S Fulda

Summary

Affiliation: Johann Wolfgang Goethe University
Country: Germany

Publications

  1. doi request reprint Regulation of apoptosis pathways in cancer stem cells
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Lett 338:168-73. 2013
  2. doi request reprint Targeting apoptosis pathways in childhood malignancies
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, 60528 Frankfurt Main, Germany
    Cancer Lett 332:369-73. 2013
  3. doi request reprint Modulation of mitochondrial apoptosis by PI3K inhibitors
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Mitochondrion 13:195-8. 2013
  4. doi request reprint Autophagy and cell death
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Autophagy 8:1250-1. 2012
  5. doi request reprint Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer
    Simone Fulda
    Goethe University Frankfurt, Institute for Experimental Cancer Research in Pediatrics, Komturstr 3a, 60528 Frankfurt, Germany
    Expert Opin Ther Targets 17:195-201. 2013
  6. ncbi request reprint Regulation of cell death and survival by resveratrol: implications for cancer therapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Anticancer Agents Med Chem 12:874-9. 2012
  7. doi request reprint Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Leukemia 26:1155-65. 2012
  8. doi request reprint Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosis
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Frankfurt, Germany
    Exp Cell Res 318:1208-12. 2012
  9. doi request reprint Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Treat Rev 38:760-6. 2012
  10. doi request reprint Targeting IAP proteins for therapeutic intervention in cancer
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Nat Rev Drug Discov 11:109-24. 2012

Collaborators

  • Guido Kroemer
  • Domagoj Vucic
  • S Cristofanon
  • I Eckhardt
  • F Basit
  • B A Abhari
  • A Tchoghandjian
  • Rebecca Berger
  • Klaus Michael Debatin
  • Christian Haag
  • F Rodel
  • C Jennewein
  • S Roesler
  • K Rajalingam
  • R Humphreys
  • D von Schweinitz
  • R Kappler
  • Sabine Karl
  • C Rodel
  • Viola Marschall
  • T Sprenger
  • Claudia Jennewein
  • J Mirsch
  • Dominic Stadel
  • Stephanie Hehlgans
  • T Liersch
  • S Reichert
  • Franz Rodel
  • Max G Bachem
  • U S Gaipl
  • Shaoxia Zhou
  • Sri Harikrishna Vellanki
  • Peter Moller
  • Silvia Cristofanon
  • Liane Wagner
  • Albert C Ludolph

Detail Information

Publications22

  1. doi request reprint Regulation of apoptosis pathways in cancer stem cells
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Lett 338:168-73. 2013
    ....
  2. doi request reprint Targeting apoptosis pathways in childhood malignancies
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, 60528 Frankfurt Main, Germany
    Cancer Lett 332:369-73. 2013
    ..This strategy is anticipated to open novel perspectives for more effective treatment options for children with cancer...
  3. doi request reprint Modulation of mitochondrial apoptosis by PI3K inhibitors
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Mitochondrion 13:195-8. 2013
    ..Thus, mitochondrial apoptotic events play an important role in PI3K inhibitor-mediated sensitization for apoptosis...
  4. doi request reprint Autophagy and cell death
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Autophagy 8:1250-1. 2012
    ....
  5. doi request reprint Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer
    Simone Fulda
    Goethe University Frankfurt, Institute for Experimental Cancer Research in Pediatrics, Komturstr 3a, 60528 Frankfurt, Germany
    Expert Opin Ther Targets 17:195-201. 2013
    ..Among those is c-FLICE-like inhibitory protein (c-FLIP), a protein that not only blocks apoptosis signaling but also regulates additional cell death pathways...
  6. ncbi request reprint Regulation of cell death and survival by resveratrol: implications for cancer therapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Anticancer Agents Med Chem 12:874-9. 2012
    ..Further elucidation of the signaling events that are regulated by resveratrol is anticipated to path the way for the transfer of resveratrol and its derivatives into clinical application for chemoprevention or treatment of human cancers...
  7. doi request reprint Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Leukemia 26:1155-65. 2012
    ..As some of these strategies have already entered the stage of clinical evaluation, for example, in leukemia, an update on this promising molecular-targeted strategy to interfere with apoptotic pathways is of broad interest...
  8. doi request reprint Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosis
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Frankfurt, Germany
    Exp Cell Res 318:1208-12. 2012
    ..Understanding the molecular mechanism that mediates this synergistic drug interaction will be critical to further optimize this approach in order to successfully translate it into a clinical setting...
  9. doi request reprint Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Treat Rev 38:760-6. 2012
    ..Thus, combination protocols using IAP antagonists together with radiotherapy may pave the avenue to more effective radiation-based treatment options for cancer patients...
  10. doi request reprint Targeting IAP proteins for therapeutic intervention in cancer
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Nat Rev Drug Discov 11:109-24. 2012
    ..This Review provides an update on IAP protein biology as well as current and future perspectives on targeting IAP proteins for therapeutic intervention in human malignancies...
  11. doi request reprint Resveratrol and derivatives for the prevention and treatment of cancer
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, D 60528 Frankfurt, Germany
    Drug Discov Today 15:757-65. 2010
    ..This review provides an overview of key derivatives of resveratrol as cancer therapeutics...
  12. pmc Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany Simone Fulda
    Oncotarget 2:418-21. 2011
    ..A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib...
  13. doi request reprint Mitochondria as therapeutic targets for the treatment of malignant disease
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt am Main, Germany
    Antioxid Redox Signal 15:2937-49. 2011
    ..Thus, engaging the mitochondrial apoptosis pathway presents an attractive possibility to activate lethal effectors in cancer cells...
  14. doi request reprint Cell death and survival signaling in oncogenesis
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstrasse 3a, Frankfurt am Main, Germany
    Klin Padiatr 222:340-4. 2010
    ..Hence, a better understanding of the molecular mechanisms that regulate cell death and survival programs in cancer cells is expected to provide the basis for the development of new diagnostic and therapeutic strategies...
  15. ncbi request reprint The role of survivin for radiation oncology: moving beyond apoptosis inhibition
    F Rodel
    Department of Radiation Therapy and Oncology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Curr Med Chem 18:191-9. 2011
    ..Although these trials do not include radiation therapy at present, survivin inhibitors may represent a novel type of molecular antagonists to improve the effectiveness of radiation therapy or chemoradio-therapy...
  16. doi request reprint RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex
    B A Abhari
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Oncogene 32:3263-73. 2013
    ....
  17. pmc ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
    S Cristofanon
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 3:e432. 2012
    ..This approach presents a promising strategy for targeting the apoptosis pathways in glioblastoma, which warrants further investigation...
  18. pmc Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
    I Eckhardt
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, 60528 Frankfurt, Germany
    Cell Death Dis 4:e936. 2013
    ..By identifying DR5 as a critical mediator of Smac mimetic-induced apoptosis, our findings provide novel insights into the determinants that control susceptibility of cancer cells to Smac mimetic. ..
  19. pmc Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
    A Tchoghandjian
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 4:e564. 2013
    ....
  20. pmc Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
    F Basit
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, Frankfurt 60528, Germany
    Cell Death Differ 20:1161-73. 2013
    ..In conclusion, GX15-070 triggers necroptosis by promoting the assembly of the necrosome on autophagosomes. These findings provide novel insights into the molecular mechanisms of GX15-070-induced non-apoptotic cell death. ..
  21. doi request reprint Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
    Christian Haag
    University Children s Hospital, Ulm, Germany
    Gut 60:225-37. 2011
    ..Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated...
  22. doi request reprint NF-κB is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis
    Rebecca Berger
    Department of Neurology, University of Ulm, Ulm, Germany
    Mol Cancer Ther 10:1867-75. 2011
    ..These results have important implications for the development of Smac mimetic-based combination protocols for radiosensitization of glioblastoma...