Beate E Kehrel

Summary

Country: Germany

Publications

  1. doi request reprint Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases
    Anne Bertling
    Department of Anesthesiology and Intensive Care, Experimental and Clinical Hemostasis, University of Muenster, Mendelstr 11, 48149 Muenster, Germany
    Arterioscler Thromb Vasc Biol 32:1979-90. 2012
  2. doi request reprint [Hemostasis management based on ROTEM(®): contra]
    Beate Kehrel
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 46:318-22. 2011
  3. ncbi request reprint Platelets: physiology and biochemistry
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Munster, Germany
    Semin Thromb Hemost 31:381-92. 2005
  4. doi request reprint Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostaseology, University Hospital, Muenster, Germany
    Thromb Haemost 103:1193-202. 2010
  5. doi request reprint Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1
    Silke Niemann
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital of Muenster, Muenster, Germany
    Thromb Haemost 102:735-42. 2009
  6. doi request reprint Microembolic signals on transcranial Doppler ultrasound are correlated with platelet activation markers, but not with platelet-leukocyte associates: a study in patients with acute stroke and in patients with asymptomatic carotid stenosis
    Martin A Ritter
    Department of Neurology, Experimental and Clinical Hemostasis, University of Munster, Munster, Germany
    Neurol Res 31:11-6. 2009
  7. doi request reprint Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols
    Anne Bertling
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University of Muenster, Muenster, Germany
    Thromb Haemost 104:270-8. 2010
  8. ncbi request reprint Staphylococcus aureus fibronectin-binding protein (FnBP)-mediated adherence to platelets, and aggregation of platelets induced by FnBPA but not by FnBPB
    Christine Heilmann
    Institute of Medical Microbiology, University of Munster, Munster, Germany
    J Infect Dis 190:321-9. 2004
  9. doi request reprint Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital of Munster, Munster, Germany
    Thromb Haemost 103:1053-64. 2010
  10. ncbi request reprint Soluble fibrin is the main mediator of Staphylococcus aureus adhesion to platelets
    Silke Niemann
    Department of Anaesthesiology and Intensive Care, University Hospital Muenster, Muenster, Germany
    Circulation 110:193-200. 2004

Collaborators

Detail Information

Publications22

  1. doi request reprint Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases
    Anne Bertling
    Department of Anesthesiology and Intensive Care, Experimental and Clinical Hemostasis, University of Muenster, Mendelstr 11, 48149 Muenster, Germany
    Arterioscler Thromb Vasc Biol 32:1979-90. 2012
    ..The staphylococcal extracellular adherence protein (Eap) functions as an adhesin for host plasma proteins. Therefore we tested the effect of Eap on platelets...
  2. doi request reprint [Hemostasis management based on ROTEM(®): contra]
    Beate Kehrel
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 46:318-22. 2011
    ..On the other hand the author values the thrombelastometry as a supplementary supportive method used directly by haemostasis specialists or in a tight cooperation with such skilled specialists...
  3. ncbi request reprint Platelets: physiology and biochemistry
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Munster, Germany
    Semin Thromb Hemost 31:381-92. 2005
    ..Finally, special emphasis is placed on important stimulatory and inhibitory signaling pathways that modulate platelet function...
  4. doi request reprint Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostaseology, University Hospital, Muenster, Germany
    Thromb Haemost 103:1193-202. 2010
    ....
  5. doi request reprint Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1
    Silke Niemann
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital of Muenster, Muenster, Germany
    Thromb Haemost 102:735-42. 2009
    ..aureus-platelet adhesion. Consequently, we hypothesise that the described mechanism of platelet-bacteria-association might represent a general and important strategy of Gram-positive bacteria during development of invasive diseases...
  6. doi request reprint Microembolic signals on transcranial Doppler ultrasound are correlated with platelet activation markers, but not with platelet-leukocyte associates: a study in patients with acute stroke and in patients with asymptomatic carotid stenosis
    Martin A Ritter
    Department of Neurology, Experimental and Clinical Hemostasis, University of Munster, Munster, Germany
    Neurol Res 31:11-6. 2009
    ..The in vivo correlates of microembolic signals (MES) are still unknown. Platelet-associates (PA) with monocytes or granulocytes or platelet aggregates only may represent these correlates...
  7. doi request reprint Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols
    Anne Bertling
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University of Muenster, Muenster, Germany
    Thromb Haemost 104:270-8. 2010
    ..albicans could contribute to its survival in the blood stream during vascular infections. The knowledge of the underlying mechanisms of the antithrombotic properties might help to treat fungal infections as well as thrombosis...
  8. ncbi request reprint Staphylococcus aureus fibronectin-binding protein (FnBP)-mediated adherence to platelets, and aggregation of platelets induced by FnBPA but not by FnBPB
    Christine Heilmann
    Institute of Medical Microbiology, University of Munster, Munster, Germany
    J Infect Dis 190:321-9. 2004
    ..The ability of Staphylococcus aureus to adhere to platelets and to induce aggregation of platelets is considered to be a critical factor in S. aureus-associated infective endocarditis...
  9. doi request reprint Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital of Munster, Munster, Germany
    Thromb Haemost 103:1053-64. 2010
    ..After haematogenesis stem cell transplantation (HSCT) the brothers showed no symptoms of bleeding or immunodeficiency and the integrin-dependent platelet and leukocyte functions normalised...
  10. ncbi request reprint Soluble fibrin is the main mediator of Staphylococcus aureus adhesion to platelets
    Silke Niemann
    Department of Anaesthesiology and Intensive Care, University Hospital Muenster, Muenster, Germany
    Circulation 110:193-200. 2004
    ..The specific role of the various factors involved in bacteria-platelet association has not yet been fully elucidated...
  11. pmc Molecular characterization of a novel Staphylococcus aureus surface protein (SasC) involved in cell aggregation and biofilm accumulation
    Katrin Schroeder
    Institute of Medical Microbiology, University Hospital of Munster, Munster, Germany
    PLoS ONE 4:e7567. 2009
    ..To form a biofilm, bacteria first attach to the surface of the medical device, and then proliferate and accumulate into multilayered cell clusters. Biofilm accumulation may be mediated by polysaccharide and protein factors...
  12. ncbi request reprint Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1)
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital of Munster, Munster, Germany
    Thromb Haemost 91:334-44. 2004
    ..Platelets from patients with acute cerebral ischemia are exhausted and desensitized to thrombin through cleavage of PAR-1, indicating that high concentrations of thrombin occur with acute cerebrovascular ischemic events in vivo...
  13. doi request reprint High-density lipoproteins, platelets and the pathogenesis of atherosclerosis
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Munster, Germany
    Clin Exp Pharmacol Physiol 37:726-35. 2010
    ..5. The present review summarizes recent advances in understanding HDL-platelet interactions and discusses the potential use of HDL-like particles in the therapy of thrombosis...
  14. doi request reprint Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids
    Martin F Brodde
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Muenster, Muenster, Germany
    Atherosclerosis 215:374-82. 2011
    ..We here investigated the role of scavenger receptor class B type I (SR-BI) and CD36 in mediating inhibitory effects of native HDL3 on thrombin-induced platelet activation...
  15. ncbi request reprint Platelet-binding domains in 2 fibrinogen-binding proteins of Staphylococcus aureus identified by phage display
    Christine Heilmann
    Institute of Medical Microbiology, University of Munster, D 48149 Munster, Germany
    J Infect Dis 186:32-9. 2002
    ..The surface-associated fraction of the C-terminal domain of coagulase or the N-terminal domain of Efb may be involved in bacterial adherence to immobilized platelets, and fibrinogen may act as a bridging molecule in that interaction...
  16. ncbi request reprint Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 279:34032-7. 2004
    ..The impaired release of the content of dense bodies may explain the defective activation of Tangier platelets by collagen and low concentrations of thrombin, but not by ADP...
  17. ncbi request reprint Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Mendelstr 11, 48149 Munster, Germany
    FASEB J 17:1490-2. 2003
    ....
  18. ncbi request reprint Arginine vasopressin compromises gut mucosal microcirculation in septic rats
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Muenster, Germany
    Crit Care Med 32:194-200. 2004
    ..However, its effects on the microvascular networks have not been studied in detail. This study was designed to determine the effects of AVP infusion on the villus microcirculation of the septic rat ileum...
  19. ncbi request reprint Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange
    Judith Lahav
    Coagulation Laboratory, Institute of Hematology, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Blood 100:2472-8. 2002
    ....
  20. pmc Human platelets attenuate Aspergillus species via granule-dependent mechanisms
    Susanne Perkhofer
    Department of Hygiene, Innsbruck Medical University, Austria
    J Infect Dis 198:1243-6. 2008
    ..05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects...
  21. ncbi request reprint Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan
    Claudia Rennemeier
    University of Wuerzburg, Research Center for Infectious Diseases, Wuerzburg, Germany
    FASEB J 21:3118-32. 2007
    ..In this scenario, peptidoglycan functions as adhesin and TSP1 acts as a molecular bridge linking gram-positive bacteria with receptors on the host cell...
  22. ncbi request reprint Normal platelet reactivity in apolipoprotein E (apo E)-deficient mouse
    Jerzy Roch Nofer
    Platelets 17:498-500. 2006