T Kietzmann

Summary

Country: Germany

Publications

  1. ncbi request reprint Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
  2. pmc Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue
    Ivana Zagotta
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
    Oxid Med Cell Longev 2013:793525. 2013
  3. ncbi request reprint Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2
    T Kietzmann
    Institut für Biochemie und Moleculare Zellbiologie, Gottingen, Germany
    FEBS Lett 388:228-32. 1996
  4. ncbi request reprint Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem Pharmacol 64:903-11. 2002
  5. ncbi request reprint Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:170-8. 2001
  6. ncbi request reprint Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 101:907-14. 2003
  7. pmc Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 354:531-7. 2001
  8. ncbi request reprint Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 94:4177-85. 1999
  9. ncbi request reprint Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 278:17927-36. 2003
  10. pmc Involvement of a local fenton reaction in the reciprocal modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 335:425-32. 1998

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
    ..The data suggest that the transcriptional induction of HO-1 gene expression by AEBSF is mediated via activation of a PKB, p38 MAPK signaling pathway...
  2. pmc Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue
    Ivana Zagotta
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
    Oxid Med Cell Longev 2013:793525. 2013
    ..Together, resveratrol can act as NF κ B inhibitor in adipocytes and thus the subsequently reduced PAI-1 expression in inflamed adipose tissue might provide a new insight towards novel treatment options of obesity. ..
  3. ncbi request reprint Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2
    T Kietzmann
    Institut für Biochemie und Moleculare Zellbiologie, Gottingen, Germany
    FEBS Lett 388:228-32. 1996
    ..These findings support the hypothesis that an H2O2-generating heme protein is involved in the O2 sensing system regulating gluconeogenic and glycolytic gene expression in response to O2...
  4. ncbi request reprint Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem Pharmacol 64:903-11. 2002
    ..Thus, our findings implicate that the cross-talk between oxygen and glucose might have a fundamental role in the regulation of several physiological and pathophysiological processes...
  5. ncbi request reprint Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:170-8. 2001
    ....
  6. ncbi request reprint Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 101:907-14. 2003
    ..Thus, the insulin-dependent activation of the PAI-1 gene expression can be mediated via the PI3K/PKB pathway and the transcription factor HIF-1 binding to the HREs in the PAI-1 gene promoter...
  7. pmc Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 354:531-7. 2001
    ..The mRNAs of the rat HIF alpha-subunits were expressed predominantly in the perivenous zone of rat liver tissue; the nuclear HIFalpha proteins, however, did not appear to be zonated...
  8. ncbi request reprint Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 94:4177-85. 1999
    ..Thus, PAI-1 induction by mild hypoxia via a HIF-1 binding HRE in the rat PAI-1 promoter appears to be the mechanism causing the increase in PAI-1 in many clinical conditions associated with O(2) deficiency...
  9. ncbi request reprint Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 278:17927-36. 2003
    ..Thus, the HO-1 CRE/AP-1 element mediates HO-1 gene induction via activation of JNK/c-Jun whereas p38 isoforms act through a different mechanism via the E-box...
  10. pmc Involvement of a local fenton reaction in the reciprocal modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 335:425-32. 1998
    ..In the same compartment, iron could be detected by electron-probe X-ray microanalysis. Thus a local Fenton reaction is involved in the O2 signalling, which modulated the glucagon- and insulin-dependent PCK gene and GK gene activation...
  11. ncbi request reprint Diminution of the O2 responsiveness of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocytes by long-term culture at venous PO2
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Kidney Int 51:542-7. 1997
    ..This diminution of O2 sensitivity of PCK induction may be due to a nuclear protein or proteins which are induced by perivenous O2 tensions and bind to the PCK promoter...
  12. ncbi request reprint Oxygen: modulator of physiological and pathophysiological processes in the liver
    T Kietzmann
    Department of Biochemistry, Faculty of Chemistry, University of Kaiserslautern
    Z Gastroenterol 44:67-76. 2006
    ..In addition, feedback mechanisms between hypoxia, HIF and the IGF axes appear to exist. Thus, the knowledge of these mechanisms may help to initiate new therapies in diseases with disturbed O2 availability...
  13. ncbi request reprint Cross-talk between the signals hypoxia and glucose at the glucose response element of the L-type pyruvate kinase gene
    A Krones
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat, Humboldtallee 23, D 37073 Gottingen, Germany
    Endocrinology 142:2707-18. 2001
    ..Our findings implicate that the cross-talk between oxygen and glucose might have a fundamental role in the regulation of several physiological and pathophysiological processes...
  14. ncbi request reprint The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site
    A Samoylenko
    , Humboldtallee 23, , Germany
    Blood 97:2657-66. 2001
    ..These results indicated that the balance between 2 transcriptional factors, HIF-1 and USF-2a, which can bind adjacent HRE sites, appears to be involved in the regulation of PAI-1 expression in many clinical conditions...
  15. ncbi request reprint Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes
    Ulrike Roth
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat, Humboldtallee 23, D 37073 Gottingen, Germany
    Biol Chem 385:239-47. 2004
    ..HIF-1alpha and HNF-4 additively activated the GK promoter, while USF-2 and HNF-4 together did not show this additive activation. Thus, HIF-1 and USF may play differential roles in the modulation of GK expression in response to O2...
  16. ncbi request reprint The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway
    Ulrike Roth
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat, Humboldtallee 23, D 37073 Gottingen, Germany
    J Biol Chem 279:2623-31. 2004
    ..Thus, a regulatory transcriptional complex consisting of HIF-1, HNF-4, and p300 appears to be involved in insulin-dependent GK gene activation...
  17. ncbi request reprint Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Mol Pharmacol 56:46-53. 1999
    ..Thus, in hepatocyte cultures, an O2 gradient in conjunction with EGF mimicked the perivenous induction by PB of the CYP2B1 gene observed in the liver in vivo...
  18. pmc Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes
    Ulrike Roth
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 365:223-8. 2002
    ..Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression...
  19. doi request reprint Opposite expression of the antioxidant heme oxygenase-1 in primary cells and tumor cells: regulation by interaction of USF-2 and Fra-1
    Anatoly Samoylenko
    Department of Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 10:1163-74. 2008
    ..Together, these data suggest that USF-2 has opposite regulatory roles for HO-1 gene expression in primary cells and tumor cell lines...
  20. ncbi request reprint Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide
    K B Sandau
    Faculty of Biology, University of Kaiserslautern, , 67663 Kaiserslautern, Germany
    J Biol Chem 276:39805-11. 2001
    ..These data indicate that diverse agonists activate HIF-1alpha under normoxic conditions by employing different signaling pathways...
  21. pmc Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1
    Alexandra Klein
    Department of Biochemistry, Faculty of Chemistry, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    Mol Biol Cell 19:3667-75. 2008
    ..These results show that STK15 gene transcription can be regulated by hypoxia and HIF-1 via HRE-2 of the STK15 promoter. Thus, tumor hypoxia may trigger overexpression of STK15 observed in various tumors...
  22. ncbi request reprint Oxidative stress and hypoxia: implications for plasminogen activator inhibitor-1 expression
    Elitsa Y Dimova
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Antioxid Redox Signal 6:777-91. 2004
    ..This article tries to summarize some aspects leading to enhanced PAI-1 production under oxidative stress or hypoxia...
  23. ncbi request reprint Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes
    Kyrylo Tron
    Abteilung Gastroenterologie und Endokrinologie, Uniklinikum, Georg August Universitat Gottingen, D 37075 Gottingen, Germany
    J Hepatol 45:72-80. 2006
    ..Heme oxygenase-1 (HO-1) can be induced by various stimuli, one of which is interleukin-6 (IL-6). Therefore, the aim of this study was to elucidate the molecular mechanisms responsible for IL-6-dependent HO-1 induction in the liver...
  24. doi request reprint FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels
    Elitsa Y Dimova
    Department of Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 13:413-24. 2010
    ....
  25. ncbi request reprint CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect
    Elitsa Y Dimova
    Department Chemistry Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Thromb Haemost 98:296-303. 2007
    ..Thus, CREB binding to the HIF-1 responsive elements in PAI-1 promoter mediates the glucagon effect in the liver...
  26. ncbi request reprint Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: lessons from the liver
    Elitsa Y Dimova
    Department Chemistry Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Thromb Haemost 100:992-1006. 2008
    ..This article will primarily focus on the regulation of PAI-1 expression in liver cells and discuss potential cross-talks between metabolic, hormonal and environmental signals...
  27. ncbi request reprint Transcriptional induction of heme oxygenase-1 gene expression by okadaic acid in primary rat hepatocyte cultures
    S Immenschuh
    Institut für Klinische Chemie und Pathobiochemie der Justus Liebig Universität Giebetaen, Giebetaen, Germany
    Mol Pharmacol 57:610-8. 2000
    ..Mutation of the cAMP response element/activator protein-1 (-665/-654) site obliterated the OA-dependent induction, suggesting that this element is involved in the transcriptional induction of the rat HO-1 gene by OA...
  28. ncbi request reprint The rat heme oxygenase-1 gene is transcriptionally induced via the protein kinase A signaling pathway in rat hepatocyte cultures
    S Immenschuh
    Department of Pediatrics, Biochemistry, and Pharmacology, Cornell University Medical College, New York, New York 10021, USA
    Mol Pharmacol 53:483-91. 1998
    ..7 to 5.5 hr. Taken together, the results of the current study demonstrate that HO-1 gene expression is induced by activation of the cAMP signal transduction pathway via a transcriptional mechanism in primary rat hepatocyte cultures...
  29. ncbi request reprint Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells
    Elitsa Y Dimova
    Department Chemistry Biochemistry, University of Kaiserslautern, Germany
    Thromb Haemost 93:1176-84. 2005
    ..Thus, IGF-1 activates human PAI-1 gene expression through activation of the PI3-kinase and ERK1/2 via HIF-1alpha...
  30. ncbi request reprint Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Thromb Haemost 89:666-73. 2003
    ..These findings indicate that p38- and PKB-dependent signalling pathways contribute to enhanced PAI-1 levels in the hypoxic response...
  31. ncbi request reprint The MAPK pathway and HIF-1 are involved in the induction of the human PAI-1 gene expression by insulin in the human hepatoma cell line HepG2
    Elitsa Y Dimova
    University of Kaiserslautern, Faculty of Chemistry, Department of Biochemistry, Erwin Schroedinger Strasse 54, 67663 Kaiserslautern, Germany
    Ann N Y Acad Sci 1090:355-67. 2006
    ..Thus, insulin-dependent PAI-1 gene expression might be regulated by the action of both HIF-1 and FoxO1 transcription factors...
  32. pmc A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression
    Qing Liu
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Proc Natl Acad Sci U S A 101:4302-7. 2004
    ..Thus, the localized Fenton reaction appears to impact the expression of hypoxia-regulated genes by means of HIF-1alpha stabilization and coactivator recruitment...
  33. ncbi request reprint Cell type-dependent regulation of the hypoxia-responsive plasminogen activator inhibitor-1 gene by upstream stimulatory factor-2
    Elitsa Y Dimova
    Department of Biochemistry, Faculty of Chemistry, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    J Biol Chem 281:2999-3005. 2006
    ....
  34. pmc FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol
    Goutham Kumar Ganjam
    Faculty of Chemistry, Department of Biochemistry, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    J Biol Chem 284:30783-97. 2009
    ..These results provide the first evidence that resveratrol represses GK expression via FoxO1 and that the interaction between FoxO1 and HNF-4 contributes to these effects of resveratrol...
  35. ncbi request reprint Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1
    Qing Liu
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 104:3993-4001. 2004
    ..Thus, calcium appeared to have a critical role in the regulation of the HIF system and subsequent activation of the PAI-1 gene expression...
  36. doi request reprint The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF
    Aline Bach
    Department of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 13:437-48. 2010
    ..These results provide evidence that quercetin inhibits the cell cycle and that induction of the HIF-system contributes to these effects of quercetin...
  37. ncbi request reprint Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6
    Kyrylo Tron
    University Hospital, Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Gottingen, Germany
    Lab Invest 85:376-87. 2005
    ....
  38. ncbi request reprint Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver
    Jacek Lenart
    Faculty of Chemistry, Department of Biochemistry, Erwin Schrodinger Strasse, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Arch Biochem Biophys 462:238-44. 2007
    ..Further, the zonation of glutamine synthetase, glucokinase and phosphoenolpyruvate carboxykinase was no longer preserved. We conclude that deficiency of mitochondrial MnSOD initiates a dysregulation of zonated gene expression in liver...
  39. ncbi request reprint Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes
    Jens Gerd Scharf
    Medizinische Klinik und Poliklinik, Georg August Universitat, Gottingen, Germany
    Endocrinology 146:5433-43. 2005
    ..Together, these results support the concept that iron, radical oxygen species, and the HIF-2 and -3 as well as the PHD pathways play important roles in mediating effects of hypoxia on IGFBP-1 gene expression in the liver...
  40. ncbi request reprint The role of hypoxia inducible factor-1 in cell metabolism--a possible target in cancer therapy
    Rachida S Bel Aiba
    University of Kaiserslautern, Faculty of Chemistry, Department of Biochemistry, Erwin Schrödinger Strasse 54, D 67663 Kaiserslautern, Germany
    Expert Opin Ther Targets 10:583-99. 2006
    ..Therefore, studying the link and the feedback mechanisms between metabolism and HIF-1alpha is of major importance to find new and specific therapeutic strategies...
  41. ncbi request reprint Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
    Thomas Kietzmann
    Faculty of Chemistry, Department of Biochemistry, Erwin Schrodinger Strasse, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Semin Cell Dev Biol 16:474-86. 2005
    ..Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized...
  42. doi request reprint Hypoxia-inducible factors: post-translational crosstalk of signaling pathways
    Elitsa Y Dimova
    Department of Chemistry Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Methods Mol Biol 647:215-36. 2010
    ..Here, we summarize current knowledge about Post-translational HIF-1 regulation and give additional information about useful methods to determine some of these various modifications...
  43. ncbi request reprint Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor
    Nico Charlier
    Department of Neonatology, Charite, Humboldt University, 14057, Berlin, Germany
    Brain Res Mol Brain Res 104:21-30. 2002
    ..The decrease in HIF-1 activity and the increase in hypoxia sensitivity may suggest that NGF act as an hierarchically organized signaling molecule...
  44. doi request reprint HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus
    Kaori Nagao
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Biol Chem 283:11841-9. 2008
    ..The cardiac abnormality in the HIF-1alpha-depleted embryo was restored with co-injection of nkx2.5 mRNA. Collectively, these findings reveal that HIF-1alpha-regulated nkx2.5 expression is required for heart development in Xenopus...
  45. ncbi request reprint Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression
    Nastiti Wijayanti
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Antioxid Redox Signal 6:802-10. 2004
    ..The results suggest that the NF-kappaB and p38 MAPK signaling pathways mediate the LPS-dependent induction of HO-1 gene expression via DNA sequences of the proximal promoter region...
  46. ncbi request reprint Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Müchen and der Technischen Universität Müchen, Munich, Germany
    Thromb Haemost 89:926-35. 2003
    ..In contrast, NFkappaB activation was enhanced in RacG12V-cells, but abolished by RacT17N. Thus, these findings suggest a mechanism explaining modified fibrinolysis and tissue remodeling in an oxidized environment...
  47. ncbi request reprint Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase
    Kai Franke
    IBA GmbH, Rudolf Wissell Str 28, 37079 Göttingen, Germany
    Antioxid Redox Signal 6:721-8. 2004
    ..These studies provide some new information regarding the role of ROS within the proteolytic processes in hepatocytes that require PAI-1...
  48. ncbi request reprint Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway
    Alexander Hess
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, Giessen D 35392, Germany
    J Biol Chem 278:45419-34. 2003
    ..The data indicate that a protein kinase C, Ras, MEKK1, p38 MAPK signaling pathway plays a major role for the transcriptional up-regulation of Prx I gene expression...
  49. ncbi request reprint Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus
    Rainald Schmidt-Kastner
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Brain Res 1001:133-42. 2004
    ..Nuclear location of BNIP3 after brain ischemia indicates a novel role for the regulation of cell survival in neurons or a general disturbance of the nuclear envelope...
  50. pmc Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner
    Daniela Flügel
    Fachbereich Chemie, Abteilung Biochemie, Universitat Kaiserslautern, Erwin Schrödinger Str Geb 54, D 67663 Kaiserslautern, Germany
    Mol Cell Biol 27:3253-65. 2007
    ..Thus, the direct regulation of HIF-1alpha stability by GSK-3 may influence physiological processes or pathophysiological situations such as metabolic diseases or tumors...
  51. pmc Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, D 80636 Munich, Germany
    Mol Biol Cell 18:4691-7. 2007
    ..Together, these findings provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the PI3K/AKT pathway and activation of NFkappaB...
  52. ncbi request reprint Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, 80636 Munich, Germany
    Thromb Haemost 93:1168-75. 2005
    ..Thus, PAK may play an important role in promoting vascular remodelling processes in pulmonary hypertension...
  53. ncbi request reprint Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures
    Johann Gross
    Department of Otorhinolaryngology, Charite Hospital, Humboldt University, Berlin, Germany
    Int J Oncol 27:807-14. 2005
    ..These findings suggest that, in HNSCC cells, hypoxia induces HIF-1alpha to stabilize and accumulate in the cell nuclei but have a cell-specific transcriptional complex...
  54. ncbi request reprint Oxygen-dependent regulation of hepatic glucose metabolism
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    Methods Enzymol 381:357-76. 2004
  55. ncbi request reprint NOX2 and NOX4 mediate proliferative response in endothelial cells
    Andreas Petry
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 8:1473-84. 2006
    ..NOX2 and NOX4, but not NOX1, equally contributed to ROS generation and proliferation under basal conditions, indicating that a complex relation between NOX homologues controls endothelial function...
  56. ncbi request reprint Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    Steve Bonello
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Lazarettstr 36, D 80636 Munich, Germany
    Arterioscler Thromb Vasc Biol 27:755-61. 2007
    ..We therefore aimed to elucidate the link between these 2 important redox-sensitive transcription factors...
  57. ncbi request reprint Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimentelle Kinderkardiologie, Klinik für Kinder Kardiologie und Angeborene Herzfehler, Deutsches Herzzentrum München an der Technischen Universität München, D 80636 München, Germany
    Biol Chem 385:249-57. 2004
    ..Thus, shifting the redox balance to a more reduced environment, thereby limiting VEGF expression, may be beneficial for treating remodeling processes during pulmonary hypertension...
  58. ncbi request reprint Inhibition of phorbol ester-dependent peroxiredoxin I gene activation by lipopolysaccharide via phosphorylation of RelA/p65 at serine 276 in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Free Radic Biol Med 44:699-710. 2008
    ..In summary, LPS-dependent inhibition of Prx I gene activation by TPA in monocytes is regulated via a pathway that involves phosphorylation of the NF-kappaB subunit p65 at serine 276...
  59. ncbi request reprint An atypical NF-kappa B-regulated pathway mediates phorbol ester-dependent heme oxygenase-1 gene activation in monocytes
    Srivatsava Naidu
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Immunol 181:4113-23. 2008
    ..Taken together, induction of HO-1 gene expression by PMA is regulated via an IkappaB kinase-independent, atypical NF-kappaB pathway that is mediated via the activation of p38 MAPK and CK2...
  60. ncbi request reprint Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6
    Youssef Abdul Jalil
    Institute of Pharmacology and Toxicology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Am J Physiol Cell Physiol 294:C579-90. 2008
    ..In summary, these results demonstrate that rAbcb6 is a glycosylated protein targeted to intracellular vesicular membranes and suggest involvement of rAbcb6 in transition metal homeostasis...