W Jelkmann

Summary

Country: Germany

Publications

  1. ncbi The role of the liver in the production of thrombopoietin compared with erythropoietin
    W Jelkmann
    Institute of Physiology, Medical University of Lubeck, Lubeck, Germany
    Eur J Gastroenterol Hepatol 13:791-801. 2001
  2. ncbi Pitfalls in the measurement of circulating vascular endothelial growth factor
    W Jelkmann
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Clin Chem 47:617-23. 2001
  3. ncbi Use of recombinant human erythropoietin as an antianemic and performance enhancing drug
    W Jelkmann
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Germany
    Curr Pharm Biotechnol 1:11-31. 2000
  4. ncbi Proinflammatory cytokines lowering erythropoietin production
    W Jelkmann
    Institute of Physiology, Medical University of Luebeck, Germany
    J Interferon Cytokine Res 18:555-9. 1998
  5. ncbi Effects of antioxidant vitamins on renal and hepatic erythropoietin production
    W Jelkmann
    Institute of Physiology, University of Lubeck, Germany
    Kidney Int 51:497-501. 1997
  6. ncbi Evidence against a major role for Ca2+ in hypoxia-induced gene expression in human hepatoma cells (Hep3B)
    E Metzen
    Institute of Physiology, Medical University of Lubeck, Germany
    J Physiol 517:651-7. 1999
  7. ncbi Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    T Hellwig-Burgel
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Lubeck, Germany
    Blood 94:1561-7. 1999
  8. ncbi Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats
    S Frede
    Institute of Physiology, University of Bonn, Germany
    Am J Physiol 273:R1067-71. 1997
  9. ncbi Biology of erythropoietin
    W Jelkmann
    Institute of Physiology, Medical University of Luebeck, Germany
    Adv Exp Med Biol 502:169-87. 2001
  10. ncbi Hepatic thrombopoietin mRNA is increased in acute inflammation
    E M Wolber
    Institute of Physiology, Medical University of Luebeck, Germany
    Thromb Haemost 86:1421-4. 2001

Collaborators

  • H Pagel
  • T Hellwig-Burgel
  • E Metzen
  • W Schobersberger
  • M H Klinger
  • E M Wolber
  • D Fuchs
  • A E Wagner
  • J Krajewski
  • J R Thompson
  • W Menzel
  • K F Wagner
  • G Huck
  • J Fandrey
  • D P Stiehl
  • T Hellwig Burgel
  • C Batmunkh
  • E Maiss
  • S Frede
  • D Vasková
  • C D Schoen
  • M M Klerks
  • J Spak
  • S Wetzel
  • D Schumacher
  • D M Katschinski
  • U Gembruch
  • M Gassmann
  • J Hasegawa
  • U Schramm
  • B Meller
  • T Hellwig
  • U Timpe
  • G Himmler
  • R Casper
  • H W Katinger
  • A Brisske
  • D Mattanovich

Detail Information

Publications23

  1. ncbi The role of the liver in the production of thrombopoietin compared with erythropoietin
    W Jelkmann
    Institute of Physiology, Medical University of Lubeck, Lubeck, Germany
    Eur J Gastroenterol Hepatol 13:791-801. 2001
    ..The indications for recombinant human thrombopoietin (rHuTPO) therapy and its impact on transfusion medicine are still under investigation...
  2. ncbi Pitfalls in the measurement of circulating vascular endothelial growth factor
    W Jelkmann
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Clin Chem 47:617-23. 2001
    ..g., in cardiovascular failures, inflammatory diseases, and malignancies. However, there are major quantitative differences in the published results. This review attempts to identify reasons for these disparities...
  3. ncbi Use of recombinant human erythropoietin as an antianemic and performance enhancing drug
    W Jelkmann
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Germany
    Curr Pharm Biotechnol 1:11-31. 2000
    ..Unequivocal methods for detection of rHu-EPO doping still need to be established...
  4. ncbi Proinflammatory cytokines lowering erythropoietin production
    W Jelkmann
    Institute of Physiology, Medical University of Luebeck, Germany
    J Interferon Cytokine Res 18:555-9. 1998
    ..Several other cytokines tested were without effect. Thus, mainly IL-1 and TNF-alpha seem to be responsible for the defect in Epo production in severe systemic and renal inflammatory diseases...
  5. ncbi Effects of antioxidant vitamins on renal and hepatic erythropoietin production
    W Jelkmann
    Institute of Physiology, University of Lubeck, Germany
    Kidney Int 51:497-501. 1997
    ..Preliminary evidence suggests that this effect of vitamin A involves increased mRNA levels of hypoxia-inducible factor 1 alpha (HIF-1 alpha)...
  6. ncbi Evidence against a major role for Ca2+ in hypoxia-induced gene expression in human hepatoma cells (Hep3B)
    E Metzen
    Institute of Physiology, Medical University of Lubeck, Germany
    J Physiol 517:651-7. 1999
    ..05). 5. Our data suggest that the calcium transient and the cytosolic Ca2+ concentration do not play a key role in hypoxia-induced EPO and VEGF production in Hep3B cells...
  7. ncbi Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    T Hellwig-Burgel
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Lubeck, Germany
    Blood 94:1561-7. 1999
    ..Thus, cytokine-induced inhibition of EPO production is not mediated by impairment of HIF-1 function. We propose that HIF-1 may be involved in modulating gene expression during inflammation...
  8. ncbi Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats
    S Frede
    Institute of Physiology, University of Bonn, Germany
    Am J Physiol 273:R1067-71. 1997
    ..Thus mediators of the immune response inhibit renal EPO gene expression in vivo, which is relevant with respect to the impaired synthesis of EPO in inflammatory diseases in humans...
  9. ncbi Biology of erythropoietin
    W Jelkmann
    Institute of Physiology, Medical University of Luebeck, Germany
    Adv Exp Med Biol 502:169-87. 2001
    ..However, the benefits of the administration of rHu-EPO to tumor patients with respect to its positive effects on tumor oxygenation, tumor growth inhibition and support of chemo- and radiotherapy is still debatable ground...
  10. ncbi Hepatic thrombopoietin mRNA is increased in acute inflammation
    E M Wolber
    Institute of Physiology, Medical University of Luebeck, Germany
    Thromb Haemost 86:1421-4. 2001
    ..Thus, reactive thrombocytosis of inflammatory disease might result from an increase in hepatic TPO production. Since platelets are involved in the immune reaction, reactive thrombocytosis may be a mechanism of host defense...
  11. ncbi Erythropoiesis stimulating agents and techniques: a challenge for doping analysts
    W Jelkmann
    Institute of Physiology, University of Luebeck, D 23538 Luebeck, Germany
    Curr Med Chem 16:1236-47. 2009
    ..The prohibited direct EPO gene transfer may become a problem in sports only in the future...
  12. ncbi Effects of neopterin and 7,8-dihydroneopterin on hypoxia-induced renal erythropoietin production
    H Pagel
    Institute of Physiology, Medical University, Lubeck, Germany
    Eur J Haematol 62:341-5. 1999
    ..In vivo, high concentrations of pteridines in renal tissue may aggravate the anaemia of inflammation...
  13. ncbi Dexamethasone impairs hypoxia-inducible factor-1 function
    A E Wagner
    Institute of Physiology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Biochem Biophys Res Commun 372:336-40. 2008
    ..Our study discloses the inhibitory action of GC on HIF-1 dependent gene expression, which may be important with respect to the impaired wound healing in DEX-treated patients...
  14. ncbi Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha
    J Krajewski
    Institute of Physiology, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany
    Cell Mol Life Sci 64:989-98. 2007
    ..We conclude that IL-1beta, at least partially, reduces hypoxia-induced EPO expression by down-regulation of HNF-4alpha...
  15. ncbi Effects of erythropoietin on brain function
    W Jelkmann
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Curr Pharm Biotechnol 6:65-79. 2005
    ..A first clinical trial has shown the neuroprotective effectiveness of the drug in cerebral ischaemia...
  16. ncbi Erythropoietin
    W Jelkmann
    Institute of Physiology, University of Lubeck, Lubeck, Germany
    J Endocrinol Invest 26:832-7. 2003
    ..Therefore, some elite athletes have misused recombinant human Epo (rhEpo), which is a beneficial anti-anemic drug in clinical practice. Indirect and direct methods to detect rhEpo doping have been recently developed...
  17. ncbi Tumor necrosis factor p55 receptor (TNF-RI) mediates the in vitro inhibition of hepatic erythropoietin production
    W Jelkmann
    Institute of Physiology, Medical University of Luebeck, Germany
    Exp Hematol 27:224-8. 1999
    ..Finally, immunoreactive TNF-RI, but not TNF-RII, fragments were measurable in cell culture supernatants. Taken together, these results suggest that the inhibition of hepatic Epo production by TNFalpha is mediated by TNF-RI signaling...
  18. ncbi Subcellular localization of thrombopoietin in human blood platelets and its release upon thrombin stimulation
    M H Klinger
    Department of Anatomy, University of Lubeck, Lubeck, Germany
    Br J Haematol 115:421-7. 2001
    ..Stored immunoreactive TPO is released upon thrombin stimulation, but only to a minor degree...
  19. ncbi Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin
    K F Wagner
    Department of Anesthesiology, The Institute of Physiology, University of Lubeck, Lubeck, Germany
    Blood 97:536-42. 2001
    ..In addition, life expectancy of the tg mice was significantly reduced to 7.4 months. Our findings suggest that severe erythrocytosis per se results in cardiac dysfunction and markedly reduced life span...
  20. ncbi Multiplex RT-PCR detection of four aphid-borne strawberry viruses in Fragaria spp. in combination with a plant mRNA specific internal control
    J R Thompson
    BBA, Institut für Pflanzenschutz im Obstbau, Schwabenheimer Strasse 101, D 69221, Dossenheim, Germany
    J Virol Methods 111:85-93. 2003
    ....
  21. ncbi Detection of four apple viruses by multiplex RT-PCR assays with coamplification of plant mRNA as internal control
    W Menzel
    Institute of Plant Diseases and Plant Protection, University of Hanover, , 30419, Hanover, Germany
    J Virol Methods 99:81-92. 2002
    ..The multiplex RT-PCR assays described are reliable, rapid and sensitive methods for the detection of these viruses, and may replace techniques need commonly like indexing by woody indicators or ELISA...
  22. ncbi Cytosolic Ca(2+) levels and DNA synthesis of human umbilical vein endothelial cell cultures are unresponsive to thrombopoietin treatment
    E Metzen
    Institut of Physiology, Medical Universit of Luebeck, Germany
    Cell Physiol Biochem 11:197-202. 2001
    ..In conclusion, our data demonstrate that HUVECs are neither structurally nor functionally responsive to TPO...
  23. ncbi The complete nucleotide sequence of plum pox virus RNA
    E Maiss
    Biologische Bundesanstalt für Land und Forstwirtschaft, Institut für Viruskrankheiten der Pflanzen, Braunschweig, F R G
    J Gen Virol 70:513-24. 1989
    ..The potential polyadenylation signal from yeast (UAUGU) was found in the 3' non-coding region of PPV-NAT and several other members of the potyvirus group...