E Kerkhoff

Summary

Country: Germany

Publications

  1. ncbi The Spir actin organizers are involved in vesicle transport processes
    E Kerkhoff
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, 97078, Wurzburg, Germany
    Curr Biol 11:1963-8. 2001
  2. ncbi Cellular functions of the Spir actin-nucleation factors
    Eugen Kerkhoff
    Institut für medizinsche Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 5, 97078 Wurzburg, Germany
    Trends Cell Biol 16:477-83. 2006
  3. ncbi The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization
    I M Otto
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Wurzburg, 97078, Germany
    Curr Biol 10:345-8. 2000
  4. ncbi Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain
    Nina Schumacher
    Theodor Boveri Institut Biozentrum, Universitat Wurzburg, Physiologische Chemie I, Am Hubland, 97074 Wurzburg, Germany
    Gene Expr Patterns 4:249-55. 2004
  5. ncbi Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
    E Kerkhoff
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Germany
    Cell Growth Differ 11:185-90. 2000
  6. ncbi Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype
    Ulrike E E Rennefahrt
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, 97078 Wurzburg, Germany
    J Biol Chem 277:29510-8. 2002
  7. pmc Regulatory interactions between two actin nucleators, Spire and Cappuccino
    Margot E Quinlan
    Bayerisches Genomforschungsnetzwerk BayGene, Institut für funktionelle Genomik, Universitat Regensburg, 93053 Regensburg, Germany
    J Cell Biol 179:117-28. 2007
  8. ncbi Drosophila Spire is an actin nucleation factor
    Margot E Quinlan
    Department of Cellular and Molecular Pharmacology, UCSF Medical School, San Francisco, California 94107, USA
    Nature 433:382-8. 2005
  9. doi Actin nucleation: bacteria get in-Spired
    Margot E Quinlan
    Nat Cell Biol 10:13-5. 2008
  10. ncbi Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling
    Troy Joseph
    Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10021, USA
    Oncogene 21:3651-8. 2002

Collaborators

  • T Raabe
  • R Pepperkok
  • K Aktories
  • Francesca D Ciccarelli
  • Margot E Quinlan
  • R Dyche Mullins
  • Nina Schumacher
  • Troy Joseph
  • Ulrike E E Rennefahrt
  • Ulf R Rapp
  • I M Otto
  • Anaid Bedrossian
  • Susanne Hilgert
  • John E Heuser
  • Manfred Gessler
  • Cornelia B Leberfinger
  • Johanna M Borawski
  • Bertram Illert
  • Paul Frankel
  • Jakob Troppmair
  • David A Foster
  • Roger Wooden
  • Annika Bryant
  • P Bork
  • U E Rennefahrt
  • U R Rapp

Detail Information

Publications12

  1. ncbi The Spir actin organizers are involved in vesicle transport processes
    E Kerkhoff
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, 97078, Wurzburg, Germany
    Curr Biol 11:1963-8. 2001
    ....
  2. ncbi Cellular functions of the Spir actin-nucleation factors
    Eugen Kerkhoff
    Institut für medizinsche Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 5, 97078 Wurzburg, Germany
    Trends Cell Biol 16:477-83. 2006
    ..Phosphorylation by mitogen-activated protein kinases and interaction with Rho GTPases have been proposed as regulatory mechanisms...
  3. ncbi The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization
    I M Otto
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Wurzburg, 97078, Germany
    Curr Biol 10:345-8. 2000
    ..Carboxy-terminal sequences of p150-Spir were phosphorylated by JNK both in vitro and in vivo. We conclude that p150-Spir is a downstream target of JNK function and provides a direct link between JNK and actin organization...
  4. ncbi Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain
    Nina Schumacher
    Theodor Boveri Institut Biozentrum, Universitat Wurzburg, Physiologische Chemie I, Am Hubland, 97074 Wurzburg, Germany
    Gene Expr Patterns 4:249-55. 2004
    ..In mouse embryos both genes are expressed in the developing nervous system. In the adult brain high expression of the genes was found in the Purkinje cells of the cerebellum and in neuronal cells of the hippocampus and dentate gyrus...
  5. ncbi Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
    E Kerkhoff
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Germany
    Cell Growth Differ 11:185-90. 2000
    ..Our studies show that the c-Raf-1 expression level is a critical parameter in tumor development and should be analyzed in more detail to evaluate its potential in the induction of cancer...
  6. ncbi Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype
    Ulrike E E Rennefahrt
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, 97078 Wurzburg, Germany
    J Biol Chem 277:29510-8. 2002
    ..Our data suggest that constitutive JNK activation elicits major aspects of cellular transformation but is unable to induce the complete set of changes which are required to establish the fully transformed phenotype...
  7. pmc Regulatory interactions between two actin nucleators, Spire and Cappuccino
    Margot E Quinlan
    Bayerisches Genomforschungsnetzwerk BayGene, Institut für funktionelle Genomik, Universitat Regensburg, 93053 Regensburg, Germany
    J Cell Biol 179:117-28. 2007
    ..In Drosophila oocytes, Spire localizes to the cortex early in oogenesis and disappears around stage 10b, coincident with the onset of cytoplasmic streaming...
  8. ncbi Drosophila Spire is an actin nucleation factor
    Margot E Quinlan
    Department of Cellular and Molecular Pharmacology, UCSF Medical School, San Francisco, California 94107, USA
    Nature 433:382-8. 2005
    ....
  9. doi Actin nucleation: bacteria get in-Spired
    Margot E Quinlan
    Nat Cell Biol 10:13-5. 2008
  10. ncbi Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling
    Troy Joseph
    Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10021, USA
    Oncogene 21:3651-8. 2002
    ..These data indicate that PLD signaling provides a novel survival signal that overcomes cell cycle arrest induced by high intensity Raf signaling...
  11. ncbi Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control
    Eugen Kerkhoff
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 5, D 97078 Wurzburg, Germany
    Biochim Biophys Acta 1589:151-9. 2002
    ..These results indicate a pro-oncogenic function of the Rac GTPase with respect to the deregulation of cell cycle control...
  12. ncbi The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold
    Francesca D Ciccarelli
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Trends Biochem Sci 28:349-52. 2003