S Fulda

Summary

Affiliation: Johann Wolfgang Goethe University
Country: Germany

Publications

  1. ncbi request reprint Molecular pathways: targeting death receptors and smac mimetics
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Clin Cancer Res 20:3915-20. 2014
  2. ncbi request reprint Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL)
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528, Frankfurt, Germany
    Adv Exp Med Biol 818:167-80. 2014
  3. ncbi request reprint Cross talk between cell death regulation and metabolism
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany Electronic address
    Methods Enzymol 542:81-90. 2014
  4. pmc ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
    S Cristofanon
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 3:e432. 2012
  5. pmc Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
    A Tchoghandjian
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 4:e564. 2013
  6. pmc How to target apoptosis signaling pathways for the treatment of pediatric cancers
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 3:22. 2013
  7. pmc Alternative cell death pathways and cell metabolism
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstraße 3a, 60528 Frankfurt, Germany
    Int J Cell Biol 2013:463637. 2013
  8. pmc Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 2:121. 2012
  9. pmc Cell death pathways as therapeutic targets in rhabdomyosarcoma
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstraße 3a, 60528 Frankfurt, Germany
    Sarcoma 2012:326210. 2012
  10. pmc Targeting apoptosis signaling pathways for anticancer therapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 1:23. 2011

Collaborators

  • R M Zwacka
  • T Seufferlein
  • Klaus Michael Debatin
  • V Braun
  • M Jung
  • L Wagner
  • D Figarella-Branger
  • R F Schlenk
  • Domagoj Vucic
  • Guido Kroemer
  • S Cristofanon
  • I Eckhardt
  • M A Westhoff
  • S Hacker
  • F Rapino
  • A Tchoghandjian
  • C Jennewein
  • S Karl
  • G Strauss
  • B A Abhari
  • Mike Andrew Westhoff
  • L Steinhart
  • F Basit
  • S Löder
  • D von Schweinitz
  • A Bangert
  • I Naumann
  • R Kappler
  • Claudia Jennewein
  • F Rodel
  • Rebecca Berger
  • A Bender
  • Christian Haag
  • D Fabricius
  • S C Lück
  • S H K Vellanki
  • K Stahnke
  • S Rutkowski
  • T Schweitzer
  • J Krauss
  • S M Eckhoff
  • S Giagkousiklidis
  • M Vogler
  • M Kilic
  • N Azoitei
  • K La Ferla-Brühl
  • H Kasperczyk
  • S Momma
  • S Roesler
  • K Rajalingam
  • Patrick Gonzalez
  • K Belz
  • Najmeh Faham
  • Lisa Nonnenmacher
  • Daniela Marx
  • Stefanie Enzenmüller
  • R Humphreys
  • S Kolodziej
  • M Fakler
  • M J M Bertrand
  • N Vanlangenakker
  • J Lausen
  • P Vandenabeele
  • I Jeremias
  • H Schoeneberger
  • B Baumann
  • J Leibacher
  • O Micheau
  • C Rodel
  • I Mader
  • T Sprenger
  • T Liersch
  • L Bullinger
  • Max G Bachem
  • B Jahrsdorfer
  • Silvia Cristofanon
  • Albert C Ludolph
  • Viola Marschall
  • Dominic Stadel
  • L Friedman
  • Sri Harikrishna Vellanki
  • Peter Moller
  • A Vollmer
  • A C Russ
  • L Breckerbohm
  • P Paschka
  • Sabine Karl
  • M Queudeville
  • U Botzenhardt
  • Stephanie Hehlgans

Detail Information

Publications63

  1. ncbi request reprint Molecular pathways: targeting death receptors and smac mimetics
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Clin Cancer Res 20:3915-20. 2014
    ..Such combinations might therefore be of special interest for being included in the ongoing evaluation of Smac mimetics in early clinical trials. Clin Cancer Res; 20(15); 3915-20. ©2014 AACR. ..
  2. ncbi request reprint Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL)
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528, Frankfurt, Germany
    Adv Exp Med Biol 818:167-80. 2014
    ..Further insights into the regulatory mechanisms of TRAIL signaling will help to better understand the determinants of TRAIL sensitivity versus resistance of human cancers. ..
  3. ncbi request reprint Cross talk between cell death regulation and metabolism
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany Electronic address
    Methods Enzymol 542:81-90. 2014
    ....
  4. pmc ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
    S Cristofanon
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 3:e432. 2012
    ..This approach presents a promising strategy for targeting the apoptosis pathways in glioblastoma, which warrants further investigation...
  5. pmc Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
    A Tchoghandjian
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 4:e564. 2013
    ....
  6. pmc How to target apoptosis signaling pathways for the treatment of pediatric cancers
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 3:22. 2013
    ..The challenge in the coming years will be to successfully transfer this knowledge into the development of innovative treatment approaches for children with cancer...
  7. pmc Alternative cell death pathways and cell metabolism
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstraße 3a, 60528 Frankfurt, Germany
    Int J Cell Biol 2013:463637. 2013
    ..A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases...
  8. pmc Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 2:121. 2012
    ..Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers...
  9. pmc Cell death pathways as therapeutic targets in rhabdomyosarcoma
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstraße 3a, 60528 Frankfurt, Germany
    Sarcoma 2012:326210. 2012
    ..This approach will likely open novel perspectives for the treatment of rhabdomyosarcoma...
  10. pmc Targeting apoptosis signaling pathways for anticancer therapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Germany
    Front Oncol 1:23. 2011
    ..This strategy should lead to more effective and individualized treatment strategies that selectively target deregulated signaling pathways in a tumor type- and patient-specific manner...
  11. pmc Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
    L Steinhart
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Cell Death Dis 4:e802. 2013
    ..The identification of a novel synergism of BV6 and demethylating agents has important implications for the development of new treatment strategies for AML...
  12. pmc Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma
    Mike Andrew Westhoff
    Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
    PLoS ONE 8:e83128. 2013
    ....
  13. pmc Regulation of cell death in cancer-possible implications for immunotherapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt Frankfurt, Germany
    Front Oncol 3:29. 2013
    ....
  14. doi request reprint Regulation of apoptosis pathways in cancer stem cells
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Lett 338:168-73. 2013
    ....
  15. doi request reprint Targeting apoptosis pathways in childhood malignancies
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, 60528 Frankfurt Main, Germany
    Cancer Lett 332:369-73. 2013
    ..This strategy is anticipated to open novel perspectives for more effective treatment options for children with cancer...
  16. doi request reprint Modulation of mitochondrial apoptosis by PI3K inhibitors
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Mitochondrion 13:195-8. 2013
    ..Thus, mitochondrial apoptotic events play an important role in PI3K inhibitor-mediated sensitization for apoptosis...
  17. doi request reprint Autophagy and cell death
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Autophagy 8:1250-1. 2012
    ....
  18. doi request reprint Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer
    Simone Fulda
    Goethe University Frankfurt, Institute for Experimental Cancer Research in Pediatrics, Komturstr 3a, 60528 Frankfurt, Germany
    Expert Opin Ther Targets 17:195-201. 2013
    ..Among those is c-FLICE-like inhibitory protein (c-FLIP), a protein that not only blocks apoptosis signaling but also regulates additional cell death pathways...
  19. ncbi request reprint Regulation of cell death and survival by resveratrol: implications for cancer therapy
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Anticancer Agents Med Chem 12:874-9. 2012
    ..Further elucidation of the signaling events that are regulated by resveratrol is anticipated to path the way for the transfer of resveratrol and its derivatives into clinical application for chemoprevention or treatment of human cancers...
  20. ncbi request reprint Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Leukemia 26:1155-65. 2012
    ..As some of these strategies have already entered the stage of clinical evaluation, for example, in leukemia, an update on this promising molecular-targeted strategy to interfere with apoptotic pathways is of broad interest...
  21. ncbi request reprint Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosis
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Frankfurt, Germany
    Exp Cell Res 318:1208-12. 2012
    ..Understanding the molecular mechanism that mediates this synergistic drug interaction will be critical to further optimize this approach in order to successfully translate it into a clinical setting...
  22. ncbi request reprint Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Cancer Treat Rev 38:760-6. 2012
    ..Thus, combination protocols using IAP antagonists together with radiotherapy may pave the avenue to more effective radiation-based treatment options for cancer patients...
  23. doi request reprint Targeting IAP proteins for therapeutic intervention in cancer
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany
    Nat Rev Drug Discov 11:109-24. 2012
    ..This Review provides an update on IAP protein biology as well as current and future perspectives on targeting IAP proteins for therapeutic intervention in human malignancies...
  24. doi request reprint Cell death and survival signaling in oncogenesis
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstrasse 3a, Frankfurt am Main, Germany
    Klin Padiatr 222:340-4. 2010
    ..Hence, a better understanding of the molecular mechanisms that regulate cell death and survival programs in cancer cells is expected to provide the basis for the development of new diagnostic and therapeutic strategies...
  25. pmc Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, 60528 Frankfurt, Germany Simone Fulda
    Oncotarget 2:418-21. 2011
    ..A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib...
  26. doi request reprint Mitochondria as therapeutic targets for the treatment of malignant disease
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt am Main, Germany
    Antioxid Redox Signal 15:2937-49. 2011
    ..Thus, engaging the mitochondrial apoptosis pathway presents an attractive possibility to activate lethal effectors in cancer cells...
  27. ncbi request reprint Resveratrol and derivatives for the prevention and treatment of cancer
    Simone Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, D 60528 Frankfurt, Germany
    Drug Discov Today 15:757-65. 2010
    ..This review provides an overview of key derivatives of resveratrol as cancer therapeutics...
  28. doi request reprint Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
    A Bangert
    University Children s Hospital, Ulm, Germany
    Oncogene 31:4677-88. 2012
    ..Thus, these findings demonstrate that HDACI represent a promising strategy to prime glioblastoma for TRAIL-induced apoptosis by targeting cFLIP...
  29. doi request reprint PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis
    A Bender
    Department of Hematology Oncology, University Children s Hospital, Ulm, Germany
    Oncogene 30:494-503. 2011
    ..Thus, targeting PI3K presents a novel and promising strategy to sensitize neuroblastoma cells for chemotherapy-induced apoptosis, which has important implications for the development of targeted therapies for neuroblastoma...
  30. ncbi request reprint Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
    S Hacker
    University Children s Hospital, Ulm, D 89075, Germany
    Oncogene 28:3097-110. 2009
    ....
  31. ncbi request reprint Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner
    L Wagner
    Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
    Oncogene 32:988-97. 2013
    ..By demonstrating that BV6 primes glioblastoma cells for TMZ in a NF-κB- and RIP1-dependent manner, these findings build the rationale for further (pre)clinical development of Smac mimetics in combination with TMZ...
  32. ncbi request reprint Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy
    K Stahnke
    Department of Pediatrics, University Children's Hospital, Ulm, Germany
    Blood 98:3066-73. 2001
    ....
  33. ncbi request reprint The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair
    M A Westhoff
    University Children s Hospital, Ulm, Germany
    Oncogene 28:3586-96. 2009
    ....
  34. doi request reprint Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
    C Jennewein
    University Children s Hospital, Ulm, Germany
    Oncogene 31:1468-74. 2012
    ..Thus, this study demonstrates for the first time that NF-κB exerts a pro-apoptotic role in TRAIL- and CD95-induced apoptosis in glioblastoma cells by facilitating DISC formation...
  35. doi request reprint Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation
    S Hacker
    University Children s Hospital, Ulm, Germany
    Oncogene 30:2275-81. 2011
    ..These findings have important clinical implications for the design of experimental treatment protocols for medulloblastoma...
  36. doi request reprint Inhibitor of apoptosis proteins in hematological malignancies
    S Fulda
    University Children s Hospital, Ulm University, Ulm, Germany
    Leukemia 23:467-76. 2009
    ..Thus, IAPs present promising targets for the development of new biomarkers and cancer therapeutics in hematological malignancies...
  37. ncbi request reprint 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG
    G Strauss
    University Children s Hospital, Ulm, Germany
    Cell Death Differ 15:332-43. 2008
    ..These results strongly indicate that oxidative damage-induced nuclear translocation of AIF and EndoG in 4-OOH-CY-treated T cells might represent an alternative death pathway in the absence of caspase activity...
  38. ncbi request reprint Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells
    M A Westhoff
    Department of Hematology Oncology, University Children s Hospital, Ulm, Germany
    Oncogene 27:5169-81. 2008
    ....
  39. pmc Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation
    F Rapino
    Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Komturstr 3a, Frankfurt, Germany
    Cell Death Dis 4:e925. 2013
    ..The identification of this antagonistic interaction of Bortezomib and microtubule-targeted drugs has important implications for the design of Bortezomib-based combination therapies. ..
  40. ncbi request reprint Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition
    S Giagkousiklidis
    University Children s Hospital, Ulm, Germany
    Oncogene 26:7006-16. 2007
    ..In conclusion, targeting XIAP, for example by small molecules, is a promising novel approach to enhance radiosensitivity of pancreatic cancer that warrants further investigation...
  41. ncbi request reprint Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation
    N Azoitei
    Department of Internal Medicine I, University of Ulm, and Children s Hospital, Ulm, Germany
    Oncogene 26:6536-45. 2007
    ..TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death...
  42. ncbi request reprint BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways
    F Rapino
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Oncogene 33:1713-24. 2014
    ....
  43. pmc Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
    F Basit
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, Frankfurt 60528, Germany
    Cell Death Differ 20:1161-73. 2013
    ..In conclusion, GX15-070 triggers necroptosis by promoting the assembly of the necrosome on autophagosomes. These findings provide novel insights into the molecular mechanisms of GX15-070-induced non-apoptotic cell death. ..
  44. ncbi request reprint NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition
    K La Ferla-Brühl
    University Children s Hospital, Ulm, Germany
    Oncogene 26:571-82. 2007
    ..Instead, proteasome inhibitors, which enhanced TRAIL-induced apoptosis in an NF-kappaB-independent manner, may open new perspectives to increase the efficacy of TRAIL-based regimens in glioblastoma, which warrants further investigation...
  45. doi request reprint Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses
    D Fabricius
    Department of Pediatrics, University of Ulm, Ulm, Germany
    Leukemia 25:1111-21. 2011
    ..Our results may stimulate the development of novel adoptive T cell transfer approaches for the management of BCP-ALL...
  46. ncbi request reprint The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma
    S Fulda
    University Children s Hospital, Ulm, Germany
    Curr Cancer Drug Targets 9:729-37. 2009
    ..Eventually, PI3K/Akt/mTOR targeting agents may open novel perspectives to improve the poor prognosis of patients with neuroblastoma especially in advanced stages of the disease...
  47. ncbi request reprint The role of survivin for radiation oncology: moving beyond apoptosis inhibition
    F Rodel
    Department of Radiation Therapy and Oncology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Curr Med Chem 18:191-9. 2011
    ..Although these trials do not include radiation therapy at present, survivin inhibitors may represent a novel type of molecular antagonists to improve the effectiveness of radiation therapy or chemoradio-therapy...
  48. ncbi request reprint RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex
    B A Abhari
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Oncogene 32:3263-73. 2013
    ....
  49. pmc Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
    I Eckhardt
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstr 3a, 60528 Frankfurt, Germany
    Cell Death Dis 4:e936. 2013
    ..By identifying DR5 as a critical mediator of Smac mimetic-induced apoptosis, our findings provide novel insights into the determinants that control susceptibility of cancer cells to Smac mimetic. ..
  50. pmc Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB
    A Tchoghandjian
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Komturstrasse 3a, Frankfurt, Germany
    Cell Death Differ 21:735-47. 2014
    ..By identifying a novel role of BV6 in promoting differentiation of GBM CSLCs, these findings provide new insights into Smac mimetic-regulated non-apoptotic functions with important implications for targeting GBM CSLCs. ..
  51. doi request reprint RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
    S Löder
    University Children s Hospital, Ulm, Germany
    Leukemia 26:1020-9. 2012
    ..These data have important implications for developing apoptosis-targeted therapies in childhood leukemia...
  52. ncbi request reprint Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    S Fulda
    University Children s Hospital, Ulm, Germany
    Oncogene 25:4798-811. 2006
    ....
  53. ncbi request reprint Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Oncogene 33:671-6. 2014
    ....
  54. ncbi request reprint Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
    M Kilic
    University Children s Hospital, Ulm, Germany
    Oncogene 26:2027-38. 2007
    ..Thus, hypoxia-inducible genes may represent novel targets for therapeutic intervention in some pediatric tumors, which warrants further investigation...
  55. ncbi request reprint 5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8
    S Fulda
    Department of Hematology Oncology, University Children s Hospital, Ulm, Germany
    Oncogene 25:5125-33. 2006
    ....
  56. doi request reprint Molecular targeted therapies for rhabdomyosarcoma: focus on hedgehog and apoptosis signaling
    S Fulda
    Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt a Main, Germany
    Klin Padiatr 225:115-9. 2013
    ..The development of molecular targeted cancer therapeutics will likely lead to more effective treatment options for patients with RMS...
  57. ncbi request reprint Apoptosis pathways and neuroblastoma therapy
    S Fulda
    University Children s Hospital, Ulm, Germany
    Curr Pharm Des 15:430-5. 2009
    ..Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma...
  58. ncbi request reprint Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
    M Vogler
    University Children s Hospital, Ulm, Germany
    Oncogene 26:248-57. 2007
    ..Thus, our findings for the first time indicate that targeting XIAP represents a promising strategy to enhance the antitumor activity of TRAIL in pancreatic cancer, which has important clinical implications...
  59. doi request reprint Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups
    S C Lück
    Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
    Leukemia 25:1728-38. 2011
    ....
  60. doi request reprint Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
    Christian Haag
    University Children s Hospital, Ulm, Germany
    Gut 60:225-37. 2011
    ..Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated...
  61. doi request reprint NF-κB is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis
    Rebecca Berger
    Department of Neurology, University of Ulm, Ulm, Germany
    Mol Cancer Ther 10:1867-75. 2011
    ..These results have important implications for the development of Smac mimetic-based combination protocols for radiosensitization of glioblastoma...