C Foerch

Summary

Affiliation: Johann Wolfgang Goethe University
Country: Germany

Publications

  1. doi request reprint Abrupt shift of the pattern of diurnal variation in stroke onset with daylight saving time transitions
    Christian Foerch
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Circulation 118:284-90. 2008
  2. ncbi request reprint [Glial fibrillary acidic protein in patients with symptoms of acute stroke : Diagnostic marker of cerebral hemorrhage]
    C Foerch
    Klinik fur Neurologie, Klinikum Goethe Universität, Schleusenweg 2 16, 60528, Frankfurt am Main, Deutschland
    Nervenarzt 85:982-9. 2014
  3. pmc Blood levels of glial fibrillary acidic protein (GFAP) in patients with neurological diseases
    Christoph A Mayer
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 8:e62101. 2013
  4. pmc Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e54203. 2013
  5. doi request reprint A beautiful stroke? A side note on the 75th anniversary of the spectacular death of the French organist and composer Louis Vierne (1870-1937)
    Christian Foerch
    Department of Neurology, Goethe University, DE 60528 Frankfurt am Main, Germany
    Cerebrovasc Dis 34:322-5. 2012
  6. ncbi request reprint Traumatic brain injury during warfarin anticoagulation: an experimental study in mice
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurotrauma 29:1150-5. 2012
  7. doi request reprint Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute stroke
    Christian Foerch
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Clin Chem 58:237-45. 2012
  8. pmc Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice
    Waltraud Pfeilschifter
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Germany
    Exp Transl Stroke Med 3:2. 2011
  9. ncbi request reprint Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Stroke 38:2491-5. 2007
  10. pmc Experimental model of warfarin-associated intracerebral hemorrhage
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Masschusetts 02129, USA
    Stroke 39:3397-404. 2008

Detail Information

Publications43

  1. doi request reprint Abrupt shift of the pattern of diurnal variation in stroke onset with daylight saving time transitions
    Christian Foerch
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Circulation 118:284-90. 2008
    ..To characterize the impact of external clock changes on the rhythmic variation in stroke onset, this parameter was recorded in patients during transition periods into and out of Daylight Saving Time (DST)...
  2. ncbi request reprint [Glial fibrillary acidic protein in patients with symptoms of acute stroke : Diagnostic marker of cerebral hemorrhage]
    C Foerch
    Klinik fur Neurologie, Klinikum Goethe Universität, Schleusenweg 2 16, 60528, Frankfurt am Main, Deutschland
    Nervenarzt 85:982-9. 2014
    ..Other areas of interest for a potential GFAP test include traumatic brain injury and malignant gliomas. ..
  3. pmc Blood levels of glial fibrillary acidic protein (GFAP) in patients with neurological diseases
    Christoph A Mayer
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 8:e62101. 2013
    ..In order to identify potential "specificity gaps" of a future GFAP test used to diagnose intracerebral hemorrhage, we measured GFAP in the blood of a large and rather unselected collective of patients with neurological diseases...
  4. pmc Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e54203. 2013
    ..However, due to potential species differences and the inability of models to fully capture the dynamics of human ICH, caution is warranted when considering the implications of these findings for human therapy...
  5. doi request reprint A beautiful stroke? A side note on the 75th anniversary of the spectacular death of the French organist and composer Louis Vierne (1870-1937)
    Christian Foerch
    Department of Neurology, Goethe University, DE 60528 Frankfurt am Main, Germany
    Cerebrovasc Dis 34:322-5. 2012
    ..From the perspective of a stroke neurologist, a reappraisal of Vierne's medical history and the events that happened during his last concert is presented...
  6. ncbi request reprint Traumatic brain injury during warfarin anticoagulation: an experimental study in mice
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurotrauma 29:1150-5. 2012
    ..Anticoagulation led to higher intracerebral blood volumes, but did not significantly worsen functional outcome. The rapid reversal of anticoagulation may be effective in preventing excess bleeding...
  7. doi request reprint Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute stroke
    Christian Foerch
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Clin Chem 58:237-45. 2012
    ..In this study the diagnostic accuracy of plasma GFAP was determined in a prospective multicenter approach...
  8. pmc Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice
    Waltraud Pfeilschifter
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Germany
    Exp Transl Stroke Med 3:2. 2011
    ..abstract:..
  9. ncbi request reprint Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Stroke 38:2491-5. 2007
    ..We investigated whether elevated pretreatment serum S100B levels predict hemorrhagic transformation (HT) in thrombolyzed patients with stroke...
  10. pmc Experimental model of warfarin-associated intracerebral hemorrhage
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Masschusetts 02129, USA
    Stroke 39:3397-404. 2008
    ..This study describes the development of a mouse model of W-ICH in which hematoma growth and outcomes can be correlated with anticoagulation parameters...
  11. doi request reprint Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: a call to set-up therapeutic studies in the very old
    Christian Foerch
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Stroke 40:1900-2. 2009
    ..The aim of the present analysis was to provide an estimate of the future number of ischemic stroke patients and the fraction thereof receiving tPA...
  12. pmc Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage
    Christian Foerch
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 29:1015-21. 2009
    ..Future studies are needed to assess the therapeutic potential emerging from our finding for human W-ICH...
  13. doi request reprint Left-sided traffic directionality may be the safer "rule of the road" for ageing populations
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Med Hypotheses 73:20-3. 2009
    ..The hemispheric asymmetry of attentional functions and its interference with traffic directionality may be taken into account in future strategies of accident prevention...
  14. pmc Invited article: searching for oracles? Blood biomarkers in acute stroke
    C Foerch
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 73:393-9. 2009
    ..Larger clinical trials are warranted to establish the sensitivity and specificity of biomarkers for routine use in clinical stroke...
  15. doi request reprint Gender imbalances induced by age limits in stroke trials
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neuroepidemiology 35:226-30. 2010
    ..In this study, we model how applying upper age limits will lead to a gender disparity in stroke trials, favouring the inclusion of men rather than women...
  16. pmc Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage
    Frieder Schlunk
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 43:246-9. 2012
    ....
  17. ncbi request reprint Sex disparity in the access of elderly patients to acute stroke care
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Stroke 38:2123-6. 2007
    ..We sought to determine whether sex disparities exist in acute stroke management, particularly with regard to early hospital admission and thrombolytic therapy...
  18. ncbi request reprint Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 35:2160-4. 2004
    ..We investigated whether measurements of serum astroglial protein S100B can predict a malignant course of infarction in acute middle cerebral artery (MCA) occlusion...
  19. ncbi request reprint Difference in recognition of right and left hemispheric stroke
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Lancet 366:392-3. 2005
    ..Difficulties in recognition of symptoms due to right hemispheric stroke challenge efforts to optimise stroke management, particularly in the critical early hours of stroke...
  20. pmc Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke
    C Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 77:181-4. 2006
    ..Biomarkers of stroke are an evolving field of clinical research. A serum marker which can differentiate between haemorrhagic and ischaemic stroke in the very early phase would help to optimise acute stroke management...
  21. pmc Survival and quality of life outcome after mechanical ventilation in elderly stroke patients
    C Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 75:988-93. 2004
    ..Our objective was to determine survival rates, functional outcome, and quality of life (QoL) in stroke patients older than 65 years requiring mechanical ventilation...
  22. pmc S100B as a surrogate marker for successful clot lysis in hyperacute middle cerebral artery occlusion
    C Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 74:322-5. 2003
    ..This study investigated whether the serum kinetic of S100B may serve as a surrogate marker of successful clot lysis and early recanalisation (<6 hours) in hyperacute proximal middle cerebral artery (MCA/M1) occlusion...
  23. ncbi request reprint [Brain infarctions caused by paradoxical embolism during long-distance flights]
    C Foerch
    Klinik fur Neurologie, Johann Wolfgang Goethe Universität Frankfurt am Main
    Dtsch Med Wochenschr 128:196-8. 2003
    ..Over the period of one year three long-distance airline passengers (aged 21, 63, and 64 years) were admitted to our department because of a first-time acute neurological deficit having occurred during their long-distance flights...
  24. ncbi request reprint Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Arch Neurol 62:1130-4. 2005
    ..An easily accessible and valid surrogate marker for interventional stroke trials is needed...
  25. ncbi request reprint Pretreatment with antiplatelet agents is not independently associated with unfavorable outcome in intracerebral hemorrhage
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 37:2165-7. 2006
    ..This study investigated the effect of preexisting antiplatelet therapy on mortality and functional outcome in patients with intracerebral hemorrhage (ICH)...
  26. ncbi request reprint Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction
    Christian Foerch
    Department of Neurology and Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 101:248-54. 2004
    ..The authors sought to determine functional impairment, disability, and health-related quality of life (QOL) outcome in long-term survivors who had undergone this procedure, and tried to identify factors related to functional outcome...
  27. doi request reprint Time trends in systemic thrombolysis in a large hospital-based stroke registry
    O C Singer
    Klinik fur Neurologie, Universitatsklinik, Goethe Universitat, Frankfurt, Deutschland
    Cerebrovasc Dis 33:316-21. 2012
    ..The purpose of this study was to determine changes in systemic thrombolysis rates within an observation period of 7 years following the approval of rtPA therapy in Germany in a large state-wide stroke data set...
  28. doi request reprint Hematoma expansion in experimental intracerebral hemorrhage is not altered by peracute treatment with recombinant tissue plasminogen activator
    W Pfeilschifter
    Goethe University Hospital, Department of Neurology, Frankfurt am Main, Germany Electronic address
    Neuroscience 250:181-8. 2013
    ..This finding needs careful consideration in future translational studies...
  29. pmc Anthropometric approximation of body weight in unresponsive stroke patients
    M W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    J Neurol Neurosurg Psychiatry 78:1331-6. 2007
    ..Instead, weight is estimated visually by the attending physician, but this is known to be inaccurate...
  30. pmc Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review
    B B Thompson
    Department of Neurology, Brown University, Providence, RI, USA
    Neurology 75:1333-42. 2010
    ..We performed a systematic review and meta-analysis to address the hypothesis that pre-ICH APT use is associated with mortality and poor functional outcome following ICH...
  31. ncbi request reprint Mechanisms and markers for hemorrhagic transformation after stroke
    A Rosell
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    Acta Neurochir Suppl 105:173-8. 2008
    ....
  32. ncbi request reprint Effect of early and delayed recanalization on infarct pattern in proximal middle cerebral artery occlusion
    Marek Humpich
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 22:51-6. 2006
    ..To investigate the effect of early (<6 h) versus delayed (>6 h) recanalization on infarct pattern in acute middle cerebral artery (MCA) occlusion...
  33. doi request reprint DESTINY II: DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY II
    Eric Juttler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 6:79-86. 2011
    ..This leads to great uncertainty in everyday clinical practice...
  34. ncbi request reprint Hemicraniectomy as a successful treatment of mass effect in acute disseminated encephalomyelitis
    S von Stuckrad-Barre
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Germany
    Neurology 61:420-1. 2003
  35. ncbi request reprint Relation between relative cerebral blood flow, relative cerebral blood volume, and mean transit time in patients with acute ischemic stroke determined by perfusion-weighted MRI
    Oliver C Singer
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    J Cereb Blood Flow Metab 23:605-11. 2003
    ....
  36. ncbi request reprint Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent
    Timo Kahles
    Department of Neurology, University Hospital, JW Goethe University Frankfurt, Schleusenweg 2 16, ZNN, 60528 Frankfurt Main, Germany
    Vascul Pharmacol 43:254-9. 2005
    ..The results of the present study indicate a major role for thrombus-thrombolytic interaction in focal cerebral ischemia with subsequent increased BBB permeability...
  37. doi request reprint Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke
    Florian Dvorak
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 27:37-41. 2009
    ..The aim of the present study was to characterise the diagnostic window of serum GFAP for differentiating between ICH and IS...
  38. pmc Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats
    Kyung Pil Park
    Neuroprotection Research Laboratory, MGH East 149 2401 Charlestown, MA 02129, USA
    Stroke 40:2836-42. 2009
    ..Here, we examined the temporal profiles of MMP-9 in blood and brain using a rat model of acute focal cerebral ischemia...
  39. ncbi request reprint Early functional recovery and the fate of the diffusion/perfusion mismatch in patients with proximal middle cerebral artery occlusion
    Oliver C Singer
    Department of Neurology, J W Goethe University Frankfurt am Main, Germany
    Cerebrovasc Dis 17:13-20. 2004
    ..The relationship between early neurological recovery, time to recanalization and the salvage of hypoperfused, but not diffusion-restricted tissue was investigated...
  40. ncbi request reprint "Economy class" stroke syndrome
    Christian Foerch
    Neurology 62:1026. 2004
  41. pmc Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage
    Arne Lauer
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Circulation 124:1654-62. 2011
    ..Using different experimental models of ICH, this study compared hematoma volume among DE-treated mice, warfarin-treated mice, and controls...
  42. ncbi request reprint Brain stem infarction caused by proximal internal carotid artery stenosis in a patient with a persisting primitive trigeminal artery
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 22:200-2. 2006
  43. ncbi request reprint Economy class stroke syndrome
    Christian Foerch
    Neurology 59:962-3; author reply 963. 2002