Aphrodite Kapurniotu

Summary

Country: Germany

Publications

  1. ncbi Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide
    Marianna Tatarek-Nossol
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, D 52074 Aachen, Germany
    Chem Biol 12:797-809. 2005
  2. ncbi Rational design, conformational studies and bioactivity of highly potent conformationally constrained calcitonin analogues
    A Kapurniotu
    Physiological chemical Institute, Department of Physical Biochemistry, University of Tubingen, Germany
    Eur J Biochem 265:606-18. 1999
  3. ncbi Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
    Aphrodite Kapurniotu
    Physiological chemical Institute, University of Tubingen, D 72076 Tubingen, Germany
    J Mol Biol 315:339-50. 2002
  4. ncbi Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt
    Athanasios Kazantzis
    Physiological chemical Institute, Department of Physical Biochemistry, University of Tubingen, Germany
    Eur J Biochem 269:780-91. 2002
  5. ncbi Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues
    John W Taylor
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Med Chem 45:1108-21. 2002
  6. ncbi Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity
    Aphrodite Kapurniotu
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, D 52074 Aachen, Germany
    Chem Biol 10:149-59. 2003
  7. ncbi Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways
    Stefan Grudzielanek
    University of Dortmund, Department of Chemistry, Otto Hahn Str 6, D 44227 Dortmund, Germany
    J Mol Biol 370:372-84. 2007
  8. pmc Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis
    Li Mei Yan
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Pauwelstrasse 30, D 52074 Aachen, Germany
    Proc Natl Acad Sci U S A 103:2046-51. 2006
  9. doi Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic
    Aleksandra Velkova
    Laboratory of Peptide Biochemistry, Center for Integrated Protein Science München, Technische Universitat Munchen, An der Saatzucht 5, 85350 Freising Weihenstephan, Germany
    Angew Chem Int Ed Engl 47:7114-8. 2008
  10. ncbi IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes
    Li Mei Yan
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Angew Chem Int Ed Engl 46:1246-52. 2007

Collaborators

  • John W Taylor
  • Marianna Tatarek-Nossol
  • Aleksandra Velkova
  • Li Mei Yan
  • Athanasios Kazantzis
  • Christian Weber
  • Erika Andreetto
  • Stefan Grudzielanek
  • Hongqi Lue
  • Jurgen Bernhagen
  • Mai Tuyet Nguyen
  • Sandra Kraemer
  • Maik Drechsler
  • Rory R Koenen
  • Alma Zernecke
  • Roland Winter
  • Anuj Shukla
  • Heinz Rehage
  • Vytautas Smirnovas
  • Gunilla Westermark
  • Konstantinos Tenidis
  • Anke Schmauder
  • Robert Kleemann
  • Pieter Koolwijk
  • Helge Fünfzig
  • Jürgen Beck
  • Michaela Waldner

Detail Information

Publications13

  1. ncbi Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide
    Marianna Tatarek-Nossol
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, D 52074 Aachen, Germany
    Chem Biol 12:797-809. 2005
    ..These results support the concept that rational N-methylation of hIAPP amyloid-core sequences may be a valuable strategy to design pancreatic-amyloid diagnostics and therapeutics for type II diabetes...
  2. ncbi Rational design, conformational studies and bioactivity of highly potent conformationally constrained calcitonin analogues
    A Kapurniotu
    Physiological chemical Institute, Department of Physical Biochemistry, University of Tubingen, Germany
    Eur J Biochem 265:606-18. 1999
    ....
  3. ncbi Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
    Aphrodite Kapurniotu
    Physiological chemical Institute, University of Tubingen, D 72076 Tubingen, Germany
    J Mol Biol 315:339-50. 2002
    ....
  4. ncbi Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt
    Athanasios Kazantzis
    Physiological chemical Institute, Department of Physical Biochemistry, University of Tubingen, Germany
    Eur J Biochem 269:780-91. 2002
    ..These results may assist to delineate the structure-function relationships of hCt and to design novel hCt agonists for the treatment of osteoporosis and other bone-disorder-related diseases...
  5. ncbi Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues
    John W Taylor
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Med Chem 45:1108-21. 2002
    ....
  6. ncbi Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity
    Aphrodite Kapurniotu
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, D 52074 Aachen, Germany
    Chem Biol 10:149-59. 2003
    ..Cyclo(17, 21)-[Lys(17), Asp(21)]Abeta(1-28) or similarly constrained Abeta sequences may find therapeutic and diagnostic applications in AD...
  7. ncbi Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways
    Stefan Grudzielanek
    University of Dortmund, Department of Chemistry, Otto Hahn Str 6, D 44227 Dortmund, Germany
    J Mol Biol 370:372-84. 2007
    ..Two such factors might be the aggregate size and the aggregate propensity to expose hydrophobic surfaces to a polar environment...
  8. pmc Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis
    Li Mei Yan
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Pauwelstrasse 30, D 52074 Aachen, Germany
    Proc Natl Acad Sci U S A 103:2046-51. 2006
    ..Moreover, our amyloid disease inhibitor design concept may be applicable to other protein aggregation diseases...
  9. doi Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic
    Aleksandra Velkova
    Laboratory of Peptide Biochemistry, Center for Integrated Protein Science München, Technische Universitat Munchen, An der Saatzucht 5, 85350 Freising Weihenstephan, Germany
    Angew Chem Int Ed Engl 47:7114-8. 2008
  10. ncbi IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes
    Li Mei Yan
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Angew Chem Int Ed Engl 46:1246-52. 2007
  11. ncbi Contribution of conformationally constrained calcitonin (Ct) analogs to the understanding of the structural and conformational requirements of calcitonin bioactivity and to the design of potent agonists
    Aphrodite Kapurniotu
    Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, D 52074 Aachen, Germany
    Curr Med Chem 11:2845-65. 2004
    ....
  12. ncbi A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions
    Mai Tuyet Nguyen
    Division of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, D 52074 Aachen, Germany
    J Biol Chem 278:33654-71. 2003
    ..We conclude that CXXC and sequence 50-65 are critical for the activities of MIF. MIF-(50-65) is a surprisingly short sequence with MIF-like functions that could be an excellent molecular template for MIF therapeutics...
  13. pmc Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, GermanyAachen, Germany
    Proc Natl Acad Sci U S A 105:16278-83. 2008
    ....