Falk Kiefer

Summary

Country: Germany

Publications

  1. ncbi request reprint Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?
    Falk Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Psychopharmacology (Berl) 162:433-7. 2002
  2. ncbi request reprint Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Arch Gen Psychiatry 60:92-9. 2003
  3. ncbi request reprint Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography method
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Can J Psychiatry 51:335-41. 2006
  4. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
  5. doi request reprint Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
    Michael Wagner
    Department of Psychiatry, University of Bonn, Germany
    Addict Biol 18:752-61. 2013
  6. ncbi request reprint The facial pattern of disgust, appetence, excited joy and relaxed joy: an improved facial EMG study
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Germany
    Scand J Psychol 46:403-9. 2005
  7. ncbi request reprint Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Psychiatry 60:784-7. 2006
  8. ncbi request reprint Combined therapy: what does acamprosate and naltrexone combination tell us?
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Alcohol Alcohol 39:542-7. 2004
  9. doi request reprint Why is disulfiram superior to acamprosate in the routine clinical setting? A retrospective long-term study in 353 alcohol-dependent patients
    Alexander Diehl
    Department of Psychiatry, Klinikum Braunschweig, Braunschweig, Germany
    Alcohol Alcohol 45:271-7. 2010
  10. ncbi request reprint Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
    Biol Psychiatry 53:345-51. 2003

Detail Information

Publications30

  1. ncbi request reprint Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?
    Falk Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Psychopharmacology (Berl) 162:433-7. 2002
    ..During alcohol withdrawal, a decreased secretion of beta E with a delayed normalization has been reported, but up to now only few data became available regarding the interaction of plasma beta E and psychopathological parameters...
  2. ncbi request reprint Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Arch Gen Psychiatry 60:92-9. 2003
    ..Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds...
  3. ncbi request reprint Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography method
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Can J Psychiatry 51:335-41. 2006
    ..We investigated facial expression of emotions (FEE) in schizophrenia patients, using an improved and highly selective facial electromyography (EMG) method, and we examined the correlation between FEE and psychopathology...
  4. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
    ..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings...
  5. doi request reprint Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
    Michael Wagner
    Department of Psychiatry, University of Bonn, Germany
    Addict Biol 18:752-61. 2013
    ..The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use...
  6. ncbi request reprint The facial pattern of disgust, appetence, excited joy and relaxed joy: an improved facial EMG study
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Germany
    Scand J Psychol 46:403-9. 2005
    ..Our findings indicate the possibility to explore the entire emotion system successfully through a state-of-the-art psychophysiological method like our EMG device...
  7. ncbi request reprint Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Psychiatry 60:784-7. 2006
    ..Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD)...
  8. ncbi request reprint Combined therapy: what does acamprosate and naltrexone combination tell us?
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Alcohol Alcohol 39:542-7. 2004
    ..It remains to be answered whether data justify the combination of both drugs in clinical practice...
  9. doi request reprint Why is disulfiram superior to acamprosate in the routine clinical setting? A retrospective long-term study in 353 alcohol-dependent patients
    Alexander Diehl
    Department of Psychiatry, Klinikum Braunschweig, Braunschweig, Germany
    Alcohol Alcohol 45:271-7. 2010
    ..To compare the long-term effectiveness of acamprosate (ACP) and disulfiram (DSF) in the treatment of alcohol dependence and their effectiveness in regard to patient characteristics, within a naturalistic outpatient treatment setting...
  10. ncbi request reprint Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
    Biol Psychiatry 53:345-51. 2003
    ....
  11. ncbi request reprint Adjunctive use of reboxetine in schizophrenia
    Thomas J Raedler
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martini str 52, 20246 Hamburg, Germany
    Eur Psychiatry 19:366-9. 2004
    ..We sought to study the efficacy and tolerability of the adjunctive use of reboxetine in a cohort of schizophrenic patients with prominent depressive or negative symptoms...
  12. doi request reprint Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age
    Vanessa Nieratschker
    Departments of Genetic Epidemiology in Psychiatry Addictive Behavior and Addiction Medicine Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany, Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Germany Institute of Neuroscience and Medicine, Research Centre Julich, Germany Department of Genomics, Life and Brain Center Institute of Human Genetics University of Bonn, Germany and German Center for Neurodegenerative Disorders DZNE, Germany
    Addict Biol 19:305-11. 2014
    ....
  13. doi request reprint The German multi-centre study on smoking-related behavior-description of a population-based case-control study
    Annette Lindenberg
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Germany
    Addict Biol 16:638-53. 2011
    ..Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper...
  14. ncbi request reprint The face of pain--a pilot study to validate the measurement of facial pain expression with an improved electromyogram method
    Karsten Wolf
    University Hospital Hamburg Eppendorf, Germany
    Pain Res Manag 10:15-9. 2005
    ..The purpose of this pilot study was to establish the validity of an improved facial electromyogram (EMG) method for the measurement of facial pain expression...
  15. pmc Suppression of the HPA axis stress-response: implications for relapse
    Byron Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Alcohol Clin Exp Res 29:1351-5. 2005
    ..b>Falk Kiefer discussed the relationship between basal HPA axis responsivity and clinical outcome following treatment with ..
  16. ncbi request reprint Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship
    Falk Kiefer
    Psychopharmacology (Berl) 164:239-40. 2002
  17. doi request reprint Acamprosate: recent findings and future research directions
    Karl Mann
    The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 32:1105-10. 2008
    ..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy...
  18. ncbi request reprint Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 13:124-9. 2008
    ..It is discussed whether especially these subjects should be targeted for pharmacological relapse prevention treatment with naltrexone...
  19. ncbi request reprint Pharmacological relapse prevention of alcoholism: clinical predictors of outcome
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 11:83-91. 2005
    ..The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials. It remains uncertain whether any differential indication for treatment exists...
  20. ncbi request reprint Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 404:103-6. 2006
    ....
  21. ncbi request reprint Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    J Psychiatr Res 39:545-51. 2005
    ..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration...
  22. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 60:74-6. 2006
    ..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism...
  23. ncbi request reprint New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence
    Falk Kiefer
    University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
    Eur J Pharmacol 526:163-71. 2005
    ..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs...
  24. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  25. ncbi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  26. ncbi request reprint Extended-release intramuscular naltrexone: a viewpoint by Falk Kiefer
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Drugs 66:1752-3. 2006
  27. doi request reprint Drugs for relapse prevention of alcoholism: ten years of progress
    Rainer Spanagel
    Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
    Trends Pharmacol Sci 29:109-15. 2008
    ..However, the heterogeneity in treatment response makes it necessary to characterize genetic and protein markers and endophenotypes for individualized pharmacotherapy...
  28. ncbi request reprint HPA-axis activity in alcoholism: examples for a gene-environment interaction
    Toni Kim Clarke
    Section of Addiction Biology, Institute of Psychiatry, King s College, London, UK
    Addict Biol 13:1-14. 2008
    ....
  29. ncbi request reprint Pharmacotherapy and behavioral intervention for alcohol dependence
    Falk Kiefer
    JAMA 296:1727-8; author reply 1728-9. 2006
  30. ncbi request reprint Measuring alcohol consumption in man--it is time for a change
    Falk Kiefer
    Addiction 101:1215-6; author reply 1216-7. 2006