost 105:1010-23. 2011
    ..Inpatients receive more rhythm control therapy. Adequate antithrombotic therapy is more often administered in specialist (cardiologist) centres...
  27. ncbi request reprint A patient with "atrial torsades de pointes"
    P Kirchhof
    Department of Cardiology and Angiology and the Institute for Arteriosclerosis Research, University of Munster, Germany
    J Cardiovasc Electrophysiol 11:806-11. 2000
    ..When the arrhythmia was initiated, a new action potential reproducibly emerged from these afterdepolarizations. To the knowledge of the authors, this is the first reported case of "atrial torsades de pointes" in a patient...
  28. doi request reprint Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Eur Heart J 30:2969-77c. 2009
    ..g. antithrombotic therapy). The reasons for these suggestions are detailed in this paper...
  29. ncbi request reprint Outcome parameters for trials in atrial fibrillation: executive summary
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Eur Heart J 28:2803-17. 2007
    ..In addition to a careful selection of a relevant primary outcome parameter, coverage of outcomes in all major domains of AF-related morbidity and mortality is desirable for any clinical trial in AF...
  30. ncbi request reprint Anterior-posterior versus anterior-lateral electrode positions for external cardioversion of atrial fibrillation: a randomised trial
    Paulus Kirchhof
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, University of Munster, Munster, Germany
    Lancet 360:1275-9. 2002
    ..We undertook a randomised trial comparing the two positions with the endpoint of successful cardioversion...
  31. ncbi request reprint Simultaneous in utero assessment of AV nodal and ventricular electrophysiologic parameters in the fetal sheep heart
    P Kirchhof
    Medizinische Klinik und Poliklinik, Innere Medizin C, Kardiologie und Angiologie, Germany
    Basic Res Cardiol 96:251-7. 2001
    ..Since overdrive pacing may help to establish the mechanism of an arrhythmia and may be used to treat fetal tachycardias, different modes of transesophageal pacing in utero were also assessed...
  32. ncbi request reprint Transient local changes in right ventricular monophasic action potentials due to ajmaline in a patient with Brugada Syndrome
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 10:1010-5. 1999
    ..Ajmaline led to a cycle length-dependent increase in RV dispersion of repolarization. Thus, right endocardial MAPs may demonstrate regionally different action potential changes that may contribute to the ECG changes in Brugada syndrome...
  33. ncbi request reprint Modification of stretch-induced shortening of repolarization by streptomycin in the isolated rabbit heart
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Pharmacol 36:711-21. 2000
    ..This may have clinically important implications for the development of new antiarrhythmic drugs...
  34. ncbi request reprint Torsade de pointes induced by ajmaline
    W Haverkamp
    Medizinische Klinik und Poliklinik, Innere Medizin C Kardiologie, Angiologie Westfälische Wilhelms Universität Münster 48129 Münster, Germany
    Z Kardiol 90:586-90. 2001
    ....
  35. ncbi request reprint Brugada syndrome and supraventricular tachyarrhythmias: a novel association?
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 12:680-5. 2001
    ..As a high induction rate of ventricular tachyarrhythmias has been reported in Brugada syndrome, we hypothesized that this also may be true for supraventricular tachycardias in these patients...
  36. ncbi request reprint In vivo recording of monophasic action potentials in awake dogs--new applications for experimental electrophysiology
    L Eckardt
    Westfalische Wilhelms Universitat, Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:169-74. 2001
    ..However, an approach for recording MAP in awake dogs without interference of anesthesia has not yet been developed...
  37. ncbi request reprint Electrophysiologic investigation in Brugada syndrome; yield of programmed ventricular stimulation at two ventricular sites with up to three premature beats
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    Eur Heart J 23:1394-401. 2002
    ..Therefore, we prospectively investigated the inducibility of VT in these patients using a uniform protocol...
  38. ncbi request reprint Effects of thoracic epidural anesthesia with and without autonomic nervous system blockade on cardiac monophasic action potentials and effective refractoriness in awake dogs
    A Meissner
    Medizinische Klinik und Poliklinik, Westfalische Wilhelms Universitat, Munster, Germany
    Anesthesiology 95:132-8; discussion 6A. 2001
    ..The authors hypothesized that an antiarrhythmic role of TEA exists, which may be related to a direct effect of TEA on myocardial repolarization...
  39. ncbi request reprint Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome
    G Moennig
    Department of Cardiology and Angiology, Westfälische Wilhelms University Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Pacing Clin Electrophysiol 24:406-15. 2001
    ..QT dispersion and QT product might be helpful in finding LQTS mutation carriers and might serve as additional ECG tools to identify asymptomatic LQTS patients...
  40. ncbi request reprint Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by alphaMHC-Cre-mediated recombination
    Boris V Skryabin
    Institute of Experimental Pathology, Universitatsklinikum Munster, Munster, Germany
    Genesis 39:288-98. 2004
    ..Doppler-echocardiographic and physiological studies in these mice demonstrate for the first time the tremendous impact of ANP/GC-A dysfunction on chronic blood volume homeostasis...
  41. pmc G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis
    Michael T Kuhlmann
    Department of Cardiology and Angiology, University of Munster, 48129 Munster, Germany
    J Exp Med 203:87-97. 2006
    ..In addition to paracrine effects potentially caused by the increased homing of BM-derived cells, these might contribute to the therapeutic effects of G-CSF...
  42. doi request reprint Arrhythmogenic right ventricular cardiomyopathy: an update on pathophysiology, genetics, diagnosis, and risk stratification
    M Paul
    Division of Cardiology, Department of Cardiovascular Medicine, University Hospital Munster, Albert Schweitzer Campus 1 Gebäude A1, 48149, Munster, Germany
    Herzschrittmacherther Elektrophysiol 23:186-95. 2012
    ..This review provides a comprehensive overview of the current literature on the pathogenesis, diagnosis, treatment, and prognosis of ARVC and sheds some light on potential new developments in these areas...
  43. pmc Approach to wide complex tachycardias in patients without structural heart disease
    L Eckardt
    Medizinische Klinik und Poliklinik C, Universitatsklinikum Munster, Munster, Germany
    Heart 92:704-11. 2006
  44. doi request reprint Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse hearts
    Christoph Waldeyer
    Department of Cardiology and Angiology, University Hospital Muenster, Munster, Germany
    Basic Res Cardiol 104:523-33. 2009
    ..Genetic background influences repolarization and arrhythmogenesis. These findings provide systematic data for the design and interpretation of arrhythmia studies in murine disease models...
  45. doi request reprint Drugs that interact with cardiac electro-mechanics: old and new targets for treatment
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Prog Biophys Mol Biol 97:497-512. 2008
    ..Several recently identified regulatory mechanisms may provide novel antiarrhythmic targets associated with the "intermediate" response of the myocardium to stretch...
  46. doi request reprint Atrial Arrhythmias in long-QT syndrome under daily life conditions: a nested case control study
    Stephan Zellerhoff
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    J Cardiovasc Electrophysiol 20:401-7. 2009
    ..Several genetic reports have associated defects in LQTS-causing genes with atrial fibrillation (AF). We therefore studied whether atrial arrhythmias occur in patients with LQTS under daily-life conditions...
  47. ncbi request reprint Load-induced changes in repolarization: evidence from experimental and clinical data
    L Eckardt
    Westfälische Wilhelms Universität Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:369-80. 2001
    ..Additional studies will further clarify the nature and clinical significance of load-related changes in repolarization and arrhythmogenesis...
  48. ncbi request reprint [German Competence Network on Atrial Fibrillation (AFNET). A nationwide cooperation for better research and patient care]
    Angelika Leute
    Kompetenznetz Vorhofflimmern, Universitatsklinikum Munster, Munster, Germany
    Med Klin (Munich) 101:662-6. 2006
    ..Experimental basic research projects are focusing on different aspects of atrial remodeling in order to find out in which way the molecular mechanisms can be manipulated by new methods of treatment. First results are presented...
  49. doi request reprint Novel non-pharmacological approaches for antiarrhythmic therapy of atrial fibrillation
    Julia Koebe
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Europace 10:433-7. 2008
    ..This review aims to provide an overview of these non-pharmacological treatment options of AF in the context of potential pathophysiological processes...
  50. ncbi request reprint Preclinical testing of drug-induced proarrhythmia: value of transgenic models
    L Fabritz
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Cardiovasc Hematol Agents Med Chem 5:289-94. 2007
    ..Today, selected murine models with alterations in K+, Na+ channels and ankyrin are available. In the future, transgenic rabbit and Zebra fish models may also be used...
  51. ncbi request reprint [Anticoagulation with atrial fibrillation]
    S Zellerhoff
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Kompetenznetz Vorhofflimmern, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Herzschrittmacherther Elektrophysiol 17:89-94. 2006
    ..New anticoagulants--especially direct thrombin antagonists--are currently evaluated in clinical trials and may in the future facilitate anticoagulation in patients with atrial fibrillation...
  52. ncbi request reprint [New knowledge in arrhythmogenesis--role of ion channels and genetic aspects]
    W Haverkamp
    Med Klinik und Poliklinik Innere Medizin C und Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Albert Schweitzer Str 33, D 48149 Munster
    Z Kardiol 89:2-9; discussion 9-10. 2000
    ..The results of these studies are not only of special interest from the scientific point of view. It is likely to assume that, in the future, they will increasingly influence the diagnosis and treatment of arrhythmias...
  53. ncbi request reprint [Clinical aspects and molecular genetics of the Jervell- and Lange-Nielsen Syndrome]
    G Mönnig
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie Universitätsklinikum Münster, Institut für Arterioskleroseforschung Westfälische Wilhelms Universität Münster Albert Schweitzer Strasse 33 48129 Münster, Germany
    Z Kardiol 91:380-8. 2002
    ..In the present paper, we review the clinical and genetic similarities and differences of the J-LN and the R-W syndrome as well as the diagnostic and therapeutic management of these patients and their family members...
  54. doi request reprint MRI of right atrial function after catheter ablation of atrial flutter
    Murat Ozgun
    Department of Radiology, St Franziskus Hospital, Muenster, Germany
    Acad Radiol 17:856-61. 2010
    ..The objective of this study was to evaluate the changes in CTI length and right atrial (RA) function after radiofrequency ablation of isthmus-dependent atrial flutter (isthmus ablation)...
  55. ncbi request reprint The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol
    Sascha Rolf
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Institute for Arteriosclerosis Research, Munster, Germany
    Eur Heart J 24:1104-12. 2003
    ..A detailed protocol for the ajmaline challenge in Brugada syndrome has not yet been described. Therefore, we prospectively studied the risks of a standardized ajmaline test...
  56. ncbi request reprint In vivo recording of monophasic action potentials in awake dogs
    Lars Eckardt
    Medizinische Klinik und Poliklinik C, Westfalische Wilhelms Universitat Munster, D 48129 Munster, Germany
    Methods 30:109-14. 2003
    ..In various canine in vivo models including in vivo models of long QT syndrome, heart failures or sudden cardiac death, the present technique permits electrophysiologic measurements without the interference of anesthesia...
  57. ncbi request reprint Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice
    Larissa Fabritz
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Cardiovasc Res 57:1085-93. 2003
    ..We therefore studied the effects of pacing and mexiletine in mice with a heterozygous knock-in DeltaKPQ SCN5A(Delta/+) deletion (SCN5A-Tg), a murine LQT3 model...
  58. doi request reprint Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T
    Christoph Stehling
    Department of Clinical Radiology, University of Muenster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Acad Radiol 15:895-900. 2008
    ..0 T. To test these hypotheses, we prospectively examined individuals with documented CMBs at 1.5 and 3.0 T...
  59. ncbi request reprint Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia
    Larissa Fabritz
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Germany
    Basic Res Cardiol 98:25-32. 2003
    ..We sought to develop a mouse heart model for such arrhythmias in order to identify the proarrhythmic potential in transgenic animals...
  60. doi request reprint The German Competence Network on Atrial Fibrillation (AFNET)
    Gunter Breithardt
    Department of Medicine C Cardiology and Angiology, University Hospital, Munster, Germany
    Herz 33:548-55. 2008
    ..The effect of preventive pacing on the recurrence of paroxysmal AF is studied in the BACE-PACE trial...
  61. ncbi request reprint Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Pharmacol Exp Ther 303:218-25. 2002
    ..This effect may be related to a rectangular pattern of action potential prolongation, whereas erythromycin and clarithromycin cause triangular action potential prolongation and induce TdP...
  62. pmc Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3
    Larissa Fabritz
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Street 33, D 48129 Munster, Germany
    Cardiovasc Res 87:60-72. 2010
    ..Beta-adrenoceptor blockers appear less effective in LQT3 than in other forms of the disease...
  63. doi request reprint Routine data from hospital information systems can support patient recruitment for clinical studies
    Martin Dugas
    Department of Medical Informatics and Biomathematics, University of Munster, Munster, Germany
    Clin Trials 7:183-9. 2010
    ..Delayed patient recruitment is a common problem in clinical studies. Hospital information systems (HIS) contain data items relevant for inclusion or exclusion criteria of these studies...
  64. doi request reprint Predictable and less predictable unwanted cardiac drugs effects: individual pre-disposition and transient precipitating factors
    Larissa Fabritz
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Basic Clin Pharmacol Toxicol 106:263-8. 2010
    ..Understanding the mechanisms of ventricular pro-dysrhythmia may allow to predict this unwanted drug effect better, and to identify novel markers for such events in the future...
  65. ncbi request reprint Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome
    Lars Eckardt
    Hospital of the Westfälischen Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 13:742-9. 2002
    ..Therefore, the body surface area of ST elevation and the presence of late potentials were compared to the inducibility of VT in patients with the characteristic ECG of Brugada syndrome...
  66. ncbi request reprint Endocardial mapping of right ventricular outflow tract tachycardia using noncontact activation mapping
    Michael Ribbing
    Department of Cardiology and Angiology, University Hospital Munster, Institute for Arteriosclerosis Research at the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 14:602-8. 2003
    ..These methods are limited in patients with nonsustained tachycardia or isolated ventricular ectopic beats. We investigated the feasibility of using noncontact mapping to guide the ablation of RVOT arrhythmias...
  67. ncbi request reprint Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors
    Larissa Fabritz
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, University Hospital Munster, Muenster, Germany
    Cardiovasc Res 62:500-8. 2004
    ..We therefore studied the effects of heart-directed overexpression of A(3) adenosine receptors (A(3)ARs) at different gene doses on sinus and atrio-ventricular (AV) nodal function in mice...
  68. ncbi request reprint Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice
    Frank U Müller
    Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48149 Munster, Germany
    J Biol Chem 280:6906-14. 2005
    ..Our results indicate that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression...
  69. ncbi request reprint Phytanic acid accumulation is associated with conduction delay and sudden cardiac death in sterol carrier protein-2/sterol carrier protein-x deficient mice
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    J Cardiovasc Electrophysiol 15:1310-6. 2004
    ....
  70. ncbi request reprint [Atrial fibrillation: molecular biology bases]
    Wilhelm Haverkamp
    Medizinische Klinik, Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Institut für Arterioskleroseforschung, Westfälischen Wilhelms Universität Münster
    Herz 27:301-5. 2002
    ..PERSPECTIVES: It is hoped that the results of future studies will not only further improve our understanding of the mechanisms underlying atrial fibrillation but may also help to develop new therapeutic strategies...
  71. ncbi request reprint Electrocardiographic risk stratification in families with congenital long QT syndrome
    Gerold Mönnig
    Department of Cardiology and Angiology, Medizinische Klinik und Poliklinik C, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Eur Heart J 27:2074-80. 2006
    ..The QT interval in the surface ECG is one of the most often used risk stratifiers in families with congenital long QT syndrome (LQTS). The best ECG lead for clinical management of LQTS families remains unclear...
  72. ncbi request reprint Arrhythmogenic right ventricular cardiomyopathy. Antiarrhythmic drugs, catheter ablation, or ICD?
    Thomas Wichter
    Department of Cardiology and Angiology, University Hospital of Munster, Munster, Germany
    Herz 30:91-101. 2005
    ....
  73. ncbi request reprint Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, Domagkstrasse 12, 48149 Munster, Germany
    Am J Physiol Heart Circ Physiol 287:H2216-25. 2004
    ..Finally, the progressive decrease in ryanodine receptor density may contribute to the decreased atrial contractility and lower heart rate during stress in 18-wk-old JCN mice...
  74. doi request reprint Right atrial scar detection after catheter ablation: Comparison of 2D and high spatial resolution 3D-late enhancement magnetic resonance imaging
    Murat Ozgun
    Department of Radiology, St Franziskus Hospital, Muenster, Germany
    Acad Radiol 18:488-94. 2011
    ....
  75. doi request reprint Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy
    Stefan Knecht
    Department of Neurology, University of Munster, A Schweitzer Street 33, 48129 Munster, Germany
    Eur Heart J 29:2125-32. 2008
    ..AF contributes to stroke and secondary cognitive decline. In the absence of manifest stroke, AF can activate coagulation and cause cerebral microembolism which could damage the brain...
  76. pmc Minimally invasive closed-chest ultrasound-guided substance delivery into the pericardial space in mice
    S Laakmann
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:227-38. 2013
    ..This pericardial injection method may be useful in the evaluation of potential genetic interventions aimed at rescuing atrial phenotypes in transgenic mouse models...
  77. pmc Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality
    Nicole Brüchert
    Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, Munster, Germany
    Am J Physiol Heart Circ Physiol 295:H1539-46. 2008
    ..Therefore, PP1 inhibitors such as I-2 could offer new therapeutic options to ameliorate the deleterious effects of heart failure...
  78. doi request reprint Prospective, multicentre validation of a simple, patient-operated electrocardiographic system for the detection of arrhythmias and electrocardiographic changes
    Gerrit Kaleschke
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, D 48129 Munster, Germany
    Europace 11:1362-8. 2009
    ..Systematic and symptom-activated ECG recordings can increase diagnostic yield in such patients. We evaluated the diagnostic accuracy of a simple, leadless, patient-operated ECG device compared with a standard 12-lead ECG...
  79. ncbi request reprint Gender differences in cardiac arrhythmias
    Eric Schulze-Bahr
    Department of Cardiology and Angiology, University Hospital Muenster, Muenster, Germany
    Herz 30:390-400. 2005
    ..The interaction of theses influences with regional cellular factors will help us in the future to analyze gender-specific factors of arrhythmogenesis and develop treatment and prevention strategies...
  80. doi request reprint Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus
    M A Tekook
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Domagkstr 12, D 48149 Munster, Germany
    Toxicon 60:1415-27. 2012
    ..judaicus, for promising pharmacological applications. Furthermore, our data suggest that the use of SOE-PCR may help to facilitate in future the high throughput of cloning and/or modification of scorpion toxin genes...
  81. ncbi request reprint Cardiovert!--or better wait a little? Systematic evidence that the initial hours of atrial fibrillation are a "special time"
    Paulus Kirchhof
    Heart Rhythm 2:1330-1. 2005
  82. ncbi request reprint A monogenic avalanche
    Paulus Kirchhof
    J Cardiovasc Electrophysiol 13:689-90. 2002
  83. ncbi request reprint Introducing the German Mouse Clinic: open access platform for standardized phenotyping
    Valerie Gailus-Durner
    Nat Methods 2:403-4. 2005
  84. ncbi request reprint Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling
    Bjorn C Knollmann
    Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Rd, N W, Washington, DC 20007, USA
    Circ Res 92:428-36. 2003
    ..We conclude that the TnT-I79N mutation causes stress-induced VT even in absence of hypertrophy and/or fibrosis, arising possibly from the combination of AP remodeling related to altered Ca2+ transients and suppression of IK1...
  85. ncbi request reprint Delayed rhythm control of atrial fibrillation may be a cause of failure to prevent recurrences: reasons for change to active antiarrhythmic treatment at the time of the first detected episode
    Francisco G Cosio
    Hospital Universitario de Getafe, Carretera de Toledo, km 12, 5 Getafe, 28905 Madrid, Spain
    Europace 10:21-7. 2008
    ....
  86. pmc Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP
    Dagmar Harzheim
    Forschungszentrum Julich, Institut für Neurowissenschaften und Biophysik, Abteilung Zelluläre Biophysik, Julich, Germany
    EMBO J 27:692-703. 2008
    ..Most importantly, our results indicate that HCN4 channels can fulfil their physiological function only when cAMP is bound...
  87. doi request reprint Catheter ablation of scar-related ventricular tachycardia: another piece of the puzzle
    Paulus Kirchhof
    Heart Rhythm 5:375-7. 2008
  88. doi request reprint Survivin determines cardiac function by controlling total cardiomyocyte number
    Bodo Levkau
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen Germany
    Circulation 117:1583-93. 2008
    ..Survivin inhibits apoptosis and regulates cell division in many organs, but its function in the heart is unknown...
  89. ncbi request reprint Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism
    Hideo A Baba
    Institute of Pathology, University of Essen, Essen, Germany
    Cardiovasc Res 59:390-9. 2003
    ....
  90. pmc Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
    Stefan Wagner
    Department of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
    J Clin Invest 116:3127-38. 2006
    ..In mice, enhanced CaMKIIdelta(C) activity predisposed to VT. Thus, CaMKII-dependent regulation of Na(+) channel function may contribute to arrhythmogenesis in HF...
  91. ncbi request reprint Semi-automated 3-dimensional intracardiac echocardiography: development and initial clinical experience of a new system to guide ablation procedures
    Christian Knackstedt
    Department of Cardiology, RWTH University Aachen, Aachen, Germany
    Heart Rhythm 3:1453-9. 2006
    ..However, updates of 3D-imaging modalities with high soft-tissue contrast are not available during ablation procedures...
  92. ncbi request reprint Atrial fibrillation, thromboembolism, and haemostasis: causal or casual associations?
    Paulus Kirchhof
    Thromb Haemost 90:973-5. 2003
  93. ncbi request reprint Hypertension begets hypertrophy begets atrial fibrillation? Insights from yet another sheep model
    Paulus Kirchhof
    Eur Heart J 27:2919-20. 2006