G Kempermann

Summary

Country: Germany

Publications

  1. pmc Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
    Tobias Plümpe
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    BMC Neurosci 7:77. 2006
  2. ncbi Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
    G Kempermann
    Max Delbrück Center for Molecular Medicine Berlin Buch, Robert Rossle Str 10, 13125 Berlin Buch, Germany
    Eur J Neurosci 16:129-36. 2002
  3. ncbi Neuroscience. Microglia: the enemy within?
    Gerd Kempermann
    Neuronal Stem Cells Research Group, Max Delbrück Centrum für Molekulare Medizin Berlin Buch, 13125 Berlin, Germany
    Science 302:1689-90. 2003
  4. ncbi Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Development 130:391-9. 2003
  5. ncbi Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
  6. pmc Natural variation and genetic covariance in adult hippocampal neurogenesis
    Gerd Kempermann
    Max Delbröck Center for Molecular Medicine, Berlin Buch, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:780-5. 2006
  7. ncbi Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression
    Gerd Kempermann
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, and Department of Neurology, Charite University Hospital, Humboldt University Berlin, Berlin, Germany
    Bipolar Disord 4:17-33. 2002
  8. ncbi Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis
    Gerd Kempermann
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA
    Brain Res Dev Brain Res 134:1-12. 2002
  9. ncbi Why new neurons? Possible functions for adult hippocampal neurogenesis
    Gerd Kempermann
    Research Group VolkswagenStiftung at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, 10117 Berlin, Germany
    J Neurosci 22:635-8. 2002
  10. ncbi Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004

Detail Information

Publications65

  1. pmc Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
    Tobias Plümpe
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    BMC Neurosci 7:77. 2006
    ..Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events...
  2. ncbi Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
    G Kempermann
    Max Delbrück Center for Molecular Medicine Berlin Buch, Robert Rossle Str 10, 13125 Berlin Buch, Germany
    Eur J Neurosci 16:129-36. 2002
    ..This result supports the hypothesis that adult neurogenesis is involved in specific aspects of hippocampal function, particularly the acquisition of new information...
  3. ncbi Neuroscience. Microglia: the enemy within?
    Gerd Kempermann
    Neuronal Stem Cells Research Group, Max Delbrück Centrum für Molekulare Medizin Berlin Buch, 13125 Berlin, Germany
    Science 302:1689-90. 2003
  4. ncbi Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Development 130:391-9. 2003
    ..These new data suggest that new neurons are recruited early from the pool of proliferating progenitor cells and lead to a lasting effect of adult neurogenesis...
  5. ncbi Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..Activity exerts not only an acute but also a sustained effect on brain plasticity...
  6. pmc Natural variation and genetic covariance in adult hippocampal neurogenesis
    Gerd Kempermann
    Max Delbröck Center for Molecular Medicine, Berlin Buch, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:780-5. 2006
    ..The use of genetic reference panels coupled with phenotyping and global transcriptome profiling thus allowed insight into the complexity of the genetic control of adult neurogenesis...
  7. ncbi Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression
    Gerd Kempermann
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, and Department of Neurology, Charite University Hospital, Humboldt University Berlin, Berlin, Germany
    Bipolar Disord 4:17-33. 2002
    ..While the 'neurogenic theory' of depression remains highly speculative today, it might stimulate the generation of sophisticated working hypotheses, useful animal experiments and the first step towards new therapeutic approaches...
  8. ncbi Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis
    Gerd Kempermann
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA
    Brain Res Dev Brain Res 134:1-12. 2002
    ..At the present time it cannot be determined whether this regulation occurs by influencing cell fate decisions or by promoting selective survival...
  9. ncbi Why new neurons? Possible functions for adult hippocampal neurogenesis
    Gerd Kempermann
    Research Group VolkswagenStiftung at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, 10117 Berlin, Germany
    J Neurosci 22:635-8. 2002
  10. ncbi Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004
    ..The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development...
  11. ncbi Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    Exp Neurol 196:342-51. 2005
    ..Thus, seizure-generated neurons might contribute to the disease process of epilepsy...
  12. doi Differential 24 h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures
    B Steiner
    Max Delbrück Center for Molecular Medicine Berlin Buch, Research Group Neuronal Stem Cells, Robert Rossle Str 10, Berlin, Germany
    Neuroscience 154:521-9. 2008
    ....
  13. ncbi Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
    P J Horner
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Neurosci 20:2218-28. 2000
    ....
  14. ncbi Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal
    G Kempermann
    Salk Institute for Biological Studies, La Jolla, California, USA
    Hippocampus 9:321-32. 1999
    ....
  15. ncbi Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1
    Golo Kronenberg
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Brain Struct Funct 212:19-35. 2007
    ..We conclude that astrogenesis in CA1 is influenced by environmental conditions. However, SVZ precursor cells do not contribute to physiological cellular plasticity in CA1...
  16. ncbi Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, 13125 Berlin, Germany
    J Comp Neurol 467:455-63. 2003
    ..These findings allow us to break down what was broadly perceived as "proliferation" in earlier experiments into the relative contribution of several cell types, representing the earliest steps of neuronal development...
  17. ncbi Paradoxical effects of learning the Morris water maze on adult hippocampal neurogenesis in mice may be explained by a combination of stress and physical activity
    D Ehninger
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, and Volkswagenstiftung Research Group, Department of Neurology, Charite University Medicine Berlin, Berlin, Germany
    Genes Brain Behav 5:29-39. 2006
    ..In addition, however, our data show that physical activity that is intricately linked to many cognitive tasks in rodents might play an important role in explaining effects of learning on cellular hippocampal plasticity...
  18. ncbi A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus
    Laurenz Wiskott
    Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    Hippocampus 16:329-43. 2006
    ..A simple network simulation demonstrates that adding new plastic neurons is indeed a successful strategy for adaptation without catastrophic interference...
  19. doi NMDA and benzodiazepine receptors have synergistic and antagonistic effects on precursor cells in adult hippocampal neurogenesis
    Dominique S Petrus
    Max Delbrück Center for Molecular Medicine MDC, Research Group Neuronal Stem Cells, Department of Experimental Neurology, Charite University Medicine Berlin, Berlin Buch, Germany
    Eur J Neurosci 29:244-52. 2009
    ..We propose that NMDA receptor-dependent signalling maintains the precursor cells in the dentate gyrus while blocking initial stages of development and promoting more advanced stages...
  20. ncbi Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia
    Golo Kronenberg
    Klinik und Poliklinik fur Neurologie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    J Cereb Blood Flow Metab 25:1613-24. 2005
    ..We hypothesize that the change in physiologic properties induced by the ischemic insult is directed toward a specific function of nestin-expressing cells...
  21. ncbi Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice
    Moritz D Brandt
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 24:603-13. 2003
    ..In these models the induction of cell proliferation was paralleled by an increase of CR-positive cells, indicating the stimulus-dependent progression from cell division to a postmitotic stage...
  22. ncbi Adult-born hippocampal neurons mature into activity-dependent responsiveness
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, Robert Rossle Str 10, D 13125 Berlin, Berlin Buch, Germany
    Eur J Neurosci 18:2707-12. 2003
    ..Thus, new neurons appear quantitatively integrated into hippocampal circuits, suggestive of a relevant contribution to hippocampal function...
  23. doi Melatonin modulates cell survival of new neurons in the hippocampus of adult mice
    Gerardo Ramirez-Rodriguez
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Berlin, Germany
    Neuropsychopharmacology 34:2180-91. 2009
    ..These results indicate that melatonin through its receptor can modulate the survival of newborn neurons in the adult hippocampus, making it the first known exogenously applicable substance with such specificity...
  24. ncbi Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Neurobiol Aging 27:1505-13. 2006
    ..We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells...
  25. ncbi Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Exp Neurol 199:291-300. 2006
    ..Thus, physiological neurogenic and gliogenic stimuli induce significant microenvironmental changes in the adult SN and improve motor behavior in the 6-OHDA lesion model of PD...
  26. ncbi Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Charite University Medicine, Berlin, Germany
    Biol Psychiatry 60:1314-23. 2006
    ..Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD)...
  27. ncbi Proliferative response of distinct hippocampal progenitor cell populations after cortical infarcts in the adult brain
    Albrecht Kunze
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Neurobiol Dis 21:324-32. 2006
    ..The present study indicates that the proliferative response of precursor cell subpopulations in the subgranular zone might differ under physiological and pathophysiological conditions...
  28. ncbi Functional significance of adult neurogenesis
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch and Volkswagenstiftung Research Group at the Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Curr Opin Neurobiol 14:186-91. 2004
    ..Nevertheless, the information that has been obtained and published so far provides ample evidence that neurons generated in the adult can function and even suggests how they might contribute to cognitive processes...
  29. ncbi An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression
    M Y Chiang
    Gene Expression Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Neuron 21:1353-61. 1998
    ..These findings not only genetically uncouple LTP and LTD but also reveal a novel and unexpected role for vitamin A in higher cognitive functions...
  30. ncbi Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes
    Vitali Filippov
    Max Delbrück Center for Molecular Medicine MDS Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 23:373-82. 2003
    ....
  31. ncbi Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
    Jason Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Eur J Neurosci 17:2042-6. 2003
    ..The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus...
  32. ncbi Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression
    Gerd Kempermann
    Max Delbrück Center for Molecular Medicine Berlin Buch, and Department of Experimental Neurology, Charite University Hospital, Humboldt University, Berlin, Germany
    Biol Psychiatry 54:499-503. 2003
    ..We therefore propose that consideration of the neurogenesis hypothesis of depression be the most prominent aspect of a more general cellular plasticity hypothesis...
  33. pmc Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Biol 6:e272. 2008
    ..The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation...
  34. ncbi Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Berlin, Germany
    Glia 46:41-52. 2004
    ....
  35. ncbi Age-dependent expression of glucocorticoid- and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus
    Ana Garcia
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Aging Cell 3:363-71. 2004
    ..This course and variability of receptor expression in aging might help to explain differential vulnerability of adult neural precursor cells to corticoid-mediated influences...
  36. ncbi Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival
    Rainer Glass
    Cellular Neuroscience Group, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Neurosci 25:2637-46. 2005
    ..Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging...
  37. pmc Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo
    J Priller
    Department of Neurology, Charite, Humboldt University, 10117 Berlin, Germany
    J Cell Biol 155:733-8. 2001
    ..Based on morphologic criteria and the expression of glutamic acid decarboxylase, the newly generated Purkinje cells were functional...
  38. ncbi Neural consequences of environmental enrichment
    H van Praag
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Neurosci 1:191-8. 2000
    ..We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning...
  39. ncbi They are not too excited: the possible role of adult-born neurons in epilepsy
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Neuron 52:935-7. 2006
    ..Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe...
  40. doi Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus
    Susanne A Wolf
    Neuronal Stem Cells Research Group, Max Delbruck Centre for Molecular Medicine, Berlin Buch, Germany
    FASEB J 23:3121-8. 2009
    ..We suggest an evolutionary relevant communication route for the brain to respond to environmental stressors like inflammation mediated by glucocorticoid levels in the hippocampus...
  41. pmc Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons
    Harish Babu
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Berlin, Germany
    PLoS ONE 2:e388. 2007
    ..Despite widespread interest in adult hippocampal neurogenesis and the use of mouse models to study it, no protocol existed for adult murine long-term precursor cell cultures with hippocampus-specific differentiation potential...
  42. doi Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
    Michael Rohe
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    J Biol Chem 283:14826-34. 2008
    ..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients...
  43. doi The antitumorigenic response of neural precursors depends on subventricular proliferation and age
    Joo Hee Walzlein
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Berlin, Germany
    Stem Cells 26:2945-54. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  44. doi CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine, Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    J Immunol 182:3979-84. 2009
    ..We propose that systemic CD4-T cell activity is required for maintaining cellular plasticity in the adult hippocampus and represents an evolutionary relevant communication route for the brain to respond to environmental changes...
  45. ncbi Adult hippocampal neurogenesis and aging
    Friederike Klempin
    Volkswagen Research Group at the Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstr 21 22, 10117 Berlin, Germany
    Eur Arch Psychiatry Clin Neurosci 257:271-80. 2007
    ..e. the maintained potential for structural plasticity that allows compensation in situations of functional losses with aging. As such we propose that adult neurogenesis might contribute to the structural correlates of successful aging...
  46. doi Mild brain ischemia induces unique physiological properties in striatal astrocytes
    Li Ping Wang
    Department of Cellular Neurosciences, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Glia 56:925-34. 2008
    ..The dominant population in the ischemic lesion constitutes a novel physiological phenotype unlike any normal astrocyte and generates a large syncytium which might be a neuroprotective response of reactive astrocytes...
  47. ncbi Adult neurogenesis and neurodegenerative disease
    Barbara Steiner
    VolkswagenStiftung Research Group, Dept of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Regen Med 1:15-28. 2006
    ....
  48. ncbi New neurons in the adult mammalian brain: synaptogenesis and functional integration
    Hongjun Song
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:10366-8. 2005
  49. pmc Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring
    Anika Bick-Sander
    Volkswagen Stiftung Research Group, Department of Experimental Neurology, Charite University Medicine, and Max Delbruck Center for Molecular Medicine, Berlin Buch, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:3852-7. 2006
    ..Our data indicate that maternal behavior and physical activity affects infantile growth-factor expression and can transiently stimulate postnatal hippocampal development in the offspring...
  50. ncbi Role of endogenous neural stem cells in neurological disease and brain repair
    Jörg Dietrich
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Adv Exp Med Biol 557:191-220. 2006
    ..The following years will have to show how we can influence andmodulate endogenous repair nisms by increasing the cellular plasticity in the young and aged CNS...
  51. ncbi Temporal and spatial dynamics of brain structure changes during extensive learning
    Bogdan Draganski
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Neurosci 26:6314-7. 2006
    ..These results indicate that the acquisition of a great amount of highly abstract information may be related to a particular pattern of structural gray matter changes in particular brain areas...
  52. ncbi Two genetic rat models of arterial hypertension show different mechanisms by which adult hippocampal neurogenesis is increased
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    Dev Neurosci 29:124-33. 2007
    ..However, in both SHR and SHRSP, cell proliferation showed an association with blood pressure recordings...
  53. ncbi A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input
    Li Ping Wang
    Cellular Neuroscience, Max Delbrueck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin, Germany
    Mol Cell Neurosci 29:181-9. 2005
    ..This early establishment of GABAergic innervation in adult neurogenesis thus mimics the pattern described for brain development...
  54. ncbi Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects
    Melissa M Holmes
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 76:216-22. 2004
    ....
  55. doi Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase
    Golo Kronenberg
    Klinik und Poliklinik fur Neurologie, Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Campus Mitte, D 10117 Berlin, Germany
    J Neurosci 28:7219-30. 2008
    ..These results indicate that impaired uracil repair is involved in neurodegeneration and neuropsychiatric dysfunction induced by experimental folate deficiency...
  56. ncbi Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells
    Jason G Emsley
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Edwards 410 EDR 410, 50 Blossom Street, Boston MA 02114, USA
    Prog Neurobiol 75:321-41. 2005
    ....
  57. doi Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98101 1304, USA
    J Neurosci 28:3707-17. 2008
    ..These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex...
  58. doi The contribution of failing adult hippocampal neurogenesis to psychiatric disorders
    Gerd Kempermann
    Center for Regenerative Therapies Dresden, Technical University of Dresden, Dresden, Germany
    Curr Opin Psychiatry 21:290-5. 2008
    ..The level of evidence in favor of such hypotheses varies, but disturbed cellular plasticity in the hippocampus may be a common aspect of several neuropsychiatric diseases...
  59. doi Physical activity and the regulation of neurogenesis in the adult and aging brain
    Klaus Fabel
    Center for Regenerative Therapies Dresden, DFG Forschungszentrum und Exzellenzcluster, Tatzberg 47 49, 01307 Dresden, Germany
    Neuromolecular Med 10:59-66. 2008
    ..This would also explain why few new neurons could be beneficial for successful aging. We here review the current stage of the knowledge how this exercise-induced regulation of neurogenesis might work...
  60. ncbi Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
    Barbara Steiner
    Max Delbrück Center for Molecular Medicine Berlin Buch, 13125 Berlin Buch, Germany
    Glia 54:805-14. 2006
    ..Our data further support the existence of proliferative precursor cells that mark the transition between glia-like states and neuronal differentiation...
  61. ncbi Selective targeting of adenoviral vectors to neural precursor cells in the hippocampus of adult mice: new prospects for in situ gene therapy
    Anke Schmidt
    Department of Vector Technology and Experimental Gene Therapy, Biomedical Research Center, Schillingallee 69, D 18057 Rostock, Germany
    Stem Cells 25:2910-8. 2007
    ..Our approach represents a novel method for specific manipulation of NPC in the adult brain and may have major implications for the use of precursor cells as therapeutic delivery vehicles in the central nervous system...
  62. ncbi Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex
    Dan Ehninger
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin
    Cereb Cortex 13:845-51. 2003
    ..The physiological 'activation' of microglia adds a new aspect to the question of microglial function in the healthy brain and of how adult brain cells can plastically react to physiological stimuli...
  63. doi The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
    Gerd Kempermann
    Genomics of Regeneration, CRTD Center for Regenerative Therapies Dresden, Tatzberg 47 49, 01307 Dresden, Germany
    Trends Neurosci 31:163-9. 2008
    ....
  64. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  65. ncbi The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...