Gesine B Jaissle
Tanimoto N, Michalakis S, Weber B, Wahl Schott C, Hammes H, Seeliger M. In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. Adv Exp Med Biol. 2016;854:619-25 pubmed publisher
Seeliger M, Grimm C, Stahlberg F, Friedburg C, Jaissle G, Zrenner E, et al
. New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet. 2001;29:70-4 pubmed
..In general, the dissection of pathophysiological processes in animal models through the introduction of additional, selective mutations is a promising concept in functional genetics. ..
Seeliger M, Brombas A, Weiler R, Humphries P, Knop G, Tanimoto N, et al
. Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision. Nat Commun. 2011;2:532 pubmed publisher
..By specific genetic and pharmacological ablation of key signal processing components, regular cone signalling can be restored, thereby identifying the sites involved in functional rod-cone interactions. ..
Occelli L, Schön C, Seeliger M, Biel M, Michalakis S, Petersen Jones S, et al
. Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa. Hum Gene Ther. 2017;: pubmed publisher
..The AAV8-PDE6A gene supplementation therapy restores rod vision in Pde6a<sup>-/-</sup> puppies and preserves retinal morphology. These positive outcomes are an important step towards a human clinical trial to treat PDE6A-RP...
Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck S, Tanimoto N, et al
. Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43). Hum Gene Ther. 2017;: pubmed publisher
..PDE6A vector developed for use in human patients. Importantly, our data show stable expression and rescue effects for a prolonged period of time, raising hope for future translational studies based on this approach...