Philipp J Kahle

Summary

Country: Germany

Publications

  1. doi request reprint DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
    Philipp J Kahle
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, 72076 Tubingen, Germany
    Free Radic Biol Med 47:1354-61. 2009
  2. ncbi request reprint alpha-Synucleinopathy models and human neuropathology: similarities and differences
    Philipp J Kahle
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076, Tubingen, Germany
    Acta Neuropathol 115:87-95. 2008
  3. ncbi request reprint Mechanisms and models of alpha-synuclein-related neurodegeneration
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Curr Neurol Neurosci Rep 6:432-6. 2006
  4. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
  5. pmc Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway
    Iria Carballo-Carbajal
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    Cell Signal 22:821-7. 2010
  6. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
  7. pmc Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1
    Jens Waak
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen 72076, Germany
    J Biol Chem 284:14245-57. 2009
  8. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
  9. pmc Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
    Guido Krebiehl
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e9367. 2010
  10. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010

Collaborators

Detail Information

Publications29

  1. doi request reprint DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
    Philipp J Kahle
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, 72076 Tubingen, Germany
    Free Radic Biol Med 47:1354-61. 2009
    ..Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke...
  2. ncbi request reprint alpha-Synucleinopathy models and human neuropathology: similarities and differences
    Philipp J Kahle
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076, Tubingen, Germany
    Acta Neuropathol 115:87-95. 2008
    ....
  3. ncbi request reprint Mechanisms and models of alpha-synuclein-related neurodegeneration
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Curr Neurol Neurosci Rep 6:432-6. 2006
    ..These recent findings provided major insights into the molecular mechanisms of alpha-synucleinopathies...
  4. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
    ....
  5. pmc Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway
    Iria Carballo-Carbajal
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    Cell Signal 22:821-7. 2010
    ..This pathway linking the two dominant PD genes LRRK2 and SNCA may offer an interesting target for drug therapy in both familial and sporadic disease...
  6. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
    ..Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders...
  7. pmc Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1
    Jens Waak
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen 72076, Germany
    J Biol Chem 284:14245-57. 2009
    ..We suggest that impairments in oxidative conformation changes of DJ-1 might contribute to PD neurodegeneration...
  8. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
    ..Thus, our data provide functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease...
  9. pmc Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
    Guido Krebiehl
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e9367. 2010
    ..Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined...
  10. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010
    ..Thus, PD-associated DJ-1 contributes to regulation of innate immunity...
  11. ncbi request reprint Regulation of PINK1-Parkin-mediated mitophagy
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Autophagy 7:266-78. 2011
    ..This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well...
  12. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
    ..In conclusion, loss of functional TDP-43 causes HDAC6 downregulation and might thereby contribute to pathogenesis...
  13. pmc TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, 72076 Tubingen, Germany
    Nucleic Acids Res 40:2668-82. 2012
    ..This indicates a novel mechanism of deregulated translational control upon TDP-43 deficiency, which might contribute to pathogenesis of the protein aggregation diseases frontotemporal dementia and amyotrophic lateral sclerosis...
  14. pmc Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice
    Heinrich Schell
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e50245. 2012
    ..Thus, the cognitive decline observed in aged αSYN transgenic mice might be due to impairment of neurotransmission and synaptic plasticity in the limbic system by distinct αSYN species...
  15. doi request reprint Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
    Christian L Klein
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    J Neurochem 111:703-15. 2009
    ..Importantly, our finding of ROCO(LRRK2) fragment-mediated LRRK2 kinase inhibition offers a novel lead for drug design and thus might have important implications for new therapeutic avenues in PD...
  16. pmc TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Otfried Mueller Str, 27, Tuebingen, 72076, Germany
    Mol Neurodegener 6:64. 2011
    ..abstract:..
  17. doi request reprint Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways
    Takafumi Hasegawa
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen, Germany
    J Neurochem 105:1700-15. 2008
    ..PD-associated mutations differentially affected the anti-apoptotic signaling of parkin. Thus, parkin contributes to DAergic neuroprotection by suppression of apoptotic stress-activated protein kinase pathways...
  18. doi request reprint TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration
    Fabienne C Fiesel
    Department of Neurodegeneration, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    FEBS J 278:3550-68. 2011
    ..In this minireview the specific functions of TDP-43 and FUS are described and discussed in the context of how TDP-43 and FUS may contribute to the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis...
  19. doi request reprint Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein
    Finja Büchel
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, 72076 Tubingen, Germany
    BMC Neurosci 14:136. 2013
    ..Therefore, mathematical or probabilistic models for the human disease are to be constructed in silico in order to predict specific processes within a cell, such as the dopamine metabolism and transport processes in a neuron...
  20. doi request reprint Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1
    Jens Waak
    Laboratory of Functional Neurogenetics, Dept of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Müller Str 27, 72076 Tubingen, Germany
    FASEB J 23:2478-89. 2009
    ..These findings identify DJ-1 as a regulator of proinflammatory responses and suggest that loss of DJ-1 contributes to PD pathogenesis by deregulation of astrocytic neuroinflammatory damage...
  21. ncbi request reprint Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
    Christian Freichel
    Pharma Research, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    Neurobiol Aging 28:1421-35. 2007
    ..Thus, age-dependent fibrillization of alphaSYN in specific cortical regions concomitant with cognitive decline may reflect dementia with Lewy bodies in a transgenic mouse model...
  22. ncbi request reprint Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    J Neurochem 82:449-57. 2002
  23. pmc Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
    Manuela Neumann
    Department of Neuropathology, Ludwig Maximilians University, Munich, Germany
    J Clin Invest 110:1429-39. 2002
    ..The transgenic mice showed a progressive deterioration of locomotor function. Thus, misfolding and hyperphosphorylation of alphaS may cause dysfunction of affected brain regions...
  24. pmc Attack on amyloid
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO Rep 4:747-51. 2003
  25. ncbi request reprint Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
    Manuela Neumann
    Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany
    Acta Neuropathol 107:489-96. 2004
    ..Our results suggest that DJ-1 is up-regulated in reactive astrocytes as well as in neuronal and glial cells with specific alpha-synucleinopathy and tauopathy...
  26. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  27. ncbi request reprint Alpha-synuclein transgenic mice: relevance to multiple system atrophy
    Gwenaelle Fillon
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, Germany
    Mov Disord 20:S64-6. 2005
    ..Moreover, it will be important to understand what defines the predilection sites most severely affected by striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C), respectively...
  28. ncbi request reprint Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  29. pmc Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
    Philipp J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University, D 80336 Munich, Germany
    EMBO Rep 3:583-8. 2002
    ..Thus, ectopic expression alpha SYN in OLs might initiate salient features of MSA pathology...