Hubertus Jarry

Summary

Country: Germany

Publications

  1. pmc Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Neuroinflammation 9:168. 2012
  2. pmc Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice
    Ba Tiep Nguyen
    Department of Endocrinology, Goettingen University Hospital, Robert Koch Str 40, 37075, Goettingen, Germany
    Genes Nutr 8:383-90. 2013
  3. ncbi request reprint Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones
    Hubertus Jarry
    Klinische und Experimentelle Endokrinologie, Universitätsfrauenklinik Göttingen, Gottingen, Germany
    Planta Med 69:945-7. 2003
  4. ncbi request reprint Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, University of Gottingen, Gottingen, Germany
    Planta Med 73:184-7. 2007
  5. ncbi request reprint Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment
    Hubertus Jarry
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, Göttingen D 37075, Germany
    Toxicology 205:87-93. 2004
  6. ncbi request reprint Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP
    H Jarry
    Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Phytomedicine 12:178-82. 2005
  7. ncbi request reprint In vitro effects of the Cimicifuga racemosa extract BNO 1055
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S31-8. 2003
  8. ncbi request reprint Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal amino acid neurotransmitter concentrations in male rats
    Hubertus Jarry
    Universitätsfrauenklinik Göttingen, Abteilung für klinische und experimentelle Endokrinologie, Gottingen, Germany
    Inhal Toxicol 16:209-15. 2004
  9. ncbi request reprint A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats
    Christiane Schlecht
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    Arch Toxicol 80:656-61. 2006
  10. ncbi request reprint Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Eur J Endocrinol 149:351-62. 2003

Collaborators

Detail Information

Publications68

  1. pmc Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Neuroinflammation 9:168. 2012
    ..In conclusion, physical exercise prior to infection increased survival in a mouse model of bacterial meningitis and stimulated neurogenesis in the dentate gyrus of the hippocampal formation...
  2. pmc Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice
    Ba Tiep Nguyen
    Department of Endocrinology, Goettingen University Hospital, Robert Koch Str 40, 37075, Goettingen, Germany
    Genes Nutr 8:383-90. 2013
    ..Human exposure to dietary genistein supplements may influence cardiac function. ..
  3. ncbi request reprint Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones
    Hubertus Jarry
    Klinische und Experimentelle Endokrinologie, Universitätsfrauenklinik Göttingen, Gottingen, Germany
    Planta Med 69:945-7. 2003
    ..The flavonoid apigenin was isolated and identified as the most active ERss-selective phytoestrogen in VAC. Other isolated compounds were vitexin and penduletin. These data demonstrate that the phytoestrogens in VAC are ERss-selective...
  4. ncbi request reprint Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, University of Gottingen, Gottingen, Germany
    Planta Med 73:184-7. 2007
    ..We report for the first time that a defined compound isolated from CR inhibits the growth of the human prostate cancer cells LNCaP...
  5. ncbi request reprint Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment
    Hubertus Jarry
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, Göttingen D 37075, Germany
    Toxicology 205:87-93. 2004
    ..Application of BP2 for 5 days proved to be a sufficient treatment period to unravel a multi-organic endocrine disrupting activity of this UV screen...
  6. ncbi request reprint Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP
    H Jarry
    Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Phytomedicine 12:178-82. 2005
    ..Thus, it is demonstrated for the first time that CR compounds potently inhibit the growth of human prostate cancer cells in vitro. This anti-proliferative effect may be mediated via the AhR...
  7. ncbi request reprint In vitro effects of the Cimicifuga racemosa extract BNO 1055
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S31-8. 2003
    ..Recently, evidence arose that CR may also contain dopaminergic compounds, which may contribute to the therapeutic activity of the extract...
  8. ncbi request reprint Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal amino acid neurotransmitter concentrations in male rats
    Hubertus Jarry
    Universitätsfrauenklinik Göttingen, Abteilung für klinische und experimentelle Endokrinologie, Gottingen, Germany
    Inhal Toxicol 16:209-15. 2004
    ....
  9. ncbi request reprint A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats
    Christiane Schlecht
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    Arch Toxicol 80:656-61. 2006
    ....
  10. ncbi request reprint Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Eur J Endocrinol 149:351-62. 2003
    ....
  11. ncbi request reprint Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats
    Holger Klammer
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Toxicology 238:192-9. 2007
    ..Thus, our results demonstrate a non-estrogenic interference of OMC within the rodent HPT axis with inadequate feedback response to impaired thyroid hormone status, indicated by decreased serum thyroid hormone and hepatic Dio1 levels...
  12. pmc Effects of chronic genistein treatment in mammary gland, uterus, and vagina
    Guillermo Rimoldi
    Department of Clinical and Experimental Endocrinology, Georg August University, Gottingen, Germany
    Environ Health Perspect 115:62-8. 2007
    ..The uterus and mammary gland are known to be negatively influenced by estrogens used in hormone therapy...
  13. ncbi request reprint Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Germany
    Toxicol Appl Pharmacol 214:1-7. 2006
    ..Many of these effects are not shared by E2. Hence, other than estrogen-receptive mechanisms may be responsible for these effects...
  14. pmc In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol
    Robert Michael Hermann
    Department of Radiotherapy and Radiooncology, University Hospital Goettingen, Robert Koch Str, 40, 37075, Goettingen, Germany
    Radiat Oncol 3:19. 2008
    ..As the majority of prostate cancers (PC) express estrogen receptors, we evaluated the combination of radiation and estrogenic stimulation (estrogen and genistein) on the radiosensitivity of PC cells in vitro...
  15. doi request reprint Long-term treatment of ovariectomized mice with estradiol or phytoestrogens as a new model to study the role of estrogenic substances in the heart
    Ba Tiep Nguyen
    Department of Endocrinology, Medical Faculty of the University of Göttingen, Gottingen, Germany
    Planta Med 78:6-11. 2012
    ..Thus, we speculate that endocrine active compounds, like the isoflavone GEN, which is used as a food additive or as a drug for the treatment of menopausal symptoms, may directly affect heart function...
  16. ncbi request reprint Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats
    Dana Seidlova-Wuttke
    Department of Endocrinology, Georg August University Goettingen, Goettingen, Germany
    Planta Med 75:1279-85. 2009
    ..The CR BNO 1055 did not show any activity pattern which would be similar to the pattern observed under EB or Ral. Therefore the observed effects of CR BNO 1055 in these organs are most likely not estrogenic in nature...
  17. ncbi request reprint Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats
    Holger Klammer
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Toxicology 215:90-6. 2005
    ..In addition to estrogenic actions of OMC, non-estrogenic effects have been found for this chemical supporting the need of a multi-organic risk assessment of putative EACs...
  18. ncbi request reprint Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) r
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, Universitäts Frauenklinik Göttingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Toxicology 213:13-24. 2005
    ..BP2 can be regarded as an estrogenic endocrine active substance whereas the effects of Lin and Proc appear not to involve estrogen receptors...
  19. doi request reprint Beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats
    Dana Seidlova-Wuttke
    Department of Endocrinology, University Medical Center Goettingen, Goettingen, Germany
    Phytomedicine 17:884-9. 2010
    ..Serum CrossLaps was lower in the Ecd and E2 group while serum Osteocalcin levels were decreased in the E2 but increased in the Ecd fed animals. Ecd has an antiosteoporotic effect which does not involve activation of ER...
  20. ncbi request reprint Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?
    Wolfgang Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S9-20. 2003
    ..The question whether soy and red clover products and/or Cimicifuga racemosa (CR) preparations are endocrine disrupters or may fulfill the criteria of the so-called phyto-SERMs will be discussed...
  21. doi request reprint Plant-derived alternative treatments for the aging male: facts and myths
    Wolfgang Wuttke
    Department of Endocrinology, University Medical Center Goettingen, Germany
    Aging Male 13:75-81. 2010
    ..Hence, soy or red clover products containing the mild estrogenic isoflavones with a slightly higher affinity to the estrogen receptor of the beta in comparison to the alpha subtype may prove to have some beneficial effects in males...
  22. doi request reprint Pharmacokinetics and metabolism of benzophenone 2 in the rat
    Christiane Schlecht
    Department of Endocrinology, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Toxicology 245:11-7. 2008
    ..Despite this rapid metabolisation and excretion, the amount of unconjugated BP2 was sufficient to induce a dose dependent estrogenic effect in the uterotrophic assay...
  23. ncbi request reprint Effects of estradiol-17beta, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Gottingen, Germany
    Maturitas 51:177-86. 2005
    ..Therefore, the Cimicifuga racemosa extract BNO 1055 may be useful to prevent osteoporosis in aged male patients with reduced testosterone production...
  24. ncbi request reprint Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats
    Christiane Schlecht
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Toxicology 205:123-30. 2004
    ....
  25. ncbi request reprint Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S39-50. 2003
    ..Whether CR has positive effects on bone and in fat tissue is currently unknown. Therefore, osteoprotective effects of the CR extract BNO 1055 and an influence on fat tissue were studied in ovariectomized rats...
  26. ncbi request reprint Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells
    Paul Thelen
    Department of Urology, Georg August University, Gottingen, Germany
    Planta Med 70:397-400. 2004
    ..These effects underline the possible therapeutic use of silibinin in the management of prostate cancer...
  27. ncbi request reprint Orchidectomized (orx) marmoset (Callithrix jacchus) as a model to study the development of osteopenia/osteoporosis
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Goettingen, Germany
    Am J Primatol 70:294-300. 2008
    ..The results indicate that male orx marmosets become osteopenic within 12 months after castration and may be a more human-like experimental model for bone research...
  28. ncbi request reprint Effects of 5-day styrene inhalation on serum prolactin and dopamine levels and on hypothalamic and striatal catecholamine concentrations in male rats
    Hubertus Jarry
    Abteilung für klinische und experimentelle Endokrinologie, Universitätsfrauenklinik Göttingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Arch Toxicol 76:657-63. 2002
    ..With the limitations inherent in any animal model, we suggest that our data indicate that styrene also has no adverse neuroendocrine effects in humans...
  29. doi request reprint Beneficial effects of beta-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats
    P Kapur
    Division of Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075, Gottingen, Germany
    Phytomedicine 17:350-5. 2010
    ..Hence, TC as well as other Ecd producing plants or pure Ecd may be of value in the prevention and treatment of osteoporosis and osteoarthritis which is of increasing importance due to aging and obesity among individuals...
  30. ncbi request reprint Isoflavones--safe food additives or dangerous drugs?
    Wolfgang Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Ageing Res Rev 6:150-88. 2007
    ..Therefore, the following question arises for the clinician: Why should soy or red clover products containing isoflavone be recommended, if the positive effects are only negligible but the adverse effects serious?..
  31. ncbi request reprint Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?
    Wolfgang Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 61:159-70. 2008
    ..The question whether soy and red clover products and/or Cimicifuga racemosa (CR) preparations are endocrine disrupters or may fulfill the criteria of the so-called phyto-SERMs will be discussed...
  32. doi request reprint Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells
    Silke Kaulfuss
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, Germany
    Mol Endocrinol 22:1606-21. 2008
    ..Leupaxin could function as a putative target for therapeutic interventions of a subset of advanced PCa...
  33. ncbi request reprint Effects of a 5-day treatment with vinclozolin on the hypothalamo-pituitary-gonadal axis in male rats
    Panida Loutchanwoot
    Department of Endocrinology, Faculty of Medicine, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Toxicology 243:105-15. 2008
    ....
  34. ncbi request reprint Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Phytomedicine 11:392-403. 2004
    ..Therefore, tectorigenin may be in the future a clinically useful selective estrogen receptor modulator...
  35. ncbi request reprint Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)--2 filters of UV light - on several uterine, vaginal and bone parameters
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Toxicol Appl Pharmacol 210:246-54. 2006
    ..Taken together, these data indicate a very weak estrogenic effect of OMC and 4MBC in the uterus and in the vagina but not in the bone where 4MBC exerted antiosteoporotic effects by a different mechanism than E2...
  36. doi request reprint Bone development in female rats maintained with soy-free or soy-containing food as determined by computer-assisted tomography and serum bone markers
    Dana Seidlova-Wuttke
    Department of Obstetrics and Gynecology, Division of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Bone Miner Metab 26:321-7. 2008
    ..Raising and keeping female rats under soy-free or soy-containing conditions has marked effects on several bone parameters that are of particular relevance in aged animals...
  37. ncbi request reprint Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Steroid Biochem Mol Biol 86:179-88. 2003
    ..Another possibility may be that the effect of silymarin and therefore possibly also of E2 in the MF may be mediated via other possibly not yet identified receptors or via an ERbeta splice variant which is not detected by our PCR-method...
  38. ncbi request reprint Radiosensitization dependent on p53 function in bronchial carcinoma cells by the isoflavone genistein and estradiol in vitro
    Robert Michael Hermann
    Department of Radiotherapy and Radiooncology, Georg August University, Gottingen, Germany
    Strahlenther Onkol 183:195-202. 2007
    ..Hormones have a different toxicity profile than radiation or cytostatic drugs. As NSCLC often express estrogen receptors (ERs), the combination of genistein or estradiol and radiation in vitro was investigated...
  39. ncbi request reprint Demonstration of a probenecid-inhibitable anion exchanger involved in the release of cortisol and cAMP and in the uptake of p-aminohippurate in bovine adrenocortical cells
    J Steffgen
    Abteilung für Nephrologie und Rheumatologie, Universitat Gottingen, Deutschland
    Cell Physiol Biochem 9:72-80. 1999
    ..In summary, the trans-stimulation and cis-inhibition experiments support the concept of an anion exchanger involved in cortisol and cyclic adenosine monophosphate release from and PAH uptake into adrenocortical cells...
  40. ncbi request reprint Evidence for PACAP to be an autocrine factor on gonadotrope cells
    A Radleff-Schlimme
    Department of Obstetrics and Gynecology, University of Gottingen, Germany
    Ann N Y Acad Sci 865:486-91. 1998
    ..Hence, our data support the hypothesis that PACAP acts as an autocrine regulator on gonadotrope cell function...
  41. ncbi request reprint Synergistic effects of prostaglandin F2alpha and tumor necrosis factor to induce luteolysis in the pig
    W Wuttke
    Department of Obstetrics and Gynecology, University of Gottingen, Germany
    Biol Reprod 58:1310-5. 1998
    ..Under the influence of macrophage-derived TNF production, E2 secretion is inhibited, and thereby PGF2alpha and TNF cause functional luteolysis...
  42. doi request reprint Evaluation of bone quality and quantity in osteoporotic mice--the effects of genistein and equol
    S Sehmisch
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Phytomedicine 17:424-30. 2010
    ..Further studies may combine these techniques with gene manipulation technology to better understand osteoporosis. Treatment with GEN resulted in improved biomechanical results and enhancement of morphologic parameters...
  43. ncbi request reprint Further evidence that preoptic anterior hypothalamic GABAergic neurons are part of the GnRH pulse and surge generator
    H Jarry
    Department of Obstetrics and Gynecology, , FRG
    Acta Endocrinol (Copenh) 118:573-9. 1988
    ..We conclude that these estrogen-respective GABAergic neurons are involved in the generation of GnRH pulses as well as in the generation of the so-called positive feedback effect of E2 on LH release.(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi request reprint Reduction of gamma-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats
    C Roth
    Children s Hospital, University of, Gottingen, Germany
    Neurosci Lett 297:45-8. 2001
    ..7399+/-1048 pM in controls, mean+/-SEM, P<0.05). Radiation induced central precocious puberty might be caused by damage to inhibitory GABAergic neurons leading to premature activation of the GnRH-pulse generator...
  45. ncbi request reprint Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model
    C Roth
    Children s Hospital, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Endocrinol 169:361-71. 2001
    ..We conclude that the ovarian and uterine effects of GnRH analogs must be considered in addition to their known pituitary effects when deciding which GnRH analog is most suitable for treating precocious puberty...
  46. ncbi request reprint GnRH antagonist cetrorelix prevents sexual maturation of peripubertal male rats
    C Roth
    Children s Hospital, University of Gottingen, Germany
    Exp Clin Endocrinol Diabetes 108:358-63. 2000
    ..Conclusion: The GnRH antagonist cetrorelix inhibits the pituitary-gonadal axis in peripubertal male rats and may be effective in treating central precocious puberty in males...
  47. ncbi request reprint Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone
    D Seidlova-Wuttke
    Abt Klin und Exp Endokrinologie, Universitäts Frauenklinik Göttingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Toxicology 205:103-12. 2004
    ..The conclusion: BP2 acts as ERalpha and ERbeta agonist mimicking effects of E2, while the effects of BPA and DBP are not pure estrogenic...
  48. ncbi request reprint Urodynamic effects of estradiol (E2) in ovariectomized (ovx) rats
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Germany
    Endocrine 23:25-32. 2004
    ..It is concluded that estrogen deprivation causes uncoordinated function of the detrusor and sphincter muscles and that this effect can be prevented by estradiol...
  49. ncbi request reprint Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications
    W Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Germany
    Phytomedicine 10:348-57. 2003
    ..Hence, it is concluded that dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome...
  50. ncbi request reprint Phytoestrogens for hormone replacement therapy?
    W Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Steroid Biochem Mol Biol 83:133-47. 2002
    ..Evidence is now available that the yet unknown compounds in Cimicifuga racemosa extracts prevent climacteric complaints and may also have antiosteoporotic effects...
  51. doi request reprint Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice
    Pawel Grzmil
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Reproduction 145:45-56. 2013
    ..We found that Ube2q1 is not expressed in the uterus of non-pregnant females but its expression is up-regulated during pregnancy. Taken together, Ube2q1 is involved in different aspects of female fertility...
  52. ncbi request reprint A norepinephrine-dependent mechanism in the preoptic/anterior hypothalamic area but not in the mediobasal hypothalamus is involved in the regulation of the gonadotropin-releasing hormone pulse generator in ovariectomized rats
    H Jarry
    Department of Obstetrics and Gynecology, , FRG
    Neuroendocrinology 51:337-44. 1990
    ..Brain perfusates were subjected to high-performance liquid chromatography-electrochemical analysis. In blood samples LH concentrations were determined.(ABSTRACT TRUNCATED AT 250 WORDS)..
  53. ncbi request reprint TSPY-LTA transgenic mice develop endocrine tumors of the pituitary and adrenal gland
    Semi Tascou
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Germany
    Mol Cell Endocrinol 200:9-18. 2003
    ..Taken together, our studies provide a novel mouse model for pituitary adenomas displaying a unique combination of hormone expression by tumor cells secreting PRL and ACTH...
  54. doi request reprint miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development
    Ahmet Ucar
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Goettingen, Germany
    Nat Genet 42:1101-8. 2010
    ..Our results identify the miR-212/132 family as one of the main regulators of the epithelial-stromal interactions that are required for proper pubertal development of the mammary gland...
  55. ncbi request reprint 5HT1A-receptor binding in the brain of cyclic and ovariectomized female rats
    G Flugge
    German Primate Centre, Gottingen, Germany
    J Neuroendocrinol 11:243-9. 1999
    ..Since the ventromedial hypothalamic nucleus contains a high number of oestrogen receptive cells, our data indicate that oestrogen up-regulates 5HT1A-receptor expression in this nucleus...
  56. ncbi request reprint In vivo demonstration of a paracrine, inhibitory action of Met-enkephalin on adrenomedullary catecholamine release in the rat
    H Jarry
    Department of Clinical and Experimental Endocrinology, University of Gottingen, West Germany
    Endocrinology 125:624-9. 1989
    ..This is demonstrated by a prolonged catecholamine secretion if opiate receptors are blocked by Nal...
  57. ncbi request reprint Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells
    P Thelen
    Department of Urology, Institute of Human Genetics, Georg August University, Gottingen, Germany
    J Urol 171:1934-8. 2004
    ....
  58. ncbi request reprint Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models
    Christian Roth
    Children s Hospital Medical Center, University of Bonn, Bonn, Germany
    Pediatr Res 55:126-33. 2004
    ..We conclude that GnRH analogue combination and especially antagonist alone treatment most directly suppress gonadotropin levels. This implies that early treatment gonadotropin flare-up associated with agonist treatment is avoidable...
  59. ncbi request reprint The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Endocrinology 148:2835-44. 2007
    ..This new challenge for endocrine regulation must be considered in the context of a still prevailing iodide deficiency in many parts of the world...
  60. ncbi request reprint Endocrine activity and developmental toxicity of cosmetic UV filters--an update
    Margret Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 205:113-22. 2004
    ..Lowest effective doses were 0.24 mg/kg/day for 3-BC and 7 mg/kg/day for 4-MBC. Fat tissue levels at 7 mg/kg 4-MBC (GC-MS) approached the range of UV filters in fish (Nagtegaal et al., 1997; Balmer et al., 2004)...
  61. ncbi request reprint Para/autocrine regulation of estrogen receptors in hippocampal neurons
    Janine Prange-Kiel
    Institute of Anatomy, University of Hamburg, Hamburg, Germany
    Hippocampus 13:226-34. 2003
    ..Our findings provide evidence for a de novo synthesis of estrogens in the hippocampus, differential regulation of estrogen receptor isoforms by estrogen and consequently for a para/autocrine loop of estrogen action in the hippocampus...
  62. ncbi request reprint Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats
    Martina Böttner
    Department of Anatomy, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Endocrinol 189:77-88. 2006
    ..Levels of aryl hydrocarbon receptor (AhR) mRNA in the pituitary were increased following OVX and attenuated by long-term E2 treatment, whereas RES did not modulate AhR mRNA expression...
  63. ncbi request reprint Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors
    Lepu Zhou
    Institute of Anatomy I, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Exp Neurol 203:72-81. 2007
    ..Re-filling of estradiol stores after their depletion due to overexcitation may therefore add to therapeutical strategies in epilepsy...
  64. ncbi request reprint Hippocampal synapses depend on hippocampal estrogen synthesis
    Oliver Kretz
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 24:5913-21. 2004
    ..However, synaptophysin expression was upregulated under these conditions. Our results point to an essential role of endogenous hippocampal estrogen synthesis in the maintenance of hippocampal spine synapses...
  65. ncbi request reprint Dietary quercetin does not affect pituitary lutenizing hormone (LH) expression and has no uterotropic effects in ovariectomized Sprague-Dawley rats
    Dominik Rachon
    Department of Immunology, Medical University of Gdansk, ul Debinki 1, 80 210 Gdansk, Poland
    Food Chem Toxicol 46:513-8. 2008
    ..The aim of this study was to investigate the potency of LH suppression and the uterotrophic effects of quercetin, a flavonoid widely present in our diet which in vitro has been shown to posses estrogenic properties...
  66. ncbi request reprint Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungszentrum EnForCé, Charite, Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Toxicology 205:95-102. 2004
    ....
  67. pmc Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis
    Janine Prange-Kiel
    Institute of Anatomy I Cellular Neurobiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    J Cell Biol 180:417-26. 2008
    ....
  68. pmc Endocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkers
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Environ Health Perspect 115:77-83. 2007
    ..However, this is not reflected adequately in current screening and assessment procedures for endocrine activity that to date determine only general parameters of thyroid function...