Franz Kehl

Summary

Country: Germany

Publications

  1. ncbi request reprint beta-Blockade Abolishes Anesthetic Preconditioning: Impact on Clinical Applicability
    Markus Lange
    Bayerische Julius Maximillans Universität, Wurzburg, Germany
    Anesthesiology 106:1062. 2007
  2. ncbi request reprint Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels
    Franz Kehl
    Department of Anesthesiology, Klinik und Poliklinik für Anästhesiologie, Zenrum Operative Medizin, Julius Maximilans Universität, Oberdürrbacher Str 6, Wurzburg 97080, Germany
    Brain Res 1021:76-81. 2004
  3. doi request reprint Peroxisome-proliferator-activated receptor γ mediates the second window of anaesthetic-induced preconditioning
    Christopher Lotz
    Department of Anesthesiology, Bayerische Julius Maximilians Universitt, Wurzburg, Germany
    Exp Physiol 96:317-24. 2011
  4. doi request reprint Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo
    Christopher Lotz
    Department of Anesthesiology, Bayerische Julius Maximilians Universitaet, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 25:66-71. 2011
  5. doi request reprint Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction
    Jan Stumpner
    Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
    Anesthesiology 111:1257-64. 2009
  6. doi request reprint Desflurane-induced cardioprotection against ischemia-reperfusion injury depends on timing
    Thorsten M Smul
    Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 23:600-6. 2009
  7. doi request reprint Propofol inhibits desflurane-induced preconditioning in rabbits
    Thorsten M Smul
    Department of Anesthesiology, Universitatsklinikum Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 25:276-81. 2011
  8. doi request reprint Time course of desflurane-induced preconditioning in rabbits
    Thorsten M Smul
    Department of Anesthesiology, University of Wurzburg, Bayerische Julius Maximilians Universität, Wurzburg 97080, Germany
    J Cardiothorac Vasc Anesth 24:91-8. 2010
  9. doi request reprint Desflurane-induced preconditioning has a threshold that is lowered by repetitive application and is mediated by beta 2-adrenergic receptors
    Markus Lange
    Department of Anesthesiology and Critical Care, University of Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 23:607-13. 2009
  10. doi request reprint Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: metoprolol blocks desflurane-induced preconditioning
    Markus Lange
    Department of Anesthesiology and Critical Care, Wurzburg, Germany
    Anesthesiology 109:72-80. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint beta-Blockade Abolishes Anesthetic Preconditioning: Impact on Clinical Applicability
    Markus Lange
    Bayerische Julius Maximillans Universität, Wurzburg, Germany
    Anesthesiology 106:1062. 2007
  2. ncbi request reprint Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels
    Franz Kehl
    Department of Anesthesiology, Klinik und Poliklinik für Anästhesiologie, Zenrum Operative Medizin, Julius Maximilans Universität, Oberdürrbacher Str 6, Wurzburg 97080, Germany
    Brain Res 1021:76-81. 2004
    ..It is concluded that sevoflurane is capable of inducing preconditioning in vitro in a dose-dependent fashion and involves activation of mitochondrial KATP channels...
  3. doi request reprint Peroxisome-proliferator-activated receptor γ mediates the second window of anaesthetic-induced preconditioning
    Christopher Lotz
    Department of Anesthesiology, Bayerische Julius Maximilians Universitt, Wurzburg, Germany
    Exp Physiol 96:317-24. 2011
    ..Desflurane governs a second window of APC by increasing the production of 15d-PGJ(2), subsequently activating PPARγ, resulting in a diminished myocardial infarct size by increasing the downstream availability of NO...
  4. doi request reprint Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo
    Christopher Lotz
    Department of Anesthesiology, Bayerische Julius Maximilians Universitaet, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 25:66-71. 2011
    ..Hence, the current study was undertaken to address the role of AMPK activation during desflurane-induced preconditioning in vivo...
  5. doi request reprint Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction
    Jan Stumpner
    Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
    Anesthesiology 111:1257-64. 2009
    ..Pim-1 kinase acts downstream of protein kinase B and was recently shown to regulate cardiomyocyte survival. The authors tested the hypothesis that IPC and anesthetic-induced preconditioning are mediated by Pim-1 kinase...
  6. doi request reprint Desflurane-induced cardioprotection against ischemia-reperfusion injury depends on timing
    Thorsten M Smul
    Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 23:600-6. 2009
    ..The authors tested the hypothesis that desflurane-induced cardioprotection depends on the timing of application and whether desflurane-induced postconditioning is mediated by nitric oxide...
  7. doi request reprint Propofol inhibits desflurane-induced preconditioning in rabbits
    Thorsten M Smul
    Department of Anesthesiology, Universitatsklinikum Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 25:276-81. 2011
    ..The authors tested the hypothesis that ischemic and desflurane-induced preconditioning are blocked by propofol...
  8. doi request reprint Time course of desflurane-induced preconditioning in rabbits
    Thorsten M Smul
    Department of Anesthesiology, University of Wurzburg, Bayerische Julius Maximilians Universität, Wurzburg 97080, Germany
    J Cardiothorac Vasc Anesth 24:91-8. 2010
    ..The authors tested the hypothesis that volatile anesthetic-induced preconditioning (APC) follows a similar time pattern as that described for ischemic preconditioning and that delayed APC is mediated by nitric oxide...
  9. doi request reprint Desflurane-induced preconditioning has a threshold that is lowered by repetitive application and is mediated by beta 2-adrenergic receptors
    Markus Lange
    Department of Anesthesiology and Critical Care, University of Wurzburg, Wurzburg, Germany
    J Cardiothorac Vasc Anesth 23:607-13. 2009
    ..Furthermore, the role of beta(2)-adrenergic receptors in anesthetic preconditioning was tested...
  10. doi request reprint Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: metoprolol blocks desflurane-induced preconditioning
    Markus Lange
    Department of Anesthesiology and Critical Care, Wurzburg, Germany
    Anesthesiology 109:72-80. 2008
    ..This study tested the hypotheses that desflurane-induced preconditioning is dose-dependently blocked by metoprolol and mediated by calcium/calmodulin-dependent protein kinase II (CaMK II)...
  11. doi request reprint Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo
    Christopher Lotz
    Department of Anesthesiology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Exp Biol Med (Maywood) 236:113-22. 2011
    ..05). In conclusion, the obtained results indicate that both PPARα and PPARγ play an essential role in remote IPC against myocardial infarction, impinging on the transcriptional control of iNOS expression...
  12. doi request reprint Activation of mitochondrial large-conductance calcium-activated K+ channels via protein kinase A mediates desflurane-induced preconditioning
    Andreas Redel
    Department of Anesthesiology, University of Wurzburg, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Anesth Analg 106:384-91, table of contents. 2008
    ..ATP-regulated K+ channels are involved in anesthetic-induced preconditioning (APC). The role of other K+ channels in APC is unclear. We tested the hypothesis that APC is mediated by large-conductance calcium-activated K+ channels (K(Ca))...
  13. ncbi request reprint Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo
    Andreas Redel
    Klinik und Poliklinik für Anästhesiologie, Universitat Wurzburg, Wurzburg, Germany
    Exp Biol Med (Maywood) 233:84-93. 2008
    ..75% +/- 2%). In the present study, we describe important methodological aspects of the murine in vivo model of acute myocardial infarction and provide evidence that, in this model, IS depends both on duration of ischemia and on REP time...
  14. ncbi request reprint Desflurane-induced preconditioning against myocardial infarction is mediated by nitric oxide
    Thorsten M Smul
    Department of Anesthesiology, Bayerische Julius Maximilians Universität, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany
    Anesthesiology 105:719-25. 2006
    ..Nitric oxide-dependent signaling plays an important role in anesthetic and ischemic preconditioning. Therefore, the authors tested the hypothesis that desflurane-induced preconditioning is mediated by nitric oxide...
  15. doi request reprint Desflurane-induced postconditioning is mediated by beta-adrenergic signaling: role of beta 1- and beta 2-adrenergic receptors, protein kinase A, and calcium/calmodulin-dependent protein kinase II
    Markus Lange
    Department of Anesthesiology and Critical Care, University of Wurzburg, Germany
    Anesthesiology 110:516-28. 2009
    ..Anesthetic preconditioning is mediated by beta-adrenergic signaling. This study was designed to elucidate the role of beta-adrenergic signaling in desflurane-induced postconditioning...
  16. doi request reprint Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria
    Virginija Jazbutyte
    Laboratory of Molecular Cardiology, Department of Medicine, University Clinics Wuerzburg, Josef Schneider Strasse 2, D20, 97080 Wuerzburg, Germany
    Biochem Biophys Res Commun 384:450-4. 2009
    ..GST pull-down experiments confirmed the interaction of ERalpha and 17beta-HSD10. These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity...
  17. ncbi request reprint On the 100th anniversary of sterile catgut kuhn: Franz Kuhn (1866-1929) and the epistemology of catgut sterilization
    Ulrich A Dietz
    University of Wuerzburg, Surgical Clinic I General and Gastrointestinal Surgery, Oberduerrbacher Strasse 6, 97080, Wuerzburg, Germany
    World J Surg 31:2275-83. 2007
    ..Perspectives for the future are explored in light of the "imperative of responsibility" of Hans Jonas...
  18. ncbi request reprint [Anesthesia in pediatric neurosurgery]
    Herbert Trautner
    Anasthesiol Intensivmed Notfallmed Schmerzther 42:442-9. 2007
    ..This review describes in detail neuropediatric anesthesiology with an emphasis on airway management, intraoperative positioning, volume therapy and intraoperative monitoring...
  19. doi request reprint Comparison of isoflurane-, sevoflurane-, and desflurane-induced pre- and postconditioning against myocardial infarction in mice in vivo
    Andreas Redel
    Department of Anesthesia and Critical Care, University of Wurzburg, 97080 Wurzburg, Germany
    Exp Biol Med (Maywood) 234:1186-91. 2009
    ....
  20. doi request reprint Validation of the GlideScope video laryngoscope in pediatric patients
    Andreas Redel
    Department of Anesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
    Paediatr Anaesth 19:667-71. 2009
    ..Data evaluating GlideScope laryngoscopy in pediatric patients are lacking. This study compared intubation times of GlideScope laryngoscopy vs Macintosh laryngoscopy in pediatric patients...
  21. ncbi request reprint The effectiveness and patient comfort of the novel streamlined pharynx airway liner (SLIPA) compared with the conventional laryngeal mask airway in ophthalmic surgery
    Markus Lange
    Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
    Anesth Analg 104:431-4. 2007
    ..The novel, disposable streamlined pharynx airway liner (SLIPA) has recently been introduced into clinical practice. It has no inflatable cuff, because the shape of the SLIPA closely resembles the anatomy of the pharynx...
  22. ncbi request reprint The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 94:841-8, table of contents. 2002
    ..IMPLICATIONS: Mitochondrial and sarcolemmal K(ATP) channels mediate ethanol-induced preconditioning independent of alterations in systemic hemodynamics or coronary collateral perfusion in vivo...
  23. ncbi request reprint Propofol alters left atrial function evaluated with pressure-volume relations in vivo
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 94:1421-6, table of contents. 2002
    ..Relaxation was unchanged. The results indicate that propofol depresses LA myocardial contractility, reduces dynamic chamber stiffness, maintains reservoir function, and impairs LA-LV coupling but does not alter LA relaxation in vivo...
  24. ncbi request reprint Isoflurane-induced preconditioning is attenuated by diabetes
    Katsuya Tanaka
    Department of Anesthesiology, Milwaukee, Wisconsin 53226
    Am J Physiol Heart Circ Physiol 282:H2018-23. 2002
    ..The results indicate that blood glucose and end-tidal isoflurane concentrations are important determinants of infarct size during anesthetic-induced preconditioning...
  25. ncbi request reprint Increases in coronary collateral blood flow produced by sevoflurane are mediated by calcium-activated potassium (BKCa) channels in vivo
    Franz Kehl
    Department of Anesthesiology, the Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee 53226, USA
    Anesthesiology 97:725-31. 2002
    ....
  26. ncbi request reprint Is isoflurane-induced preconditioning dose related?
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 96:675-80. 2002
    ..The authors tested the hypothesis that isoflurane decreases myocardial infarct size in a dose-dependent fashion in vivo...
  27. ncbi request reprint Isoflurane does not produce a second window of preconditioning against myocardial infarction in vivo
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 95:1162-8, table of contents. 2002
    ..The results indicate that isoflurane does not produce a SWOP when administered 24 h before prolonged myocardial ischemia in vivo...
  28. ncbi request reprint Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: evaluation with pressure-volume relationships
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiothorac Vasc Anesth 17:709-14. 2003
    ..The hypothesis was tested that isoflurane alters LA mechanics evaluated with pressure-volume relations...
  29. ncbi request reprint Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species
    Katsuya Tanaka
    Department of Anesthesiology, Pharmacology and Toxicology, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 97:1485-90. 2002
    ..We tested the hypothesis that ROS mediate isoflurane-induced preconditioning in vivo...
  30. ncbi request reprint Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats
    Ralphiel S Payne
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, 530 S Jackson Street, Louisville, KY 40292, USA
    Brain Res 1034:147-52. 2005
    ..Sevoflurane-induced preconditioning confers neuroprotection during an early as well as late time window...
  31. ncbi request reprint Anesthetic preconditioning as the alternative to ischemic preconditioning
    Markus Lange
    J Thorac Cardiovasc Surg 131:252-3; author reply 253. 2006
  32. ncbi request reprint Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice
    Tobias Eckle
    Dept of Anesthesiology and Intensive Care Medicine, Tübingen Univ Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Am J Physiol Heart Circ Physiol 291:H2533-40. 2006
    ..Further studies on cardiac IP using transgenic mice may consider this technique...
  33. ncbi request reprint Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo
    Markus Lange
    Department of Pharmacology, Bayerische Julius Maximilians Universität, Germany
    Anesthesiology 105:503-10. 2006
    ..Anesthetic and ischemic preconditioning share similar signal transduction pathways. The authors tested the hypothesis that the beta1-adrenergic signal transduction pathway mediates anesthetic and ischemic preconditioning in vivo...
  34. ncbi request reprint Beta-blockers and anesthetic preconditioning: friend or foe?
    Markus Lange
    Can J Anaesth 54:320-1; author reply 321. 2007
  35. ncbi request reprint N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:1384-90. 2003
    ..The authors tested the hypothesis that scavenging reactive oxygen species with N-acetylcysteine will restore protection against myocardial infarction produced by isoflurane in vivo...
  36. doi request reprint Simvastatin restores ischemic preconditioning in the presence of hyperglycemia through a nitric oxide-mediated mechanism
    Weidong Gu
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 108:634-42. 2008
    ..The authors tested the hypothesis that simvastatin restores the beneficial effects of IPC during hyperglycemia through a nitric oxide-mediated mechanism...
  37. ncbi request reprint Adenosine type 1 (A1) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cardiol 88:175-82. 2003
    ..Chronic consumption of small amounts of ethanol protects myocardium from ischemic injury. We tested the hypothesis that adenosine type 1 (A(1)) receptors mediate these beneficial effects...
  38. ncbi request reprint Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, 53226, USA
    Anesthesiology 96:183-8. 2002
    ..The authors tested the hypothesis that acute hyperglycemia interferes with isoflurane-induced preconditioning in vivo...