Gesine B Jaissle

Summary

Country: Germany

Publications

  1. Tanimoto N, Michalakis S, Weber B, Wahl Schott C, Hammes H, Seeliger M. In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. Adv Exp Med Biol. 2016;854:619-25 pubmed publisher
  2. request reprint
    Seeliger M, Grimm C, Stahlberg F, Friedburg C, Jaissle G, Zrenner E, et al. New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet. 2001;29:70-4 pubmed
    ..In general, the dissection of pathophysiological processes in animal models through the introduction of additional, selective mutations is a promising concept in functional genetics. ..
  3. Seeliger M, Brombas A, Weiler R, Humphries P, Knop G, Tanimoto N, et al. Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision. Nat Commun. 2011;2:532 pubmed publisher
    ..By specific genetic and pharmacological ablation of key signal processing components, regular cone signalling can be restored, thereby identifying the sites involved in functional rod-cone interactions. ..
  4. Occelli L, Schön C, Seeliger M, Biel M, Michalakis S, Petersen Jones S, et al. Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa. Hum Gene Ther. 2017;: pubmed publisher
    ..The AAV8-PDE6A gene supplementation therapy restores rod vision in Pde6a<sup>-/-</sup> puppies and preserves retinal morphology. These positive outcomes are an important step towards a human clinical trial to treat PDE6A-RP...
  5. Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck S, Tanimoto N, et al. Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43). Hum Gene Ther. 2017;: pubmed publisher
    ..PDE6A vector developed for use in human patients. Importantly, our data show stable expression and rescue effects for a prolonged period of time, raising hope for future translational studies based on this approach...