Wilfried Dimpfel

Summary

Affiliation: Justus-Liebig-University Giessen
Country: Germany

Publications

  1. doi Pharmacological modulation of dopaminergic brain activity and its reflection in spectral frequencies of the rat electropharmacogram
    Wilfried Dimpfel
    Justus Liebig University Giessen, Giessen, Germany
    Neuropsychobiology 58:178-86. 2008
  2. ncbi Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG)
    Wilfried Dimpfel
    Justus Liebig University Giessen Germany, c o NeuroCode AG, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur Neuropsychopharmacol 15:673-82. 2005
  3. pmc Effect of Neurexan on the pattern of EEG frequencies in rats
    Wilfried Dimpfel
    Justus Liebig University Giessen, NeuroCode AG, Wetzlar, Germany
    BMC Complement Altern Med 12:126. 2012
  4. doi Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat
    Wilfried Dimpfel
    Justus Liebig University, Wetzlar, Germany
    J Ethnopharmacol 149:583-9. 2013
  5. ncbi Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin
    W Dimpfel
    Justus Liebig University of Giessen, D 35392 Giessen, Germany
    Nutr Neurosci 10:169-80. 2007
  6. pmc Characterization of atypical antipsychotic drugs by a late decrease of striatal alpha1 spectral power in the electropharmacogram of freely moving rats
    W Dimpfel
    Justus Liebig University Giessen, Hessen, Germany
    Br J Pharmacol 152:538-48. 2007
  7. ncbi Neurophysiological characterization of a functionally active drink containing extracts of ginkgo and ginseng by source density analysis of the human EEG
    W Dimpfel
    Justus Liebig University of Giessen, D 35392 Giessen, Germany
    Nutr Neurosci 9:213-24. 2006
  8. ncbi Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms
    Wilfried Dimpfel
    Justus Liebig University Giessen, c o NeuroCode AG, Sportparkstr 9, 35578 Wetzlar, Germany
    Eur J Med Res 13:200-4. 2008
  9. ncbi Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro
    Wilfried Dimpfel
    University of Giessen c o NeuroCode AG D 35578 Wetzlar, Sportpark Str 9, Germany
    J Pharm Pharmacol 58:375-9. 2006
  10. ncbi Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers
    W Dimpfel
    NeuroCode AG, Kurt Schumacher Strasse 9, D 35440 Linden, Germany
    Eur J Med Res 9:423-31. 2004

Collaborators

Detail Information

Publications24

  1. doi Pharmacological modulation of dopaminergic brain activity and its reflection in spectral frequencies of the rat electropharmacogram
    Wilfried Dimpfel
    Justus Liebig University Giessen, Giessen, Germany
    Neuropsychobiology 58:178-86. 2008
    ..Particular frequencies of electropharmacograms have been attributed to cholinergic, noradrenergic or dopaminergic mediated neurotransmission. This investigation deals with changes induced by L-DOPA or dopamine D2 receptor agonists...
  2. ncbi Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG)
    Wilfried Dimpfel
    Justus Liebig University Giessen Germany, c o NeuroCode AG, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur Neuropsychopharmacol 15:673-82. 2005
    ....
  3. pmc Effect of Neurexan on the pattern of EEG frequencies in rats
    Wilfried Dimpfel
    Justus Liebig University Giessen, NeuroCode AG, Wetzlar, Germany
    BMC Complement Altern Med 12:126. 2012
    ..The efficacy of Neurexan, a multicomponent, low-dose medication, has been demonstrated in observational studies, but its exact mechanism of action has not been determined...
  4. doi Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat
    Wilfried Dimpfel
    Justus Liebig University, Wetzlar, Germany
    J Ethnopharmacol 149:583-9. 2013
    ..Rhodiola and Sideritis developed similar frequency patterns comparable to a psychostimulant drug (methylphenidate) as well to an antidepressive drug (paroxetine). ..
  5. ncbi Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin
    W Dimpfel
    Justus Liebig University of Giessen, D 35392 Giessen, Germany
    Nutr Neurosci 10:169-80. 2007
    ..Thus, decaffeinated extract of green tea still has a stimulating effect despite the lack of caffeine presumably due to its high content in L-theanine and theogallin as found in preclinical experiments...
  6. pmc Characterization of atypical antipsychotic drugs by a late decrease of striatal alpha1 spectral power in the electropharmacogram of freely moving rats
    W Dimpfel
    Justus Liebig University Giessen, Hessen, Germany
    Br J Pharmacol 152:538-48. 2007
    ..The present investigation was undertaken to investigate the difference between atypical and typical antipsychotic drugs...
  7. ncbi Neurophysiological characterization of a functionally active drink containing extracts of ginkgo and ginseng by source density analysis of the human EEG
    W Dimpfel
    Justus Liebig University of Giessen, D 35392 Giessen, Germany
    Nutr Neurosci 9:213-24. 2006
    ..3 ms) as well as increases of amplitude (from 2.07 to 3.95 microV) of the auditory P300 potential at the electrode position Pz point to a possible improvement of attention, however, the difference did not reach statistical significance...
  8. ncbi Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms
    Wilfried Dimpfel
    Justus Liebig University Giessen, c o NeuroCode AG, Sportparkstr 9, 35578 Wetzlar, Germany
    Eur J Med Res 13:200-4. 2008
    ..Thus, the present investigation has shown evidence that a valerian/hops fluid extract can be used successfully using a single administration...
  9. ncbi Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro
    Wilfried Dimpfel
    University of Giessen c o NeuroCode AG D 35578 Wetzlar, Sportpark Str 9, Germany
    J Pharm Pharmacol 58:375-9. 2006
    ..In summary, the results provide the possibility for use of both compounds to control pathophysiological disturbances of brain excitability in drug abuse, migraine and epilepsy...
  10. ncbi Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers
    W Dimpfel
    NeuroCode AG, Kurt Schumacher Strasse 9, D 35440 Linden, Germany
    Eur J Med Res 9:423-31. 2004
    ..The data are further proof that recording computer aided quantitative EEG is a very fruitful and promising approach in psychophysiology...
  11. doi Rat electropharmacograms of the flavonoids rutin and quercetin in comparison to those of moclobemide and clinically used reference drugs suggest antidepressive and/or neuroprotective action
    Wilfried Dimpfel
    Justus Liebig University Giessen, c o NeuroCode AG, Sportparkstr 9, D 35578 Wetzlar, Germany
    Phytomedicine 16:287-94. 2009
    ..Data suggest antidepressant capabilities for rutin and quercetin with inhibition of monoamino oxidase at least as part of the mechanism of action. Both compounds should be tested clinically in patients with symptoms of depression...
  12. doi Electropharmacograms of rasagiline, its metabolite aminoindan and selegiline in the freely moving rat
    Wilfried Dimpfel
    Justus Liebig University Giessen, Sportparkstrasse 9, Wetzlar, Germany
    Neuropsychobiology 62:213-20. 2010
    ..The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline...
  13. pmc Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro
    W Dimpfel
    Justus Liebig University Giessen, c o NeuroCode AG, Sportparkstr, 9, D 35578 Wetzlar, Germany
    BMC Pharmacol 11:2. 2011
    ....
  14. pmc Early effect of NEURAPAS® balance on current source density (CSD) of human EEG
    Wilfried Dimpfel
    Justus Liebig University c o NeuroCode AG, Sportparkstr, 9, 35578 Wetzlar, Germany
    BMC Psychiatry 11:123. 2011
    ..NEURAPAS® balance is a mixture of these three extracts and has been designed to cover this complex of psychiatric conditions. The study was initiated to quantitatively assess the effect of this combination on brain electric activity...
  15. ncbi Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: II. Characterization in the freely moving rat by means of quantitative field potential analysis
    Wilfried Dimpfel
    University of Giessen c o NeuroCode AG D 35578 Wetzlar, Sportpark Str 9, Germany
    J Pharm Pharmacol 59:1397-403. 2007
    ..These compounds could be classified by comparison with reference drugs using discriminant analysis as being antidepressive and cognition enhancing, respectively. The extract appeared among those drugs having stimulatory effects...
  16. ncbi Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in-vitro
    Wilfried Dimpfel
    University of Giessen c o NeuroCode AG D 35578 Wetzlar, Sportpark Str 9, Germany
    J Pharm Pharmacol 59:1131-6. 2007
    ..The results are in line with the observation that the tested green tea extract improves cognition at concomitant mental relaxation in man...
  17. doi Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects
    Wilfried Dimpfel
    Justus Liebig University Giessen, Wetzlar, Germany
    J Altern Complement Med 17:427-34. 2011
    ..This study aimed at using quantitative assessment of human electric brain activity during mental work for determining acute effects of ingested oat herb extract on cognitive performance...
  18. ncbi Central action of a fixed Valerian-hops extract combination (Ze 91019) in freely moving rats
    W Dimpfel
    Justus Liebig Universitat Giessen, Giessen, Germany
    Eur J Med Res 11:496-500. 2006
    ..The results are therefore in line with the view that the fixed extract combination Ze 91019 works as an adenosine agonist via inhibition of cholinergic transmission leading to sedation and sleep...
  19. ncbi Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states
    W Dimpfel
    Pro Science, Private Research Clinic GmbH med Forschung und Entwicklung, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur J Med Res 8:183-91. 2003
    ....
  20. ncbi Gender difference in electrical brain activity during presentation of various film excerpts with different emotional content
    W Dimpfel
    Pro Science Research Clinic GmbH med Forschung und Entwicklung, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur J Med Res 8:192-8. 2003
    ..The data are further proof that recording the computer aided quantitative EEG is a very fruitful and promising approach in psychophysiology...
  21. ncbi Preclinical data base of pharmaco-specific rat EEG fingerprints (tele-stereo-EEG)
    W Dimpfel
    Pro Science Research Clinic GmbH med Forschung und Entwicklung, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur J Med Res 8:199-207. 2003
    ..Finally the recognition of new indications of already launched drugs not only becomes feasible but has resulted in filing of new indication patents...
  22. ncbi Validation of an EEG-derived spectral frequency index (SFx) for continuous monitoring of sleep depth in humans
    W Dimpfel
    Pro Science Private Research Clinic GmbH med Forschung und Entwicklung, Kurt Schumacher Strasse 9, D 35440 Linden, Germany
    Eur J Med Res 3:453-60. 1998
    ..79 indicating a substantial matching between the manually staged score and the SFx. We therefore conclude that the SFx is a suitable and objective indicator of sleep depth in humans...
  23. ncbi Pharmacodynamic properties of St. John's wort-A single blind neurophysiological study in healthy subjects comparing two commercial preparations
    W Dimpfel
    Pro Science Private Research Clinic GmbH, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur J Med Res 4:303-12. 1999
    ..In summary quantitative EEG proved to be able to discriminate between different extracts of St. John's wort with respect to time of effect and profile changes on neuronal communication structure...
  24. ncbi Evidence for neuronal dysfunction in migraine: concurrence between specific qEEG findings and clinical drug response--a retrospective analysis-
    B Vonderheid-Guth
    Pro Science Private Research Clinic GmbH, Kurt Schumacher Str 9, D 35440 Linden, Germany
    Eur J Med Res 5:473-83. 2000
    ..The aim of this analysis was to verify objective correlates of the clinical improvement of migraine in patients by means of quantitative topographical EEG (qEEG)...